{"id":"https://openalex.org/W4309360435","doi":"https://doi.org/10.1111/1440-1681.13738","title":"Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats","display_name":"Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats","publication_year":2022,"publication_date":"2022-11-18","ids":{"openalex":"https://openalex.org/W4309360435","doi":"https://doi.org/10.1111/1440-1681.13738","pmid":"https://pubmed.ncbi.nlm.nih.gov/36398458","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9898104"},"language":"en","primary_location":{"id":"doi:10.1111/1440-1681.13738","doi":"https://doi.org/10.1111/1440-1681.13738","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1440-1681.13738","pdf_url":null,"source":{"id":"https://openalex.org/S168193669","display_name":"Clinical and Experimental Pharmacology and Physiology","issn_l":"0305-1870","issn":["0305-1870","1440-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Pharmacology and Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9898104","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078725664","display_name":"Carlos J. Rodr\u00edguez\u2010Ortiz","orcid":"https://orcid.org/0000-0003-2688-947X","observed_orcids":["https://orcid.org/0000-0003-2688-947X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos J. Rodriguez\u2010Ortiz","raw_affiliation_strings":["Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063234127","display_name":"Max Andrew Thorwald","orcid":"https://orcid.org/0000-0003-0095-5344","observed_orcids":["https://orcid.org/0000-0003-0095-5344"]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max A. Thorwald","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Merced, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Merced, California, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059104619","display_name":"Rub\u00e9n Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-8174-2556","observed_orcids":["https://orcid.org/0000-0001-8174-2556"]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben Rodriguez","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Merced, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Merced, California, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018650152","display_name":"Marina Mejias\u2010Ortega","orcid":"https://orcid.org/0000-0001-7781-9426","observed_orcids":["https://orcid.org/0000-0001-7781-9426"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210164724","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga","ror":"https://ror.org/05n3asa33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210164724"]},{"id":"https://openalex.org/I82767444","display_name":"Universidad de M\u00e1laga","ror":"https://ror.org/036b2ww28","country_code":"ES","type":"education","lineage":["https://openalex.org/I82767444"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Marina Mejias\u2010Ortega","raw_affiliation_strings":["Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA","Centro de Investigaci\u00f3n Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain","Department of Cell Biology, Genetics and Physiology, Instituto de Investigacion Biomedica de Malaga-IBIMA, Facultad de Ciencias, Universidad de Malaga, Malaga, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain","institution_ids":["https://openalex.org/I4210086696"]},{"raw_affiliation_string":"Department of Cell Biology, Genetics and Physiology, Instituto de Investigacion Biomedica de Malaga-IBIMA, Facultad de Ciencias, Universidad de Malaga, Malaga, Spain","institution_ids":["https://openalex.org/I4210164724","https://openalex.org/I82767444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066185018","display_name":"Zanett Kieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zanett Kieu","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Merced, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Merced, California, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057939255","display_name":"Neilabjo Maitra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neilabjo Maitra","raw_affiliation_strings":["Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052856409","display_name":"Charlesice Hawkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlesice Hawkins","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Merced, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Merced, California, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075641833","display_name":"Joanna Valenzuela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna Valenzuela","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Merced, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Merced, California, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marcus Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Peng","raw_affiliation_strings":["Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049861668","display_name":"Akira Nishiyama","orcid":"https://orcid.org/0000-0001-5971-820X","observed_orcids":["https://orcid.org/0000-0001-5971-820X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akira Nishiyama","raw_affiliation_strings":["Department of Pharmacology, Kagawa Medical University, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Kagawa Medical University, Kagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036162154","display_name":"Rudy Martin Ortiz","orcid":"https://orcid.org/0000-0003-3715-7194","observed_orcids":["https://orcid.org/0000-0003-3715-7194"]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rudy M. Ortiz","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Merced, California, USA"],"raw_orcid":"https://orcid.org/0000-0003-3715-7194","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Merced, California, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"last","author":{"id":null,"display_name":"Masashi Kitazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masashi Kitazawa","raw_affiliation_strings":["Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Occupational and Environmental Health, Department of Environmental and Occupational Health, Department of Medicine, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036162154"],"corresponding_institution_ids":["https://openalex.org/I156087764","https://openalex.org/I204250578"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":0.8794,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.70951569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"50","issue":"3","first_page":"228","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.4097000062465668,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.4097000062465668,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.19930000603199005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.19089999794960022,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olmesartan","display_name":"olmesartan","score":0.9959999918937683},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9769999980926514},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9869999885559082},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6600000262260437},{"id":"https://openalex.org/keywords/oletf-rats","display_name":"OLETF rats","score":0.9160000085830688},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6420000195503235},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7350000143051147},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.9570000171661377},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/psd-95","display_name":"PSD-95","score":0.9819999933242798},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.7300000190734863},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8619999885559082},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2779766728","wikidata":"https://www.wikidata.org/wiki/Q421156","display_name":"Olmesartan","level":3,"score":0.9748777151107788},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7042471170425415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6986403465270996},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6154824495315552},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.5108384490013123},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4650005102157593},{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.43929746747016907},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33345383405685425},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12119424343109131},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.11349031329154968}],"mesh":[{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020334","descriptor_name":"Rats, Inbred OLETF","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/1440-1681.13738","doi":"https://doi.org/10.1111/1440-1681.13738","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1440-1681.13738","pdf_url":null,"source":{"id":"https://openalex.org/S168193669","display_name":"Clinical and Experimental Pharmacology and Physiology","issn_l":"0305-1870","issn":["0305-1870","1440-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Pharmacology and Physiology","raw_type":"journal-article"},{"id":"pmid:36398458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36398458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental pharmacology & physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9898104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9898104","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Exp Pharmacol Physiol","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6n79m0xg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6n79m0xg","pdf_url":"https://escholarship.org/content/qt6n79m0xg/qt6n79m0xg.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Experimental Pharmacology and Physiology, vol 50, iss 3","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9898104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9898104","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Exp Pharmacol Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1383215468","display_name":null,"funder_award_id":"HL-091767","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1925151583","display_name":null,"funder_award_id":"T37 MD-001480","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G6015975298","display_name":"Glycobiology-based cellular slow cycling for the development of anti-ageing drugs","funder_award_id":"22K19712","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G610998863","display_name":"UCSC MHIRT Research Training Grant","funder_award_id":"5t37md001480-25","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6348781400","display_name":"Mechanisms of Oxidative Stress and Inflammation during Prolonged Fasting and Slee","funder_award_id":"R01HL091767","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8773137275","display_name":"Environmental copper exposure and its impact on microglial Abeta clearance","funder_award_id":"R01ES024331","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1506717124","https://openalex.org/W1579973761","https://openalex.org/W1593069239","https://openalex.org/W1624178692","https://openalex.org/W1970006557","https://openalex.org/W1975596483","https://openalex.org/W2000087476","https://openalex.org/W2002192631","https://openalex.org/W2009021229","https://openalex.org/W2016246535","https://openalex.org/W2017443057","https://openalex.org/W2031204813","https://openalex.org/W2032352736","https://openalex.org/W2035396820","https://openalex.org/W2041418210","https://openalex.org/W2044773944","https://openalex.org/W2050498580","https://openalex.org/W2056344654","https://openalex.org/W2056976690","https://openalex.org/W2057857036","https://openalex.org/W2060924841","https://openalex.org/W2071076354","https://openalex.org/W2072357288","https://openalex.org/W2077785499","https://openalex.org/W2086149931","https://openalex.org/W2087968524","https://openalex.org/W2088250482","https://openalex.org/W2090016088","https://openalex.org/W2091296420","https://openalex.org/W2094958540","https://openalex.org/W2123220577","https://openalex.org/W2124821727","https://openalex.org/W2132051579","https://openalex.org/W2142090603","https://openalex.org/W2149041533","https://openalex.org/W2153187506","https://openalex.org/W2154165296","https://openalex.org/W2159785173","https://openalex.org/W2163500283","https://openalex.org/W2167731943","https://openalex.org/W2168620413","https://openalex.org/W2171245653","https://openalex.org/W2263406196","https://openalex.org/W2295242965","https://openalex.org/W2299031675","https://openalex.org/W2331095351","https://openalex.org/W2475261460","https://openalex.org/W2552399604","https://openalex.org/W2572710398","https://openalex.org/W2609756621","https://openalex.org/W2797183733","https://openalex.org/W2798136647","https://openalex.org/W2840121374","https://openalex.org/W2852127953","https://openalex.org/W2897022642","https://openalex.org/W2971485030","https://openalex.org/W2985008563","https://openalex.org/W3017000375","https://openalex.org/W3049428549","https://openalex.org/W3123815017","https://openalex.org/W3130437983","https://openalex.org/W3183767550"],"related_works":["https://openalex.org/W2047844622","https://openalex.org/W4378649140","https://openalex.org/W3016514788","https://openalex.org/W3174253357","https://openalex.org/W2088250482","https://openalex.org/W2493167368","https://openalex.org/W2029500371","https://openalex.org/W4315779747","https://openalex.org/W3022291310","https://openalex.org/W3135853220"],"abstract_inverted_index":{"Metabolic":[0],"syndrome":[1],"(MetS)":[2],"is":[3,12,183],"a":[4,164],"rapidly":[5],"increasing":[6],"health":[7],"concern":[8],"during":[9,48],"midlife":[10],"and":[11,39,65,102,106,135,170,198,226],"an":[13],"emerging":[14],"risk":[15],"factor":[16],"for":[17,36,92],"the":[18,46,62,71,112,121,139,143,162,176,218,224],"development":[19],"of":[20,100,114,123,138,142,178,187,190,201,220],"neurodegenerative":[21,196],"diseases,":[22],"such":[23],"as":[24,146,148],"Alzheimer's":[25],"disease":[26],"(AD).":[27],"While":[28],"angiotensin":[29,202],"receptor":[30,203],"blockers":[31],"(ARB)":[32],"are":[33,50],"widely":[34],"used":[35],"MetS-associated":[37],"hypertension":[38],"kidney":[40],"disease,":[41],"its":[42],"therapeutic":[43],"potential":[44],"in":[45,111,156,161,167,180,223],"brain":[47,63,113,225],"MetS":[49,69,179],"not":[51],"well-described.":[52],"Here,":[53,78],"we":[54,79],"tested":[55],"whether":[56],"treatment":[57,84,132,213],"with":[58,68,85,128,185,231],"ARB":[59,83],"could":[60],"alleviate":[61],"pathology":[64],"inflammation":[66],"associated":[67,127,184,230],"using":[70],"Otsuka":[72],"Long-Evans":[73],"Tokushima":[74],"Fatty":[75],"(OLETF)":[76],"rat.":[77],"report":[80],"that":[81,175,193,199],"chronic":[82],"olmesartan":[86,131,212],"(10":[87],"mg/kg/day":[88],"by":[89],"oral":[90],"gavage":[91],"6":[93],"weeks)":[94],"partially":[95],"but":[96],"significantly":[97],"ameliorated":[98],"accumulation":[99],"oxidized":[101],"ubiquitinated":[103],"proteins,":[104],"astrogliosis":[105],"transformation":[107],"to":[108,208],"neurotoxic":[109],"astrocytes":[110],"old":[115,157],"OLETF":[116,158,181],"rats,":[117,159],"which":[118,152],"otherwise":[119,154],"exhibit":[120],"progression":[122,177],"these":[124,209],"pathological":[125],"hallmarks":[126],"MetS.":[129,232],"Additionally,":[130],"restored":[133],"claudin-5":[134],"ZO-1,":[136],"markers":[137],"structural":[140],"integrity":[141,192],"blood-brain":[144],"barrier":[145],"well":[147],"synaptic":[149],"protein":[150],"PSD-95,":[151],"were":[153],"decreased":[155],"particularly":[160],"hippocampus,":[163],"critical":[165],"region":[166],"cognition,":[168],"memory":[169],"AD.":[171],"These":[172],"data":[173],"demonstrate":[174],"rats":[182],"deterioration":[186],"various":[188],"aspects":[189],"neuronal":[191],"may":[194,214],"manifest":[195],"conditions":[197],"overactivation":[200],"directly":[204],"or":[205,216],"indirectly":[206],"contributes":[207],"detriments.":[210],"Thus,":[211],"slow":[215],"delay":[217],"onset":[219],"degenerative":[221],"process":[222],"subsequent":[227],"neurological":[228],"disorders":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-26T00:00:00"}