{"id":"https://openalex.org/W4309845708","doi":"https://doi.org/10.33920/med-03-2211-03","title":"Possibilities of structure modifying therapy of subcompensated gonarthrosis","display_name":"Possibilities of structure modifying therapy of subcompensated gonarthrosis","publication_year":2022,"publication_date":"2022-11-20","ids":{"openalex":"https://openalex.org/W4309845708","doi":"https://doi.org/10.33920/med-03-2211-03"},"language":"en","primary_location":{"id":"doi:10.33920/med-03-2211-03","doi":"https://doi.org/10.33920/med-03-2211-03","is_oa":false,"landing_page_url":"https://doi.org/10.33920/med-03-2211-03","pdf_url":null,"source":{"id":"https://openalex.org/S4306511536","display_name":"Glavvra\u010d (Chief Medical Officer)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glavvra\u010d (Chief Medical Officer)","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4309845708"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"FSBE Institution of Higher Education \"","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FSBE Institution of Higher Education \"","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062748287","display_name":"Timur Bulatovich Minasov","orcid":"https://orcid.org/0000-0003-1916-3830","observed_orcids":["https://orcid.org/0000-0003-1916-3830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. B. Minasov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1916-3830","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"of the Ministry of Health of the Russian Federation","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"of the Ministry of Health of the Russian Federation","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024454910","display_name":"\u0411. \u0428. \u041c\u0438\u043d\u0430\u0441\u043e\u0432","orcid":"https://orcid.org/0000-0002-1733-9823","observed_orcids":["https://orcid.org/0000-0002-1733-9823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. S. Minasov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1733-9823","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025473981","display_name":"Akop Ovikovich Ginoyan","orcid":"https://orcid.org/0000-0001-7461-4417","observed_orcids":["https://orcid.org/0000-0001-7461-4417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. O. Ginoyan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7461-4417","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060486726","display_name":"Alfiya Kamilevna Imaeva","orcid":"https://orcid.org/0000-0002-3421-0212","observed_orcids":["https://orcid.org/0000-0002-3421-0212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. K. Imaeva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3421-0212","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069530036","display_name":"D. S. Vishnyakov","orcid":"https://orcid.org/0000-0001-7339-0589","observed_orcids":["https://orcid.org/0000-0001-7339-0589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. S. Vishnyakov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038666001","display_name":"R. Z. Nurlygayanov","orcid":"https://orcid.org/0000-0002-3026-5814","observed_orcids":["https://orcid.org/0000-0002-3026-5814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Z. Nurlygayanov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3026-5814","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090404326","display_name":"Ekaterina Rishatovna Yakupova","orcid":"https://orcid.org/0000-0002-5496-0766","observed_orcids":["https://orcid.org/0000-0002-5496-0766","https://orcid.org/0009-0009-6601-3131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. R. Yakupova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5496-0766","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"11","first_page":"21","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/diacerein","display_name":"diacerein","score":0.9459999799728394},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9599999785423279},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6069999933242798},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.984000027179718},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.6209999918937683},{"id":"https://openalex.org/keywords/elastase","display_name":"elastase","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6908520460128784},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6881979703903198},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5634053945541382},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4907761514186859},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4655274748802185},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4632493257522583},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.43186402320861816},{"id":"https://openalex.org/C2780024818","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Hyaline cartilage","level":5,"score":0.43019339442253113},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.4187442660331726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40034911036491394},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.36157873272895813},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1392514705657959},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13013052940368652},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10401245951652527},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07394331693649292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.055296123027801514}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33920/med-03-2211-03","doi":"https://doi.org/10.33920/med-03-2211-03","is_oa":false,"landing_page_url":"https://doi.org/10.33920/med-03-2211-03","pdf_url":null,"source":{"id":"https://openalex.org/S4306511536","display_name":"Glavvra\u010d (Chief Medical Officer)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glavvra\u010d (Chief Medical Officer)","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2782610639","https://openalex.org/W2991485542","https://openalex.org/W3008980028"],"related_works":["https://openalex.org/W2509047746","https://openalex.org/W2236515728","https://openalex.org/W2075529839","https://openalex.org/W4320507029","https://openalex.org/W2153277119","https://openalex.org/W1196314022","https://openalex.org/W4384695829","https://openalex.org/W2372364918","https://openalex.org/W2148593604","https://openalex.org/W4413783661"],"abstract_inverted_index":{"This":[0],"study":[1],"shows":[2],"that":[3],"a":[4,10,15,20],"combined":[5],"treatment":[6],"regimen":[7],"consisting":[8],"of":[9,26,29,42,61],"NSAID":[11],"group":[12],"drug":[13,63],"and":[14,38,45,51],"slow-acting":[16],"chondroprotective":[17],"agent":[18],"has":[19,34],"positive":[21],"effect":[22,37,60],"in":[23],"the":[24,30,40,55,59,62],"therapy":[25],"subcompensated":[27],"osteoarthritis":[28],"knee":[31],"joint.":[32],"Diacerein":[33],"an":[35],"anti-inflammatory":[36],"inhibits":[39],"activity":[41],"interleukin-1,":[43],"interleukin-6,":[44],"TNF-alpha,":[46],"as":[47,49],"well":[48],"collagenase":[50],"elastase,":[52],"which":[53,68],"destroy":[54],"hyaline":[56],"cartilage.":[57],"However,":[58],"does":[64],"not":[65],"occur":[66],"immediately,":[67],"justifies":[69],"its":[70],"combination":[71],"with":[72],"NSAIDs.":[73]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-29T00:00:00"}