{"id":"https://openalex.org/W4309288392","doi":"https://doi.org/10.1016/j.semnephrol.2022.10.003","title":"Systemic Effects of Tamm-Horsfall Protein in Kidney Disease","display_name":"Systemic Effects of Tamm-Horsfall Protein in Kidney Disease","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4309288392","doi":"https://doi.org/10.1016/j.semnephrol.2022.10.003","pmid":"https://pubmed.ncbi.nlm.nih.gov/36411194"},"language":"en","primary_location":{"id":"doi:10.1016/j.semnephrol.2022.10.003","doi":"https://doi.org/10.1016/j.semnephrol.2022.10.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semnephrol.2022.10.003","pdf_url":null,"source":{"id":"https://openalex.org/S67786158","display_name":"Seminars in Nephrology","issn_l":"0270-9295","issn":["0270-9295","1558-4488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Nephrology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086216223","display_name":"Kaice A. LaFavers","orcid":"https://orcid.org/0000-0003-2052-6248","observed_orcids":["https://orcid.org/0000-0003-2052-6248"]},"institutions":[{"id":"https://openalex.org/I255400825","display_name":"Indiana University Hospital","ror":"https://ror.org/05rbkcx47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I255400825","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kaice A. LaFavers","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN. Electronic address: klafaver@iu.edu","Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN. Electronic address: klafaver@iu.edu","institution_ids":["https://openalex.org/I255400825","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088183139","display_name":"Tarek M. El\u2010Achkar","orcid":"https://orcid.org/0000-0003-4645-3614","observed_orcids":["https://orcid.org/0000-0003-4645-3614"]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarek M. El-Achkar","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN; Department of Anatomy Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN; Roudebush VA Medical Center, Indianapolis, IN","Department of Anatomy Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN","Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Roudebush VA Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN; Department of Anatomy Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN; Roudebush VA Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Anatomy Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Roudebush VA Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086216223"],"corresponding_institution_ids":["https://openalex.org/I255400825","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":3070,"currency":"USD","value_usd":3070},"apc_paid":null,"fwci":0.1841,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.2122871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":97},"biblio":{"volume":"42","issue":"3","first_page":"151277","last_page":"151277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uromodulin","display_name":"uromodulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.753000020980835},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.5870000123977661},{"id":"https://openalex.org/keywords/kidney-stone-formation","display_name":"kidney stone formation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ion-channel-modulation","display_name":"ion channel modulation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/trpm2","display_name":"TRPM2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9879999756813049},{"id":"https://openalex.org/keywords/macrophage-function","display_name":"macrophage function","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C74460091","wikidata":"https://www.wikidata.org/wiki/Q420024","display_name":"Tamm\u2013Horsfall protein","level":3,"score":0.7835973501205444},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6719284057617188},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6570757031440735},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6363133788108826},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5210727453231812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5187889933586121},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35325711965560913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3252105712890625}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050053","descriptor_name":"TRPM Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058949","descriptor_name":"Uromodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.semnephrol.2022.10.003","doi":"https://doi.org/10.1016/j.semnephrol.2022.10.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semnephrol.2022.10.003","pdf_url":null,"source":{"id":"https://openalex.org/S67786158","display_name":"Seminars in Nephrology","issn_l":"0270-9295","issn":["0270-9295","1558-4488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Nephrology","raw_type":"journal-article"},{"id":"pmid:36411194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36411194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in nephrology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G267501874","display_name":"The protective role of kidney-derived Tamm Horsfall protein (Uromodulin) in sepsis","funder_award_id":"K99DK127216","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3569240001","display_name":"Understanding the Function of Tamm-Horsfall Protein in Acute kidney Injury.","funder_award_id":"R01DK111651","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5687363813","display_name":null,"funder_award_id":"1K99DK127216-01","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8581196973","display_name":"Center for Advanced Renal Microscopic Analysis","funder_award_id":"P30DK079312","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1964042466","https://openalex.org/W1980357331","https://openalex.org/W1982460960","https://openalex.org/W1997849573","https://openalex.org/W2000787151","https://openalex.org/W2003850645","https://openalex.org/W2014594852","https://openalex.org/W2014755416","https://openalex.org/W2018462584","https://openalex.org/W2026659096","https://openalex.org/W2037879146","https://openalex.org/W2044153948","https://openalex.org/W2046122623","https://openalex.org/W2052431369","https://openalex.org/W2059781533","https://openalex.org/W2104342472","https://openalex.org/W2104793625","https://openalex.org/W2121793978","https://openalex.org/W2132165659","https://openalex.org/W2149038276","https://openalex.org/W2149368867","https://openalex.org/W2151251464","https://openalex.org/W2169314667","https://openalex.org/W2196647469","https://openalex.org/W2263502853","https://openalex.org/W2325341766","https://openalex.org/W2333983113","https://openalex.org/W2499766589","https://openalex.org/W2541811369","https://openalex.org/W2546142619","https://openalex.org/W2560673323","https://openalex.org/W2562592980","https://openalex.org/W2588878740","https://openalex.org/W2593934696","https://openalex.org/W2602038846","https://openalex.org/W2749209988","https://openalex.org/W2750659915","https://openalex.org/W2767197383","https://openalex.org/W2769466539","https://openalex.org/W2793294907","https://openalex.org/W2848463175","https://openalex.org/W2884510934","https://openalex.org/W2888256116","https://openalex.org/W2894064654","https://openalex.org/W2895513629","https://openalex.org/W2907695702","https://openalex.org/W2945406940","https://openalex.org/W2968030085","https://openalex.org/W2978953656","https://openalex.org/W2990525323","https://openalex.org/W2994626994","https://openalex.org/W3006371393","https://openalex.org/W3015663146","https://openalex.org/W3028255664","https://openalex.org/W3039726380","https://openalex.org/W3083735728","https://openalex.org/W3085327969","https://openalex.org/W3089406615","https://openalex.org/W3092908302","https://openalex.org/W3112963515","https://openalex.org/W3125489952","https://openalex.org/W3159719254","https://openalex.org/W3198246889","https://openalex.org/W3204634253","https://openalex.org/W4210535930","https://openalex.org/W4221068086","https://openalex.org/W4283688683"],"related_works":["https://openalex.org/W2052431369","https://openalex.org/W2769466539","https://openalex.org/W7099467246","https://openalex.org/W2020696278","https://openalex.org/W6943641915","https://openalex.org/W7101226949","https://openalex.org/W2014755416","https://openalex.org/W2911139160","https://openalex.org/W2307995681","https://openalex.org/W2788779566"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-25T00:00:00"}
