{"id":"https://openalex.org/W4309705181","doi":"https://doi.org/10.3390/medicina58111680","title":"Assessing the Safety of Total Intravenous Anesthesia with Remimazolam in General Anesthesia for Transcatheter Aortic Valve Implantation of Severe Aortic Valve Stenosis: A Case Series","display_name":"Assessing the Safety of Total Intravenous Anesthesia with Remimazolam in General Anesthesia for Transcatheter Aortic Valve Implantation of Severe Aortic Valve Stenosis: A Case Series","publication_year":2022,"publication_date":"2022-11-19","ids":{"openalex":"https://openalex.org/W4309705181","doi":"https://doi.org/10.3390/medicina58111680","pmid":"https://pubmed.ncbi.nlm.nih.gov/36422219","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9699221"},"language":"en","primary_location":{"id":"doi:10.3390/medicina58111680","doi":"https://doi.org/10.3390/medicina58111680","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58111680","pdf_url":"https://www.mdpi.com/1648-9144/58/11/1680/pdf?version=1669104055","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1648-9144/58/11/1680/pdf?version=1669104055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065007246","display_name":"Yu Yil Kim","orcid":"https://orcid.org/0000-0003-3455-9251","observed_orcids":["https://orcid.org/0000-0003-3455-9251"]},"institutions":[{"id":"https://openalex.org/I4210106328","display_name":"Presbyterian Medical Center","ror":"https://ror.org/01fvnb423","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210106328"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu-Yil Kim","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3455-9251","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea","institution_ids":["https://openalex.org/I4210106328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077575622","display_name":"Hyun Joo Heo","orcid":"https://orcid.org/0000-0003-2507-6629","observed_orcids":["https://orcid.org/0000-0003-2507-6629"]},"institutions":[{"id":"https://openalex.org/I4210106328","display_name":"Presbyterian Medical Center","ror":"https://ror.org/01fvnb423","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210106328"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Joo Heo","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-2507-6629","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea","institution_ids":["https://openalex.org/I4210106328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388851","display_name":"Ji-Hye Lee","orcid":"https://orcid.org/0000-0003-3269-3844","observed_orcids":["https://orcid.org/0000-0003-3269-3844","https://orcid.org/0009-0009-8423-9142"]},"institutions":[{"id":"https://openalex.org/I4210106328","display_name":"Presbyterian Medical Center","ror":"https://ror.org/01fvnb423","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210106328"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ji-Hye Lee","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3269-3844","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea","institution_ids":["https://openalex.org/I4210106328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056120675","display_name":"Hyung Gu Cho","orcid":"https://orcid.org/0000-0002-6653-7578","observed_orcids":["https://orcid.org/0000-0002-6653-7578"]},"institutions":[{"id":"https://openalex.org/I4210106328","display_name":"Presbyterian Medical Center","ror":"https://ror.org/01fvnb423","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210106328"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung-Gu Cho","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea","institution_ids":["https://openalex.org/I4210106328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004316263","display_name":"Geonbo Kim","orcid":"https://orcid.org/0000-0003-0621-9655","observed_orcids":["https://orcid.org/0000-0003-0621-9655"]},"institutions":[{"id":"https://openalex.org/I4210106328","display_name":"Presbyterian Medical Center","ror":"https://ror.org/01fvnb423","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210106328"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Geonbo Kim","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju 54987, Republic of Korea","institution_ids":["https://openalex.org/I4210106328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100388851"],"corresponding_institution_ids":["https://openalex.org/I4210106328"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1885},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1885},"fwci":2.9149,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.90742213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"58","issue":"11","first_page":"1680","last_page":"1680"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/remimazolam","display_name":"remimazolam","score":0.9980000257492065},{"id":"https://openalex.org/keywords/total-intravenous-anesthesia","display_name":"total intravenous anesthesia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/transcatheter-aortic-valve-replacement","display_name":"transcatheter aortic valve implantation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/severe-aortic-stenosis","display_name":"severe aortic stenosis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hemodynamic-stability","display_name":"hemodynamic stability","score":0.7799999713897705},{"id":"https://openalex.org/keywords/anesthesia-induction","display_name":"anesthesia induction","score":0.8429999947547913},{"id":"https://openalex.org/keywords/anesthesia-maintenance","display_name":"anesthesia maintenance","score":0.8920000195503235},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.830691933631897},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.7245243191719055},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.7060184478759766},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6762047410011292},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.5480591654777527},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.5270909070968628},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.41711264848709106},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2667935788631439}],"mesh":[{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000771","descriptor_name":"Anesthesia, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065467","descriptor_name":"Transcatheter Aortic Valve Replacement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/medicina58111680","doi":"https://doi.org/10.3390/medicina58111680","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58111680","pdf_url":"https://www.mdpi.com/1648-9144/58/11/1680/pdf?version=1669104055","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},{"id":"pmid:36422219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36422219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:9699221","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9699221/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:69b6350cc0314b44900db907fab16d16","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/69b6350cc0314b44900db907fab16d16","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina, Vol 58, Iss 11, p 1680 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/medicina58111680","doi":"https://doi.org/10.3390/medicina58111680","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58111680","pdf_url":"https://www.mdpi.com/1648-9144/58/11/1680/pdf?version=1669104055","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309705181.pdf","grobid_xml":"https://content.openalex.org/works/W4309705181.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2007475240","https://openalex.org/W2031407102","https://openalex.org/W2133051185","https://openalex.org/W2174801246","https://openalex.org/W2261482988","https://openalex.org/W2324884202","https://openalex.org/W2464376081","https://openalex.org/W2921388585","https://openalex.org/W2922215374","https://openalex.org/W2998786011","https://openalex.org/W3000153718","https://openalex.org/W3024474933","https://openalex.org/W3081389099","https://openalex.org/W3084186802","https://openalex.org/W3086792377","https://openalex.org/W3135222717","https://openalex.org/W3193194912","https://openalex.org/W3194788012","https://openalex.org/W3207340311","https://openalex.org/W4200264384","https://openalex.org/W4200265687","https://openalex.org/W4206661803","https://openalex.org/W4240324388","https://openalex.org/W4280531102"],"related_works":["https://openalex.org/W4307329547","https://openalex.org/W3194788012","https://openalex.org/W4410903694","https://openalex.org/W4399033817","https://openalex.org/W4297988419","https://openalex.org/W7006423178","https://openalex.org/W7213943933","https://openalex.org/W4413888711","https://openalex.org/W4405713214","https://openalex.org/W4200265687"],"abstract_inverted_index":{"Background":[0],"and":[1,20,38,49,60,76,88,99],"Objectives:":[2],"In":[3,31],"patients":[4,57,81,105],"with":[5,58,72,106],"severe":[6],"aortic":[7,27],"stenosis":[8],"(sAS),":[9],"it":[10],"is":[11],"crucial":[12],"to":[13],"maintain":[14],"hemodynamic":[15,44,86],"stability":[16,45],"during":[17,46],"the":[18,36],"induction":[19,48,73,98],"maintenance":[21,77,100],"of":[22,40,69,101],"general":[23,70,102],"anesthesia":[24,67,71,103],"for":[25,64,97],"transcatheter":[26],"valve":[28],"implantation":[29],"(TAVI).":[30],"this":[32],"study,":[33],"we":[34],"assessed":[35],"efficacy":[37],"safety":[39],"remimazolam":[41,61],"in":[42,104],"maintaining":[43],"anesthetic":[47],"maintenance.":[50],"Cases:":[51],"TAVI":[52,83],"was":[53,62],"performed":[54],"on":[55],"seven":[56],"sAS,":[59],"administered":[63],"total":[65],"intravenous":[66],"(TIVA)":[68],"(3.0":[74],"mg/kg/h)":[75],"(1.0":[78],"mg/kg/h).":[79],"All":[80],"underwent":[82],"without":[84],"major":[85],"concerns":[87],"later":[89],"recovered.":[90],"Conclusions:":[91],"Remimazolam":[92],"can":[93],"be":[94],"safely":[95],"used":[96],"sAS":[107],"when":[108],"performing":[109],"TAVI.":[110]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-11-29T00:00:00"}