{"id":"https://openalex.org/W4310106465","doi":"https://doi.org/10.1182/blood-2022-157981","title":"SETD2 Regulates Nuclear Division to Achieve Polyploidization in Megakaryocyte","display_name":"SETD2 Regulates Nuclear Division to Achieve Polyploidization in Megakaryocyte","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310106465","doi":"https://doi.org/10.1182/blood-2022-157981"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-157981","doi":"https://doi.org/10.1182/blood-2022-157981","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-157981","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100333427","display_name":"Lei Chen","orcid":"https://orcid.org/0000-0001-9668-8708","observed_orcids":["https://orcid.org/0000-0001-9668-8708"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Chen","raw_affiliation_strings":["1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044951727","display_name":"Jingkun Liu","orcid":"https://orcid.org/0000-0002-4566-1465","observed_orcids":["https://orcid.org/0000-0002-4566-1465"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingkun Liu","raw_affiliation_strings":["1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081321231","display_name":"Kunying Chen","orcid":"https://orcid.org/0000-0002-5117-7493","observed_orcids":["https://orcid.org/0000-0002-5117-7493"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kunying Chen","raw_affiliation_strings":["1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030174835","display_name":"Yanxun Su","orcid":"https://orcid.org/0000-0001-8840-1156","observed_orcids":["https://orcid.org/0000-0001-8840-1156"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanxun Su","raw_affiliation_strings":["1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102497475","display_name":"Ying Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Lei","raw_affiliation_strings":["1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070873696","display_name":"Jia Si","orcid":"https://orcid.org/0000-0001-7045-8349","observed_orcids":["https://orcid.org/0000-0001-7045-8349"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jia Si","raw_affiliation_strings":["1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436769","display_name":"Jie Zhang","orcid":"https://orcid.org/0000-0002-5902-3317","observed_orcids":["https://orcid.org/0000-0002-5902-3317","https://orcid.org/0000-0003-0802-0893"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101890244","display_name":"Zhaojun Zhang","orcid":"https://orcid.org/0000-0003-0490-6507","observed_orcids":["https://orcid.org/0000-0003-0490-6507"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaojun Zhang","raw_affiliation_strings":["2CAS Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center of Bioinformation, Beijing, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2CAS Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center of Bioinformation, Beijing, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022404028","display_name":"Weiguo Zou","orcid":"https://orcid.org/0000-0003-2516-0302","observed_orcids":["https://orcid.org/0000-0003-2516-0302"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Weiguo Zou","raw_affiliation_strings":["3Shanghai Institute of Microsurgery On Extremities, and Department of Orthopedic, Shanghai, CHN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Shanghai Institute of Microsurgery On Extremities, and Department of Orthopedic, Shanghai, CHN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108053413","display_name":"Xiaohui Zhang","orcid":"https://orcid.org/0000-0003-4730-256X","observed_orcids":["https://orcid.org/0000-0003-4730-256X","https://orcid.org/0000-0002-2145-6643"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaohui Zhang","raw_affiliation_strings":["4Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007461026","display_name":"Matthew Thomas Rondina","orcid":"https://orcid.org/0000-0003-3455-3730","observed_orcids":["https://orcid.org/0000-0003-3455-3730"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210164726","display_name":"George E. Wahlen Department of VA Medical Center","ror":"https://ror.org/05n5drh21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540","https://openalex.org/I4210164726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew T. Rondina","raw_affiliation_strings":["5George E Wahlen VAMC Geriatric Research and Education Clinical Center, SLC, UT","6Department of Medicine, Division of General Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5George E Wahlen VAMC Geriatric Research and Education Clinical Center, SLC, UT","institution_ids":["https://openalex.org/I4210164726"]},{"raw_affiliation_string":"6Department of Medicine, Division of General Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080950028","display_name":"Qian\u2010Fei Wang","orcid":"https://orcid.org/0000-0002-0086-2626","observed_orcids":["https://orcid.org/0000-0002-0086-2626"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qian-Fei Wang","raw_affiliation_strings":["1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080950028","display_name":"Qian\u2010Fei Wang","orcid":"https://orcid.org/0000-0002-0086-2626","observed_orcids":["https://orcid.org/0000-0002-0086-2626"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian-fei Wang","raw_affiliation_strings":["1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China., Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5022404028","https://openalex.org/A5030174835","https://openalex.org/A5044951727","https://openalex.org/A5070873696","https://openalex.org/A5080950028","https://openalex.org/A5081321231","https://openalex.org/A5100333427","https://openalex.org/A5100436769","https://openalex.org/A5101890244","https://openalex.org/A5102497475","https://openalex.org/A5108053413"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I2801577699","https://openalex.org/I4210124809"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"Supplement 1","first_page":"5730","last_page":"5731"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/setd2","display_name":"SETD2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endomitosis","display_name":"endomitosis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/polyploidization","display_name":"polyploidization","score":0.8259999752044678},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.921999990940094},{"id":"https://openalex.org/keywords/nuclear-division","display_name":"nuclear division","score":0.9079999923706055},{"id":"https://openalex.org/keywords/nucleoplasmic-bridges","display_name":"nucleoplasmic bridges","score":0.8199999928474426},{"id":"https://openalex.org/keywords/microtubule-depolymerization","display_name":"microtubule depolymerization","score":0.8980000019073486},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/platelet-formation","display_name":"platelet formation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cytokinesis","display_name":"cytokinesis","score":0.31700000166893005},{"id":"https://openalex.org/keywords/bone-marrow-megakaryocytes","display_name":"bone marrow megakaryocytes","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cord-blood-cd34-cells","display_name":"cord blood CD34+ cells","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.751786470413208},{"id":"https://openalex.org/C45472230","wikidata":"https://www.wikidata.org/wiki/Q1447198","display_name":"Cytokinesis","level":4,"score":0.7510980367660522},{"id":"https://openalex.org/C145226528","wikidata":"https://www.wikidata.org/wiki/Q1340781","display_name":"Endoreduplication","level":4,"score":0.7360581755638123},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6750122904777527},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.6460742950439453},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5933239459991455},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5001449584960938},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.457329124212265},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.45044082403182983},{"id":"https://openalex.org/C3453395","wikidata":"https://www.wikidata.org/wiki/Q6935034","display_name":"Multipolar spindles","level":5,"score":0.4103715717792511},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3626682758331299},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3334583044052124},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26989856362342834},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.18477296829223633},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.15281668305397034}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-157981","doi":"https://doi.org/10.1182/blood-2022-157981","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-157981","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W196867602","https://openalex.org/W2767020540","https://openalex.org/W2063612625","https://openalex.org/W2066535719","https://openalex.org/W4393167137","https://openalex.org/W7034586302","https://openalex.org/W2016327627","https://openalex.org/W1990974808","https://openalex.org/W2333666017","https://openalex.org/W2979559846"],"abstract_inverted_index":{"Megakaryocytes":[0],"(MKs)":[1],"undergo":[2],"a":[3,81,223,227,286,292,445],"fascinating":[4],"endomitosis":[5,197,247,305,481],"process":[6,26,195],"to":[7,18,45,51,191,221,232,251,321,327,485],"become":[8],"naturally":[9],"large":[10],"multilobulated,":[11],"polyploid":[12],"nuclei":[13],"cells":[14,124,220,234,278],"that":[15,171,262,301,350,375,401,449,457,472,516],"give":[16],"rise":[17],"platelets.":[19],"Two":[20],"key":[21],"steps":[22],"involving":[23],"in":[24,31,86,143,149,226,341,363,424,496,523,534],"this":[25,437],"are":[27,319],"the":[28,104,129,137,144,148,158,193,199,204,216,266,275,280,308,333,342,355,358,380,402,413,433,451,497,500,519,535],"controlled":[29],"failure":[30],"cytokinesis":[32,40],"(cytoplasm":[33],"division)":[34],"and":[35,55,63,84,125,147,337,344,418,513,525],"karyokinesis":[36,296,383,416,501],"(nuclear":[37],"division).":[38],"The":[39],"defect":[41,74,309,381,417,502],"has":[42],"been":[43],"reported":[44],"be":[46,322],"regulated":[47,76],"by":[48,136,202,384,443,463,482],"factors":[49],"related":[50],"abnormal":[52,532],"actomyosin":[53],"ring":[54],"cleavage":[56],"furrow":[57],"formation":[58,141],"such":[59],"as":[60,114,116,291,324,390],"RhoA,":[61],"MYH9":[62],"Rac1.":[64],"In":[65,240,467],"contrast,":[66],"it":[67],"remains":[68],"largely":[69,441],"unknown":[70],"how":[71,183],"nuclear":[72],"division":[73],"is":[75,474],"during":[77,179,503],"MK":[78,419,434,461,480,504],"endomitosis.":[79,505],"Using":[80],"mouse":[82,145],"model":[83,146],"an":[85,173,425,430,475],"vitro":[87,150,524],"differentiation":[88,151],"system,":[89],"we":[90,187,331,399],"found":[91,208,349,400],"SETD2":[92,102,184,209,244,263,273,302,353,366,378,391,473,507],"expression":[93],"markedly":[94],"declined":[95],"when":[96],"MKs":[97,117,133,163,211,512],"underwent":[98],"polyploidization.":[99,420],"Knockdown":[100],"of":[101,107,132,139,156,160,196,214,243,272,277,282,310,335,346,352,357,361,377,382,404,415,427,432,479,499,521],"increased":[103,246,274,368],"high":[105,161,510],"ploidy":[106,131,162,225,438,511],"primary":[108],"bone":[109],"marrow":[110],"(BM)":[111],"murine":[112],"MKs,":[113],"well":[115],"derived":[118],"from":[119],"cultured":[120],"human":[121],"cord-blood":[122],"CD34+":[123],"MEG-01":[126],"cells.":[127],"Furthermore,":[128],"higher":[130,224],"was":[134,165,440],"accompanied":[135],"increase":[138,431,439],"platelet":[140,514],"both":[142],"system.":[152],"With":[153],"forced":[154],"overexpression":[155,242,367],"SETD2,":[157,172],"proportion":[159,356],"(\u22658N)":[164],"remarkably":[166],"decreased.":[167],"These":[168,259,298,372,489],"data":[169,373,455],"suggest":[170,300,374],"\u03b1-tubulin":[174,394],"methyltransferase,":[175],"negatively":[176],"regulates":[177,185,460],"polyploidization":[178,462,533],"megakaryopoiesis.":[180],"To":[181],"investigate":[182],"endomitosis,":[186],"employed":[188],"live-cell":[189],"imaging":[190],"monitor":[192],"whole":[194],"at":[198,395],"single-cell":[200],"level":[201],"observing":[203],"spindle":[205,317,407],"geometry.":[206],"We":[207,348],"deficient":[210],"were":[212,409],"capable":[213],"completing":[215],"endomitotic":[217,267],"cycle,":[218],"allowing":[219],"reach":[222],"significantly":[228,245],"shorter":[229],"time":[230,249],"compared":[231,250],"control":[233,252],"(2.9":[235],"hours":[236,255],"vs.":[237,256],"4.9":[238],"hours).":[239,258],"comparison,":[241],"cycle":[248],"conditions":[253],"(5.2":[254],"4.3":[257],"results":[260,299],"show":[261],"deficiency":[264],"accelerates":[265],"cell":[268],"cycle.":[269],"Moreover,":[270,421],"loss":[271,351,376],"percentage":[276],"within":[279],"presence":[281,343],"nucleoplasmic":[283],"bridges":[284],"(NPBs),":[285],"thin":[287],"DNA":[288],"link":[289],"referred":[290],"characteristic":[293],"structure":[294],"for":[295],"defect.":[297],"may":[303,508],"regulate":[304],"through":[306],"facilitating":[307],"karyokinesis.":[311],"During":[312],"karyokinesis,":[313],"microtubules":[314],"localized":[315],"near":[316,406],"poles":[318,408],"need":[320],"depolymerized":[323,338,359,369,386],"force-generating":[325],"apparatus":[326],"separate":[328],"nuclei.":[329],"Thus,":[330],"measured":[332],"amount":[334],"polymerized":[336],"microtubule":[339,370,387,465,487],"forms":[340],"absence":[345,426],"SETD2.":[347],"decreased":[354],"form":[360],"tubulin":[362,447],"spindles,":[364],"while":[365],"forms.":[371],"promotes":[379],"reducing":[385],"state.":[388],"Mechanistically,":[389],"could":[392,517],"trimethylate":[393],"lysine":[396],"40":[397],"(\u03b1-tubK40me3),":[398],"levels":[403],"\u03b1-TubK40me3":[405,428,459,484],"inversely":[410],"correlated":[411],"with":[412,429,531],"degree":[414],"SETD2-deficiency":[422],"resulted":[423],"ploidy.":[435],"And":[436],"reversed":[442],"overexpressing":[444],"mutant":[446],"protein":[448],"mimics":[450],"\u03b1-tubK40me3.":[452],"Together,":[453],"these":[454],"indicate":[456],"SETD2-mediated":[458],"influencing":[464],"dynamics.":[466,488],"summary,":[468],"our":[469],"study":[470],"reveals":[471],"important,":[476],"novel":[477],"regulator":[478],"regulating":[483],"influence":[486],"findings":[490],"help":[491,526],"fill":[492],"current":[493],"knowledge":[494],"gaps":[495],"mechanism":[498],"Targeting":[506],"improve":[509],"production":[515],"promote":[518],"regeneration":[520],"platelets":[522],"treat":[527],"megakaryocytic":[528],"dysplasia":[529],"diseases":[530],"future.":[536]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2022-11-30T00:00:00"}