{"id":"https://openalex.org/W4310106136","doi":"https://doi.org/10.1182/blood-2022-159562","title":"Sustained Complement C1s Inhibition with Sutimlimab in Patients with Cold Agglutinin Disease Results in Continued Efficacy during Part B of the Randomized Placebo-Controlled Phase 3 Cadenza Study (NCT03347422)","display_name":"Sustained Complement C1s Inhibition with Sutimlimab in Patients with Cold Agglutinin Disease Results in Continued Efficacy during Part B of the Randomized Placebo-Controlled Phase 3 Cadenza Study (NCT03347422)","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310106136","doi":"https://doi.org/10.1182/blood-2022-159562"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-159562","doi":"https://doi.org/10.1182/blood-2022-159562","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-159562","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021867932","display_name":"Alexander Roeth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Roeth","raw_affiliation_strings":["1Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032982255","display_name":"Sigbj\u00f8rn Berentsen","orcid":"https://orcid.org/0000-0002-3425-4653","observed_orcids":["https://orcid.org/0000-0002-3425-4653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sigbj\u00f8rn Berentsen","raw_affiliation_strings":["2Department of Research and Innovation, Haugesund Hospital, Haugesund, NOR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Research and Innovation, Haugesund Hospital, Haugesund, NOR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034535532","display_name":"Wilma Barcellini","orcid":"https://orcid.org/0000-0003-1428-9944","observed_orcids":["https://orcid.org/0000-0003-1428-9944"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Wilma Barcellini","raw_affiliation_strings":["3Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013365708","display_name":"Shirley D\u2019Sa","orcid":"https://orcid.org/0000-0003-0840-3499","observed_orcids":["https://orcid.org/0000-0003-0840-3499"]},"institutions":[{"id":"https://openalex.org/I1340918713","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shirley D'Sa","raw_affiliation_strings":["4UCLH Centre for Waldenstr\u00f6m's Macroglobulinemia and Related Conditions, University College London Hospitals NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4UCLH Centre for Waldenstr\u00f6m's Macroglobulinemia and Related Conditions, University College London Hospitals NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1340918713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080941679","display_name":"Bernd Jilma","orcid":"https://orcid.org/0000-0001-5652-7977","observed_orcids":["https://orcid.org/0000-0001-5652-7977"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Bernd Jilma","raw_affiliation_strings":["5Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056136082","display_name":"Marc Michel","orcid":"https://orcid.org/0000-0002-9822-7400","observed_orcids":["https://orcid.org/0000-0002-9822-7400"]},"institutions":[{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Michel","raw_affiliation_strings":["6Henri-Mondor University Hospital, Assistance Publique-H\u00f4pitaux de Paris, UPEC, Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Henri-Mondor University Hospital, Assistance Publique-H\u00f4pitaux de Paris, UPEC, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I197681013","https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056971594","display_name":"Ilene Ceil Weitz","orcid":"https://orcid.org/0000-0001-8906-1552","observed_orcids":["https://orcid.org/0000-0001-8906-1552"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilene C. Weitz","raw_affiliation_strings":["7Keck School of Medicine of USC, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Keck School of Medicine of USC, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035403921","display_name":"Masaki Yamaguchi","orcid":"https://orcid.org/0000-0003-4177-761X","observed_orcids":["https://orcid.org/0000-0003-4177-761X"]},"institutions":[{"id":"https://openalex.org/I4210119324","display_name":"Ishikawa Prefectural Central Hospital","ror":"https://ror.org/02cv4ah81","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210119324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Yamaguchi","raw_affiliation_strings":["8Ishikawa Prefectural Central Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Ishikawa Prefectural Central Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210119324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001384797","display_name":"Jun\u2010ichi Nishimura","orcid":"https://orcid.org/0000-0001-5026-693X","observed_orcids":["https://orcid.org/0000-0001-5026-693X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-ichi Nishimura","raw_affiliation_strings":["9Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025773174","display_name":"Josephine M. I. Vos","orcid":"https://orcid.org/0000-0003-3229-9556","observed_orcids":["https://orcid.org/0000-0003-3229-9556"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Josephine M.I. Vos","raw_affiliation_strings":["10Department of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018652145","display_name":"Joan Cid","orcid":"https://orcid.org/0000-0001-5445-4508","observed_orcids":["https://orcid.org/0000-0001-5445-4508"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joan Cid","raw_affiliation_strings":["11Apheresis & Cellular Therapy Unit, Department of Hemotherapy and Hemostasis, ICMHO, IDIBAPS, Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Apheresis & Cellular Therapy Unit, Department of Hemotherapy and Hemostasis, ICMHO, IDIBAPS, Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090178709","display_name":"Michael Storek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Storek","raw_affiliation_strings":["12Sanofi, Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Sanofi, Cambridge,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nancy Wong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy Wong","raw_affiliation_strings":["12Sanofi, Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Sanofi, Cambridge,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039248631","display_name":"Ronnie Yoo","orcid":"https://orcid.org/0009-0009-8826-6404","observed_orcids":["https://orcid.org/0009-0009-8826-6404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronnie Yoo","raw_affiliation_strings":["13Sanofi, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Sanofi, Boston, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100693671","display_name":"Jennifer P Wang","orcid":"https://orcid.org/0000-0002-2556-9100","observed_orcids":["https://orcid.org/0000-0002-2556-9100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Wang","raw_affiliation_strings":["12Sanofi, Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Sanofi, Cambridge,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006872020","display_name":"Deepthi S. Vagge","orcid":"https://orcid.org/0009-0000-9537-992X","observed_orcids":["https://orcid.org/0009-0000-9537-992X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deepthi Vagge","raw_affiliation_strings":["14IQVIA, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14IQVIA, Bangalore, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059101355","display_name":"Marek Ward\u0119cki","orcid":"https://orcid.org/0000-0003-4188-2647","observed_orcids":["https://orcid.org/0000-0003-4188-2647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marek Wardecki","raw_affiliation_strings":["15Sanofi, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Sanofi, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080379216","display_name":"Frank E. Shafer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111804","display_name":"Sanofi (United States)","ror":"https://ror.org/027vj4x92","country_code":"US","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Shafer","raw_affiliation_strings":["16Sanofi, Bridgewater,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16Sanofi, Bridgewater,","institution_ids":["https://openalex.org/I4210111804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michelle Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111804","display_name":"Sanofi (United States)","ror":"https://ror.org/027vj4x92","country_code":"US","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Lee","raw_affiliation_strings":["16Sanofi, Bridgewater,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16Sanofi, Bridgewater,","institution_ids":["https://openalex.org/I4210111804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031024904","display_name":"Catherine M. Broome","orcid":"https://orcid.org/0000-0003-1507-2851","observed_orcids":["https://orcid.org/0000-0003-1507-2851"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine M. Broome","raw_affiliation_strings":["17Division of Hematology, MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17Division of Hematology, MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2802534011"]}]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.383,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51245924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"140","issue":"Supplement 1","first_page":"2825","last_page":"2827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cold-agglutinin-disease","display_name":"cold agglutinin disease","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sutimlimab","display_name":"sutimlimab","score":0.9929999709129333},{"id":"https://openalex.org/keywords/complement-c1","display_name":"complement C1","score":0.625},{"id":"https://openalex.org/keywords/autoimmune-hemolytic-anemia","display_name":"autoimmune hemolytic anemia","score":0.8389999866485596},{"id":"https://openalex.org/keywords/long-term-efficacy-and-safety","display_name":"long-term efficacy and safety","score":0.6129999756813049},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hemolysis-markers","display_name":"hemolysis markers","score":0.7950000166893005},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.5270000100135803},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.621999979019165},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6650000214576721},{"id":"https://openalex.org/keywords/open-label-extension","display_name":"open-label extension","score":0.6209999918937683},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6700000166893005},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2777884830","wikidata":"https://www.wikidata.org/wiki/Q3961632","display_name":"Cold agglutinin disease","level":4,"score":0.8613837957382202},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7018569707870483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6752187609672546},{"id":"https://openalex.org/C2910849039","wikidata":"https://www.wikidata.org/wiki/Q3606543","display_name":"Cold Agglutinin","level":3,"score":0.5707956552505493},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.48398399353027344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45513641834259033},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4381648302078247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3560619354248047},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.325626939535141},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.24377533793449402},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15529277920722961},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1480642855167389},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.09455007314682007},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.09310975670814514},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-159562","doi":"https://doi.org/10.1182/blood-2022-159562","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-159562","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400764939","https://openalex.org/W4385707594","https://openalex.org/W3211965020","https://openalex.org/W4389246640","https://openalex.org/W4385698180","https://openalex.org/W4378640301","https://openalex.org/W4281636030","https://openalex.org/W2950910845","https://openalex.org/W4310161863","https://openalex.org/W4400749133"],"abstract_inverted_index":{"Background:":[0],"Cold":[1],"agglutinin":[2],"disease":[3],"(CAD)":[4],"is":[5,21],"a":[6,22,106,495,511,592,603,658,679],"rare":[7],"chronic":[8],"autoimmune":[9],"hemolytic":[10,67,187],"anemia":[11],"characterized":[12],"by":[13,31,261,526,561],"classical":[14],"complement":[15],"pathway":[16],"(CP)-mediated":[17],"hemolysis.":[18],"Sutimlimab":[19],"(SUT)":[20],"first-in-class":[23],"humanized":[24],"monoclonal":[25],"antibody":[26],"that":[27,443],"prevents":[28],"CP":[29,441,634],"activation":[30],"selectively":[32],"inhibiting":[33],"C1s;":[34],"both":[35],"the":[36,44,77,90,156,171,206,219,244,274,302,306,336,368,400,409,418,447,482,527,562,610,624,688],"alternative":[37],"and":[38,61,69,80,133,148,188,198,213,230,259,283,289,305,311,331,339,356,430,437,457,474,557,647,668,676,690],"lectin":[39],"pathways":[40],"remain":[41],"intact.":[42],"In":[43,98,293,488],"randomized,":[45],"double-blind,":[46],"placebo-controlled":[47],"Part":[48,92,99,140,146,160,224,228,232,238,277,294,354,359,377,392,397,467,472,480,489,505,600,698],"A":[49,141,229,278,355,393,468],"(26":[50],"weeks)":[51],"of":[52,71,82,95,108,193,252,256,276,318,435,440,449,477,513,518,566,580,594,605,609,645,653,666],"Phase":[53],"3":[54],"CADENZA,":[55],"SUT":[56,83,123,151,264,288,303,337,351,375,401,464,478,525,560,615,686,695],"treatment":[57,84,208,265,352,465,629,696],"resulted":[58],"in":[59,64,85,185,223,297,301,314,335,353,358,367,376,382,391,396,399,417,427,452,459,466,471,479,504,541,599,663,682,697],"rapid":[60,310],"sustained":[62,300,357,395,643,677],"improvements":[63,296,652],"hemoglobin":[65],"(Hb),":[66],"markers":[68],"quality":[70],"life":[72],"(QoL).":[73],"Aims:":[74],"To":[75],"report":[76],"long-term":[78],"safety":[79,660],"efficacy":[81,253],"patients":[86,102,138,221,242,366,493,500,509,544,684],"with":[87,103,234,350,433,463,545,591,612,630],"CAD":[88,104],"from":[89,182],"open-label":[91],"B":[93,147,378,398],"extension":[94],"CADENZA.":[96],"Methods:":[97],"A,":[100,225],"eligible":[101,143],"without":[105],"history":[107,593],"recent":[109],"blood":[110,199],"transfusion":[111],"(\u22641":[112],"during":[113,118],"previous":[114],"12":[115],"months;":[116],"0":[117,132],"last":[119,157,172],"6":[120],"months),":[121],"received":[122,494],"or":[124,583],"placebo":[125],"(PBO)":[126],"through":[127,446],"intravenous":[128],"infusions":[129],"on":[130,671],"Days":[131],"7,":[134],"then":[135],"biweekly.":[136],"All":[137],"completing":[139,237],"were":[142,299,327,363,394,469,539,553,587,673],"to":[144,165,248,414,524,559,619,623,649,678,694],"enter":[145],"receive":[149],"biweekly":[150],"for":[152,287,365,549],"\u22651":[153,496,502],"year":[154],"after":[155],"patient":[158,590],"completed":[159,227],"A.":[161],"Efficacy":[162,178],"data":[163,202],"up":[164],"Week":[166,321,407,424],"79":[167,322],"as":[168,170,522,555],"well":[169],"available":[173],"patients'":[174],"values":[175],"are":[176],"reported.":[177,574,588],"endpoints":[179],"included":[180],"change":[181],"baseline":[183],"(BL)":[184],"Hb,":[186,428],"pharmacodynamic":[189],"markers,":[190],"Functional":[191],"Assessment":[192],"Chronic":[194],"Illness":[195],"Therapy":[196],"(FACIT)-Fatigue,":[197],"transfusions.":[200],"Safety":[201],"was":[203,279,348,444,520,573,616],"recorded":[204],"throughout":[205,687],"study;":[207],"emergent":[209],"adverse":[210],"event":[211],"(TEAE)":[212],"serious":[214,578],"TEAE":[215,503],"(TESAE).":[216],"Results:":[217],"Of":[218],"42":[220],"enrolled":[222],"39":[226],"entered":[231],"B,":[233,295,473,481,490],"32":[235],"(82.1%)":[236],"B;":[239,360],"7":[240],"(17.9%)":[241,508],"discontinued":[243],"study":[245,689],"prematurely,":[246],"due":[247,618],"TESAE":[249,517,565,604,621],"(n=1),":[250],"lack":[251],"(n=3),":[254],"withdrawal":[255,260],"consent":[257],"(n=2)":[258],"sponsor":[262],"(n=1).":[263],"rapidly":[266,674],"improved":[267],"Hb":[268,272,298,315,325,638],"levels;":[269],"mean":[270,323,383,410,453,637],"(SE)":[271,324],"at":[273,320,406,423],"end":[275,448],"11.51":[280],"(0.40)":[281,285],"g/dL":[282,286,330,334],"9.43":[284],"PBO":[290,598],"groups,":[291,341],"respectively.":[292],"group":[304,308,370,403,420,484],"ex-PBO":[307,340,369,419,483],"saw":[309],"comparable":[312,415,486],"increases":[313,458],"upon":[316,475],"initiation":[317,476],"SUT;":[319],"levels":[326,416,461,639],"11.86":[328],"(0.54)":[329],"11.76":[332],"(0.58)":[333],"only":[338,402],"respectively":[342],"(Panel":[343,379],"A).":[344],"Mean":[345],"total":[346,512],"bilirubin":[347,646],"normalized":[349],"similar":[361,680],"decreases":[362],"observed":[364,390,462,540],"when":[371],"they":[372],"started":[373],"receiving":[374],"B).":[380],"Improvements":[381,426,662],"[SE]":[384],"FACIT-Fatigue":[385,411,431,654],"scores":[386],"(BL:":[387],"32.96":[388],"[1.79])":[389],"(44.31":[404],"[2.19]":[405],"87);":[408],"score":[412],"increased":[413],"(41.40":[421],"[2.71]":[422],"87).":[425],"bilirubin,":[429],"correlated":[432],"normalization":[434,644],"C4":[436],"near-complete":[438],"inhibition":[439,665],"activity,":[442],"maintained":[445,470,636],"treatment.":[450],"Reductions":[451],"absolute":[454],"reticulocyte":[455],"count":[456],"haptoglobin":[460],"reached":[485],"levels.":[487],"9":[491],"(23.1%)":[492],"transfusion.":[497],"Thirty-six":[498],"(92.3%)":[499],"experienced":[501,510,602],"B.":[506,699],"Seven":[507],"11":[514],"TESAEs;":[515],"one":[516],"hypertension":[519],"assessed":[521,554],"related":[523],"investigator.":[528],"Thromboembolic":[529],"events":[530,552,579],"(transient":[531],"ischemic":[532],"attack":[533],"[n=1];":[534],"deep":[535],"vein":[536],"thrombosis":[537],"[n=1])":[538],"2":[542],"(5.1%)":[543],"underlying":[546],"risk":[547],"factors":[548],"thromboembolism.":[550],"Both":[551],"non-serious":[556],"unrelated":[558],"Investigator.":[563],"One":[564,589],"infection":[567,570],"(urinary":[568],"tract":[569],"Grade":[571],"\u22653)":[572],"No":[575],"meningococcal":[576],"infections,":[577],"hypersensitivity,":[581],"anaphylaxis":[582],"systemic":[584],"lupus":[585],"erythematosus":[586],"tobacco":[595],"use":[596],"(received":[597],"A)":[601],"squamous":[606],"cell":[607],"carcinoma":[608],"lung":[611],"fatal":[613],"outcome.":[614],"withdrawn":[617],"this":[620],"prior":[622],"patient's":[625],"death.":[626],"Conclusion:":[627],"Long-term":[628],"SUT,":[631],"an":[632],"anti-C1s":[633],"inhibitor,":[635],">11":[640],"g/dL,":[641],"achieved":[642,675],"led":[648],"clinically":[650],"meaningful":[651],"scores,":[655],"while":[656],"maintaining":[657],"favourable":[659,669],"profile.":[661],"anemia,":[664],"hemolysis":[667],"effects":[670],"QoL":[672],"extent":[681],"those":[683,691],"administered":[685],"who":[692],"switched":[693],"Figure":[700],"1View":[701,704],"largeDownload":[702,705],"PPTFigure":[703],"PPT":[706],"Close":[707],"modal":[708]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-11-30T00:00:00"}