{"id":"https://openalex.org/W4310096231","doi":"https://doi.org/10.1182/blood-2022-158694","title":"Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia","display_name":"Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310096231","doi":"https://doi.org/10.1182/blood-2022-158694"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-158694","doi":"https://doi.org/10.1182/blood-2022-158694","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-158694","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028974486","display_name":"Olli Dufva","orcid":"https://orcid.org/0000-0002-8084-0282","observed_orcids":["https://orcid.org/0000-0002-8084-0282"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Olli Dufva","raw_affiliation_strings":["1Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061588223","display_name":"Heikki A Kuusanm\u00e4ki","orcid":"https://orcid.org/0000-0002-1903-0408","observed_orcids":["https://orcid.org/0000-0002-1903-0408"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["DK","FI"],"is_corresponding":false,"raw_author_name":"Heikki Kuusanm\u00e4ki","raw_affiliation_strings":["2Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland","3Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"3Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025335008","display_name":"Markus J. V. V\u00e4h\u00e4-Koskela","orcid":"https://orcid.org/0000-0001-7764-7820","observed_orcids":["https://orcid.org/0000-0001-7764-7820"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Markus Vaha-Koskela","raw_affiliation_strings":["4Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Finland, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Finland, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037129838","display_name":"Aino\u2010Maija Lepp\u00e4","orcid":"https://orcid.org/0000-0003-0849-1759","observed_orcids":["https://orcid.org/0000-0003-0849-1759"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Aino-Maija Lepp\u00e4","raw_affiliation_strings":["5Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058714222","display_name":"Jani Huuhtanen","orcid":"https://orcid.org/0000-0003-2750-4033","observed_orcids":["https://orcid.org/0000-0003-2750-4033"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jani Huuhtanen","raw_affiliation_strings":["6Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","7Department of Computer Science, Aalto University School of Science, Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"7Department of Computer Science, Aalto University School of Science, Espoo, Finland","institution_ids":["https://openalex.org/I9927081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017560855","display_name":"Ida V\u00e4nttinen","orcid":"https://orcid.org/0009-0002-9764-3477","observed_orcids":["https://orcid.org/0009-0002-9764-3477"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ida V\u00e4nttinen","raw_affiliation_strings":["2Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050056974","display_name":"Petra Johanna Nygren","orcid":"https://orcid.org/0000-0003-1723-3970","observed_orcids":["https://orcid.org/0000-0003-1723-3970"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Petra Johanna Nygren","raw_affiliation_strings":["1Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089207174","display_name":"Jay Klievink","orcid":"https://orcid.org/0000-0002-4081-5840","observed_orcids":["https://orcid.org/0000-0002-4081-5840"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jay Klievink","raw_affiliation_strings":["1Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075652479","display_name":"Jonas Bouhlal","orcid":"https://orcid.org/0000-0002-7920-3390","observed_orcids":["https://orcid.org/0000-0002-7920-3390"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jonas Bouhlal","raw_affiliation_strings":["6Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031300613","display_name":"Petri P\u00f6l\u00f6nen","orcid":"https://orcid.org/0000-0001-6128-9985","observed_orcids":["https://orcid.org/0000-0001-6128-9985"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Petri P\u00f6l\u00f6nen","raw_affiliation_strings":["8Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360359","display_name":"Qi Zhang","orcid":"https://orcid.org/0000-0002-7918-8952","observed_orcids":["https://orcid.org/0000-0002-7918-8952"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["9Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088386462","display_name":"Shady Adnan Awad","orcid":"https://orcid.org/0000-0001-6205-7799","observed_orcids":["https://orcid.org/0000-0001-6205-7799"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Shady Adnan Awad","raw_affiliation_strings":["6Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013364899","display_name":"Cristina Mancebo-P\u00e9rez","orcid":"https://orcid.org/0000-0001-5960-5168","observed_orcids":["https://orcid.org/0000-0001-5960-5168"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Cristina Mancebo","raw_affiliation_strings":["10Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044105452","display_name":"Joseph J Saad","orcid":"https://orcid.org/0000-0001-7701-0328","observed_orcids":["https://orcid.org/0000-0001-7701-0328"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Joseph Saad","raw_affiliation_strings":["5Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007815385","display_name":"Juho Jalmari Miettinen","orcid":"https://orcid.org/0000-0002-3987-1693","observed_orcids":["https://orcid.org/0000-0002-3987-1693"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Juho J. Miettinen","raw_affiliation_strings":["11University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026802182","display_name":"Komal Kumar Javarappa","orcid":"https://orcid.org/0000-0001-7750-167X","observed_orcids":["https://orcid.org/0000-0001-7750-167X"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Komal Kumar Javarappa","raw_affiliation_strings":["12Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090087937","display_name":"Sofia Aakko","orcid":"https://orcid.org/0000-0003-1330-9288","observed_orcids":["https://orcid.org/0000-0003-1330-9288"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sofia Aakko","raw_affiliation_strings":["13Institute of Molecular Medicine Finland (FIMM), Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Institute of Molecular Medicine Finland (FIMM), Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040796609","display_name":"Tanja M. Ruokoranta","orcid":"https://orcid.org/0000-0003-4825-8599","observed_orcids":["https://orcid.org/0000-0003-4825-8599"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tanja Ruokoranta","raw_affiliation_strings":["2Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089248994","display_name":"Samuli Eldfors","orcid":"https://orcid.org/0000-0001-5056-4750","observed_orcids":["https://orcid.org/0000-0001-5056-4750"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Samuli Eldfors","raw_affiliation_strings":["5Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Merja Hein\u00e4niemi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Merja Hein\u00e4niemi","raw_affiliation_strings":["14Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087038443","display_name":"Ulla Wartiovaara\u2010Kautto","orcid":"https://orcid.org/0000-0002-2803-2712","observed_orcids":["https://orcid.org/0000-0002-2803-2712"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ulla Wartiovaara-Kautto","raw_affiliation_strings":["15Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112374856","display_name":"Marina Konopleva","orcid":"https://orcid.org/0000-0002-9347-2212","observed_orcids":["https://orcid.org/0000-0002-9347-2212"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Konopleva","raw_affiliation_strings":["16Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063732976","display_name":"Mikko A. I. Ker\u00e4nen","orcid":"https://orcid.org/0000-0001-8027-499X","observed_orcids":["https://orcid.org/0000-0001-8027-499X"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikko A Ker\u00e4nen","raw_affiliation_strings":["17Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050873337","display_name":"Kimmo Porkka","orcid":"https://orcid.org/0000-0003-4112-5902","observed_orcids":["https://orcid.org/0000-0003-4112-5902"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kimmo Porkka","raw_affiliation_strings":["15Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067760174","display_name":"Krister Wennerberg","orcid":"https://orcid.org/0000-0002-1352-4220","observed_orcids":["https://orcid.org/0000-0002-1352-4220"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["DK","FI"],"is_corresponding":false,"raw_author_name":"Krister Wennerberg","raw_affiliation_strings":["18Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland","19Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"raw_affiliation_string":"19Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064764393","display_name":"Mika Kontro","orcid":"https://orcid.org/0000-0001-6353-0664","observed_orcids":["https://orcid.org/0000-0001-6353-0664"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mika Kontro","raw_affiliation_strings":["20Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"20Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061939140","display_name":"Caroline Akemi Heckman","orcid":"https://orcid.org/0000-0002-4324-8706","observed_orcids":["https://orcid.org/0000-0002-4324-8706"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Caroline A. Heckman","raw_affiliation_strings":["5Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008868111","display_name":"Satu M. Mustjoki","orcid":"https://orcid.org/0000-0002-0816-8241","observed_orcids":["https://orcid.org/0000-0002-0816-8241"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Satu Mustjoki","raw_affiliation_strings":["1Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":1.7924,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.86821461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"140","issue":"Supplement 1","first_page":"101","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythroid-differentiation","display_name":"erythroid differentiation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8730000257492065},{"id":"https://openalex.org/keywords/venetoclax-resistance","display_name":"venetoclax resistance","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7440000176429749},{"id":"https://openalex.org/keywords/a-1331852","display_name":"A-1331852","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bcl-xl-inhibitors","display_name":"Bcl-xL inhibitors","score":0.6570000052452087},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6150000095367432},{"id":"https://openalex.org/keywords/crispr-cas9-screening","display_name":"CRISPR-Cas9 screen","score":0.6859999895095825},{"id":"https://openalex.org/keywords/rnai-screen","display_name":"RNAi screen","score":0.8090000152587891},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C2778378607","wikidata":"https://www.wikidata.org/wiki/Q4677933","display_name":"Acute megakaryoblastic leukemia","level":3,"score":0.7251468896865845},{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.6536946892738342},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.614791989326477},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5827966928482056},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5557093024253845},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5532556772232056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.508169412612915},{"id":"https://openalex.org/C192196715","wikidata":"https://www.wikidata.org/wiki/Q14916151","display_name":"GATA1","level":4,"score":0.42583024501800537},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.4108333885669708},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2930084466934204},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.23967278003692627},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.23365017771720886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16181305050849915},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.08288183808326721}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-158694","doi":"https://doi.org/10.1182/blood-2022-158694","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-158694","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2951793360","https://openalex.org/W2950616151","https://openalex.org/W4412530191","https://openalex.org/W7160488198","https://openalex.org/W7110664935","https://openalex.org/W7213290652","https://openalex.org/W4386024128","https://openalex.org/W4283381579","https://openalex.org/W4386881796","https://openalex.org/W2984631533"],"abstract_inverted_index":{"Myeloid":[0],"neoplasms":[1],"with":[2,15,44,65,74,165,266,308,315,375,423,450,462,519],"erythroid":[3,9,16,45,75,112,128,157,212,253,267,309,510],"or":[4,46,76,247,310,471],"megakaryocytic":[5,47,77,311],"differentiation":[6,48,78,312],"include":[7],"pure":[8],"leukemia":[10,21,42,160,256],"(PEL),":[11],"myelodysplastic":[12],"syndrome":[13],"(MDS)":[14],"features,":[17],"and":[18,24,30,96,103,113,129,135,158,213,220,229,254,260,268,281,349,361,402,511,514],"acute":[19,40],"megakaryoblastic":[20,114,131,159,214,255,269,512],"(FAB":[22],"M7)":[23],"are":[25],"characterized":[26],"by":[27,445],"poor":[28],"prognosis":[29],"limited":[31],"treatment":[32,192,422,434],"options.":[33],"Hypothesizing":[34],"that":[35,71],"the":[36,81,177,184,191,199,208,250,289,346,354,393,397,408,417,424,451,463,467,472],"distinct":[37],"lineage":[38],"of":[39,91,193,202,211,240,252,263,279,300,303,328,353,396],"myeloid":[41],"(AML)":[43],"may":[49],"confer":[50],"specific":[51],"vulnerabilities,":[52],"we":[53,116,205,356,440],"sought":[54],"to":[55,183,276,320,340,385,399,523],"identify":[56,108],"selective":[57],"dependencies":[58,110,210],"in":[59,63,111,126,163,190,455,483,509],"these":[60],"rare":[61],"subtypes":[62,180,278],"comparison":[64,164],"other":[66,137,170,231,277,282,330,386,448],"AML":[67,72,132,138,171,179,194,232,280,305,331,517],"types.":[68],"We":[69],"show":[70],"cells":[73,299,371],"depend":[79],"on":[80,369],"anti-apoptotic":[82],"protein":[83],"BCL-XL,":[84,243],"rather":[85],"than":[86],"BCL-2,":[87],"using":[88,216,416],"a":[89,122,286,390,412,484,496,505],"combination":[90,443],"ex":[92,313,362,486],"vivo":[93,363,487],"drug":[94,347,366],"sensitivity":[95,348,367,395,522],"resistance":[97,404],"testing,":[98],"genetic":[99,209],"perturbation,":[100],"transcriptomic":[101],"profiling":[102,368],"mouse":[104,413],"xenograft":[105,414],"experiments.":[106],"To":[107,197,343,432],"druggable":[109],"leukemias,":[115],"screened":[117],"over":[118,495],"500":[119],"drugs":[120],"across":[121],"10,000-fold":[123],"concentration":[124,457],"range":[125],"four":[127],"two":[130,373],"cell":[133,139,161,167,233,257,387,420],"lines":[134,140,162,168],"used":[136,188],"as":[141,153,489,491,504],"controls":[142],"(Figure":[143,173,195],"A).":[144,196],"The":[145,378],"high-throughput":[146],"screens":[147],"identified":[148,271],"BCL-XL-selective":[149],"inhibitors":[150],"including":[151],"A-1331852":[152,427,454],"highly":[154],"effective":[155],"against":[156],"15":[166,230],"representing":[169],"types":[172],"B).":[174],"In":[175,323,411],"contrast,":[176,324],"erythroid/megakaryoblastic":[178],"were":[181],"resistant":[182],"BCL-2":[185,468],"inhibitor":[186,426,453,465,469],"venetoclax":[187,403],"clinically":[189],"confirm":[198],"on-target":[200],"mechanism":[201],"BCL-XL":[203,293,341,400,425,452,460,503],"inhibition,":[204],"next":[206],"evaluated":[207],"leukemias":[215,270,513],"public":[217],"genome-scale":[218],"CRISPR-Cas9":[219],"RNAi":[221],"screening":[222],"data":[223],"from":[224,318,372],"5":[225,301],"erythroid,":[226],"3":[227],"megakaryoblastic,":[228],"lines.":[234,258],"This":[235],"analysis":[236],"demonstrated":[237],"striking":[238],"essentiality":[239],"BCL2L1":[241,273,382],"encoding":[242],"but":[244],"not":[245],"BCL2":[246],"MCL1,":[248],"for":[249,288,392,478],"survival":[251],"Single-cell":[259],"bulk":[261],"transcriptomics":[262,360],"patient":[264,306,332],"samples":[265,307,333],"high":[272],"expression":[274,351,383],"compared":[275,384],"hematological":[283],"malignancies,":[284],"providing":[285,389],"basis":[287,391],"observed":[290,405],"functional":[291],"dependencies.":[292],"inhibition":[294,401,461],"effectively":[295,428],"killed":[296],"bone":[297],"marrow":[298],"out":[302,327],"8":[304],"vivo,":[314],"IC50":[316],"ranging":[317],"0.6":[319],"55":[321],"nM.":[322],"only":[325],"one":[326],"40":[329],"was":[334],"sensitive":[335],"(IC50":[336],"<":[337],"60":[338],"nM)":[339],"inhibition.":[342],"better":[344],"understand":[345],"gene":[350],"profiles":[352],"blasts,":[355],"performed":[357],"integrated":[358],"single-cell":[359,409],"flow":[364],"cytometry-based":[365],"mononuclear":[370],"patients":[374],"erythroid/megakaryocytic":[376],"AML.":[377],"blasts":[379,398],"showed":[380,476],"enriched":[381],"populations,":[388],"increased":[394],"also":[406],"at":[407],"resolution.":[410],"model":[415],"HEL":[418],"erythroleukemia":[419],"line,":[421],"reduced":[429,521],"tumor":[430],"burden.":[431],"find":[433],"regimens":[435],"enabling":[436],"long-term":[437,492],"disease":[438],"control,":[439],"explored":[441],"potential":[442,477,506],"treatments":[444,493],"testing":[446],"6":[447],"compounds":[449],"8x8":[456],"matrices.":[458],"Combining":[459],"JAK":[464],"ruxolitinib,":[466],"venetoclax,":[470],"hypomethylating":[473],"agent":[474],"azacitidine":[475],"more":[479],"durable":[480],"responses":[481],"both":[482],"3-day":[485],"assay":[488],"well":[490],"spanning":[494],"month.":[497],"Collectively,":[498],"our":[499],"results":[500],"suggest":[501],"targeting":[502],"therapy":[507],"option":[508],"highlight":[515],"an":[516],"subgroup":[518],"potentially":[520],"venetoclax-based":[524],"treatments.":[525],"Figure":[526],"1View":[527,530],"largeDownload":[528,531],"PPTFigure":[529],"PPT":[532],"Close":[533],"modal":[534]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-30T00:00:00"}