{"id":"https://openalex.org/W4310071459","doi":"https://doi.org/10.1016/j.ejmech.2022.114940","title":"Discovery of orally active 1,4,5,6,8-pentaazaacenaphthylens as novel, selective, and potent covalent BTK inhibitors for the treatment of rheumatoid arthritis","display_name":"Discovery of orally active 1,4,5,6,8-pentaazaacenaphthylens as novel, selective, and potent covalent BTK inhibitors for the treatment of rheumatoid arthritis","publication_year":2022,"publication_date":"2022-11-25","ids":{"openalex":"https://openalex.org/W4310071459","doi":"https://doi.org/10.1016/j.ejmech.2022.114940","pmid":"https://pubmed.ncbi.nlm.nih.gov/36462441"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmech.2022.114940","doi":"https://doi.org/10.1016/j.ejmech.2022.114940","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2022.114940","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009601820","display_name":"Xiaobao Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobao Fang","raw_affiliation_strings":["School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386373","display_name":"Chunxiao Liu","orcid":"https://orcid.org/0000-0002-3675-3122","observed_orcids":["https://orcid.org/0000-0002-3675-3122"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunxiao Liu","raw_affiliation_strings":["School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342359","display_name":"Kun Zhang","orcid":"https://orcid.org/0000-0002-7596-5224","observed_orcids":["https://orcid.org/0000-0002-7596-5224"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zhang","raw_affiliation_strings":["School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044263519","display_name":"Wanping Yang","orcid":"https://orcid.org/0000-0002-8828-8410","observed_orcids":["https://orcid.org/0000-0002-8828-8410"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanping Yang","raw_affiliation_strings":["School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037970535","display_name":"Zewen Wu","orcid":"https://orcid.org/0000-0001-9124-4577","observed_orcids":["https://orcid.org/0000-0001-9124-4577","https://orcid.org/0009-0008-9651-4319"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zewen Wu","raw_affiliation_strings":["School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045827445","display_name":"Shige Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shige Shen","raw_affiliation_strings":["School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036229908","display_name":"Yule Ma","orcid":"https://orcid.org/0009-0004-5386-9962","observed_orcids":["https://orcid.org/0009-0004-5386-9962","https://orcid.org/0000-0002-6109-7606"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yule Ma","raw_affiliation_strings":["School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101444311","display_name":"Xun Lu","orcid":"https://orcid.org/0000-0003-3082-613X","observed_orcids":["https://orcid.org/0000-0003-3082-613X"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xun Lu","raw_affiliation_strings":["School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019756461","display_name":"Yadong Chen","orcid":"https://orcid.org/0000-0002-2189-9356","observed_orcids":["https://orcid.org/0000-0002-2189-9356"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yadong Chen","raw_affiliation_strings":["School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: ydchen@cpu.edu.cn","School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China"],"raw_orcid":"https://orcid.org/0000-0002-2189-9356","affiliations":[{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: ydchen@cpu.edu.cn","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]},{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100771173","display_name":"Tao Lu","orcid":"https://orcid.org/0000-0002-5948-4762","observed_orcids":["https://orcid.org/0000-0002-5948-4762"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Lu","raw_affiliation_strings":["School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: lutao@cpu.edu.cn","School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: lutao@cpu.edu.cn","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]},{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101786148","display_name":"Qinghua Hu","orcid":"https://orcid.org/0000-0003-1045-5466","observed_orcids":["https://orcid.org/0000-0003-1045-5466"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qinghua Hu","raw_affiliation_strings":["School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: huqh@cpu.edu.cn","School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: huqh@cpu.edu.cn","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yulei Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yulei Jiang","raw_affiliation_strings":["School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: jiangyulei@cpu.edu.cn","School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: jiangyulei@cpu.edu.cn","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China","institution_ids":["https://openalex.org/I161716053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019756461","https://openalex.org/A5100771173","https://openalex.org/A5101786148"],"corresponding_institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"],"apc_list":{"value":4570,"currency":"USD","value_usd":4570},"apc_paid":null,"fwci":0.5404,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.63584662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"246","issue":null,"first_page":"114940","last_page":"114940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.4124000072479248,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.4124000072479248,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.1185000017285347,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.1062999963760376,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase","display_name":"Bruton's tyrosine kinase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.9359999895095825},{"id":"https://openalex.org/keywords/covalent-kinase-inhibitors","display_name":"covalent kinase inhibitors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.9110000133514404},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/target-occupancy","display_name":"target occupancy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9120000004768372},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.9606577157974243},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6157367825508118},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.6156104207038879},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5976126790046692},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.55971759557724},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4645068347454071},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34167903661727905},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3092866837978363},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2556261420249939},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2023223638534546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18679594993591309}],"mesh":[{"descriptor_ui":"D000077329","descriptor_name":"Agammaglobulinaemia Tyrosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejmech.2022.114940","doi":"https://doi.org/10.1016/j.ejmech.2022.114940","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2022.114940","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:36462441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36462441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3404668988","display_name":null,"funder_award_id":"81973188","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3511173994","display_name":null,"funder_award_id":"CPU2018GF02","funder_id":"https://openalex.org/F4320321542","funder_display_name":"China Pharmaceutical University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321542","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718"},{"id":"https://openalex.org/F4320335782","display_name":"Double First Class University Plan","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1976912963","https://openalex.org/W2010993054","https://openalex.org/W2026720602","https://openalex.org/W2042271164","https://openalex.org/W2053305824","https://openalex.org/W2055796403","https://openalex.org/W2095194823","https://openalex.org/W2095408122","https://openalex.org/W2115086589","https://openalex.org/W2120377900","https://openalex.org/W2145138842","https://openalex.org/W2152265294","https://openalex.org/W2258682798","https://openalex.org/W2322586343","https://openalex.org/W2512656347","https://openalex.org/W2743273314","https://openalex.org/W2760270300","https://openalex.org/W2770172979","https://openalex.org/W2776130700","https://openalex.org/W2788356134","https://openalex.org/W2792062848","https://openalex.org/W2875612503","https://openalex.org/W2921811013","https://openalex.org/W2924170743","https://openalex.org/W2944582362","https://openalex.org/W2966475886","https://openalex.org/W2972482801","https://openalex.org/W3006726493","https://openalex.org/W3093133909","https://openalex.org/W3138340528","https://openalex.org/W3194931521","https://openalex.org/W3199680482","https://openalex.org/W3210474562","https://openalex.org/W4220932642","https://openalex.org/W4223930092","https://openalex.org/W4225133395"],"related_works":["https://openalex.org/W3140938089","https://openalex.org/W2891335972","https://openalex.org/W2778678639","https://openalex.org/W2954400172","https://openalex.org/W4309039494","https://openalex.org/W2019216438","https://openalex.org/W2924170743","https://openalex.org/W3023630350","https://openalex.org/W2788356134","https://openalex.org/W2413351312"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-30T00:00:00"}