{"id":"https://openalex.org/W4309408940","doi":null,"title":"A new pyroptosis-related signature for predicting the immune status and injury of liver ischemia-reperfusion.","display_name":"A new pyroptosis-related signature for predicting the immune status and injury of liver ischemia-reperfusion.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4309408940","pmid":"https://pubmed.ncbi.nlm.nih.gov/36398223","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9641426"},"language":"en","primary_location":{"id":"pmid:36398223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36398223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9641426/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031497244","display_name":"Meijin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097525","display_name":"Youjiang Medical College for Nationalities","ror":"https://ror.org/00wemg618","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097525"]},{"id":"https://openalex.org/I4210130692","display_name":"Affiliated Hospital of Youjiang Medical University for Nationalities","ror":"https://ror.org/0358v9d31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130692"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meijin Huang","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital of Jinan University Guangzhou, Guangdong, P. R. China","Department of Infectious Diseases, Affiliated Hospital of Youjiang Nationalities Medical College Baise, Guangxi, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital of Jinan University Guangzhou, Guangdong, P. R. China","institution_ids":["https://openalex.org/I4210162753"]},{"raw_affiliation_string":"Department of Infectious Diseases, Affiliated Hospital of Youjiang Nationalities Medical College Baise, Guangxi, P. R. China","institution_ids":["https://openalex.org/I4210097525","https://openalex.org/I4210130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112378342","display_name":"Jingyi Xie","orcid":"https://orcid.org/0009-0008-5705-6992","observed_orcids":["https://orcid.org/0009-0008-5705-6992"]},"institutions":[{"id":"https://openalex.org/I4210097525","display_name":"Youjiang Medical College for Nationalities","ror":"https://ror.org/00wemg618","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Xie","raw_affiliation_strings":["Department of Oncology, People's Hospital of Baise Baise 533000, Guangxi, P. R. China","Youjiang Medical University for Nationalities Baise, Guangxi, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, People's Hospital of Baise Baise 533000, Guangxi, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Youjiang Medical University for Nationalities Baise, Guangxi, P. R. China","institution_ids":["https://openalex.org/I4210097525"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xike Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097525","display_name":"Youjiang Medical College for Nationalities","ror":"https://ror.org/00wemg618","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xike Xie","raw_affiliation_strings":["Youjiang Medical University for Nationalities Baise, Guangxi, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Youjiang Medical University for Nationalities Baise, Guangxi, P. R. China","institution_ids":["https://openalex.org/I4210097525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101584332","display_name":"Juan He","orcid":"https://orcid.org/0000-0002-9363-1244","observed_orcids":["https://orcid.org/0000-0002-9363-1244"]},"institutions":[{"id":"https://openalex.org/I4210097525","display_name":"Youjiang Medical College for Nationalities","ror":"https://ror.org/00wemg618","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan He","raw_affiliation_strings":["Youjiang Medical University for Nationalities Baise, Guangxi, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Youjiang Medical University for Nationalities Baise, Guangxi, P. R. China","institution_ids":["https://openalex.org/I4210097525"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mingyue Xiong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingyue Xiong","raw_affiliation_strings":["Department of Hematology, People's Hospital of Baise Baise, Guangxi, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, People's Hospital of Baise Baise, Guangxi, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066745545","display_name":"Tingzhuang Yi","orcid":"https://orcid.org/0000-0002-4709-7247","observed_orcids":["https://orcid.org/0000-0002-4709-7247"]},"institutions":[{"id":"https://openalex.org/I4210097525","display_name":"Youjiang Medical College for Nationalities","ror":"https://ror.org/00wemg618","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097525"]},{"id":"https://openalex.org/I4210130692","display_name":"Affiliated Hospital of Youjiang Medical University for Nationalities","ror":"https://ror.org/0358v9d31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingzhuang Yi","raw_affiliation_strings":["Department of Oncology, Affiliated Hospital of Youjiang Medical University for Nationalities Baise, Guangxi, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Affiliated Hospital of Youjiang Medical University for Nationalities Baise, Guangxi, P. R. China","institution_ids":["https://openalex.org/I4210097525","https://openalex.org/I4210130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5117137745","display_name":"Youpeng Chen","orcid":"https://orcid.org/0000-0002-9677-2333","observed_orcids":["https://orcid.org/0000-0002-9677-2333"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youpeng Chen","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital of Jinan University Guangzhou, Guangdong, P. R. China","Department of Infectious Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University Shenzhen, Guangdong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital of Jinan University Guangzhou, Guangdong, P. R. China","institution_ids":["https://openalex.org/I4210162753"]},{"raw_affiliation_string":"Department of Infectious Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University Shenzhen, Guangdong, P. R. China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2106,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41423654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"10","first_page":"7566","last_page":"7577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.3402999937534332,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.3402999937534332,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.23029999434947968,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.10639999806880951,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepatic-ischemia-reperfusion-injury","display_name":"hepatic ischemia-reperfusion injury","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pyroptosis-related-genes","display_name":"pyroptosis-related genes","score":0.925000011920929},{"id":"https://openalex.org/keywords/risk-signature","display_name":"risk signature","score":0.6819999814033508},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.902999997138977},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.5789999961853027},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ciap2","display_name":"cIAP2","score":0.968999981880188},{"id":"https://openalex.org/keywords/a3-adenosine-receptor","display_name":"A3 adenosine receptor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.7879999876022339},{"id":"https://openalex.org/keywords/irf-1","display_name":"IRF1","score":0.7590000033378601},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.9810000061988831},{"id":"https://openalex.org/keywords/rela","display_name":"RelA","score":0.7210000157356262},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.3009999990463257}],"concepts":[{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.9389598369598389},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5567601323127747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5394955277442932},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5067320466041565},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43496447801589966},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4167829751968384},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4163303077220917},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40062159299850464},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.374042809009552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24911871552467346},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.22274062037467957},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1638486385345459}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:36398223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36398223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9641426","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9641426/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9641426","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9641426/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1261642005","https://openalex.org/W1976415987","https://openalex.org/W2007450401","https://openalex.org/W2057758077","https://openalex.org/W2098302593","https://openalex.org/W2133353550","https://openalex.org/W2158501840","https://openalex.org/W2168540880","https://openalex.org/W2739873258","https://openalex.org/W2883053621","https://openalex.org/W2888027311","https://openalex.org/W2890683530","https://openalex.org/W2890892320","https://openalex.org/W2895833591","https://openalex.org/W2898088953","https://openalex.org/W2902365548","https://openalex.org/W2925647169","https://openalex.org/W2950360205","https://openalex.org/W2965919415","https://openalex.org/W3003652178","https://openalex.org/W3048484045","https://openalex.org/W3080525029","https://openalex.org/W3110045126","https://openalex.org/W3120954470","https://openalex.org/W3121002362","https://openalex.org/W3138163241","https://openalex.org/W3160550363","https://openalex.org/W3163830093","https://openalex.org/W3184102753","https://openalex.org/W3205438117","https://openalex.org/W4210619361"],"related_works":["https://openalex.org/W4408489297","https://openalex.org/W4417401338","https://openalex.org/W4413816816","https://openalex.org/W4406241506","https://openalex.org/W4401549109","https://openalex.org/W7118002378","https://openalex.org/W7117581426","https://openalex.org/W4400068764","https://openalex.org/W4408462988","https://openalex.org/W4400643068"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Pyroptosis":[1],"is":[2],"a":[3,47],"type":[4],"of":[5,16,29,99,170,194,208,235,243,258,264],"programmed":[6],"cell":[7,86],"death.":[8],"This":[9],"study":[10,231],"aimed":[11],"to":[12,53,63,68,82,94],"explore":[13],"the":[14,30,55,69,84,96,116,155,161,168,174,184,192,200,206,216,221,227,236,240,255,262],"roles":[15],"key":[17],"pyroptosis-related":[18,38,72,113,164,244,259],"genes":[19,39,44,114,165,224,245,260],"in":[20,226,246,261],"liver":[21,247],"ischemia-reperfusion":[22,266],"injury.":[23,267],"METHODS:":[24],"After":[25],"collection":[26],"and":[27,110,118,134,149,197,211,239],"standardization":[28],"transcriptome":[31],"data":[32],"from":[33,183],"GSE12720":[34],"database,":[35],"differentially":[36,70,111],"expressed":[37,71,112],"were":[40,51],"identified.":[41],"The":[42],"risk":[43,169,185],"screened":[45],"by":[46,203,215],"random":[48,156],"forest":[49,157],"model":[50,158],"used":[52,62,93],"establish":[54],"line":[56],"graph":[57],"model.":[58,187],"Consensus":[59],"clustering":[60],"was":[61,80,92,126,141,199,213],"classify":[64],"all":[65],"samples":[66],"according":[67],"genes.":[73,104],"Single-sample":[74],"Gene":[75],"Set":[76],"Enrichment":[77],"Analysis":[78],"(ssGSEA)":[79],"performed":[81],"investigate":[83],"immune":[85],"infiltration":[87],"after":[88],"hepatic":[89,171,265],"ischemia-reperfusion.":[90,172,248],"Cytoscape":[91],"visualize":[95],"regulatory":[97],"network":[98],"transcription":[100],"factor":[101],"(TF)-microRNA":[102],"(miRNA)-target":[103],"RESULTS:":[105],"We":[106],"identified":[107],"18":[108,123],"significantly":[109],"between":[115],"disease":[117],"normal":[119],"samples.":[120],"Among":[121],"these":[122],"genes,":[124],"IL1\u03b2":[125],"positively":[127],"correlated":[128,143],"with":[129,144],"CXCL8":[130,150],"(r":[131,136,146,151],"=":[132,137,147,152],"0.791)":[133],"BIRC3":[135],"0.78),":[138],"while":[139,205],"ADORA3":[140],"negatively":[142],"GZMB":[145],"-0.567)":[148],"-0.566).":[153],"Furthermore,":[154],"constructed":[159],"using":[160],"top":[162],"10":[163],"could":[166,181],"predict":[167],"Importantly,":[173],"decision":[175],"curve":[176],"analysis":[177],"showed":[178],"that":[179,191],"patients":[180],"benefit":[182],"prediction":[186],"Moreover,":[188],"we":[189],"found":[190],"expression":[193,207,237],"TXNIP,":[195],"IRF1,":[196],"GJA1":[198],"mostly":[201],"regulated":[202,214],"miRNAs,":[204],"BIRC3,":[209],"NF\u03baB1,":[210],"TXNIP":[212],"TF":[217],"RELA.":[218],"RELA":[219],"had":[220],"most":[222],"hub":[223],"involved":[225],"regulation.":[228],"CONCLUSION:":[229],"Our":[230,249],"provides":[232],"an":[233],"overview":[234],"landscape":[238],"functional":[241],"significance":[242],"findings":[250],"also":[251],"shed":[252],"light":[253],"on":[254],"clinical":[256],"application":[257],"treatment":[263]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-11-27T00:00:00"}
