{"id":"https://openalex.org/W4309740539","doi":"https://doi.org/10.3390/brainsci12111580","title":"The Association between High Mobility Group Box 1 and Stroke-Associated Pneumonia in Acute Ischemic Stroke Patients","display_name":"The Association between High Mobility Group Box 1 and Stroke-Associated Pneumonia in Acute Ischemic Stroke Patients","publication_year":2022,"publication_date":"2022-11-19","ids":{"openalex":"https://openalex.org/W4309740539","doi":"https://doi.org/10.3390/brainsci12111580","pmid":"https://pubmed.ncbi.nlm.nih.gov/36421903","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9688221"},"language":"en","primary_location":{"id":"doi:10.3390/brainsci12111580","doi":"https://doi.org/10.3390/brainsci12111580","is_oa":true,"landing_page_url":"https://doi.org/10.3390/brainsci12111580","pdf_url":"https://www.mdpi.com/2076-3425/12/11/1580/pdf?version=1668844001","source":{"id":"https://openalex.org/S122317144","display_name":"Brain Sciences","issn_l":"2076-3425","issn":["2076-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3425/12/11/1580/pdf?version=1668844001","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yan E","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan E","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017011286","display_name":"Qiwen Deng","orcid":"https://orcid.org/0000-0003-4324-8009","observed_orcids":["https://orcid.org/0000-0003-4324-8009"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiwen Deng","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085895492","display_name":"Guomei Shi","orcid":"https://orcid.org/0000-0002-7145-0573","observed_orcids":["https://orcid.org/0000-0002-7145-0573"]},"institutions":[{"id":"https://openalex.org/I4210106952","display_name":"Taixing People's Hospital","ror":"https://ror.org/02ez0zm48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guomei Shi","raw_affiliation_strings":["Department of Neurology, Taixing People\u2019s Hospital, Taixing 225400, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Taixing People\u2019s Hospital, Taixing 225400, China","institution_ids":["https://openalex.org/I4210106952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650031","display_name":"Zhongyuan Li","orcid":"https://orcid.org/0000-0001-5470-7149","observed_orcids":["https://orcid.org/0000-0001-5470-7149"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongyuan Li","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021690285","display_name":"Chengfang Liu","orcid":"https://orcid.org/0000-0002-3399-5978","observed_orcids":["https://orcid.org/0000-0002-3399-5978"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengfang Liu","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358918","display_name":"Siyu Wang","orcid":"https://orcid.org/0000-0002-7397-6210","observed_orcids":["https://orcid.org/0000-0002-7397-6210"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyu Wang","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059907851","display_name":"Hui-Wen Lian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiwen Lian","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101488625","display_name":"Haiming Cao","orcid":"https://orcid.org/0000-0001-8271-4653","observed_orcids":["https://orcid.org/0000-0001-8271-4653"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiming Cao","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088544018","display_name":"Xiaohao Zhang","orcid":"https://orcid.org/0000-0002-8916-8592","observed_orcids":["https://orcid.org/0000-0002-8916-8592"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohao Zhang","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043503539","display_name":"Yingdong Zhang","orcid":"https://orcid.org/0000-0002-6470-5064","observed_orcids":["https://orcid.org/0000-0002-6470-5064"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingdong Zhang","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065259624","display_name":"Pengyu Gong","orcid":"https://orcid.org/0000-0002-2980-6513","observed_orcids":["https://orcid.org/0000-0002-2980-6513"]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pengyu Gong","raw_affiliation_strings":["Department of Neurology, The Affiliated Hospital of Nantong University, Nantong 226000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Affiliated Hospital of Nantong University, Nantong 226000, China","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060887077","display_name":"Teng Jiang","orcid":"https://orcid.org/0000-0003-4170-1156","observed_orcids":["https://orcid.org/0000-0003-4170-1156"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Teng Jiang","raw_affiliation_strings":["Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060887077","https://openalex.org/A5065259624"],"corresponding_institution_ids":["https://openalex.org/I4210086801","https://openalex.org/I4405277390","https://openalex.org/I83519826"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2094},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2094},"fwci":0.5409,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.64044778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"11","first_page":"1580","last_page":"1580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11358","display_name":"Dysphagia Assessment and Management","score":0.14390000700950623,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-mobility-group-box-1","display_name":"high mobility group box 1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/stroke-associated-pneumonia","display_name":"stroke-associated pneumonia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pneumonia-risk-prediction","display_name":"pneumonia risk prediction","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.8668776750564575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8198332786560059},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.8064507246017456},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7656147480010986},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.6186800599098206},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6175128221511841},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6132820248603821},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.606808602809906},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.5646403431892395},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/brainsci12111580","doi":"https://doi.org/10.3390/brainsci12111580","is_oa":true,"landing_page_url":"https://doi.org/10.3390/brainsci12111580","pdf_url":"https://www.mdpi.com/2076-3425/12/11/1580/pdf?version=1668844001","source":{"id":"https://openalex.org/S122317144","display_name":"Brain Sciences","issn_l":"2076-3425","issn":["2076-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9688221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9688221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sci","raw_type":"Text"},{"id":"pmid:36421903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36421903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:382f5576bd014696a7e6d964d320f47d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/382f5576bd014696a7e6d964d320f47d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Sciences, Vol 12, Iss 11, p 1580 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/brainsci12111580","doi":"https://doi.org/10.3390/brainsci12111580","is_oa":true,"landing_page_url":"https://doi.org/10.3390/brainsci12111580","pdf_url":"https://www.mdpi.com/2076-3425/12/11/1580/pdf?version=1668844001","source":{"id":"https://openalex.org/S122317144","display_name":"Brain Sciences","issn_l":"2076-3425","issn":["2076-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2500813175","display_name":null,"funder_award_id":"BK20221175","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309740539.pdf","grobid_xml":"https://content.openalex.org/works/W4309740539.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1614438016","https://openalex.org/W1992932447","https://openalex.org/W2067395123","https://openalex.org/W2075035271","https://openalex.org/W2103066461","https://openalex.org/W2137812201","https://openalex.org/W2138595885","https://openalex.org/W2569387348","https://openalex.org/W2885011330","https://openalex.org/W2897423402","https://openalex.org/W2930384432","https://openalex.org/W2946329631","https://openalex.org/W2953282350","https://openalex.org/W2954173187","https://openalex.org/W3012314530","https://openalex.org/W3037461866","https://openalex.org/W3111607518","https://openalex.org/W3142724140","https://openalex.org/W3197715981","https://openalex.org/W3213613777","https://openalex.org/W3216605625","https://openalex.org/W4200485500","https://openalex.org/W4206501402","https://openalex.org/W4206806812","https://openalex.org/W4221079437","https://openalex.org/W4221126856","https://openalex.org/W4280574237","https://openalex.org/W4281286962","https://openalex.org/W4283370099","https://openalex.org/W4284968207","https://openalex.org/W4285677155","https://openalex.org/W4285727660","https://openalex.org/W4292178757","https://openalex.org/W4292756624"],"related_works":["https://openalex.org/W3042035385","https://openalex.org/W3092225711","https://openalex.org/W4402652985","https://openalex.org/W4416139625","https://openalex.org/W7202352809","https://openalex.org/W4220922592","https://openalex.org/W7215057942","https://openalex.org/W2722320394","https://openalex.org/W4296050370","https://openalex.org/W4400959521"],"abstract_inverted_index":{"Objective:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,57,80,96,245],"investigate":[5],"the":[6,37,59,82,85,117,125,132,143,150,157,197],"association":[7,86,229],"between":[8,87,230],"high-mobility-group":[9],"box":[10],"1":[11],"(HMGB1)":[12],"and":[13,43,63,90,167,176,207,216,232],"stroke-associated":[14],"pneumonia":[15],"(SAP)":[16],"in":[17,28,116,124,142,156,196,253],"acute":[18],"ischemic":[19],"stroke":[20],"(AIS)":[21],"patients.":[22,255],"Methods:":[23],"AIS":[24,103,254],"patients":[25,104,109,141],"were":[26,34,46,55,78,105,120],"enrolled":[27],"two":[29],"centers.":[30],"The":[31,112],"serum":[32],"samples":[33],"collected":[35],"within":[36],"first":[38,133],"24":[39],"h":[40],"after":[41],"admission,":[42],"HMGB1":[44,72,88,115,136,147,185,231,241],"levels":[45,113],"measured":[47],"by":[48],"enzyme-linked":[49],"immunosorbent":[50],"assay.":[51],"Logistic":[52],"regression":[53],"models":[54],"used":[56],"calculate":[58],"odds":[60],"ratio":[61],"(OR)":[62],"95%":[64,163,173,182,203,213,222],"confidence":[65],"interval":[66],"(95%":[67],"CI)":[68],"of":[69,84,101,114,135,146,153,251],"SAP":[70,118,155,191,233,252],"for":[71,235],"concentrations.":[73],"Restricted":[74],"cubic":[75],"splines":[76],"(RCS)":[77],"performed":[79],"explore":[81],"shapes":[83],"concentrations":[89],"SAP.":[91,111],"Results:":[92],"From":[93],"January":[94],"2022":[95],"May":[97],"2022,":[98],"a":[99,139,193,227,248],"total":[100],"420":[102],"enrolled.":[106],"Ninety-six":[107],"(22.9%)":[108],"develop":[110],"group":[119,127,137,148],"higher":[121],"than":[122],"those":[123],"non-SAP":[126],"(p":[128,234],"<":[129],"0.001).":[130],"Using":[131],"quartile":[134,145],"as":[138,192,247],"reference,":[140],"fourth":[144],"had":[149],"highest":[151],"likelihood":[152],"experiencing":[154],"unadjusted":[158,198],"model":[159,169,178,199,209,218],"(OR":[160,170,179,200,210,219],"=":[161,171,180,201,211,220,238],"3.687;":[162],"CI:":[164,174,183,204,214,223],"1.851\u22127.344),":[165],"age-":[166,206],"sex-adjusted":[168,208],"3.511;":[172],"1.725\u22127.147),":[175],"multivariable-adjusted":[177,217],"2.701;":[181],"1.045\u22126.981).":[184],"was":[186],"also":[187],"independently":[188],"associated":[189],"with":[190],"continuous":[194],"variable":[195],"1.132;":[202],"1.069\u22121.199),":[205],"1.131;":[212],"1.066\u22121.200),":[215],"1.096;":[221],"1.011\u22121.188).":[224],"RCS":[225],"showed":[226],"linear":[228,236],"trend":[237],"0.008)":[239],"Conclusions:":[240],"might":[242],"be":[243],"able":[244],"act":[246],"potential":[249],"biomarker":[250]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-11-29T00:00:00"}