{"id":"https://openalex.org/W4310103732","doi":"https://doi.org/10.1182/blood-2022-159617","title":"Targeting IDH1-Mutated Pre-Leukemic Hematopoietic Stem Cells in Myeloid Disease, Including CCUS and AML","display_name":"Targeting IDH1-Mutated Pre-Leukemic Hematopoietic Stem Cells in Myeloid Disease, Including CCUS and AML","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310103732","doi":"https://doi.org/10.1182/blood-2022-159617"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-159617","doi":"https://doi.org/10.1182/blood-2022-159617","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-159617","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081722419","display_name":"Niklas Landberg","orcid":"https://orcid.org/0000-0001-6752-6507","observed_orcids":["https://orcid.org/0000-0001-6752-6507"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niklas Landberg","raw_affiliation_strings":["1Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Lund, Sweden","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069712978","display_name":"Thomas K\u00f6hnke","orcid":"https://orcid.org/0000-0001-7454-6282","observed_orcids":["https://orcid.org/0000-0001-7454-6282"]},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Koehnke","raw_affiliation_strings":["2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090254870","display_name":"Yusuke Nakauchi","orcid":"https://orcid.org/0000-0002-6943-3811","observed_orcids":["https://orcid.org/0000-0002-6943-3811"]},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yusuke Nakauchi","raw_affiliation_strings":["2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042159998","display_name":"Amy C. Fan","orcid":"https://orcid.org/0000-0003-1612-1862","observed_orcids":["https://orcid.org/0000-0003-1612-1862"]},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Fan","raw_affiliation_strings":["2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036834903","display_name":"Daiki Karigane","orcid":"https://orcid.org/0000-0002-4017-5193","observed_orcids":["https://orcid.org/0000-0002-4017-5193"]},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daiki Karigane","raw_affiliation_strings":["2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087476873","display_name":"Dani\u00e8l Thomas","orcid":"https://orcid.org/0000-0002-0837-1231","observed_orcids":["https://orcid.org/0000-0002-0837-1231"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Daniel Thomas","raw_affiliation_strings":["3Adelaide Medical School, University of Adelaide,, The University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Adelaide Medical School, University of Adelaide,, The University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074919402","display_name":"Ravindra Majeti","orcid":"https://orcid.org/0000-0002-5814-0984","observed_orcids":["https://orcid.org/0000-0002-5814-0984"]},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravindra Majeti","raw_affiliation_strings":["2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.3635,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.62118595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"140","issue":"Supplement 1","first_page":"2234","last_page":"2235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/idh2-mutation","display_name":"IDH2 mutation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/clonal-cytopenia-of-undetermined-significance","display_name":"clonal cytopenia of undetermined significance","score":0.9909999966621399},{"id":"https://openalex.org/keywords/2-hydroxyglutarate","display_name":"2-hydroxyglutarate","score":0.8970000147819519},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.6119999885559082},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.675661563873291},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6028299331665039},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6023759245872498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5927078127861023},{"id":"https://openalex.org/C2776059313","wikidata":"https://www.wikidata.org/wiki/Q21116031","display_name":"IDH2","level":5,"score":0.5788476467132568},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5416783094406128},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.536762535572052},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5258660316467285},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5232973694801331},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4649336040019989},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4451253116130829},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.4436529278755188},{"id":"https://openalex.org/C2483381","wikidata":"https://www.wikidata.org/wiki/Q18030194","display_name":"NPM1","level":5,"score":0.42633068561553955},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3385685980319977},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33352336287498474},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.30402958393096924},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.1492660939693451},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12660104036331177},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.11541682481765747},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-159617","doi":"https://doi.org/10.1182/blood-2022-159617","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-159617","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389671533","https://openalex.org/W4401077678","https://openalex.org/W4385658524","https://openalex.org/W4410597204","https://openalex.org/W4405042130","https://openalex.org/W2560968765","https://openalex.org/W2588158263","https://openalex.org/W2078635416","https://openalex.org/W2581722981","https://openalex.org/W4310106120"],"abstract_inverted_index":{"Introduction:":[0],"Mutations":[1],"in":[2,12,20,66,99,230,241,280,361,468,503,516],"isocitrate":[3],"dehydrogenase":[4],"1":[5],"(IDH1)":[6],"and":[7,15,131,144,150,180,199,206,225,233,261,273,367,399,420,437,445,473,496],"IDH2":[8,132,221,262],"have":[9,290,508],"been":[10],"reported":[11],"clonal":[13,243],"hematopoiesis":[14],"are":[16,73],"recurrent,":[17],"early":[18],"events":[19],"the":[21,38,44,64,67,88,109,237,271,343,348,359,369,405,427,497],"development":[22,39],"of":[23,32,40,46,63,85,90,112,245,250,276,372,434,471],"acute":[24],"myeloid":[25],"leukemia":[26],"(AML).":[27],"A":[28],"subsequent":[29,169],"stepwise":[30],"acquisition":[31],"additional":[33],"genetic":[34],"aberrations":[35],"leads":[36],"to":[37,94,96,117,201,215,289,296,320,334,404,412],"frank":[41],"leukemia.":[42],"At":[43],"time":[45,89],"AML":[47,100,192,401,517],"diagnosis,":[48],"rare":[49,124],"pre-leukemic":[50,125,522],"hematopoietic":[51,79,142],"stem":[52,80,143],"cells":[53,81,116,146,158,252,285,409],"(pHSC)":[54],"can":[55,482],"be":[56,318],"detected":[57],"containing":[58],"some,":[59],"but":[60,265],"not":[61,501],"all,":[62],"mutations":[65,449,495],"corresponding":[68],"leukemia,":[69],"although":[70],"these":[71,115,123,251],"pHSCs":[72,86,185,390,436,485],"phenotypically":[74],"indistinguishable":[75],"from":[76,186,191,391,396],"residual":[77,438],"wildtype":[78,137,439,456,472],"(HSC).":[82],"The":[83,479],"frequency":[84],"at":[87],"diagnosis":[91],"is":[92,491,500],"known":[93,344],"correlate":[95],"overall":[97],"survival":[98],"patients":[101,193],"(Corces":[102],"et":[103,306],"al,":[104,307],"Nat":[105],"Genet":[106],"2016),":[107],"indicating":[108],"potential":[110,509],"relevance":[111],"therapeutically":[113,322],"targeting":[114],"prevent":[118],"relapse.":[119],"Methods:":[120],"To":[121,327,383],"model":[122],"cells,":[126],"we":[127,330,388],"introduced":[128],"IDH1":[129,218,259,337,340,398,455,494],"R132H":[130,219,260,284,324,366,378],"R140Q":[133,222,263],"mutants":[134],"or":[135,220,339,351,418],"their":[136],"counterparts":[138],"into":[139],"human":[140],"CD34+":[141,212],"progenitor":[145],"(HSPC)":[147],"using":[148,450],"CRISPR/Cas9":[149],"AAV6-mediated":[151],"homology":[152],"directed":[153],"repair":[154],"(HDR).":[155],"Successfully":[156],"edited":[157],"were":[159,194,286,410,443],"then":[160],"sorted":[161,389,428],"by":[162,197,208,303,365],"FACS":[163,198],"based":[164],"on":[165],"GFP":[166],"expression":[167],"for":[168,423,447,493],"analyses":[170,269],"including":[171],"2HG":[172,224],"quantification,":[173],"colony":[174,203,231,362,379,424],"formation,":[175],"differentiation":[176,234],"capacity,":[177,235],"RNA":[178],"sequencing,":[179],"metabolic":[181,293,312],"assays.":[182],"Additionally,":[183],"primary":[184,397],"diagnostic":[187,392],"bone":[188,393],"marrow":[189,394],"aspirates":[190],"also":[195],"isolated":[196],"subjected":[200,411],"treatment,":[202],"formation":[204,232,363,380],"assays,":[205],"genotyping":[207],"ddPCR.":[209],"Results:":[210],"Human":[211],"HSPCs":[213,332],"engineered":[214,333],"express":[216,335],"either":[217],"produced":[223],"showed":[226],"a":[227,297,354,432,469],"striking":[228],"reduction":[229],"recapitulating":[236],"cytopenic":[238],"phenotype":[239,406],"observed":[240],"IDH-mutated":[242],"cytopenia":[244],"undetermined":[246],"significance":[247],"(CCUS).":[248],"RNA-seq":[249],"revealed":[253,270],"large":[254],"transcriptomic":[255],"changes":[256],"shared":[257],"between":[258],"mutations,":[264],"gene":[266],"set":[267],"enrichment":[268],"specific":[272,492],"significant":[274],"downregulation":[275],"oxidative":[277],"phosphorylation-related":[278],"genes":[279],"R132H-mutated":[281],"cells.":[282,326],"These":[283,311,408,506],"further":[287,384],"confirmed":[288],"lower":[291],"basal":[292],"activity":[294],"coupled":[295],"higher":[298],"mitochondrial":[299],"dependency":[300],"as":[301,353,518,520,525],"determined":[302],"SCENITH":[304],"(Arg\u00fcello":[305],"Cell":[308],"Metab":[309],"2021).":[310],"alterations":[313],"suggested":[314],"that":[315,453],"it":[316],"might":[317],"possible":[319],"selectively":[321],"target":[323],"mutated":[325],"evaluate":[328],"this,":[329],"treated":[331],"GFP,":[336],"wildtype,":[338],"R132H,":[341],"with":[342,414],"mutant-specific":[345],"inhibitor":[346],"ivosidenib,":[347,416],"OXPHOS-inhibitor":[349,480],"IACS-010759,":[350],"DMSO":[352],"control.":[355],"Strikingly,":[356],"ivosidenib":[357,487],"restored":[358],"defect":[360],"conferred":[364],"increased":[368],"total":[370],"number":[371],"colonies":[373,442,457,475],"whereas":[374,463,486],"IACS-010759":[375,419,461,481],"effectively":[376],"inhibited":[377],"(Figure":[381,476],"1A).":[382],"investigate":[385],"this":[386],"vulnerability,":[387],"samples":[395,402],"IDH2-mutated":[400,504],"according":[403],"CD45dimCD3-CD19-CD20-CD34+CD38-CD99-TIM3-.":[407],"treatment":[413,462],"DMSO,":[415],"enasidenib,":[417],"subsequently":[421],"plated":[422],"formation.":[425],"Because":[426],"cell":[429],"population":[430],"contained":[431],"mixture":[433,470],"mutant":[435,474],"HSCs,":[440],"all":[441,464],"picked":[444],"genotyped":[446],"IDH":[448],"ddPCR,":[451],"revealing":[452],"only":[454],"grew":[458],"out":[459],"after":[460],"other":[465],"conditions":[466,523],"resulted":[467],"1B).":[477],"Conclusions:":[478],"eradicate":[483],"IDH1-mutated":[484,521],"cannot.":[488],"This":[489],"effect":[490,499],"same":[498],"seen":[502],"pHSCs.":[505],"results":[507],"clinical":[510],"implications":[511],"when":[512],"considering":[513],"therapeutic":[514],"options":[515],"well":[519],"such":[524],"CCUS.":[526],"Figure":[527],"1View":[528,531],"largeDownload":[529,532],"PPTFigure":[530],"PPT":[533],"Close":[534],"modal":[535]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-11-30T00:00:00"}
