{"id":"https://openalex.org/W4309515951","doi":"https://doi.org/10.1039/d2nr05528g","title":"Silica nanoparticle remodeling under mild conditions: versatile one step conversion of mesoporous to hollow nanoparticles with simultaneous payload loading","display_name":"Silica nanoparticle remodeling under mild conditions: versatile one step conversion of mesoporous to hollow nanoparticles with simultaneous payload loading","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4309515951","doi":"https://doi.org/10.1039/d2nr05528g","pmid":"https://pubmed.ncbi.nlm.nih.gov/36408868","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9970696"},"language":"en","primary_location":{"id":"doi:10.1039/d2nr05528g","doi":"https://doi.org/10.1039/d2nr05528g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2nr05528g","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9970696","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007179548","display_name":"Cassandra C. Shaffer","orcid":"https://orcid.org/0000-0002-2309-5802","observed_orcids":["https://orcid.org/0000-0002-2309-5802"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassandra C. Shaffer","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001169009","display_name":"Canjia Zhai","orcid":"https://orcid.org/0000-0002-5348-2790","observed_orcids":["https://orcid.org/0000-0002-5348-2790"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Canjia Zhai","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011239395","display_name":"Jordan L. Chasteen","orcid":"https://orcid.org/0000-0003-4896-0169","observed_orcids":["https://orcid.org/0000-0003-4896-0169"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan L. Chasteen","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA"],"raw_orcid":"https://orcid.org/0000-0003-4896-0169","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113424582","display_name":"Tatyana Orlova","orcid":"https://orcid.org/0000-0003-0113-6025","observed_orcids":["https://orcid.org/0000-0003-0113-6025"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatyana Orlova","raw_affiliation_strings":["Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN 46556, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070869174","display_name":"Maksym A. Zhukovskyi","orcid":"https://orcid.org/0009-0003-5703-6469","observed_orcids":["https://orcid.org/0009-0003-5703-6469"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maksym Zhukovskyi","raw_affiliation_strings":["Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN 46556, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072628812","display_name":"Bradley D. Smith","orcid":"https://orcid.org/0000-0003-4120-3210","observed_orcids":["https://orcid.org/0000-0003-4120-3210"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bradley D. Smith","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA"],"raw_orcid":"https://orcid.org/0000-0003-4120-3210","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072628812"],"corresponding_institution_ids":["https://openalex.org/I107639228"],"apc_list":null,"apc_paid":null,"fwci":0.1322,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.25709554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"47","first_page":"17514","last_page":"17518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10735","display_name":"Mesoporous Materials and Catalysis","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10735","display_name":"Mesoporous Materials and Catalysis","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.06419999897480011,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11852","display_name":"Clay minerals and soil interactions","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1906","display_name":"Geochemistry and Petrology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesoporous-silica-nanoparticles","display_name":"mesoporous silica nanoparticles","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hollow-nanoparticles","display_name":"hollow nanoparticles","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dye-loading","display_name":"dye loading","score":0.7630000114440918},{"id":"https://openalex.org/keywords/drug-loading","display_name":"drug loading","score":0.8939999938011169},{"id":"https://openalex.org/keywords/one-step-conversion","display_name":"one-step conversion","score":0.7020000219345093},{"id":"https://openalex.org/keywords/mild-heating","display_name":"mild heating","score":0.6240000128746033},{"id":"https://openalex.org/keywords/nanoparticle-assembly","display_name":"nanoparticle assembly","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.8117493391036987},{"id":"https://openalex.org/C2777496208","wikidata":"https://www.wikidata.org/wiki/Q17156473","display_name":"Mesoporous silica","level":4,"score":0.7904455065727234},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.673760175704956},{"id":"https://openalex.org/C82776694","wikidata":"https://www.wikidata.org/wiki/Q380049","display_name":"Mesoporous material","level":3,"score":0.6358871459960938},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.44776612520217896},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.4430503845214844},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.43541219830513},{"id":"https://openalex.org/C2781052500","wikidata":"https://www.wikidata.org/wiki/Q2230313","display_name":"Shell (structure)","level":2,"score":0.424685537815094},{"id":"https://openalex.org/C190818770","wikidata":"https://www.wikidata.org/wiki/Q6964123","display_name":"Nanoreactor","level":3,"score":0.4149879813194275},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.2064412236213684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18346941471099854},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15513569116592407},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.06498119235038757},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1039/d2nr05528g","doi":"https://doi.org/10.1039/d2nr05528g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2nr05528g","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:36408868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36408868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9970696","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9970696","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanoscale","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9970696","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9970696","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanoscale","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2982022049","display_name":"Self-Immolative Bolaamphiphiles for Signal Transduction Across Bilayer Membranes","funder_award_id":"2103598","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4098600993","display_name":"Molecular Probes for Biomembrane Recognition","funder_award_id":"R35GM136212","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7228514165","display_name":"Chemistry-Biochemistry-Biology Interface (CBBI) Program at Notre Dame","funder_award_id":"T32GM075762","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1616398204","https://openalex.org/W1929164375","https://openalex.org/W1964989229","https://openalex.org/W1990555651","https://openalex.org/W2012556606","https://openalex.org/W2035009246","https://openalex.org/W2038379069","https://openalex.org/W2041608400","https://openalex.org/W2046198040","https://openalex.org/W2048332080","https://openalex.org/W2060463490","https://openalex.org/W2088376374","https://openalex.org/W2092770524","https://openalex.org/W2116214229","https://openalex.org/W2129958133","https://openalex.org/W2322542768","https://openalex.org/W2517898463","https://openalex.org/W2518509288","https://openalex.org/W2547002701","https://openalex.org/W2580767461","https://openalex.org/W2615884758","https://openalex.org/W2737245689","https://openalex.org/W2753899156","https://openalex.org/W2781572814","https://openalex.org/W2782098908","https://openalex.org/W2885814196","https://openalex.org/W2888188873","https://openalex.org/W2895408565","https://openalex.org/W2898282427","https://openalex.org/W2937279328","https://openalex.org/W2945184931","https://openalex.org/W2965950773","https://openalex.org/W2970610221","https://openalex.org/W2974709888","https://openalex.org/W3015840796","https://openalex.org/W3023473415","https://openalex.org/W3080646746","https://openalex.org/W3081347168","https://openalex.org/W3085813886","https://openalex.org/W3096920643","https://openalex.org/W3106987369","https://openalex.org/W3108568626","https://openalex.org/W3113101209","https://openalex.org/W3120619581","https://openalex.org/W3135258731","https://openalex.org/W3154675779","https://openalex.org/W3160211742","https://openalex.org/W3206962907","https://openalex.org/W3216950378","https://openalex.org/W4205604627","https://openalex.org/W4206899532","https://openalex.org/W4212805633","https://openalex.org/W4223624834","https://openalex.org/W4282921641","https://openalex.org/W4285803962"],"related_works":["https://openalex.org/W2883150222","https://openalex.org/W3083026971","https://openalex.org/W3127713296","https://openalex.org/W2332995911","https://openalex.org/W7127786516","https://openalex.org/W2089901344","https://openalex.org/W3186111960","https://openalex.org/W2044098260","https://openalex.org/W2157914600","https://openalex.org/W2604366516"],"abstract_inverted_index":{"A":[0],"binary":[1],"mixture":[2],"of":[3,32],"mesoporous":[4],"silica":[5],"nanoparticles":[6],"plus":[7],"organic":[8],"polyammonium":[9],"additive":[10,45],"(dye":[11],"or":[12],"drug)":[13],"is":[14,27,46],"cleanly":[15],"converted":[16],"upon":[17],"mild":[18],"heating":[19],"into":[20],"hollow":[21],"nanoparticles.":[22],"The":[23],"remodeled":[24],"nanoparticle":[25],"shell":[26],"an":[28],"organized":[29],"nanoscale":[30],"assembly":[31],"globular":[33],"additive/silica":[34],"subunits":[35],"and":[36],"cancer":[37],"cell":[38],"assays":[39],"show":[40],"that":[41],"a":[42],"loaded":[43],"drug":[44],"bioavailable.":[47]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-28T00:00:00"}