{"id":"https://openalex.org/W4309441967","doi":"https://doi.org/10.15407/ubj94.04.036","title":"Localization and level of proapoptotic protein regulators in a rat lung tissue during development of acute experimental bronchopneumonia","display_name":"Localization and level of proapoptotic protein regulators in a rat lung tissue during development of acute experimental bronchopneumonia","publication_year":2022,"publication_date":"2022-11-10","ids":{"openalex":"https://openalex.org/W4309441967","doi":"https://doi.org/10.15407/ubj94.04.036"},"language":"en","primary_location":{"id":"doi:10.15407/ubj94.04.036","doi":"https://doi.org/10.15407/ubj94.04.036","is_oa":true,"landing_page_url":"https://doi.org/10.15407/ubj94.04.036","pdf_url":"http://ukrbiochemjournal.org/wp-content/uploads/2022/11/Ziablitsev_94_4.pdf","source":{"id":"https://openalex.org/S2738255883","display_name":"The Ukrainian Biochemical Journal","issn_l":"0201-8470","issn":["0201-8470","2409-4943","2413-5003"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321837","host_organization_name":"National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.","host_organization_lineage":["https://openalex.org/P4310321837"],"host_organization_lineage_names":["National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Ukrainian Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://ukrbiochemjournal.org/wp-content/uploads/2022/11/Ziablitsev_94_4.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030809138","display_name":"Denis S. Ziablitsev","orcid":"https://orcid.org/0000-0002-2671-2343","observed_orcids":["https://orcid.org/0000-0002-2671-2343"]},"institutions":[{"id":"https://openalex.org/I84407627","display_name":"Bogomolets National Medical University","ror":"https://ror.org/03edafd86","country_code":"UA","type":"education","lineage":["https://openalex.org/I84407627"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"D. S. Ziablitsev","raw_affiliation_strings":["Bogomolets National medical University, kyiv, Ukraine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bogomolets National medical University, kyiv, Ukraine;","institution_ids":["https://openalex.org/I84407627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073117199","display_name":"Artem A. Tykhomyrov","orcid":"https://orcid.org/0000-0003-2063-4636","observed_orcids":["https://orcid.org/0000-0003-2063-4636"]},"institutions":[{"id":"https://openalex.org/I149851306","display_name":"National Academy of Sciences of Ukraine","ror":"https://ror.org/00je4t102","country_code":"UA","type":"government","lineage":["https://openalex.org/I149851306"]},{"id":"https://openalex.org/I4210148994","display_name":"Palladin Institute of Biochemistry","ror":"https://ror.org/05hatwc22","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210148994"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"A. O. Tykhomyrov","raw_affiliation_strings":["Palladin Institute of Biochemistry, National academy of Sciences of Ukraine, kyiv;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palladin Institute of Biochemistry, National academy of Sciences of Ukraine, kyiv;","institution_ids":["https://openalex.org/I149851306","https://openalex.org/I4210148994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109536340","display_name":"Olena O. Dyadyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800007259","display_name":"Shupyk National Healthcare University of Ukraine","ror":"https://ror.org/02cyra061","country_code":"UA","type":"education","lineage":["https://openalex.org/I2800007259"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"O. O. Dyadyk","raw_affiliation_strings":["Shupyk National healthcare University of Ukraine, kyiv;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shupyk National healthcare University of Ukraine, kyiv;","institution_ids":["https://openalex.org/I2800007259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073693947","display_name":"S. V. Kolesnikova","orcid":"https://orcid.org/0000-0003-0345-705X","observed_orcids":["https://orcid.org/0000-0003-0345-705X"]},"institutions":[{"id":"https://openalex.org/I84407627","display_name":"Bogomolets National Medical University","ror":"https://ror.org/03edafd86","country_code":"UA","type":"education","lineage":["https://openalex.org/I84407627"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"S. V. Kolesnikova","raw_affiliation_strings":["Bogomolets National medical University, kyiv, Ukraine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bogomolets National medical University, kyiv, Ukraine;","institution_ids":["https://openalex.org/I84407627"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042212049","display_name":"Sergiy V. Ziablitsev","orcid":"https://orcid.org/0000-0002-5309-3728","observed_orcids":["https://orcid.org/0000-0002-5309-3728"]},"institutions":[{"id":"https://openalex.org/I84407627","display_name":"Bogomolets National Medical University","ror":"https://ror.org/03edafd86","country_code":"UA","type":"education","lineage":["https://openalex.org/I84407627"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"S. V. Ziablitsev","raw_affiliation_strings":["Bogomolets National medical University, kyiv, Ukraine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bogomolets National medical University, kyiv, Ukraine;","institution_ids":["https://openalex.org/I84407627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.146,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.29552888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"94","issue":"4","first_page":"36","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9520000219345093},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hemorrhagic-pneumonia","display_name":"hemorrhagic pneumonia","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/pro-apoptotic-proteins","display_name":"pro-apoptotic proteins","score":0.7020000219345093},{"id":"https://openalex.org/keywords/rat-lung","display_name":"rat lung","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7831453084945679},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7155278325080872},{"id":"https://openalex.org/C2776835828","wikidata":"https://www.wikidata.org/wiki/Q734512","display_name":"Bronchopneumonia","level":2,"score":0.6032288074493408},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5756718516349792},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5621499419212341},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.551531970500946},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4409046173095703},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.4407924711704254},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.424153208732605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3887335956096649},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36673903465270996},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.352273166179657},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3459107577800751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3254043459892273},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2977635860443115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26011955738067627},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.19174489378929138},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1354636549949646}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.15407/ubj94.04.036","doi":"https://doi.org/10.15407/ubj94.04.036","is_oa":true,"landing_page_url":"https://doi.org/10.15407/ubj94.04.036","pdf_url":"http://ukrbiochemjournal.org/wp-content/uploads/2022/11/Ziablitsev_94_4.pdf","source":{"id":"https://openalex.org/S2738255883","display_name":"The Ukrainian Biochemical Journal","issn_l":"0201-8470","issn":["0201-8470","2409-4943","2413-5003"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321837","host_organization_name":"National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.","host_organization_lineage":["https://openalex.org/P4310321837"],"host_organization_lineage_names":["National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Ukrainian Biochemical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.15407/ubj94.04.036","doi":"https://doi.org/10.15407/ubj94.04.036","is_oa":true,"landing_page_url":"https://doi.org/10.15407/ubj94.04.036","pdf_url":"http://ukrbiochemjournal.org/wp-content/uploads/2022/11/Ziablitsev_94_4.pdf","source":{"id":"https://openalex.org/S2738255883","display_name":"The Ukrainian Biochemical Journal","issn_l":"0201-8470","issn":["0201-8470","2409-4943","2413-5003"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321837","host_organization_name":"National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.","host_organization_lineage":["https://openalex.org/P4310321837"],"host_organization_lineage_names":["National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Ukrainian Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309441967.pdf","grobid_xml":"https://content.openalex.org/works/W4309441967.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W607174673","https://openalex.org/W1833464397","https://openalex.org/W1993383063","https://openalex.org/W1994725375","https://openalex.org/W2024160120","https://openalex.org/W2031015108","https://openalex.org/W2034574190","https://openalex.org/W2089374773","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2135943414","https://openalex.org/W2239384431","https://openalex.org/W2342612813","https://openalex.org/W3027918021","https://openalex.org/W3092655175","https://openalex.org/W3114700381","https://openalex.org/W3185675234","https://openalex.org/W3199807733","https://openalex.org/W6707066833"],"related_works":["https://openalex.org/W7135106385","https://openalex.org/W2499004835","https://openalex.org/W2385361613","https://openalex.org/W2352739560","https://openalex.org/W2902260352","https://openalex.org/W1505696422","https://openalex.org/W2350339959","https://openalex.org/W2382370792","https://openalex.org/W3043032745","https://openalex.org/W2355249182"],"abstract_inverted_index":{"Apoptosis":[0],"plays":[1],"an":[2],"important":[3],"role":[4],"in":[5,21,45,50,145],"the":[6,37,46,51,85,88,102,121,125,135,141,152,163],"development":[7,153],"of":[8,31,42,48,57,94,107,128,143,149,154,162],"acute":[9],"inflammatory":[10],"lung":[11],"injury":[12],"(AILI)":[13],"and":[14,27,39,60,63,73,110,124,158],"its":[15],"consequences,":[16],"which":[17],"can":[18],"be":[19],"realized":[20],"different":[22],"cells":[23],"with":[24,54,84,117],"distinct":[25],"intensity":[26,41],"rate.":[28],"The":[29,91,105],"aim":[30],"this":[32],"study":[33],"was":[34,77,99,113,132],"to":[35],"determine":[36],"distribution":[38],"expression":[40],"apoptosis":[43,144],"markers":[44],"lungs":[47],"rats":[49],"AILI":[52,150],"model":[53],"endotracheal":[55],"introduction":[56],"capron":[58],"thread":[59],"LPS.":[61],"Immunoblotting":[62],"immunohistochemical":[64],"studies":[65],"were":[66],"performed":[67],"using":[68],"monoclonal":[69],"antibodies":[70],"against":[71],"Bax":[72,80,95],"caspase-3":[74,112,130],"proteins.":[75],"It":[76],"shown":[78],"that":[79],"level":[81,106],"increased":[82,116],"significantly":[83],"peak":[86,93,127],"on":[87,101,120,134],"7th":[89],"day.":[90,104,137],"second":[92,126],"40":[96],"dimeric":[97],"form":[98],"noted":[100],"21st":[103,136],"both":[108],"pro-caspase-3":[109],"active":[111,129],"also":[114],"dramatically":[115],"a":[118],"maximum":[119],"5th":[122],"day":[123],"content":[131],"observed":[133],"These":[138],"changes":[139],"reflected":[140],"activation":[142],"key":[146],"trigger":[147],"periods":[148],"during":[151],"exudative":[155],"hemorrhagic":[156],"pneumonia":[157],"subsequent":[159],"fibrotic":[160],"remodeling":[161],"lungs.":[164],"Keywords:":[165],"AILI,":[166],"apoptosis,":[167],"Bax,":[168],"caspase-3,":[169],"lipopolysaccharide":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-11-27T00:00:00"}