{"id":"https://openalex.org/W4309740543","doi":"https://doi.org/10.3390/cancers14225697","title":"RAD51 Is Implicated in DNA Damage, Chemoresistance and Immune Dysregulation in Solid Tumors","display_name":"RAD51 Is Implicated in DNA Damage, Chemoresistance and Immune Dysregulation in Solid Tumors","publication_year":2022,"publication_date":"2022-11-20","ids":{"openalex":"https://openalex.org/W4309740543","doi":"https://doi.org/10.3390/cancers14225697","pmid":"https://pubmed.ncbi.nlm.nih.gov/36428789","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9688595"},"language":"en","primary_location":{"id":"doi:10.3390/cancers14225697","doi":"https://doi.org/10.3390/cancers14225697","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14225697","pdf_url":"https://www.mdpi.com/2072-6694/14/22/5697/pdf?version=1668927820","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/14/22/5697/pdf?version=1668927820","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084310044","display_name":"Chengcheng Liao","orcid":"https://orcid.org/0000-0003-0408-6684","observed_orcids":["https://orcid.org/0000-0003-0408-6684"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Chengcheng Liao","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning 530021, China","VA Health Care System, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning 530021, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]},{"raw_affiliation_string":"VA Health Care System, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112389374","display_name":"Srikanth Talluri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srikanth Talluri","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","VA Health Care System, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"VA Health Care System, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103176292","display_name":"Jiangning Zhao","orcid":"https://orcid.org/0000-0003-3830-2672","observed_orcids":["https://orcid.org/0000-0003-3830-2672"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiangning Zhao","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","VA Health Care System, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"VA Health Care System, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058738548","display_name":"Shidai Mu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shidai Mu","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","VA Health Care System, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"VA Health Care System, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103420970","display_name":"Subodh Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subodh Kumar","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","VA Health Care System, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"VA Health Care System, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027257617","display_name":"Jialan Shi","orcid":"https://orcid.org/0000-0001-5642-5436","observed_orcids":["https://orcid.org/0000-0001-5642-5436"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jialan Shi","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","Department of Medicine, Harvard Medical School, Boston, MA 02215, USA","VA Health Care System, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"VA Health Care System, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036264384","display_name":"Leutz Buon","orcid":"https://orcid.org/0009-0000-5990-1936","observed_orcids":["https://orcid.org/0009-0000-5990-1936"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leutz Buon","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil C. Munshi","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","Department of Medicine, Harvard Medical School, Boston, MA 02215, USA","VA Health Care System, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"VA Health Care System, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masood A. Shammas","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","VA Health Care System, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"VA Health Care System, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I2801671727"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5063099799"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801671727","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":1.5498,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.83391181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"14","issue":"22","first_page":"5697","last_page":"5697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rad51","display_name":"RAD51","score":0.9980000257492065},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.996999979019165},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9309999942779541},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/rad51-inhibitors","display_name":"RAD51 inhibitors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dna-end-resection","display_name":"DNA end resection","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.5120000243186951},{"id":"https://openalex.org/keywords/pd-1-signaling","display_name":"PD-1 signaling","score":0.8220000267028809},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.5889999866485596},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.6959999799728394},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.6899999976158142},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.42899999022483826},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3970000147819519},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.8073775768280029},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.7091373801231384},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6320029497146606},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5747924447059631},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.5482693910598755},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5312100648880005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47368624806404114},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.43809205293655396},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.43203413486480713},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39781689643859863},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2511848211288452},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13132834434509277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09065774083137512},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.07955548167228699},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.0},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers14225697","doi":"https://doi.org/10.3390/cancers14225697","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14225697","pdf_url":"https://www.mdpi.com/2072-6694/14/22/5697/pdf?version=1668927820","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9688595","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9688595","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:36428789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36428789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f8083ed7ba8d4759b2c4e37978a9f722","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f8083ed7ba8d4759b2c4e37978a9f722","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 14, Iss 5697, p 5697 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers14225697","doi":"https://doi.org/10.3390/cancers14225697","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14225697","pdf_url":"https://www.mdpi.com/2072-6694/14/22/5697/pdf?version=1668927820","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2526122010","display_name":null,"funder_award_id":"P01-155258","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2987995130","display_name":null,"funder_award_id":"2020M673555XB","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G3298659785","display_name":null,"funder_award_id":"2018GXNSFBA281026","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G3606480858","display_name":null,"funder_award_id":"I01BX001584-01","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G3611842040","display_name":null,"funder_award_id":"2020M673555XB","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3643881707","display_name":null,"funder_award_id":"I01BX001584-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3668218448","display_name":null,"funder_award_id":"I01 BX001584","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4903016686","display_name":null,"funder_award_id":"82260042","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4933731489","display_name":"SPORE in Multiple Myeloma","funder_award_id":"P50CA100707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5993965870","display_name":null,"funder_award_id":"2018GXNSFBA281026","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6931075798","display_name":null,"funder_award_id":"82260042","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G7074122679","display_name":null,"funder_award_id":"P01-155258","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G7985978177","display_name":null,"funder_award_id":"5P50 CA100707","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G8378304111","display_name":null,"funder_award_id":"82260042","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309740543.pdf","grobid_xml":"https://content.openalex.org/works/W4309740543.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W768337726","https://openalex.org/W1564453109","https://openalex.org/W1970561675","https://openalex.org/W1979385111","https://openalex.org/W2004568915","https://openalex.org/W2029130715","https://openalex.org/W2030797511","https://openalex.org/W2031176449","https://openalex.org/W2034527116","https://openalex.org/W2035858672","https://openalex.org/W2045506022","https://openalex.org/W2048888997","https://openalex.org/W2051296872","https://openalex.org/W2052547134","https://openalex.org/W2057347731","https://openalex.org/W2067466498","https://openalex.org/W2070504952","https://openalex.org/W2071411482","https://openalex.org/W2077436902","https://openalex.org/W2085192138","https://openalex.org/W2109879947","https://openalex.org/W2110878284","https://openalex.org/W2113417622","https://openalex.org/W2136223090","https://openalex.org/W2141599203","https://openalex.org/W2145200068","https://openalex.org/W2158542519","https://openalex.org/W2159546722","https://openalex.org/W2163671315","https://openalex.org/W2321915429","https://openalex.org/W2518520516","https://openalex.org/W2598228858","https://openalex.org/W2795227812","https://openalex.org/W2893714831","https://openalex.org/W2902530726","https://openalex.org/W2910361233","https://openalex.org/W3088065982","https://openalex.org/W3164146079","https://openalex.org/W4280601762","https://openalex.org/W6678569700","https://openalex.org/W6783353920"],"related_works":["https://openalex.org/W3088065982","https://openalex.org/W2598228858","https://openalex.org/W3183763111","https://openalex.org/W7204707261","https://openalex.org/W4414471663","https://openalex.org/W2085483134","https://openalex.org/W211438262","https://openalex.org/W2166927455","https://openalex.org/W2984934173","https://openalex.org/W2034409892"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,347],"normal":[2],"cells,":[3],"homologous":[4,35],"recombination":[5],"(HR)":[6],"is":[7,30,400],"tightly":[8],"regulated":[9],"and":[10,21,38,52,77,85,103,112,124,150,185,190,197,228,242,265,272,290,326,354,387,396,404,410,419,438],"plays":[11],"an":[12],"important":[13],"role":[14,70],"in":[15,49,73,80,109,118,187,195,198,234,248,301,307,312,385,402,422],"the":[16,249],"maintenance":[17],"of":[18,26,64,71,97,105,143,147,154,170,174,203,206,225,251,269,282,297,316,382,394,426],"genomic":[19,61,74,171,266,291,411],"integrity":[20],"stability":[22],"through":[23],"precise":[24],"repair":[25,43,325],"DNA":[27,42,137,148,155,239,257,263,285,288,298,324,334,361,405,408],"damage.":[28],"RAD51":[29,98,115,175,207,219,232,283,293,345,369,376,395,427],"a":[31,125,134,178,199,278,313],"recombinase":[32],"that":[33,57,323,381],"mediates":[34,60],"base":[36],"pairing":[37],"strand":[39,243],"exchange":[40,244],"during":[41],"by":[44,140,165,214,319,333,344,360,368],"HR.":[45],"Our":[46],"previous":[47],"data":[48],"multiple":[50],"myeloma":[51],"esophageal":[53],"adenocarcinoma":[54],"(EAC)":[55],"show":[56],"dysregulated":[58],"HR":[59,72,129,398],"instability.":[62,267,292],"Purpose":[63],"this":[65],"study":[66],"was":[67,116,131,163,181,212],"to":[68,94,415],"investigate":[69,95],"instability,":[75],"chemoresistance":[76],"immune":[78,107,389,417],"dysregulation":[79,418],"solid":[81,441],"tumors":[82],"including":[83],"colon":[84,191,229,271],"breast":[86,111,189,227,273,437],"cancers.":[87,114],"METHODS:":[88],"The":[89],"GEO":[90],"dataset":[91],"were":[92,331,357],"used":[93],"correlation":[96],"expression":[99,104,142,210,220,377,393],"with":[100,222,277,372,380],"patient":[101],"survival":[102,224],"various":[106],"markers":[108],"EAC,":[110,188,226,270,435],"colorectal":[113],"inhibited":[117,238,284],"cancer":[119,192,230,235,274,303],"cell":[120,193,236,275,304,327],"lines":[121,194,237,276],"using":[122,133,158],"shRNAs":[123],"small":[126,279],"molecule":[127,280],"inhibitor.":[128,346,370],"activity":[130,245,399],"evaluated":[132],"plasmid-based":[135],"assay,":[136],"breaks":[138,264,289,409],"assessed":[139,182],"evaluating":[141],"\u03b3-H2AX":[144],"(a":[145,152,168],"marker":[146,153,169],"breaks)":[149],"p-RPA32":[151],"end":[156,240],"resection)":[157],"Western":[159],"blotting.":[160],"Genomic":[161],"instability":[162,412],"monitored":[164,213],"investigating":[166],"micronuclei":[167],"instability).":[172],"Impact":[173,205],"inhibitor":[176,208,281,294],"and/or":[177],"DNA-damaging":[179],"agent":[180,300,336,363],"on":[183,209],"viability":[184],"apoptosis":[186],"vitro":[196,308],"subcutaneous":[200,314],"tumor":[201],"model":[202,315],"EAC.":[204,317],"profile":[211],"RNA":[215,320],"sequencing.":[216],"RESULTS:":[217],"Elevated":[218,392],"correlated":[221,379],"poor":[223,420],"patients.":[231],"knockdown":[233],"resection":[241],"(key":[246],"steps":[247],"initiation":[250],"HR)":[252],"as":[253,255,309,311,352,431],"well":[254,310],"spontaneous":[256,403],"breaks,":[258],"whereas":[259,337,364],"its":[260],"overexpression":[261],"increased":[262],"Treatment":[268],"breaking":[286,299,335,362],"agent-induced":[287,407],"potentiated":[295],"cytotoxicity":[296],"all":[302],"types":[305],"tested":[306],"Evaluation":[318],"sequencing":[321],"demonstrated":[322],"cycle":[328],"related":[329],"pathways":[330,350],"induced":[332,359],"their":[338,365],"induction":[339,366],"either":[340],"prevented":[341,367],"or":[342],"reversed":[343],"addition,":[348],"immune-related":[349],"such":[351],"PD-1":[353],"Interferon":[355],"Signaling":[356],"also":[358,378],"Consistent":[371],"these":[373],"observations,":[374],"elevated":[375],"genes":[383],"involved":[384,401],"inflammation":[386],"other":[388,440],"surveillance.":[390],"CONCLUSIONS:":[391],"associated":[397],"damaging":[406],"thus":[413],"contributing":[414],"chemoresistance,":[416],"prognosis":[421],"cancer.":[423],"Therefore,":[424],"inhibitors":[425],"have":[428],"great":[429],"potential":[430],"therapeutic":[432],"agents":[433],"for":[434],"colon,":[436],"probably":[439],"tumors.":[442]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-29T00:00:00"}