{"id":"https://openalex.org/W4310103499","doi":"https://doi.org/10.1182/blood-2022-162361","title":"Metabolic Biomarkers Affecting Cell Proliferation and Prognosis in Polycythemia Vera","display_name":"Metabolic Biomarkers Affecting Cell Proliferation and Prognosis in Polycythemia Vera","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310103499","doi":"https://doi.org/10.1182/blood-2022-162361"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-162361","doi":"https://doi.org/10.1182/blood-2022-162361","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-162361","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100745990","display_name":"Ziqing Wang","orcid":"https://orcid.org/0000-0003-0982-309X","observed_orcids":["https://orcid.org/0000-0003-0982-309X"]},"institutions":[{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqing Wang","raw_affiliation_strings":["1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080065732","display_name":"Yan Lv","orcid":"https://orcid.org/0000-0001-7387-7477","observed_orcids":["https://orcid.org/0000-0001-7387-7477"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Lv","raw_affiliation_strings":["2China Academy of Chinese Medical Sciences, Beijing, CHN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2China Academy of Chinese Medical Sciences, Beijing, CHN","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020413986","display_name":"Erpeng Yang","orcid":"https://orcid.org/0000-0002-4353-3101","observed_orcids":["https://orcid.org/0000-0002-4353-3101"]},"institutions":[{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erpeng Yang","raw_affiliation_strings":["3Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Scie, Beijing, CHN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Scie, Beijing, CHN","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044474957","display_name":"Yujin Li","orcid":"https://orcid.org/0000-0003-1103-3273","observed_orcids":["https://orcid.org/0000-0003-1103-3273"]},"institutions":[{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujin Li","raw_affiliation_strings":["3Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Scie, Beijing, CHN","4Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, CHN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Scie, Beijing, CHN","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"4Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, CHN","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088797740","display_name":"Dehao Wang","orcid":"https://orcid.org/0000-0002-3767-862X","observed_orcids":["https://orcid.org/0000-0002-3767-862X"]},"institutions":[{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dehao Wang","raw_affiliation_strings":["5Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, CHN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, CHN","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100775185","display_name":"Yumeng Li","orcid":"https://orcid.org/0000-0002-9986-5201","observed_orcids":["https://orcid.org/0000-0002-9986-5201","https://orcid.org/0009-0002-8833-8884","https://orcid.org/0009-0004-0201-258X"]},"institutions":[{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yumeng Li","raw_affiliation_strings":["3Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Scie, Beijing, CHN","4Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, CHN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Scie, Beijing, CHN","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"4Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, CHN","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046650801","display_name":"Weiyi LIU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyi LIU","raw_affiliation_strings":["6Xiyuan Hospital, China Academy of Chinese Medical Sciences, BEIJING, CHN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Xiyuan Hospital, China Academy of Chinese Medical Sciences, BEIJING, CHN","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009049596","display_name":"Mingqian Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingqian Sun","raw_affiliation_strings":["1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088351805","display_name":"Xiaomei Hu","orcid":"https://orcid.org/0000-0002-7955-7041","observed_orcids":["https://orcid.org/0000-0002-7955-7041"]},"institutions":[{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hu Xiaomei","raw_affiliation_strings":["7XiYuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7XiYuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210127599","https://openalex.org/I4210141683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20643742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"Supplement 1","first_page":"3015","last_page":"3016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serum-metabolomics","display_name":"serum metabolomics","score":0.5910000205039978},{"id":"https://openalex.org/keywords/metabolic-biomarkers","display_name":"metabolic biomarkers","score":0.9509999752044678},{"id":"https://openalex.org/keywords/jak2-mutation","display_name":"JAK2 mutation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/sphingolipid-metabolism","display_name":"sphingolipid metabolism","score":0.9240000247955322},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.8619999885559082},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7170000076293945},{"id":"https://openalex.org/keywords/glutamine-and-glutamate-metabolism","display_name":"glutamine and glutamate metabolism","score":0.7369999885559082},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.5799999833106995},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8029999732971191},{"id":"https://openalex.org/keywords/metabolic-pathway-enrichment","display_name":"metabolic pathway enrichment","score":0.41999998688697815},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.8485748767852783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4706522524356842},{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.459308922290802},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44160059094429016},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3511989414691925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34220588207244873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3308371901512146},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-162361","doi":"https://doi.org/10.1182/blood-2022-162361","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-162361","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2903749170","https://openalex.org/W1967929647","https://openalex.org/W2280077426","https://openalex.org/W2298406731","https://openalex.org/W4254731314","https://openalex.org/W1543124619","https://openalex.org/W1935306343","https://openalex.org/W2983094663","https://openalex.org/W46251904","https://openalex.org/W2469439755"],"abstract_inverted_index":{"Background":[0],"Polycythemia":[1],"vera":[2],"(PV)":[3],"is":[4,24,39],"a":[5,40,118,378,529,596],"malignant":[6,44],"clonal":[7],"hematological":[8],"disease":[9],"of":[10,17,26,30,43,46,52,59,66,110,121,125,135,155,197,201,265,299,445,478,508,526,531,535,545,559,575,578,591,601],"hematopoietic":[11],"stem":[12],"cells":[13,448],"characterized":[14],"by":[15],"proliferation":[16,45,271,444],"peripheral":[18,32,67,446],"blood":[19,33,68,350,447],"cells,":[20,48],"and":[21,57,75,113,140,147,169,218,227,231,240,252,283,294,309,329,349,357,376,386,388,409,417,421,431,439,467,500,533,550,580],"JAK2":[22,292,338,347,364,370,383,437,584],"mutation":[23,348],"one":[25],"the":[27,50,55,107,122,126,132,136,152,187,198,202,263,291,315,320,344,443,454,473,476,483,497,503,538,573,576,581,588,599],"main":[28],"causes":[29],"PV":[31,60,74,111,156,167,273,354,366,372,450,458,579],"cell":[34,37,270,351],"proliferation.":[35],"Abnormal":[36],"metabolism":[38,53,251,255],"new":[41],"feature":[42],"tumor":[47],"but":[49],"role":[51],"in":[54,106,138,191,259,272,314,319,353,363,369,449,482,562],"pathogenesis":[56,577],"prognosis":[58,561,600],"remains":[61],"unclear.":[62],"Methods":[63],"Metabolic":[64],"profiling":[65],"sera":[69],"from":[70,145],"32":[71],"patients":[72,112,157,168,367,373,459,563],"with":[73,87,214,281,337,405,415,436,515,528,564],"20":[76],"HCs":[77],"was":[78,93,520],"performed":[79,117,194],"using":[80],"liquid":[81],"chromatography-mass":[82],"spectrometry":[83],"(LC-MS).":[84],"Partial":[85],"least-squares":[86],"latent":[88],"structure":[89],"discriminant":[90],"analysis":[91,120,196],"(PLS-DA)":[92],"used":[94,491,554],"for":[95,277,572,598],"data":[96,144],"analysis.":[97],"Results":[98],"To":[99,185,261],"assess":[100],"whether":[101],"there":[102,207],"were":[103,158,174,208,256,311,334,360,402,412,486],"significant":[104,379],"changes":[105],"metabolic":[108,123,189,199,211,267,557],"profiles":[109,124],"healthy":[114],"controls,":[115],"we":[116,162,193,275,342,396,426],"multifactorial":[119],"two":[127],"groups.":[128,296],"Figure":[129,603],"1":[130],"shows":[131],"score":[133],"plots":[134],"PLS-DA":[137],"positive":[139,146,380],"negative":[141,148],"modes.":[142],"Both":[143],"modes":[149],"suggested":[150],"that":[151,287,398,428],"serum":[153],"metabolites":[154,165,279,286,481,514],"significantly":[159,257,289,312,361,487],"changed.":[160],"Subsequently,":[161],"identified":[163,176],"endogenous":[164,278,480,513],"between":[166,290,346,382,583],"HCs.":[170],"These":[171],"potential":[172,509,556,589],"biomarkers":[173,499,510,558,590],"eventually":[175],"as":[177,555],"fatty":[178,245],"acids,":[179,183],"acylcarnitine,":[180],"sphingolipids,":[181],"amino":[182,253],"etc.":[184],"clarify":[186],"abnormal":[188],"pathways":[190,200,212],"PV,":[192,215],"enrichment":[195],"biomarkers.":[203],"The":[204,297],"results":[205],"showed":[206],"9":[209],"important":[210,570],"associated":[213,280,435],"namely:":[216],"D-glutamine":[217],"D-glutamate":[219],"metabolism,":[220,222,224,229,233,235,247,249],"sphingolipid":[221,250],"pyruvate":[223],"alanine,":[225],"aspartate":[226],"glutamate":[228],"arginine":[230,238],"proline":[232],"tryptophan":[234],"lysine":[236],"degradation,":[237],"biosynthesis":[239],"glycolysis/gluconeogenesis":[241],"(Figure":[242],"2).":[243],"Therefore,":[244,425,542],"acid":[246,254],"glucose":[248],"altered":[258],"PV.":[260,565,602],"explore":[262],"effect":[264],"JAK2-associated":[266],"abnormalities":[268],"on":[269],"patients,":[274],"screened":[276],"JAK2,":[282],"found":[284,377,397,521],"7":[285],"differed":[288],"mutated":[293,365],"unmutated":[295,371],"levels":[298,333,359,390,401,411,477,544],"Cer(d18:2/22:6-2OH(7S,":[300,325,399,429,546],"17S)),":[301,547],"SM(d18:0/PGF1\u03b1),":[302,548],"CerP(d18:1/16:0),":[303],"glutamic":[304],"acid,":[305,307],"lactic":[306],"melibiose":[308],"xylose":[310],"higher":[313,362],"JAK2-mutated":[316],"group":[317,465,469,485],"than":[318,368],"JAK2-unmutated":[321],"group.":[322],"Among":[323],"them,":[324],"17S))":[326,400,430],"(r=0.817;":[327],"P<0.001)":[328],"SM(d18:0/PGF1\u03b1)":[330,410,432],"(r=0.463;":[331],"P=0.021)":[332],"positively":[335,403,413],"correlated":[336,404,414],"mutational":[339,384],"burden.":[340],"Then":[341],"evaluated":[343],"relationship":[345,582],"count":[352],"patients.":[355,451],"PLT":[356,389,418],"HCT":[358],"(P=0.006;":[374],"P=0.044)":[375],"correlation":[381],"burden":[385],"WBC":[387,406,416],"(r=0.62,":[391],"P=0.001;":[392],"r=0.55,":[393],"P=0.007).":[394],"Finally,":[395],"(r=0.650,":[407],"P<0.001),":[408],"(r=0.444,":[419],"P=0.011":[420],"r=0.623;":[422],"P<0.001,":[423],"respectively).":[424],"speculate":[427],"are":[433],"closely":[434],"mutations":[438],"may":[440,594],"contribute":[441],"to":[442,453,472,495,522],"According":[452],"prognostic":[455],"point":[456],"system,":[457],"can":[460],"be":[461,553],"divided":[462],"into":[463],"low-risk":[464,474],"(n=11)":[466],"intermediate/high-risk":[468,484],"(n=21).":[470],"Compared":[471],"group,":[475],"8":[479],"elevated.":[488],"We":[489],"next":[490],"binary":[492],"logistic":[493],"regression":[494],"analyze":[496],"combined":[498],"then":[501],"determine":[502],"ROC":[504],"curve.":[505],"A":[506],"set":[507],"containing":[511],"four":[512],"an":[516,524,569],"AUC":[517,525],">":[518],"0.77":[519],"provide":[523,595],"0.952,":[527],"sensitivity":[530],"90.905%":[532],"specificity":[534],"90.909%":[536],"at":[537],"optimal":[539],"cutoff":[540],"point.":[541],"elevated":[543],"CerP(d18:1/16:0)":[549],"octadec-13-enoylcarnitine":[551],"could":[552],"poor":[560],"Conclusion":[566],"Metabonomics":[567],"provides":[568],"tool":[571],"study":[574,593],"gene":[585],"mutation.":[586],"Furthermore,":[587],"this":[592],"reference":[597],"1View":[604,607],"largeDownload":[605,608],"PPTFigure":[606],"PPT":[609],"Close":[610],"modal":[611]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}