{"id":"https://openalex.org/W4309739999","doi":"https://doi.org/10.3389/fimmu.2022.1043827","title":"Molecular subtypes and a prognostic model for hepatocellular carcinoma based on immune- and immunogenic cell death-related lncRNAs","display_name":"Molecular subtypes and a prognostic model for hepatocellular carcinoma based on immune- and immunogenic cell death-related lncRNAs","publication_year":2022,"publication_date":"2022-11-21","ids":{"openalex":"https://openalex.org/W4309739999","doi":"https://doi.org/10.3389/fimmu.2022.1043827","pmid":"https://pubmed.ncbi.nlm.nih.gov/36479122","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9720162"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.1043827","doi":"https://doi.org/10.3389/fimmu.2022.1043827","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.1043827","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2022.1043827","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089573208","display_name":"Mingang He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingang He","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035492444","display_name":"Wenchao Gu","orcid":"https://orcid.org/0000-0002-1505-9887","observed_orcids":["https://orcid.org/0000-0002-1505-9887"]},"institutions":[{"id":"https://openalex.org/I4210163796","display_name":"Pudong New Area People's Hospital","ror":"https://ror.org/02hx18343","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163796"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenchao Gu","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210163796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101460457","display_name":"Yang Gao","orcid":"https://orcid.org/0000-0001-6513-2926","observed_orcids":["https://orcid.org/0000-0001-6513-2926"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Gao","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414317","display_name":"Ying Liu","orcid":"https://orcid.org/0000-0002-7698-3184","observed_orcids":["https://orcid.org/0000-0002-7698-3184"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454196","display_name":"Jie Liu","orcid":"https://orcid.org/0000-0003-2046-3021","observed_orcids":["https://orcid.org/0000-0003-2046-3021"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Liu","raw_affiliation_strings":["Cancer Center, Shandong Public Health Clinical Center, Public Health Clinical Center Affiliated to Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Shandong Public Health Clinical Center, Public Health Clinical Center Affiliated to Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000632526","display_name":"Zengjun Li","orcid":"https://orcid.org/0000-0003-0787-8089","observed_orcids":["https://orcid.org/0000-0003-0787-8089"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zengjun Li","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000632526","https://openalex.org/A5100454196"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210100830","https://openalex.org/I4210163399"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.6975,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.59902649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"1043827","last_page":"1043827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8730000257492065},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.9890000224113464},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.7490000128746033},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.9319999814033508},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.7059999704360962},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.7509999871253967},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.656000018119812},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.7799999713897705},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.7080000042915344},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7849644422531128},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6691579222679138},{"id":"https://openalex.org/C2777877232","wikidata":"https://www.wikidata.org/wiki/Q17144704","display_name":"Immunogenic cell death","level":4,"score":0.6242232918739319},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4694518446922302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4088088572025299},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4086528420448303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39916807413101196},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37231242656707764},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2413778007030487},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.18519222736358643},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09753850102424622}],"mesh":[{"descriptor_ui":"D000079527","descriptor_name":"Immunogenic Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2022.1043827","doi":"https://doi.org/10.3389/fimmu.2022.1043827","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.1043827","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9720162","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9720162/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9720162/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:36479122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36479122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:160e232012674d66b12d7d11bfd47814","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/160e232012674d66b12d7d11bfd47814","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.1043827","doi":"https://doi.org/10.3389/fimmu.2022.1043827","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.1043827","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334121","display_name":"Natural Science Fund for Distinguished Young Scholars of Shandong Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309739999.pdf","grobid_xml":"https://content.openalex.org/works/W4309739999.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W110572178","https://openalex.org/W622302770","https://openalex.org/W1515233324","https://openalex.org/W1757407923","https://openalex.org/W1942176190","https://openalex.org/W1957438118","https://openalex.org/W1967329857","https://openalex.org/W1980638418","https://openalex.org/W1991098379","https://openalex.org/W1995273540","https://openalex.org/W2000307707","https://openalex.org/W2028366196","https://openalex.org/W2032183472","https://openalex.org/W2032580087","https://openalex.org/W2035126508","https://openalex.org/W2035747243","https://openalex.org/W2037505430","https://openalex.org/W2047902191","https://openalex.org/W2052730188","https://openalex.org/W2052968488","https://openalex.org/W2059409197","https://openalex.org/W2062069198","https://openalex.org/W2067632426","https://openalex.org/W2070904697","https://openalex.org/W2073759231","https://openalex.org/W2085364628","https://openalex.org/W2091415498","https://openalex.org/W2093424661","https://openalex.org/W2095485692","https://openalex.org/W2097995306","https://openalex.org/W2105396178","https://openalex.org/W2111161262","https://openalex.org/W2120426523","https://openalex.org/W2137823095","https://openalex.org/W2142153200","https://openalex.org/W2146512944","https://openalex.org/W2151305493","https://openalex.org/W2153268494","https://openalex.org/W2155062057","https://openalex.org/W2162035071","https://openalex.org/W2163252162","https://openalex.org/W2164681766","https://openalex.org/W2166339706","https://openalex.org/W2254632051","https://openalex.org/W2320170108","https://openalex.org/W2395680368","https://openalex.org/W2416408028","https://openalex.org/W2418717866","https://openalex.org/W2507880739","https://openalex.org/W2536322725","https://openalex.org/W2546700240","https://openalex.org/W2565382901","https://openalex.org/W2606367731","https://openalex.org/W2740869100","https://openalex.org/W2748551035","https://openalex.org/W2759973322","https://openalex.org/W2763732021","https://openalex.org/W2794056534","https://openalex.org/W2795867722","https://openalex.org/W2803594824","https://openalex.org/W2810823862","https://openalex.org/W2827674523","https://openalex.org/W2901146253","https://openalex.org/W2902415760","https://openalex.org/W2913388824","https://openalex.org/W2915006341","https://openalex.org/W2921653583","https://openalex.org/W2931898234","https://openalex.org/W2941844036","https://openalex.org/W2969843242","https://openalex.org/W2971701160","https://openalex.org/W3005839752","https://openalex.org/W3011090137","https://openalex.org/W3027286012","https://openalex.org/W3035017398","https://openalex.org/W3037575536","https://openalex.org/W3048190741","https://openalex.org/W3092129070","https://openalex.org/W3095503363","https://openalex.org/W3134753458","https://openalex.org/W3149391158","https://openalex.org/W3159311544","https://openalex.org/W3164786943","https://openalex.org/W3168883753","https://openalex.org/W3169282445","https://openalex.org/W3173898085","https://openalex.org/W3188844495","https://openalex.org/W3196688236","https://openalex.org/W3206974297","https://openalex.org/W4205657036","https://openalex.org/W4223995082","https://openalex.org/W4236093791","https://openalex.org/W4281632331","https://openalex.org/W4283813884","https://openalex.org/W4288750994","https://openalex.org/W4303579533","https://openalex.org/W6604485291","https://openalex.org/W6796619197"],"related_works":["https://openalex.org/W4385851124","https://openalex.org/W4376647663","https://openalex.org/W4395013994","https://openalex.org/W4306249795","https://openalex.org/W4366696867","https://openalex.org/W4406135439","https://openalex.org/W4308325168","https://openalex.org/W4379209665","https://openalex.org/W4379966486","https://openalex.org/W4281552266"],"abstract_inverted_index":{"Background":[0],"Accumulating":[1],"evidence":[2],"shows":[3],"that":[4,177,293],"immunogenic":[5,39],"cell":[6,40,221],"death":[7],"(ICD)":[8],"enhances":[9],"immunotherapy":[10],"effectiveness.":[11],"In":[12],"this":[13],"study,":[14],"we":[15],"aimed":[16],"to":[17,70,172,241,257],"develop":[18,173],"a":[19,78,85,155,174,287],"prognostic":[20,79,175,181,288],"model":[21,176],"combining":[22],"ICD,":[23],"immunity,":[24],"and":[25,38,51,64,68,84,101,111,148,168,187,230,244,250,275,286,300],"long":[26],"non-coding":[27],"RNA":[28],"biomarkers":[29],"for":[30,107],"predicting":[31],"hepatocellular":[32],"carcinoma":[33],"(HCC)":[34],"outcomes.":[35,185],"Methods":[36],"Immune-":[37],"death-related":[41],"lncRNAs":[42],"(IICDLs)":[43],"were":[44,55,104,120,125,170],"identified":[45,283],"from":[46],"The":[47],"Cancer":[48],"Genome":[49],"Atlas":[50],"Ensembl":[52],"databases.":[53],"IICDLs":[54,83,119,164,292],"extracted":[56],"based":[57,81,87,290],"on":[58,82,88,291],"the":[59,188,297],"results":[60],"of":[61,117,123,183],"differential":[62],"expression":[63],"univariate":[65],"Cox":[66],"analyses":[67],"used":[69],"generate":[71],"molecular":[72,109,145,248,284],"subtypes":[73,110,146,249,285],"using":[74],"ConsensusClusterPlus.":[75],"We":[76],"created":[77],"signature":[80,289],"nomogram":[86],"risk":[89,112,251],"scores.":[90],"Clinical":[91],"characteristics,":[92],"immune":[93,95,220,235],"landscapes,":[94],"checkpoint":[96,236],"blocking":[97],"(ICB)":[98],"responses,":[99],"stemness,":[100],"chemotherapy":[102,259],"responses":[103,256],"also":[105],"analyzed":[106],"different":[108,255],"groups.":[113],"Result":[114],"A":[115],"total":[116],"81":[118],"identified,":[121],"20":[122],"which":[124],"significantly":[126,254],"associated":[127],"with":[128,134,140,150,305],"overall":[129],"survival":[130,157],"(OS)":[131],"in":[132,152,161,303],"patients":[133,139,151,304],"HCC.":[135,306],"Cluster":[136],"analysis":[137],"divided":[138],"HCC":[141,184],"into":[142],"two":[143],"distinct":[144],"(C1":[147],"C2),":[149],"C1":[153,186],"having":[154],"shorter":[156],"time":[158],"than":[159],"those":[160],"C2.":[162],"Four":[163],"(TMEM220-AS1,":[165],"LINC02362,":[166],"LINC01554,":[167],"LINC02499)":[169],"selected":[171],"was":[178],"an":[179],"independent":[180],"factor":[182],"high-risk":[189],"group":[190],"had":[191],"worse":[192],"OS":[193],"(hazard":[194],"ratio":[195],">":[196],"1.5,":[197],"p":[198],"<":[199,205,211,217,265,269,273,278],"0.01),":[200],"higher":[201,207,213],"T":[202,224],"stage":[203,209],"(p":[204,210,216,264,268,272,277],"0.05),":[206,212,218],"clinical":[208,298],"pathological":[214],"grade":[215],"low":[219,234],"infiltration":[222],"(CD4+":[223],"cells,":[225,227],"B":[226],"macrophages,":[228],"neutrophils,":[229],"myeloid":[231],"dendritic":[232],"cells),":[233],"gene":[237],"expression,":[238],"poor":[239],"response":[240,302],"ICB":[242],"therapy,":[243],"high":[245],"stemness.":[246],"Different":[247],"groups":[252],"showed":[253],"several":[258],"drugs,":[260],"such":[261],"as":[262],"doxorubicin":[263],"0.001),":[266,270,274],"5-fluorouracil":[267],"gemcitabine":[271],"sorafenib":[276],"0.01).":[279],"Conclusion":[280],"Our":[281],"study":[282],"could":[294],"help":[295],"predict":[296],"prognosis":[299],"treatment":[301]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-11-29T00:00:00"}