{"id":"https://openalex.org/W4309962995","doi":"https://doi.org/10.1016/j.clnesp.2022.11.017","title":"Impact of \u00df-hydroxy-\u00df-methylbutyrate (HMB) in critically ill patients on the endocrine axis \u2013 A post-hoc cohort study of the HMB-ICU trial","display_name":"Impact of \u00df-hydroxy-\u00df-methylbutyrate (HMB) in critically ill patients on the endocrine axis \u2013 A post-hoc cohort study of the HMB-ICU trial","publication_year":2022,"publication_date":"2022-11-25","ids":{"openalex":"https://openalex.org/W4309962995","doi":"https://doi.org/10.1016/j.clnesp.2022.11.017","pmid":"https://pubmed.ncbi.nlm.nih.gov/36657898"},"language":"en","primary_location":{"id":"doi:10.1016/j.clnesp.2022.11.017","doi":"https://doi.org/10.1016/j.clnesp.2022.11.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clnesp.2022.11.017","pdf_url":null,"source":{"id":"https://openalex.org/S2764915710","display_name":"Clinical Nutrition ESPEN","issn_l":"2405-4577","issn":["2405-4577"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nutrition ESPEN","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004104018","display_name":"Olivier Pantet","orcid":"https://orcid.org/0000-0002-6195-8947","observed_orcids":["https://orcid.org/0000-0002-6195-8947"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Olivier Pantet","raw_affiliation_strings":["Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address: Olivier.Pantet@chuv.ch","Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6195-8947","affiliations":[{"raw_affiliation_string":"Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address: Olivier.Pantet@chuv.ch","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035556085","display_name":"Marina Ver\u00e7oza Viana","orcid":"https://orcid.org/0000-0001-9564-4885","observed_orcids":["https://orcid.org/0000-0001-9564-4885"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4210097146","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210097146"]}],"countries":["BR","CH"],"is_corresponding":false,"raw_author_name":"Marina V. Viana","raw_affiliation_strings":["Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Critical Care Unit, Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil","Critical Care Unit, Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil","Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-9564-4885","affiliations":[{"raw_affiliation_string":"Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Critical Care Unit, Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723","https://openalex.org/I2802229882","https://openalex.org/I4210097146"]},{"raw_affiliation_string":"Critical Care Unit, Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723","https://openalex.org/I4210097146"]},{"raw_affiliation_string":"Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003725112","display_name":"MARI\u00cbLLE P. K. J. ENGELEN","orcid":"https://orcid.org/0000-0001-9884-2553","observed_orcids":["https://orcid.org/0000-0001-9884-2553"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mari\u00eblle P.K.J. Engelen","raw_affiliation_strings":["Center for Translational Research in Aging and Longevity, Texas A&M University, College Station, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Aging and Longevity, Texas A&M University, College Station, United States","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073459667","display_name":"Nicolaas E.P. Deutz","orcid":"https://orcid.org/0000-0001-5845-6447","observed_orcids":["https://orcid.org/0000-0001-5845-6447"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolaas E.P. Deutz","raw_affiliation_strings":["Center for Translational Research in Aging and Longevity, Texas A&M University, College Station, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Aging and Longevity, Texas A&M University, College Station, United States","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088737848","display_name":"St\u00e9phanie Gran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Gran","raw_affiliation_strings":["Service of Clinical Chemistry, Lausanne University Hospital (CHUV), Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Clinical Chemistry, Lausanne University Hospital (CHUV), Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031660292","display_name":"Mette M. Berger","orcid":"https://orcid.org/0000-0001-5427-1648","observed_orcids":["https://orcid.org/0000-0001-5427-1648"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mette M. Berger","raw_affiliation_strings":["Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5427-1648","affiliations":[{"raw_affiliation_string":"Service of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004104018"],"corresponding_institution_ids":["https://openalex.org/I2802229882"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.3045,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.52364398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"53","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-hydroxy-beta-methylbutyrate","display_name":"beta-hydroxy-beta-methylbutyrate","score":0.9570000171661377},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.8700000047683716},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.8220000267028809},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.781000018119812},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9869999885559082},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.9800000190734863},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9789999723434448},{"id":"https://openalex.org/keywords/muscle-mass-preservation","display_name":"muscle mass preservation","score":0.5509999990463257},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9182319641113281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6403602361679077},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6327826380729675},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5632475018501282},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.5429350137710571},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5356926918029785},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.47425901889801025},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.45064952969551086},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3306991457939148},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.clnesp.2022.11.017","doi":"https://doi.org/10.1016/j.clnesp.2022.11.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clnesp.2022.11.017","pdf_url":null,"source":{"id":"https://openalex.org/S2764915710","display_name":"Clinical Nutrition ESPEN","issn_l":"2405-4577","issn":["2405-4577"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nutrition ESPEN","raw_type":"journal-article"},{"id":"pmid:36657898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36657898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical nutrition ESPEN","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:iris.unil.ch:iris/39577","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/39577","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_1F0E37B45CD2","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_1F0E37B45CD2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical nutrition ESPEN, vol. 53, pp. 1-6","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323831","display_name":"Universit\u00e9 de Lausanne","ror":"https://ror.org/019whta54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1870461993","https://openalex.org/W1969709912","https://openalex.org/W1977836459","https://openalex.org/W1985395664","https://openalex.org/W2027839256","https://openalex.org/W2049495815","https://openalex.org/W2110851043","https://openalex.org/W2115730703","https://openalex.org/W2118240638","https://openalex.org/W2129894754","https://openalex.org/W2156318742","https://openalex.org/W2170128875","https://openalex.org/W2208931577","https://openalex.org/W2257285672","https://openalex.org/W2612068365","https://openalex.org/W2612702080","https://openalex.org/W2613086497","https://openalex.org/W2748094183","https://openalex.org/W2763120795","https://openalex.org/W2793442106","https://openalex.org/W2893877102","https://openalex.org/W2946968686","https://openalex.org/W2963110082","https://openalex.org/W2972560698","https://openalex.org/W2995904710","https://openalex.org/W3000788519","https://openalex.org/W3011737478","https://openalex.org/W3071809284","https://openalex.org/W3082806478","https://openalex.org/W3092864403","https://openalex.org/W3155423631","https://openalex.org/W3186749525","https://openalex.org/W3194978427","https://openalex.org/W6999989807"],"related_works":["https://openalex.org/W7161424828","https://openalex.org/W1977836459","https://openalex.org/W2527971562","https://openalex.org/W2015226336","https://openalex.org/W2077832891","https://openalex.org/W2418172869","https://openalex.org/W2416423748","https://openalex.org/W2059156857","https://openalex.org/W2464816150","https://openalex.org/W2076269126"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-11-30T00:00:00"}