{"id":"https://openalex.org/W4310073420","doi":"https://doi.org/10.1016/j.bbi.2022.11.012","title":"B lymphocytes ameliorate Alzheimer\u2019s disease-like neuropathology via interleukin-35","display_name":"B lymphocytes ameliorate Alzheimer\u2019s disease-like neuropathology via interleukin-35","publication_year":2022,"publication_date":"2022-11-24","ids":{"openalex":"https://openalex.org/W4310073420","doi":"https://doi.org/10.1016/j.bbi.2022.11.012","pmid":"https://pubmed.ncbi.nlm.nih.gov/36427805"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbi.2022.11.012","doi":"https://doi.org/10.1016/j.bbi.2022.11.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbi.2022.11.012","pdf_url":null,"source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4310073420"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025148955","display_name":"Weixi Feng","orcid":"https://orcid.org/0000-0002-7201-5688","observed_orcids":["https://orcid.org/0000-0002-7201-5688"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weixi Feng","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China. Electronic address: weixif@njmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China. Electronic address: weixif@njmu.edu.cn","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435005","display_name":"Yanli Zhang","orcid":"https://orcid.org/0000-0001-8173-2024","observed_orcids":["https://orcid.org/0000-0001-8173-2024"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanli Zhang","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023426146","display_name":"Shixin Ding","orcid":"https://orcid.org/0000-0001-8224-4735","observed_orcids":["https://orcid.org/0000-0001-8224-4735"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shixin Ding","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100712817","display_name":"Sijia Chen","orcid":"https://orcid.org/0000-0001-6246-0940","observed_orcids":["https://orcid.org/0000-0001-6246-0940"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sijia Chen","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734916","display_name":"Tianqi Wang","orcid":"https://orcid.org/0000-0003-0261-7357","observed_orcids":["https://orcid.org/0000-0003-0261-7357","https://orcid.org/0009-0009-5549-4435","https://orcid.org/0000-0001-9777-0922"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianqi Wang","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443555","display_name":"Ze Wang","orcid":"https://orcid.org/0000-0002-8339-5567","observed_orcids":["https://orcid.org/0000-0002-8339-5567"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze Wang","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008149388","display_name":"Ying Zou","orcid":"https://orcid.org/0000-0001-9857-2549","observed_orcids":["https://orcid.org/0000-0001-9857-2549"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zou","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051862060","display_name":"Chengyu Sheng","orcid":"https://orcid.org/0000-0002-7352-4871","observed_orcids":["https://orcid.org/0000-0002-7352-4871"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengyu Sheng","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378100","display_name":"Yan Chen","orcid":"https://orcid.org/0000-0002-6573-4545","observed_orcids":["https://orcid.org/0000-0002-6573-4545"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Chen","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006299617","display_name":"Yingting Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingting Pang","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055626874","display_name":"Charles Marshall","orcid":"https://orcid.org/0000-0001-7005-6868","observed_orcids":["https://orcid.org/0000-0001-7005-6868"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Marshall","raw_affiliation_strings":["Department of Physical Therapy, University of Kentucky Center of Excellence in Rural Health, Hazard, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, University of Kentucky Center of Excellence in Rural Health, Hazard, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101817574","display_name":"Jingping Shi","orcid":"https://orcid.org/0000-0003-2577-9957","observed_orcids":["https://orcid.org/0000-0003-2577-9957"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingping Shi","raw_affiliation_strings":["Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085677100","display_name":"Maiken Nedergaard","orcid":"https://orcid.org/0000-0001-6502-6031","observed_orcids":["https://orcid.org/0000-0001-6502-6031"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maiken Nedergaard","raw_affiliation_strings":["Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340644","display_name":"Qian Li","orcid":"https://orcid.org/0000-0003-0359-5604","observed_orcids":["https://orcid.org/0000-0003-0359-5604"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qian Li","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China. Electronic address: liqian2019@njmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China. Electronic address: liqian2019@njmu.edu.cn","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013586047","display_name":"Ming Xiao","orcid":"https://orcid.org/0000-0001-5528-9102","observed_orcids":["https://orcid.org/0000-0001-5528-9102"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Xiao","raw_affiliation_strings":["Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China. Electronic address: mingx@njmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China; Center for Global Health, Nanjing Medical University, Nanjing 211166, China; Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China. Electronic address: mingx@njmu.edu.cn","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5013586047","https://openalex.org/A5025148955","https://openalex.org/A5100340644"],"corresponding_institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":null,"fwci":4.7047,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.97002141,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"108","issue":null,"first_page":"16","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9649999737739563},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/il-35","display_name":"IL-35","score":0.996999979019165},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bace1","display_name":"BACE1","score":0.7160000205039978},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.8410000205039978},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.8529999852180481},{"id":"https://openalex.org/keywords/peripheral-immune-system","display_name":"peripheral immune system","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5600000023841858},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.5627688765525818},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5315960049629211},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5156313180923462},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5109659433364868},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.46463775634765625},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45189806818962097},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.45063087344169617},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.44622886180877686},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4448337256908417},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4441303610801697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4268590807914734},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40095987915992737},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.35309898853302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34465107321739197},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3086400032043457},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3074081838130951},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3056153655052185},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.18088534474372864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10949856042861938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbi.2022.11.012","doi":"https://doi.org/10.1016/j.bbi.2022.11.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbi.2022.11.012","pdf_url":null,"source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},{"id":"pmid:36427805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36427805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, behavior, and immunity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1320648350","display_name":null,"funder_award_id":"82071199","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6123799559","display_name":null,"funder_award_id":"81871117","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6368565198","display_name":null,"funder_award_id":"BK20190655","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1499647695","https://openalex.org/W1588685142","https://openalex.org/W1767010801","https://openalex.org/W1810076817","https://openalex.org/W1831873206","https://openalex.org/W1966922635","https://openalex.org/W1976302032","https://openalex.org/W1987466952","https://openalex.org/W1997460269","https://openalex.org/W2006236831","https://openalex.org/W2011885084","https://openalex.org/W2045007926","https://openalex.org/W2057146995","https://openalex.org/W2104154119","https://openalex.org/W2110729320","https://openalex.org/W2127716652","https://openalex.org/W2129199831","https://openalex.org/W2167183660","https://openalex.org/W2275744255","https://openalex.org/W2293892300","https://openalex.org/W2314634699","https://openalex.org/W2469685265","https://openalex.org/W2548767848","https://openalex.org/W2587700289","https://openalex.org/W2616912806","https://openalex.org/W2634812549","https://openalex.org/W2637192554","https://openalex.org/W2734999907","https://openalex.org/W2748113140","https://openalex.org/W2753593979","https://openalex.org/W2801009360","https://openalex.org/W2805223889","https://openalex.org/W2883628966","https://openalex.org/W2890806217","https://openalex.org/W2892318814","https://openalex.org/W2921026962","https://openalex.org/W2924627473","https://openalex.org/W2968653314","https://openalex.org/W2976163884","https://openalex.org/W3000319248","https://openalex.org/W3025895001","https://openalex.org/W3085338548","https://openalex.org/W3095091383","https://openalex.org/W3128855378","https://openalex.org/W3153691873","https://openalex.org/W4200477198","https://openalex.org/W4220934355","https://openalex.org/W4229071038","https://openalex.org/W4281390737","https://openalex.org/W4293658342","https://openalex.org/W4302010994"],"related_works":["https://openalex.org/W4253092337","https://openalex.org/W3108652697","https://openalex.org/W4313407980","https://openalex.org/W4415274371","https://openalex.org/W4414340996","https://openalex.org/W4283373900","https://openalex.org/W2011460566","https://openalex.org/W1978567629","https://openalex.org/W2342031861"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2022-11-30T00:00:00"}