{"id":"https://openalex.org/W4310106092","doi":"https://doi.org/10.1182/blood-2022-165785","title":"Sex Dimorphism in the Bone Marrow Niche Contributes to Gender Difference in Mouse Hematopoiesis","display_name":"Sex Dimorphism in the Bone Marrow Niche Contributes to Gender Difference in Mouse Hematopoiesis","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310106092","doi":"https://doi.org/10.1182/blood-2022-165785"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-165785","doi":"https://doi.org/10.1182/blood-2022-165785","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-165785","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101506871","display_name":"Xiaojing Cui","orcid":"https://orcid.org/0000-0003-0330-7772","observed_orcids":["https://orcid.org/0000-0003-0330-7772"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaojing Cui","raw_affiliation_strings":["1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112582928","display_name":"Bowen Yan","orcid":"https://orcid.org/0000-0003-4730-6763","observed_orcids":["https://orcid.org/0000-0003-4730-6763"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bowen Yan","raw_affiliation_strings":["2Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685684","display_name":"Cuiping Zhang","orcid":"https://orcid.org/0000-0001-6255-4373","observed_orcids":["https://orcid.org/0000-0001-6255-4373"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cuiping Zhang","raw_affiliation_strings":["1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112860802","display_name":"Xinghui Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinghui Zhao","raw_affiliation_strings":["1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619675","display_name":"Jinpeng Liu","orcid":"https://orcid.org/0000-0003-4100-0237","observed_orcids":["https://orcid.org/0000-0003-4100-0237"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinpeng Liu","raw_affiliation_strings":["3Markey Cancer Center, University of Kentucky, Lexington, KY","4Department of Internal Medicine, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Markey Cancer Center, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"raw_affiliation_string":"4Department of Internal Medicine, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078924265","display_name":"Daheng He","orcid":"https://orcid.org/0000-0003-0399-2466","observed_orcids":["https://orcid.org/0000-0003-0399-2466"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daheng He","raw_affiliation_strings":["3Markey Cancer Center, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Markey Cancer Center, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342205","display_name":"Chi Wang","orcid":"https://orcid.org/0000-0001-8984-4995","observed_orcids":["https://orcid.org/0000-0001-8984-4995"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi Wang","raw_affiliation_strings":["3Markey Cancer Center, University of Kentucky, Lexington, KY","4Department of Internal Medicine, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Markey Cancer Center, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"raw_affiliation_string":"4Department of Internal Medicine, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781093","display_name":"Daohong Zhou","orcid":"https://orcid.org/0000-0002-2400-6461","observed_orcids":["https://orcid.org/0000-0002-2400-6461","https://orcid.org/0000-0002-7771-6299"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daohong Zhou","raw_affiliation_strings":["5Department of Biochemistry & Structural Biology, University of Texas Health at San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Biochemistry & Structural Biology, University of Texas Health at San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031985832","display_name":"Ying Liang","orcid":"https://orcid.org/0000-0003-4533-5472","observed_orcids":["https://orcid.org/0000-0003-4533-5472","https://orcid.org/0000-0002-2384-1676"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Liang","raw_affiliation_strings":["1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23502954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"Supplement 1","first_page":"5768","last_page":"5769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sexual-dimorphism","display_name":"sexual dimorphism","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lsk-cells","display_name":"LSK cells","score":0.703000009059906},{"id":"https://openalex.org/keywords/hematopoietic-engraftment","display_name":"hematopoietic engraftment","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hsc-quiescence","display_name":"HSC quiescence","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hsc-apoptosis","display_name":"HSC apoptosis","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7895331978797913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7893368005752563},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6608650088310242},{"id":"https://openalex.org/C105083479","wikidata":"https://www.wikidata.org/wiki/Q181497","display_name":"Sexual dimorphism","level":2,"score":0.6406123638153076},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6157022714614868},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.610866129398346},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5930061340332031},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.5715998411178589},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4997725486755371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42587709426879883},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41349613666534424},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3529120981693268},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1640883982181549},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14990517497062683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11197581887245178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.049345970153808594}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-165785","doi":"https://doi.org/10.1182/blood-2022-165785","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-165785","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/10","score":0.4000000059604645,"display_name":"Reduced inequalities"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4406664927","https://openalex.org/W4312330427","https://openalex.org/W4399389425","https://openalex.org/W4283020464","https://openalex.org/W4398177325","https://openalex.org/W6960538345","https://openalex.org/W2084319477","https://openalex.org/W7171535965","https://openalex.org/W202292150","https://openalex.org/W323114195"],"abstract_inverted_index":{"Sex":[0],"dimorphism":[1,81,569],"can":[2,405],"be":[3,599],"found":[4,183,513,551],"in":[5,14,21,24,53,58,91,94,165,193,197,246,393,399,447,496,519,523,547,557,562,573,603,610],"hematopoietic":[6,18,206,435,572,587],"stem":[7,137,339],"and":[8,33,88,98,113,120,133,178,187,220,225,231,249,304,311,317,333,370,373,484,550,577,589,623],"progenitor":[9,51],"cells,":[10],"as":[11,13,475,477],"well":[12],"the":[15,47,74,95,209,227,275,283,292,325,343,348,374,433,441,448,454,462,520,532,558,600],"development":[16],"of":[17,49,67,135,217,331,385,494,503,535,541,593,608,617],"lineages,":[19],"resulting":[20,164,561],"sexual":[22],"dimorphisms":[23],"normal":[25,45,78,571],"hematopoiesis.":[26],"Furthermore,":[27,60],"males":[28],"are":[29,342,438],"at":[30,324],"higher":[31,65,118,131,392,615],"risk":[32],"have":[34,63,103,255],"a":[35,64,459,491,574,583,605],"worse":[36],"prognosis":[37],"for":[38,258,409,586],"most":[39,349],"hematologic":[40],"malignancies":[41],"than":[42,57,70,106,123,140,196,242,261,359,397],"females.":[43],"Under":[44],"conditions,":[46],"number":[48,134,384],"circulating":[50],"cells":[52,115,138,158,190,224,228,239,245,303,308,335,340,364,471],"women":[54],"is":[55,82,280,413,458],"lower":[56,121,606],"men.":[59],"female":[61,89,107,141,156,162,175,179,188,198,221,232,243,250,262,310,360,371,400,524,548],"mice":[62,93,102,129,313,355],"rate":[66],"HSC":[68,259,410,621],"division":[69],"male":[71,87,101,124,128,154,160,172,186,194,202,218,230,248,253,269,272,312,354,369,394,403,425,478,497,528,611],"mice.":[72,108,142,236,361],"However,":[73],"molecular":[75,294],"mechanism":[76,442,602],"underlying":[77,293,443,601],"hematopoiesis":[79,90],"sex":[80,351,417,568,595],"largely":[83],"unknown.":[84],"We":[85,143,182,421,437,488,543],"compared":[86,526],"C57BL/6":[92],"steady":[96],"state":[97],"discovered":[99,423],"that":[100,184,201,268,398,424,465,490,514,552],"more":[104,256,357,428,501],"HSCs":[105],"Female":[109,470],"LSK":[110,125,302,363],"(Lineage-,":[111,314],"Sca-1+,":[112],"cKit+)":[114],"also":[116],"had":[117,130],"apoptosis":[119],"quiescence":[122],"cells.":[126,479],"Additionally,":[127],"percentage":[132],"mesenchymal":[136],"(MSC)":[139,341],"then":[144,366],"conducted":[145],"two":[146],"sex/gender":[147],"mismatch":[148,418],"transplantation":[149,167,211,287,419],"experiments.":[150],"First,":[151],"we":[152,213,296,512],"injected":[153,226],"or":[155,161],"BM":[157,223],"into":[159,229],"recipients,":[163,199],"four":[166],"groups":[168],"(male":[169],"to":[170,173,176,180,271,500,527,531,614],"male,":[171,177],"female,":[174],"female).":[181],"both":[185,247],"donor":[189,238,244,270],"engraft":[191,240],"better":[192,205,241,290,407,584],"recipients":[195,254,273],"suggesting":[200],"niche":[203,344,450],"provides":[204],"engraftment.":[207],"In":[208,566],"secondary":[210],"setting,":[212],"mixed":[214],"equal":[215],"numbers":[216],"(CD45.1)":[219],"(CD45.2)":[222],"CD45.1/CD45.2":[233],"chimeric":[234],"recipient":[235],"Male":[237,580],"recipients.":[251,263],"Consistently,":[252],"support":[257,408,585],"regeneration":[260],"Altogether,":[264],"these":[265],"data":[266],"suggest":[267],"produce":[274],"best":[276],"engraftment":[277,588,622],"outcome.":[278],"This":[279],"consistent":[281,414],"with":[282,347,353,368,415],"clinic":[284],"bone":[285,305],"marrow":[286,306],"result.":[288,420],"To":[289],"understand":[291],"mechanism,":[295],"performed":[297],"single-cell":[298],"RNA":[299],"sequencing":[300],"on":[301,320,453,461],"stromal":[307,334,396],"from":[309],"CD45-,":[315],"Ter119-,":[316],"CD71-).":[318],"Based":[319],"gene":[321,460,486],"expression":[322,446,540,592,616],"profiling":[323],"single":[326],"cell":[327,575],"level,":[328],"different":[329],"populations":[330],"HSPCs":[332],"were":[336,365],"clustered.":[337],"Mesenchymal":[338],"cellular":[345],"component":[346],"significant":[350],"difference,":[352],"having":[356],"MSCs":[358,404,498,525,549,581],"The":[362,383],"co-cultured":[367],"MSCs,":[372,529],"cobblestone":[375],"colony":[376],"formation":[377],"(CAFC)":[378],"was":[379,390,516,555],"assessed":[380],"over":[381],"time.":[382],"CAFC":[386],"day":[387],"35":[388],"colonies":[389],"significantly":[391],"MSC":[395,426,612],"MSCs.":[401],"Therefore,":[402],"thus":[406,505,538],"function,":[411],"which":[412,430,604,619],"our":[416],"further":[422],"secrete":[427],"Cxcl12,":[429,618],"may":[431,598],"underlie":[432],"increased":[434,533,556,563],"regeneration.":[436,590],"currently":[439],"investigating":[440],"Cxcl12":[444,507,521,559,564],"differential":[445],"male/female":[449],"by":[451],"focusing":[452],"Kdm5c":[455,457,495,515,546],"gene.":[456],"X":[463],"chromosome":[464],"has":[466],"escaped":[467],"Xist":[468],"inactivation.":[469],"therefore":[472],"express":[473],"twice":[474],"much":[476],"It":[480],"specifically":[481],"demethylates":[482],"H3K4me3/me2":[483],"inhibits":[485],"transcription.":[487,508],"hypothesize":[489],"low":[492],"level":[493,534,607],"leads":[499,613],"methylation":[502],"H3K4me3,":[504,537],"increasing":[506],"By":[509],"using":[510],"Chip-qPCR,":[511],"highly":[517],"enriched":[518],"promoter":[522],"leading":[530],"demethylated":[536],"reducing":[539],"Cxcl12.":[542],"next":[544],"knockdown":[545],"methylated":[553],"H3K4me3":[554],"promotor,":[560],"expression.":[565],"conclusion,":[567],"affects":[570],"intrinsic":[576],"extrinsic":[578],"mechanism.":[579],"provide":[582],"Differential":[591],"Kdm5c,":[594],"chromosome-specific":[596],"gene,":[597],"KDM5C":[609],"promotes":[620],"maintenance.":[624]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-11-30T00:00:00"}