{"id":"https://openalex.org/W4309410569","doi":"https://doi.org/10.1097/mat.0000000000001848","title":"Kinetic and Dynamic Effects on Degradation of von Willebrand Factor","display_name":"Kinetic and Dynamic Effects on Degradation of von Willebrand Factor","publication_year":2022,"publication_date":"2022-11-17","ids":{"openalex":"https://openalex.org/W4309410569","doi":"https://doi.org/10.1097/mat.0000000000001848","pmid":"https://pubmed.ncbi.nlm.nih.gov/36399789"},"language":"en","primary_location":{"id":"doi:10.1097/mat.0000000000001848","doi":"https://doi.org/10.1097/mat.0000000000001848","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mat.0000000000001848","pdf_url":null,"source":{"id":"https://openalex.org/S8999885","display_name":"ASAIO Journal","issn_l":"1058-2916","issn":["1058-2916","1538-943X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10143388/pdf/mat-69-467.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030256065","display_name":"Choon\u2010Sik Jhun","orcid":"https://orcid.org/0000-0003-2980-3504","observed_orcids":["https://orcid.org/0000-0003-2980-3504"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Choon-Sik Jhun","raw_affiliation_strings":["Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065260406","display_name":"Li\u2010Chong Xu","orcid":"https://orcid.org/0000-0001-6503-0655","observed_orcids":["https://orcid.org/0000-0001-6503-0655"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lichong Xu","raw_affiliation_strings":["Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063690163","display_name":"Christopher A. Siedlecki","orcid":"https://orcid.org/0000-0003-2163-4099","observed_orcids":["https://orcid.org/0000-0003-2163-4099"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher Siedlecki","raw_affiliation_strings":["Department of Biomedical Engineering, College of Engineering, The Pennsylvania State University, University Park, Pennsylvania","Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0003-2163-4099","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, College of Engineering, The Pennsylvania State University, University Park, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015801300","display_name":"Carlo Bartoli","orcid":"https://orcid.org/0000-0002-4339-3727","observed_orcids":["https://orcid.org/0000-0002-4339-3727","https://orcid.org/0000-0002-0474-3552"]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo R. Bartoli","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Geisinger Medical Center, Danville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Geisinger Medical Center, Danville, Pennsylvania","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091093068","display_name":"Eric E. Yeager","orcid":"https://orcid.org/0000-0003-3385-5139","observed_orcids":["https://orcid.org/0000-0003-3385-5139"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric Yeager","raw_affiliation_strings":["Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103472208","display_name":"Branka Lukic","orcid":"https://orcid.org/0000-0002-1604-2294","observed_orcids":["https://orcid.org/0000-0002-1604-2294"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Branka Lukic","raw_affiliation_strings":["Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021218438","display_name":"Christopher M. Scheib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher M. Scheib","raw_affiliation_strings":["Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067783529","display_name":"Raymond K. Newswanger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raymond Newswanger","raw_affiliation_strings":["Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046394134","display_name":"Joshua P. Cysyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua P. Cysyk","raw_affiliation_strings":["Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029035012","display_name":"Chan Shen","orcid":"https://orcid.org/0000-0001-5680-3134","observed_orcids":["https://orcid.org/0000-0001-5680-3134"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chan Shen","raw_affiliation_strings":["Division of Outcomes Research and Quality, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Outcomes Research and Quality, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013018968","display_name":"Karl Bohnenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karl Bohnenberger","raw_affiliation_strings":["Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064736695","display_name":"Jason Weiss","orcid":"https://orcid.org/0000-0003-2859-7980","observed_orcids":["https://orcid.org/0000-0003-2859-7980"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William J. Weiss","raw_affiliation_strings":["Department of Biomedical Engineering, College of Engineering, The Pennsylvania State University, University Park, Pennsylvania","Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, College of Engineering, The Pennsylvania State University, University Park, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010891348","display_name":"Gerson Rosenberg","orcid":"https://orcid.org/0000-0002-1924-6903","observed_orcids":["https://orcid.org/0000-0002-1924-6903"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gerson Rosenberg","raw_affiliation_strings":["Department of Biomedical Engineering, College of Engineering, The Pennsylvania State University, University Park, Pennsylvania","Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, College of Engineering, The Pennsylvania State University, University Park, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Division of Applied Biomedical Engineering, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010891348","https://openalex.org/A5013018968","https://openalex.org/A5021218438","https://openalex.org/A5030256065","https://openalex.org/A5046394134","https://openalex.org/A5063690163","https://openalex.org/A5064736695","https://openalex.org/A5065260406","https://openalex.org/A5067783529","https://openalex.org/A5091093068","https://openalex.org/A5103472208"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":null,"apc_paid":null,"fwci":0.7803,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.73351426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"69","issue":"5","first_page":"467","last_page":"474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.046300001442432404,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/high-molecular-weight-multimers","display_name":"high molecular weight multimers","score":0.9110000133514404},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/left-ventricular-assist-device","display_name":"left ventricular assist device","score":0.8799999952316284},{"id":"https://openalex.org/keywords/reynolds-number","display_name":"Reynolds number","score":0.8270000219345093},{"id":"https://openalex.org/keywords/exposure-time","display_name":"exposure time","score":0.949999988079071},{"id":"https://openalex.org/keywords/laminar-flow","display_name":"laminar flow","score":0.8040000200271606},{"id":"https://openalex.org/keywords/transitional-flow","display_name":"transitional flow","score":0.6579999923706055},{"id":"https://openalex.org/keywords/platelet-poor-plasma","display_name":"platelet-poor plasma","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C76563973","wikidata":"https://www.wikidata.org/wiki/Q189452","display_name":"Laminar flow","level":2,"score":0.6684712171554565},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.6684684753417969},{"id":"https://openalex.org/C182748727","wikidata":"https://www.wikidata.org/wiki/Q178932","display_name":"Reynolds number","level":3,"score":0.5570131540298462},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5394763350486755},{"id":"https://openalex.org/C196558001","wikidata":"https://www.wikidata.org/wiki/Q190132","display_name":"Turbulence","level":2,"score":0.5278542041778564},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.47342827916145325},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3215097188949585},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3204253911972046},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.3169204592704773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3059929311275482},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22344309091567993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16694223880767822},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014842","descriptor_name":"von Willebrand Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014842","descriptor_name":"von Willebrand Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014842","descriptor_name":"von Willebrand Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014842","descriptor_name":"von Willebrand Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/mat.0000000000001848","doi":"https://doi.org/10.1097/mat.0000000000001848","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mat.0000000000001848","pdf_url":null,"source":{"id":"https://openalex.org/S8999885","display_name":"ASAIO Journal","issn_l":"1058-2916","issn":["1058-2916","1538-943X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO Journal","raw_type":"journal-article"},{"id":"pmid:36399789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36399789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO journal (American Society for Artificial Internal Organs : 1992)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10143388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10143388","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10143388/pdf/mat-69-467.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ASAIO J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10143388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10143388","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10143388/pdf/mat-69-467.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ASAIO J","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/1","display_name":"No poverty","score":0.550000011920929}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5776293493","display_name":"Degradation Mechanism of Multimeric Structure of von Willebrand Factor","funder_award_id":"20TPA35490030","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G693450408","display_name":null,"funder_award_id":"R01 HL136369","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309410569.pdf","grobid_xml":"https://content.openalex.org/works/W4309410569.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W631163618","https://openalex.org/W1499200316","https://openalex.org/W1879572961","https://openalex.org/W1983406676","https://openalex.org/W1994879150","https://openalex.org/W1999680744","https://openalex.org/W2006527490","https://openalex.org/W2013735549","https://openalex.org/W2016225850","https://openalex.org/W2028961595","https://openalex.org/W2035454293","https://openalex.org/W2035645006","https://openalex.org/W2035917135","https://openalex.org/W2038891873","https://openalex.org/W2055992037","https://openalex.org/W2091695565","https://openalex.org/W2106109080","https://openalex.org/W2113085354","https://openalex.org/W2134941807","https://openalex.org/W2157306375","https://openalex.org/W2171779947","https://openalex.org/W2177914538","https://openalex.org/W2327852714","https://openalex.org/W2334555511","https://openalex.org/W2346698849","https://openalex.org/W2419779208","https://openalex.org/W2561502499","https://openalex.org/W2613972821","https://openalex.org/W2796113371","https://openalex.org/W2892875495","https://openalex.org/W2898806359","https://openalex.org/W2898969170","https://openalex.org/W2906396451","https://openalex.org/W2962076761","https://openalex.org/W2984398218","https://openalex.org/W2993727089","https://openalex.org/W3098581765","https://openalex.org/W3099368254","https://openalex.org/W3140809061","https://openalex.org/W4200110896"],"related_works":["https://openalex.org/W3128269287","https://openalex.org/W1143221572","https://openalex.org/W2152090065","https://openalex.org/W71690741","https://openalex.org/W1537999034","https://openalex.org/W2368924260","https://openalex.org/W4321452459","https://openalex.org/W2047210461","https://openalex.org/W2055294852","https://openalex.org/W4310832293"],"abstract_inverted_index":{"The":[0,34,78,112,121],"loss":[1],"of":[2,8,36,45,49,68,105,164,191],"high":[3,30],"molecular":[4],"weight":[5],"multimers":[6],"(HMWM)":[7],"von":[9],"Willebrand":[10],"factor":[11],"(vWF)":[12],"in":[13,47,98,188],"aortic":[14],"stenosis":[15],"(AS)":[16],"and":[17,53,74,137,179,196],"continuous-flow":[18],"left":[19],"ventricular":[20],"assist":[21],"devices":[22],"(cf-LVADs)":[23],"is":[24,39,200],"believed":[25],"to":[26,40],"be":[27],"associated":[28],"with":[29,171],"turbulent":[31,138],"blood":[32],"shear.":[33],"objective":[35],"this":[37],"study":[38],"understand":[41],"the":[42,99,117,172,189],"degradation":[43,152,190],"mechanism":[44],"HMWM":[46,165],"terms":[48],"exposure":[50,72,100],"time":[51,101],"(kinetic)":[52],"flow":[54,113,157],"regime":[55],"(dynamics)":[56],"within":[57],"clinically":[58],"relevant":[59],"pathophysiologic":[60],"conditions.":[61],"A":[62],"custom":[63],"high-shear":[64],"rotary":[65],"device":[66,122],"capable":[67],"creating":[69],"fully":[70],"controlled":[71],"times":[73],"flows":[75],"was":[76,80,114,123,153],"used.":[77],"system":[79],"set":[81],"so":[82],"that":[83],"human":[84],"platelet-poor":[85],"plasma":[86],"flowed":[87],"through":[88],"at":[89,143,155,158,166],"1.75":[90],"ml/sec,":[91,93],"0.76":[92],"or":[94,108],"0.38":[95],"ml/sec":[96],"resulting":[97],"(":[102,175,181,204],"texp":[103,146,161,169,180,197],")":[104],"22,":[106],"50,":[107],"100":[109],"ms,":[110],"respectively.":[111],"characterized":[115],"by":[116,148],"Reynolds":[118],"number":[119],"(Re).":[120],"run":[124],"under":[125],"laminar":[126,156],"(Re":[127,131,139],"=":[128,132,135,140,183,206],"1,500),":[129],"transitional":[130],"3,000;":[133],"Re":[134,174,195],"3,500),":[136],"4,500)":[141],"conditions":[142],"a":[144,167],"given":[145,160,168],"followed":[147],"multimer":[149],"analysis.":[150],"No":[151],"observed":[154],"all":[159],".":[162],"Degradation":[163],"increases":[170],"Re.":[173],"p":[176,182,205],"<":[177],"0.0001)":[178],"0.0034)":[184],"are":[185],"significant":[186,203],"factors":[187],"HMWM.":[192],"Interaction":[193],"between":[194],",":[198],"however,":[199],"not":[201],"always":[202],"0.73).":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
