{"id":"https://openalex.org/W4309294258","doi":"https://doi.org/10.1101/2022.11.14.22282124","title":"Foetal Allogeneic Intracerebroventricular Neural Stem Cell Transplantation in People with Secondary Progressive Multiple Sclerosis: A phase I dose-escalation clinical trial","display_name":"Foetal Allogeneic Intracerebroventricular Neural Stem Cell Transplantation in People with Secondary Progressive Multiple Sclerosis: A phase I dose-escalation clinical trial","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4309294258","doi":"https://doi.org/10.1101/2022.11.14.22282124"},"language":"en","primary_location":{"id":"doi:10.1101/2022.11.14.22282124","doi":"https://doi.org/10.1101/2022.11.14.22282124","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.11.14.22282124","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/11/28/2022.11.14.22282124.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2022/11/28/2022.11.14.22282124.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050954680","display_name":"Maurizio Angelo Leone","orcid":"https://orcid.org/0000-0002-6339-5738","observed_orcids":["https://orcid.org/0000-0002-6339-5738"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"MA Leone","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044049530","display_name":"Maurizio Gelati","orcid":"https://orcid.org/0000-0002-4828-9849","observed_orcids":["https://orcid.org/0000-0002-4828-9849"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Gelati","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017519909","display_name":"Daniela Celeste Profico","orcid":"https://orcid.org/0000-0001-5721-0410","observed_orcids":["https://orcid.org/0000-0001-5721-0410"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"DC Profico","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004360690","display_name":"C Conti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Conti","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002818720","display_name":"Cristina Spera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Spera","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085878408","display_name":"Gianmarco Muzi","orcid":"https://orcid.org/0000-0002-5657-2812","observed_orcids":["https://orcid.org/0000-0002-5657-2812"]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Muzi","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038526057","display_name":"Valentina Grespi","orcid":"https://orcid.org/0000-0002-1439-5969","observed_orcids":["https://orcid.org/0000-0002-1439-5969"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V Grespi","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020783071","display_name":"Ilaria Bicchi","orcid":"https://orcid.org/0000-0002-6521-8962","observed_orcids":["https://orcid.org/0000-0002-6521-8962"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"I Bicchi","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015108018","display_name":"Claudia Ricciolini","orcid":"https://orcid.org/0000-0001-5956-313X","observed_orcids":["https://orcid.org/0000-0001-5956-313X"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Ricciolini","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069053140","display_name":"Daniela Ferrari","orcid":"https://orcid.org/0000-0001-7251-9854","observed_orcids":["https://orcid.org/0000-0001-7251-9854"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Ferrari","raw_affiliation_strings":["BTBS Universit\u00e0 Bicocca, piazza della Scienza 2, 20126, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BTBS Universit\u00e0 Bicocca, piazza della Scienza 2, 20126, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044511142","display_name":"Michele M. Zarrelli","orcid":"https://orcid.org/0000-0001-7768-1762","observed_orcids":["https://orcid.org/0000-0001-7768-1762"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Zarrelli","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031511874","display_name":"Luigi Amoruso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Amoruso","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019611237","display_name":"Giuliana Placentino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Placentino","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074308994","display_name":"Paola Crociani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Crociani","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029980093","display_name":"F. Apollo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Apollo","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066867190","display_name":"Pietro Di Viesti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Di Viesti","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024641178","display_name":"Danilo Fogli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Fogli","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035993851","display_name":"Teresa Popolizio","orcid":"https://orcid.org/0000-0002-9364-9663","observed_orcids":["https://orcid.org/0000-0002-9364-9663"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"T Popolizio","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067217593","display_name":"Carlo Colosimo","orcid":"https://orcid.org/0000-0002-2216-3973","observed_orcids":["https://orcid.org/0000-0002-2216-3973"]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Colosimo","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049540144","display_name":"Domenico Frondizi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Frondizi","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034166316","display_name":"Giuseppe Stipa","orcid":"https://orcid.org/0000-0001-9474-9618","observed_orcids":["https://orcid.org/0000-0001-9474-9618"]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Stipa","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080743983","display_name":"Elettra Tinella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Tinella","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072948671","display_name":"Alessandro Ciampini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Ciampini","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081660884","display_name":"Simonetta Sabatini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Sabatini","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063219286","display_name":"F Paci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Paci","raw_affiliation_strings":["AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AOSP Santa Maria, via Tristano di Joannuccio 1, 05100, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033855420","display_name":"Giada Silveri","orcid":"https://orcid.org/0000-0002-0837-9655","observed_orcids":["https://orcid.org/0000-0002-0837-9655"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Silveri","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043940401","display_name":"Claudio Gobbi","orcid":"https://orcid.org/0000-0002-7554-0664","observed_orcids":["https://orcid.org/0000-0002-7554-0664"]},"institutions":[{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"C Gobbi","raw_affiliation_strings":["Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland","Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002840754","display_name":"Emanuele Pravat\u00e0","orcid":"https://orcid.org/0000-0002-5225-2993","observed_orcids":["https://orcid.org/0000-0002-5225-2993"]},"institutions":[{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"E Pravat\u00e0","raw_affiliation_strings":["Department of Neuroradiology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland","Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland","Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland","institution_ids":[]},{"raw_affiliation_string":"Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004356264","display_name":"E Zecca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"E Zecca","raw_affiliation_strings":["Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland","Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011923771","display_name":"RF Balzano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RF Balzano","raw_affiliation_strings":["Department of Neuroradiology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045590592","display_name":"Jens K\u00fchle","orcid":"https://orcid.org/0000-0002-6963-8892","observed_orcids":["https://orcid.org/0000-0002-6963-8892"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J Kuhle","raw_affiliation_strings":["Department of Neurology, University Hospital Basel, and University of Basel/Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Basel, and University of Basel/Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076684145","display_name":"Massimiliano Copetti","orcid":"https://orcid.org/0000-0002-7960-5947","observed_orcids":["https://orcid.org/0000-0002-7960-5947"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Copetti","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069861798","display_name":"Andrea Fontana","orcid":"https://orcid.org/0000-0002-6660-5315","observed_orcids":["https://orcid.org/0000-0002-6660-5315"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Fontana","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036893941","display_name":"Massimo Carella","orcid":"https://orcid.org/0000-0002-6830-6829","observed_orcids":["https://orcid.org/0000-0002-6830-6829"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Carella","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031518942","display_name":"G D\u2019Aloisio","orcid":"https://orcid.org/0000-0003-2084-4553","observed_orcids":["https://orcid.org/0000-0003-2084-4553"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G D\u2019Aloisio","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L Abate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Abate","raw_affiliation_strings":["IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002129539","display_name":"Yendry Ventura\u2010Carmenate","orcid":"https://orcid.org/0000-0002-5373-3414","observed_orcids":["https://orcid.org/0000-0002-5373-3414"]},"institutions":[{"id":"https://openalex.org/I4405254299","display_name":"Abu Dhabi Stem Cells Center","ror":"https://ror.org/01nbken06","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I4405254299"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Y Ventura Carmenate","raw_affiliation_strings":["Abu Dhabi Stem Cell Center, Abu Dhabi, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0002-5373-3414","affiliations":[{"raw_affiliation_string":"Abu Dhabi Stem Cell Center, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I4405254299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001612039","display_name":"Stefano Pluchino","orcid":"https://orcid.org/0000-0002-6267-9472","observed_orcids":["https://orcid.org/0000-0002-6267-9472"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Pluchino","raw_affiliation_strings":["Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0QQ Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0QQ Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4389425352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058920811","display_name":"Luca Peruzzotti\u2010Jametti","orcid":"https://orcid.org/0000-0002-9396-5607","observed_orcids":["https://orcid.org/0000-0002-9396-5607"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L Peruzzotti-Jametti","raw_affiliation_strings":["Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0QQ Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0QQ Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4389425352"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109901846","display_name":"AL Vescovi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"AL Vescovi","raw_affiliation_strings":["BTBS Universit\u00e0 Bicocca, piazza della Scienza 2, 20126, Milan, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BTBS Universit\u00e0 Bicocca, piazza della Scienza 2, 20126, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]},{"raw_affiliation_string":"IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini , 703 San Giovanni Rotondo, Foggia, Italy","institution_ids":["https://openalex.org/I2800188116"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5109901846"],"corresponding_institution_ids":["https://openalex.org/I2800188116","https://openalex.org/I66752286"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-progressive-multiple-sclerosis","display_name":"secondary progressive multiple sclerosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6480000019073486},{"id":"https://openalex.org/keywords/disability-progression","display_name":"disability progression","score":0.5120000243186951},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.41600000858306885},{"id":"https://openalex.org/keywords/neurophysiological-parameters","display_name":"neurophysiological parameters","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8302781581878662},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8276044130325317},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6860874891281128},{"id":"https://openalex.org/C2780892749","wikidata":"https://www.wikidata.org/wiki/Q929518","display_name":"Expanded Disability Status Scale","level":3,"score":0.6483474373817444},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6132559776306152},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.539138913154602},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.520551323890686},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5040249228477478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4859825074672699},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4599439799785614},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40943247079849243},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17183366417884827}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.11.14.22282124","doi":"https://doi.org/10.1101/2022.11.14.22282124","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.11.14.22282124","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/11/28/2022.11.14.22282124.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.11.14.22282124","doi":"https://doi.org/10.1101/2022.11.14.22282124","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.11.14.22282124","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/11/28/2022.11.14.22282124.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309294258.pdf","grobid_xml":"https://content.openalex.org/works/W4309294258.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1979195646","https://openalex.org/W1996222694","https://openalex.org/W2016044475","https://openalex.org/W2020873495","https://openalex.org/W2027285375","https://openalex.org/W2046521512","https://openalex.org/W2052301691","https://openalex.org/W2063487753","https://openalex.org/W2066990533","https://openalex.org/W2067198472","https://openalex.org/W2094613247","https://openalex.org/W2100752721","https://openalex.org/W2105490558","https://openalex.org/W2106226653","https://openalex.org/W2112165124","https://openalex.org/W2137267666","https://openalex.org/W2152125093","https://openalex.org/W2165915651","https://openalex.org/W2169119462","https://openalex.org/W2287473555","https://openalex.org/W2332607547","https://openalex.org/W2402394910","https://openalex.org/W2414317844","https://openalex.org/W2788731808","https://openalex.org/W2945776234","https://openalex.org/W2977770887","https://openalex.org/W3006455337","https://openalex.org/W3121385540","https://openalex.org/W4283816611","https://openalex.org/W4308721287"],"related_works":["https://openalex.org/W4383334721","https://openalex.org/W4389047249","https://openalex.org/W4313831005","https://openalex.org/W4316036369","https://openalex.org/W2806469986","https://openalex.org/W2594030872","https://openalex.org/W1546962095","https://openalex.org/W2945776234","https://openalex.org/W4389442735","https://openalex.org/W1565884409"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Advanced":[2],"cell":[3,360],"therapeutics":[4,361],"are":[5,343],"emerging":[6],"as":[7,216,249],"potentially":[8],"effective":[9,369],"treatments":[10],"for":[11,338,362],"chronic":[12],"neurological":[13],"diseases,":[14],"including":[15],"secondary":[16,122],"progressive":[17],"multiple":[18],"sclerosis":[19],"(SPMS).":[20],"Here":[21],"we":[22],"report":[23],"the":[24,74,101,115,125,176,202,211,232,236,240,244,252,305,317,349,354,366],"results":[25],"of":[26,79,82,95,105,128,162,239,246,284,310,319,358,368],"a":[27,60,91,111,159,300,322,332,363,374],"phase":[28,61],"I":[29],"trial":[30],"in":[31,49,85,243,288],"which":[32],"good":[33],"manufacturing":[34],"practice-grade":[35],"foetal":[36,285],"allogeneic":[37,83,129,286],"human":[38],"neural":[39],"stem":[40],"cells":[41],"(hNSCs)":[42],"were":[43,124,148,199,214,219],"implanted":[44],"via":[45],"intracerebroventricular":[46,282],"(ICV)":[47],"injection":[48,283],"15":[50],"individuals":[51],"with":[52,290],"active":[53],"and":[54,77,103,119,138,140,150,154,183,218,261,277,295,328,330,347,352],"non-active":[55],"SPMS.":[56],"Methods":[57],"This":[58],"is":[59,292,373],"I,":[62],"open-label,":[63],"multicentre,":[64],"dose-escalation,":[65],"international":[66],"study.":[67],"The":[68,121,156,281,308],"primary":[69],"objective":[70],"was":[71,174,180,190],"to":[72,110,188,221,231,256,345],"assess":[73,257],"feasibility,":[75],"safety,":[76],"tolerability":[78],"ICV":[80],"injections":[81],"hNSCs":[84,130,287,320],"patients":[86,147],"affected":[87],"by":[88,251],"SPMS":[89,146,248,291,339],"over":[90],"study":[92,203],"follow":[93,206],"up":[94,207],"12":[96],"months.":[97],"We":[98],"also":[99],"evaluated":[100],"number":[102],"type":[104,274],"adverse":[106,312],"events":[107],"(AEs)":[108],"leading":[109],"maximum":[112],"tolerated":[113,294],"dose,":[114],"general":[116],"health":[117],"status,":[118],"mortality.":[120],"objectives":[123],"therapeutic":[126,336,356],"benefit":[127],"using":[131],"assessment":[132],"scales,":[133],"magnetic":[134],"resonance":[135],"imaging":[136],"(MRI),":[137],"laboratory":[139],"neurophysiologic":[141,262],"parameters.":[142],"Findings":[143],"Fifteen":[144],"unrelated":[145],"enrolled":[149],"treated":[151],"between":[152,326],"2018":[153],"2020.":[155],"participants":[157,241,298],"had":[158],"median":[160],"age":[161],"49.8":[163],"years.":[164,192],"Their":[165],"mean":[166,177,184],"extended":[167],"disability":[168],"status":[169],"scale":[170],"(EDSS)":[171],"at":[172],"enrolment":[173],"7.6,":[175],"disease":[178,370],"duration":[179],"22":[181],"years,":[182],"time":[185],"from":[186,316],"diagnosis":[187],"progression":[189,245],"10.1":[191],"Neither":[193],"treatment-related":[194],"deaths":[195],"nor":[196],"serious":[197],"AEs":[198,213],"reported":[200],"during":[201,304],"(1":[204],"year":[205],"after":[208],"treatment).":[209],"All":[210],"other":[212,226],"classified":[215],"non-serious":[217],"associated":[220],"non-study":[222],"concomitant":[223],"therapy":[224],"or":[225],"medical":[227],"conditions":[228],"not":[229],"connected":[230],"experimental":[233],"treatment.":[234],"During":[235],"study,":[237],"none":[238],"worsened":[242],"their":[247,258],"shown":[250],"evaluation":[253],"scales":[254],"implemented":[255],"progress.":[259],"Laboratory":[260],"parameters":[263],"showed":[264,271],"no":[265],"clinically":[266],"significant":[267,273],"variations.":[268],"MRI":[269],"follow-up":[270],"non-clinically":[272],"1,":[275],"2,":[276],"3":[278],"changes.":[279],"Interpretation":[280],"people":[289],"feasible,":[293],"safe.":[296],"Study":[297],"displayed":[299],"substantial":[301],"clinical":[302,377],"stability":[303],"12-month":[306],"follow-up.":[307],"absence":[309],"relevant":[311],"reactions":[313],"(Ars)":[314],"arising":[315],"transplantation":[318],"indicates":[321],"short-term":[323],"neutral":[324],"balance":[325],"benefits":[327],"risks":[329],"suggests":[331],"concrete,":[333],"though":[334],"perspective":[335],"possibility":[337],"patients.":[340],"Further":[341],"studies":[342],"needed":[344],"confirm":[346],"extend":[348],"findings":[350],"herein":[351],"evaluate":[353],"actual":[355],"potential":[357],"advanced":[359],"condition":[364],"where":[365],"lack":[367],"modifying":[371],"therapies":[372],"major":[375],"unmet":[376],"need.":[378]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-11-25T00:00:00"}