{"id":"https://openalex.org/W4310102772","doi":"https://doi.org/10.1182/blood-2022-170970","title":"Clinical Significance of a Miniscule GPI(-) Granulocyte Population in Patients with Bone Marrow Failure","display_name":"Clinical Significance of a Miniscule GPI(-) Granulocyte Population in Patients with Bone Marrow Failure","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310102772","doi":"https://doi.org/10.1182/blood-2022-170970"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-170970","doi":"https://doi.org/10.1182/blood-2022-170970","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-170970","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057094281","display_name":"Dung Cao Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Dung Cao Tran","raw_affiliation_strings":["1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023542193","display_name":"Kohei Thi Hosokawa","orcid":"https://orcid.org/0000-0002-3423-1523","observed_orcids":["https://orcid.org/0000-0002-3423-1523"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Hosokawa","raw_affiliation_strings":["1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074757623","display_name":"Hiroki Mizumaki","orcid":"https://orcid.org/0000-0002-9933-4638","observed_orcids":["https://orcid.org/0000-0002-9933-4638"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Mizumaki","raw_affiliation_strings":["1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036181929","display_name":"Yoshitaka Zaimoku","orcid":"https://orcid.org/0000-0002-4108-5245","observed_orcids":["https://orcid.org/0000-0002-4108-5245"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitaka Zaimoku","raw_affiliation_strings":["1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034343487","display_name":"Hiroyuki Takamatsu","orcid":"https://orcid.org/0000-0001-9515-0017","observed_orcids":["https://orcid.org/0000-0001-9515-0017"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Takamatsu","raw_affiliation_strings":["1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054578501","display_name":"Hirohito Yamazaki","orcid":"https://orcid.org/0000-0003-3018-2098","observed_orcids":["https://orcid.org/0000-0003-3018-2098"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirohito Yamazaki","raw_affiliation_strings":["2Division of Transfusion Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Transfusion Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025923701","display_name":"Ken Ishiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Ishiyama","raw_affiliation_strings":["1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066039877","display_name":"Toshihiro Miyamoto","orcid":"https://orcid.org/0000-0002-6533-1594","observed_orcids":["https://orcid.org/0000-0002-6533-1594","https://orcid.org/0000-0001-5941-4679"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Miyamoto","raw_affiliation_strings":["1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028349481","display_name":"Shinji Nakao","orcid":"https://orcid.org/0000-0002-9674-624X","observed_orcids":["https://orcid.org/0000-0002-9674-624X"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Nakao","raw_affiliation_strings":["1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"Supplement 1","first_page":"11453","last_page":"11454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.2451999932527542,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.05810000002384186,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pig-a-mutation","display_name":"PIG-A mutation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/acquired-aplastic-anemia","display_name":"acquired aplastic anemia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/bone-marrow-failure","display_name":"bone marrow failure","score":0.8560000061988831},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.8529999852180481},{"id":"https://openalex.org/keywords/immune-mediated-bone-marrow-failure","display_name":"immune-mediated bone marrow failure","score":0.6869999766349792},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/thrombopoietin-receptor-agonists","display_name":"thrombopoietin receptor agonists","score":0.871999979019165},{"id":"https://openalex.org/keywords/anabolic-androgenic-steroids","display_name":"anabolic steroids","score":0.859000027179718},{"id":"https://openalex.org/keywords/pure-red-cell-aplasia","display_name":"pure red cell aplasia","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6322320103645325},{"id":"https://openalex.org/C2780525284","wikidata":"https://www.wikidata.org/wiki/Q7882181","display_name":"Bone marrow failure","level":4,"score":0.5797842741012573},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5745798349380493},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.5289777517318726},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4967382550239563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48748016357421875},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48483073711395264},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4434436559677124},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2767384648323059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24842128157615662},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07556256651878357},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-170970","doi":"https://doi.org/10.1182/blood-2022-170970","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-170970","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3211727180","https://openalex.org/W4388496744","https://openalex.org/W2560787696","https://openalex.org/W2092567639","https://openalex.org/W2576328609","https://openalex.org/W3093657567","https://openalex.org/W2559696406","https://openalex.org/W4386347170","https://openalex.org/W3144394462","https://openalex.org/W2033594330"],"abstract_inverted_index":{"[Background]":[0],"Small":[1],"(0.003-1.0%)":[2],"populations":[3,50],"of":[4,31,71,73,89,99,109,153,166,201,206,244,273,334,354,375,382,396,404,422,439,443,462,474,502,540,559,611,617,630,652,664,677,683],"glycosylphosphatidylinositol":[5],"(GPI)-deficient":[6],"granulocytes":[7],"(Grs)":[8],"(sPNH-GPs)":[9],"are":[10,25,53,64,647],"often":[11],"detected":[12,391],"in":[13,66,91,102,115,126,130,160,216,281,330,356,367,393,417,458,504,561,579,582,593,600,640,657,668],"patients":[14,104,129,147,183,211,237,260,399,410,449,482,506,563,581,595,602,641,670],"with":[15,148,252,261,300,342,372,400,483,507,511,603,637,642,649],"acquired":[16],"aplastic":[17],"anemia":[18,274],"(AA)":[19],"and":[20,24,77,93,192,289,295,345,431,460,543,599],"low-risk":[21],"myelodysplastic":[22],"syndromes,":[23],"thought":[26],"to":[27,123,163,240,276,413,426,498,516,566,568,607,672],"represent":[28],"a":[29,269,298,308,380,401,518,615,658],"marker":[30,616],"immune-mediated":[32,116],"bone":[33],"marrow":[34],"(BM)":[35],"failure.":[36],"On":[37],"the":[38,67,94,107,151,164,199,204,331,352,373,376,397,420,446,463,475,493,530,538,549,580,609,627,650,655,662],"other":[39,169,635],"hand,":[40],"our":[41,119,175],"recent":[42],"studies":[43],"revealed":[44],"that":[45,106,159,324,336,468,495,571,589,646,675,682],"miniscule":[46],"(<0.003%)":[47],"GPI(-)":[48],"Gr":[49],"(mPNH-GPs),":[51],"which":[52,245,378,622,686],"derived":[54],"from":[55,181,286,297,681],"mono-":[56],"or":[57,232,320,619,633],"oligo-clonal":[58],"PIGA-mutated":[59,110],"hematopoietic":[60],"stem":[61],"cells":[62],"(HSCs),":[63],"detectable":[65,534],"peripheral":[68],"blood":[69,80],"(PB)":[70],"80%":[72,366],"healthy":[74],"individuals":[75],"(HIs)":[76],"some":[78,127,634],"cord":[79],"(CB)":[81],"samples":[82,180,285,296],"(ASH":[83],"2021,":[84],"#2181).":[85],"The":[86,249,362,500,557],"high":[87,96],"prevalence":[88,98,152,353,363,381],"mPNH-GPs":[90,125,154,167,314,355,388,503,526,560,590,612,653,665,688],"HIs":[92,161,288,357],"similarly":[95],"(60%)":[97],"PNH-phenotype":[100],"Grs":[101,139,214,335,467,477,513,522,585,598],"AA":[103,128,186,254,405,440,448,505,562,594,605],"suggest":[105],"proliferation":[108],"HSCs":[111,632,636],"may":[112,155,574,613],"inevitably":[113],"occur":[114],"AA.":[117],"However,":[118],"earlier":[120],"study":[121],"failed":[122,565],"detect":[124],"long-term":[131],"remission":[132,217,418,553],"who":[133,184,267,450,485,564],"possessed":[134,465,490],"HLA-class":[135],"I":[136],"allele-lacking":[137],"(HLA[-])":[138],"after":[140,218,229,424,441,537,545],"immunosuppressive":[141],"therapy":[142],"(IST)":[143],"(unpublished":[144],"data).":[145],"In":[146,386],"long-standing":[149,604,643],"AA,":[150,644,685],"be":[156,614,624],"lower":[157],"than":[158],"due":[162],"replacement":[165],"by":[168,626],"aberrant":[170],"Grs.":[171],"[Methods]":[172],"To":[173],"test":[174],"hypothesis,":[176],"we":[177],"examined":[178],"PB":[179,284],"40":[182,398],"developed":[185],"1-43":[187],"(median":[188,472],"11)":[189],"years":[190],"previously":[191],"were":[193,215,238,246,279,305,315,328,337,390,411,416,451,457,486,523,527,591],"all":[194,241,368],"negative":[195,452,487],"for":[196,198,311,453,470,488],"sPNH-GPs":[197,489],"presence":[200,610,663],"mPNH-GPs.":[202],"At":[203],"time":[205,421],"sampling,":[207],"28":[208],"including":[209],"6":[210,546],"possessing":[212,596],"HLA(-)":[213,466,512,597,631],"IST":[219,414,569],"(n=8),":[220],"thrombopoietin-receptor":[221],"agonists":[222],"(TPO-RAs,":[223],"n=14),":[224],"anabolic":[225],"steroids":[226],"(AS)":[227],"(n=3)":[228],"failing":[230],"IST,":[231,608],"spontaneous":[233,437],"resolution":[234,438],"(n=3).":[235],"Eight":[236],"refractory":[239,412,606],"therapies,":[242],"3":[243,435],"transfusion":[247],"dependent.":[248],"remaining":[250],"4":[251,319,481],"non-severe":[253],"had":[255,268],"not":[256,577],"been":[257,576],"treated.":[258],"Four":[259],"pure":[262],"red":[263],"cell":[264],"aplasia":[265],"(PRCA)":[266],"12-32":[270],"year":[271],"history":[272,403],"responding":[275,425,671],"cyclosporine":[277],"(CsA)":[278],"included":[280],"this":[282],"analysis.":[283],"93":[287],"22":[290],"CB":[291],"served":[292],"as":[293,307],"controls,":[294],"patient":[299,520,550],"chronic":[301],"myeloid":[302],"leukemia":[303],"(CML)":[304],"used":[306],"positive":[309,317],"control":[310],"clonal":[312,509,628],"hematopoiesis.":[313],"deemed":[316],"when":[318,548],"more":[321],"CD11bhigh":[322],"dots":[323],"formed":[325],"tight":[326],"clusters":[327],"present":[329],"FLAER-":[332],"fraction":[333],"enriched":[338],"using":[339],"microbeads":[340],"coated":[341],"PE-labeled":[343],"anti-CD55":[344],"anti-CD59":[346],"antibodies.":[347],"[Results]":[348],"We":[349],"first":[350],"determined":[351],"(n=93)":[358],"at":[359,419,529,654],"different":[360,369],"ages.":[361],"was":[364],"approximately":[365],"age":[370],"groups":[371],"exception":[374],"CB,":[377],"showed":[379],"40.9%":[383],"(Figure":[384,406,478,554],"1).":[385,407],"contrast,":[387],"(0.101-1.998x10-3%)":[389],"only":[392,455],"7":[394,409],"(17.5%)":[395],"long":[402],"These":[408],"but":[415,532],"sampling":[423],"TPO-RAs":[427],"(n=3,":[428],"Figure":[429,691],"2)":[430],"AS":[432],"(n=1);":[433],"while":[434],"experienced":[436],"cessation":[442],"treatment.":[444],"Of":[445],"33":[447],"mPNH-GPs,":[454,491],"8":[456,464],"remission,":[459],"5":[461],"accounted":[469],"75%-99%":[471],"96%)":[473],"total":[476],"2).":[479,555],"All":[480],"PRCA":[484,669,678],"despite":[492],"fact":[494],"they":[496],"responded":[497],"CsA.":[499],"lack":[501],"complete":[508],"hematopoiesis":[510],"prompted":[514],"us":[515],"examine":[517],"CML":[519,659],"whose":[521],"100%":[524],"BCR-ABL-positive.":[525],"undetectable":[528,592],"diagnosis,":[531],"became":[533],"2":[535],"weeks":[536],"initiation":[539],"nilotinib":[541],"therapy,":[542],"increased":[544],"months":[547],"achieved":[551],"cytogenetic":[552],"[Discussion]":[556],"persistence":[558],"respond":[567],"suggests":[570,674],"immune":[572],"mechanisms":[573],"have":[575],"involved":[578],"whom":[583],"GPI-deficient":[584],"remained":[586],"miniscule.":[587],"Given":[588],"many":[601],"oligo-":[618],"poly-clonal":[620],"hematopoiesis,":[621],"can":[623],"eliminated":[625],"expansion":[629,667],"intrinsic":[638],"abnormalities":[639],"findings":[645],"compatible":[648],"absence":[651],"diagnosis":[656],"patient.":[660],"Lastly,":[661],"without":[666],"CsA":[673],"immunopathogenesis":[676],"is":[679],"distinct":[680],"CsA-responsive":[684],"turns":[687],"into":[689],"sPNH-GPs.":[690],"1View":[692,695],"largeDownload":[693,696],"PPTFigure":[694],"PPT":[697],"Close":[698],"modal":[699]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-11-30T00:00:00"}
