{"id":"https://openalex.org/W4310108046","doi":"https://doi.org/10.1182/blood-2022-167362","title":"Real-World Study of the Use of Iguratimod to Treat Chronic/Refractory ITP","display_name":"Real-World Study of the Use of Iguratimod to Treat Chronic/Refractory ITP","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310108046","doi":"https://doi.org/10.1182/blood-2022-167362"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-167362","doi":"https://doi.org/10.1182/blood-2022-167362","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-167362","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071362089","display_name":"Zhuo\u2010Yu An","orcid":"https://orcid.org/0000-0003-0976-160X","observed_orcids":["https://orcid.org/0000-0003-0976-160X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuo-Yu An","raw_affiliation_strings":["1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of HSCT, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of HSCT, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101488390","display_name":"Yejun Wu","orcid":"https://orcid.org/0000-0003-0134-0333","observed_orcids":["https://orcid.org/0000-0003-0134-0333"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye-Jun Wu","raw_affiliation_strings":["1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of HSCT, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of HSCT, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046348283","display_name":"Yun He","orcid":"https://orcid.org/0000-0002-2818-1953","observed_orcids":["https://orcid.org/0000-0002-2818-1953"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun He","raw_affiliation_strings":["2Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematology Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematology Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054252496","display_name":"Xiaolu Zhu","orcid":"https://orcid.org/0000-0002-2632-7218","observed_orcids":["https://orcid.org/0000-0002-2632-7218","https://orcid.org/0000-0002-9555-7420"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolu Zhu","raw_affiliation_strings":["2Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematology Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematology Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100812599","display_name":"Hai\u2010Xia Fu","orcid":"https://orcid.org/0000-0002-4485-5276","observed_orcids":["https://orcid.org/0000-0002-4485-5276"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haixia Fu","raw_affiliation_strings":["3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046424825","display_name":"Feng\u2010Rong Wang","orcid":"https://orcid.org/0000-0001-6778-1962","observed_orcids":["https://orcid.org/0000-0001-6778-1962"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengrong Wang","raw_affiliation_strings":["4Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051211027","display_name":"Xiao\u2010Dong Mo","orcid":"https://orcid.org/0000-0002-9881-7945","observed_orcids":["https://orcid.org/0000-0002-9881-7945"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Dong Mo","raw_affiliation_strings":["5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320649","display_name":"Yuanyuan Zhang","orcid":"https://orcid.org/0000-0002-3662-4398","observed_orcids":["https://orcid.org/0000-0002-3662-4398"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zhang","raw_affiliation_strings":["3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112199163","display_name":"Wei Han","orcid":"https://orcid.org/0009-0000-0429-266X","observed_orcids":["https://orcid.org/0009-0000-0429-266X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Han","raw_affiliation_strings":["5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108049720","display_name":"Huan Chen","orcid":"https://orcid.org/0009-0003-3022-1840","observed_orcids":["https://orcid.org/0009-0003-3022-1840","https://orcid.org/0009-0006-3833-1990","https://orcid.org/0000-0001-8648-1631"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Chen","raw_affiliation_strings":["5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394234","display_name":"Yao Chen","orcid":"https://orcid.org/0000-0001-5460-0149","observed_orcids":["https://orcid.org/0000-0001-5460-0149"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Chen","raw_affiliation_strings":["3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]},{"raw_affiliation_string":"5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114036036","display_name":"Chen-Hua Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenhua Yan","raw_affiliation_strings":["3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100457613","display_name":"Yu\u2010Hong Chen","orcid":"https://orcid.org/0009-0009-8356-0153","observed_orcids":["https://orcid.org/0009-0009-8356-0153"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Hong Chen","raw_affiliation_strings":["3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]},{"raw_affiliation_string":"5Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101717591","display_name":"Ting\u2010Ting Han","orcid":"https://orcid.org/0000-0001-5047-9249","observed_orcids":["https://orcid.org/0000-0001-5047-9249"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Han","raw_affiliation_strings":["3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068526324","display_name":"Yingjun Chang","orcid":"https://orcid.org/0000-0002-6124-6050","observed_orcids":["https://orcid.org/0000-0002-6124-6050"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingjun Chang","raw_affiliation_strings":["2Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematology Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematology Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035514027","display_name":"Xiang\u2010Yu Zhao","orcid":"https://orcid.org/0000-0002-8139-1773","observed_orcids":["https://orcid.org/0000-0002-8139-1773"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangyu Zhao","raw_affiliation_strings":["6PEKING UNIVERSITY People's HOSPITAL, Beijing, CHN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6PEKING UNIVERSITY People's HOSPITAL, Beijing, CHN","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424031","display_name":"Lan\u2010Ping Xu","orcid":"https://orcid.org/0000-0002-0267-1081","observed_orcids":["https://orcid.org/0000-0002-0267-1081","https://orcid.org/0000-0001-6625-9523"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanping Xu","raw_affiliation_strings":["3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072208411","display_name":"Kai\u2010Yan Liu","orcid":"https://orcid.org/0000-0002-6751-7827","observed_orcids":["https://orcid.org/0000-0002-6751-7827"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaiyan Liu","raw_affiliation_strings":["7Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037029781","display_name":"Xiao\u2010Jun Huang","orcid":"https://orcid.org/0000-0002-2145-6643","observed_orcids":["https://orcid.org/0000-0002-2145-6643","https://orcid.org/0000-0003-1253-7465"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Huang","raw_affiliation_strings":["8Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088505823","display_name":"Xiaohui Zhang","orcid":"https://orcid.org/0000-0002-6513-8604","observed_orcids":["https://orcid.org/0000-0002-6513-8604","https://orcid.org/0000-0003-0245-6792"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Zhang","raw_affiliation_strings":["3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"Supplement 1","first_page":"5567","last_page":"5568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iguratimod","display_name":"iguratimod","score":0.9020000100135803},{"id":"https://openalex.org/keywords/immune-thrombocytopenic-purpura","display_name":"idiopathic thrombocytopenic purpura","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chronic-immune-thrombocytopenic-purpura","display_name":"chronic ITP","score":0.7799999713897705},{"id":"https://openalex.org/keywords/refractory-itp","display_name":"refractory ITP","score":0.9950000047683716},{"id":"https://openalex.org/keywords/platelet-count-response","display_name":"platelet count response","score":0.7310000061988831},{"id":"https://openalex.org/keywords/antiplatelet-antibodies","display_name":"antiplatelet antibodies","score":0.7080000042915344},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.7310000061988831},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cytokine-inhibition","display_name":"cytokine inhibition","score":0.5799999833106995},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6919999718666077},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.44600000977516174},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.4429999887943268},{"id":"https://openalex.org/keywords/autoimmune-disease-treatment","display_name":"autoimmune disease therapy","score":0.39399999380111694},{"id":"https://openalex.org/keywords/bleeding-score","display_name":"bleeding score","score":0.3709999918937683},{"id":"https://openalex.org/keywords/long-term-remission","display_name":"long-term remission","score":0.6499999761581421},{"id":"https://openalex.org/keywords/antiphospholipid-syndrome","display_name":"antiphospholipid syndrome","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7888457179069519},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7414090037345886},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4905780851840973},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.48175740242004395},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4744195342063904},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-167362","doi":"https://doi.org/10.1182/blood-2022-167362","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-167362","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7108711796","https://openalex.org/W4389232162","https://openalex.org/W3095951016","https://openalex.org/W4389232165","https://openalex.org/W4405048332","https://openalex.org/W2997807559","https://openalex.org/W4389246592","https://openalex.org/W2994724058","https://openalex.org/W4386917782","https://openalex.org/W7108645045"],"abstract_inverted_index":{"Introduction:":[0],"Immune":[1],"thrombocytopenia":[2,166],"(ITP)":[3],"is":[4,24,30,130,208,242],"an":[5],"acquired,":[6],"organ-specific,":[7],"autoimmune":[8,206],"disease":[9],"and":[10,46,60,65,72,101,116,128,186,194,213,241,272,300,303,331,335,346,388,412,424,438,452,471,478],"one":[11],"of":[12,41,52,69,93,98,126,160,188,203,219,227,232,246,333,342,361,366,375,379,403,476],"the":[13,39,50,67,96,102,124,184,201,217,225,230,362,377,393,401,427,430,436,474,480],"most":[14,416],"common":[15],"bleeding":[16,344,383],"disorders":[17],"that":[18,29,134,147,176,200],"seriously":[19],"endangers":[20],"human":[21],"health.":[22],"Iguratimod":[23,48,467],"a":[25,34,131,180,324,484],"small":[26],"molecule":[27],"compound":[28],"widely":[31],"used":[32,138],"as":[33,459],"novel":[35],"antirheumatic":[36],"drug":[37],"in":[38,44,79,123,153,167,205,238,327,432,455,473],"treatment":[40,85,187,231,475,486],"rheumatoid":[42,82],"arthritis":[43,83],"China":[45],"Japan.":[47],"inhibits":[49],"production":[51,68,119],"several":[53],"inflammatory":[54],"cytokines,":[55],"including":[56],"IL-1,":[57],"IL-6,":[58],"IL-8,":[59],"tumor":[61],"necrosis":[62],"factor":[63],"(TNF),":[64],"reduces":[66],"immunoglobulins.":[70],"Th1":[71],"Th17":[73],"cell":[74],"counts":[75],"were":[76,250,259,265,275,422,443,464],"significantly":[77],"reduced":[78,420],"patients":[80,154,248,264,274,283,291,296,305,363,380,399,428,442],"with":[81,86,155,169,210,252,354,381,435],"after":[84,287],"iguratimod.":[87],"The":[88,158,235,415,441],"low":[89],"long-term":[90],"remission":[91],"rate":[92],"ITP":[94,170,477],"makes":[95],"investigation":[97],"its":[99],"pathogenesis":[100,125],"search":[103],"for":[104,162,183,254,267,277,487],"new":[105,181,485],"treatments":[106],"important":[107,121],"clinical":[108,143,192],"problems":[109],"to":[110,139,223,293,298,307,369,386,446,482],"be":[111,137,179],"solved.":[112],"Abnormal":[113],"T-cell":[114,173],"function":[115],"anti-platelet":[117,164],"antibody":[118],"play":[120],"roles":[122],"ITP,":[127],"iguratimod":[129,148,161,177,204,228,253],"therapeutic":[132],"agent":[133],"could":[135],"potentially":[136],"treat":[140],"ITP.":[141,189,233,488],"Previous":[142],"studies":[144,193],"have":[145,197],"shown":[146,199],"can":[149],"increase":[150,326],"platelet":[151,319,329,337],"levels":[152],"dry":[156],"syndrome.":[157],"potential":[159,481],"treating":[163],"antibody-mediated":[165],"mice":[168],"by":[171,315,408],"modulating":[172],"differentiation":[174],"suggests":[175],"may":[178],"approach":[182],"prevention":[185],"Recent":[190],"retrospective":[191],"case":[195],"reports":[196],"also":[198],"use":[202,402],"diseases":[207],"associated":[209],"good":[211,469],"safety":[212,472],"efficacy.":[214],"In":[215],"conclusion,":[216],"aim":[218],"this":[220],"study":[221,236,351,394],"was":[222,352],"investigate":[224],"effect":[226],"on":[229],"Methods:":[234],"began":[237],"December":[239],"2020":[240],"ongoing.":[243],"A":[244],"total":[245],"76":[247],"who":[249],"treated":[251,266,276],"at":[255,278,322],"least":[256,279,323],"3":[257,288,373,411],"months":[258,374],"selected.":[260],"Of":[261],"these,":[262],"51":[263],"more":[268],"than":[269],"6":[270,413],"months,":[271],"30":[273],"12":[280],"months.":[281,414],"Five":[282],"withdrew":[284],"from":[285],"observation":[286],"months:":[289],"two":[290],"due":[292,297,306],"NR,":[294],"three":[295],"epidemic":[299],"financial":[301],"reasons,":[302],"no":[304,453],"AE.":[308],"Key":[309],"secondary":[310],"endpoints":[311],"included":[312],"initial":[313],"response":[314],"Day":[316],"14":[317],"(OR,":[318],"count":[320,338],"\u226530\u00d7109/L,":[321],"2-fold":[325],"baseline":[328,391],"count,":[330],"absence":[332],"bleeding;":[334],"CR,":[336],"\u2265":[339],"100\u00d7109/L),":[340],"duration":[341],"response,":[343],"scores,":[345],"adverse":[347],"events":[348],"(AEs).":[349],"This":[350],"registered":[353],"ClinicalTrials.gov":[355],"().":[356],"Results:":[357],"At":[358,396],"baseline,":[359,397],"73.5%":[360],"reported":[364,400],"symptoms":[365,384],"grade":[367],"1":[368],"4":[370],"bleeding.":[371],"After":[372],"treatment,":[376],"proportion":[378],"any":[382],"decreased":[385,407],"61.8%":[387],"remained":[389],"below":[390],"throughout":[392],"period.":[395],"63":[398],"concomitant":[404],"medications,":[405],"which":[406],"36.5%":[409],"between":[410],"frequently":[417],"discontinued":[418],"or":[419,462],"medications":[421],"glucocorticoids":[423],"rituximab.":[425],"All":[426],"took":[429],"medication":[431],"strict":[433],"accordance":[434],"instructions":[437],"medical":[439],"advice.":[440],"monitored":[444],"monthly":[445],"assess":[447],"blood,":[448],"liver,":[449],"kidney":[450],"function,":[451],"abnormalities":[454],"laboratory":[456],"tests,":[457],"such":[458],"elevated":[460],"transaminases":[461],"lymphocytopenia,":[463],"observed.":[465],"Conclusions:":[466],"has":[468,479],"efficacy":[470],"become":[483]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-11-30T00:00:00"}
