{"id":"https://openalex.org/W4309246745","doi":"https://doi.org/10.1212/wnl.0000000000201489","title":"Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease","display_name":"Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease","publication_year":2022,"publication_date":"2022-11-16","ids":{"openalex":"https://openalex.org/W4309246745","doi":"https://doi.org/10.1212/wnl.0000000000201489","pmid":"https://pubmed.ncbi.nlm.nih.gov/36384659","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9946179"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000201489","doi":"https://doi.org/10.1212/wnl.0000000000201489","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000201489","pdf_url":"https://n.neurology.org/content/neurology/early/2022/11/16/WNL.0000000000201489.full.pdf","source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://n.neurology.org/content/neurology/early/2022/11/16/WNL.0000000000201489.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002209738","display_name":"Jian V. Huang","orcid":"https://orcid.org/0000-0002-3931-5013","observed_orcids":["https://orcid.org/0000-0002-3931-5013"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Jian Huang","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-3931-5013","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102943226","display_name":"Bowen Su","orcid":"https://orcid.org/0009-0008-7608-3777","observed_orcids":["https://orcid.org/0009-0008-7608-3777"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Bowen Su","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063484484","display_name":"Ville Karhunen","orcid":"https://orcid.org/0000-0001-6064-1588","observed_orcids":["https://orcid.org/0000-0001-6064-1588"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI","GB","SG"],"is_corresponding":false,"raw_author_name":"Ville Karhunen","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK","Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054061856","display_name":"Dipender Gill","orcid":"https://orcid.org/0000-0001-7312-7078","observed_orcids":["https://orcid.org/0000-0001-7312-7078"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Dipender Gill","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":"https://orcid.org/0000-0001-7312-7078","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022150335","display_name":"Verena Zuber","orcid":"https://orcid.org/0000-0001-9827-1877","observed_orcids":["https://orcid.org/0000-0001-9827-1877"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Verena Zuber","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":"https://orcid.org/0000-0001-9827-1877","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068169867","display_name":"Ari Ahola\u2010Olli","orcid":"https://orcid.org/0000-0002-4451-3487","observed_orcids":["https://orcid.org/0000-0002-4451-3487"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["FI","GB","SG","US"],"is_corresponding":false,"raw_author_name":"Ari Ahola-Olli","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA","Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071566621","display_name":"Saranya Palaniswamy","orcid":"https://orcid.org/0000-0003-4145-540X","observed_orcids":["https://orcid.org/0000-0003-4145-540X"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Saranya Palaniswamy","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061547158","display_name":"JUHA P. AUVINEN","orcid":"https://orcid.org/0000-0003-2067-4056","observed_orcids":["https://orcid.org/0000-0003-2067-4056"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Juha Auvinen","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030462166","display_name":"Karl\u2010Heinz Herzig","orcid":"https://orcid.org/0000-0003-4460-2604","observed_orcids":["https://orcid.org/0000-0003-4460-2604"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","PL","SG"],"is_corresponding":false,"raw_author_name":"Karl-Heinz Herzig","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037726389","display_name":"Sirkka M Keinanen-Kiukaanniemi","orcid":"https://orcid.org/0000-0003-1218-6925","observed_orcids":["https://orcid.org/0000-0003-1218-6925"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["FI","GB","SG"],"is_corresponding":false,"raw_author_name":"Sirkka Kein\u00e4nen-Kiukaanniemi","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","Unit of Primary Care, Oulu University Hospital, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Unit of Primary Care, Oulu University Hospital, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079691994","display_name":"Marko Salmi","orcid":"https://orcid.org/0000-0002-1913-7408","observed_orcids":["https://orcid.org/0000-0002-1913-7408"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Marko Salmi","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085886525","display_name":"Sirpa Jalkanen","orcid":"https://orcid.org/0000-0002-1922-9732","observed_orcids":["https://orcid.org/0000-0002-1922-9732"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Sirpa Jalkanen","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":"https://orcid.org/0000-0002-1922-9732","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081986241","display_name":"Terho J. Lehtim\u00e4ki","orcid":"https://orcid.org/0000-0002-2555-4427","observed_orcids":["https://orcid.org/0000-0002-2555-4427"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Terho Lehtim\u00e4ki","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":"https://orcid.org/0000-0002-2555-4427","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066237154","display_name":"Veikko V Salomaa","orcid":"https://orcid.org/0000-0001-7563-5324","observed_orcids":["https://orcid.org/0000-0001-7563-5324"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Veikko Salomaa","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":"https://orcid.org/0000-0001-7563-5324","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060131080","display_name":"Olli Tuomas Raitakari","orcid":"https://orcid.org/0000-0001-9365-3702","observed_orcids":["https://orcid.org/0000-0001-9365-3702"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["FI","GB","SG"],"is_corresponding":false,"raw_author_name":"Olli T. Raitakari","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland","Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0001-9365-3702","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007"]},{"raw_affiliation_string":"Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070529061","display_name":"Paul McMahan Matthews","orcid":"https://orcid.org/0000-0002-1619-8328","observed_orcids":["https://orcid.org/0000-0002-1619-8328","https://orcid.org/0009-0004-7086-4303"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Paul M. Matthews","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","UK Dementia Research Institute at Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-1619-8328","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"UK Dementia Research Institute at Imperial College London, London, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034710571","display_name":"Paul Elliott","orcid":"https://orcid.org/0000-0002-7511-5684","observed_orcids":["https://orcid.org/0000-0002-7511-5684","https://orcid.org/0000-0002-7641-2103"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4392738229","display_name":"MRC Centre for Environment and Health","ror":"https://ror.org/01vw4c203","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4392738229","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Paul Elliott","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK","UK Dementia Research Institute at Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-7511-5684","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I4392738229","https://openalex.org/I47508984"]},{"raw_affiliation_string":"UK Dementia Research Institute at Imperial College London, London, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009120205","display_name":"Konstantinos K. Tsilidis","orcid":"https://orcid.org/0000-0002-8452-8472","observed_orcids":["https://orcid.org/0000-0002-8452-8472","https://orcid.org/0000-0002-2830-0596"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","GR","SG"],"is_corresponding":false,"raw_author_name":"Konstantinos K. Tsilidis","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068508022","display_name":"Marjo\u2010Riitta J\u00e4rvelin","orcid":"https://orcid.org/0000-0002-2149-0630","observed_orcids":["https://orcid.org/0000-0002-2149-0630","https://orcid.org/0000-0003-0271-9732"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I4392738229","display_name":"MRC Centre for Environment and Health","ror":"https://ror.org/01vw4c203","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4392738229","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI","GB","SG"],"is_corresponding":false,"raw_author_name":"Marjo-riitta Jarvelin","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","Biocenter Oulu, University of Oulu, Oulu, Finland","Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK","Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK","MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK","Unit of Primary Care, Oulu University Hospital, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Biocenter Oulu, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK","institution_ids":["https://openalex.org/I59433898"]},{"raw_affiliation_string":"MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I4392738229","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Unit of Primary Care, Oulu University Hospital, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020053314","display_name":"Ioanna Tzoulaki","orcid":"https://orcid.org/0000-0002-4275-9328","observed_orcids":["https://orcid.org/0000-0002-4275-9328"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Ioanna Tzoulaki","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":"https://orcid.org/0000-0002-4275-9328","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081896930","display_name":"Abbas Dehghan","orcid":"https://orcid.org/0000-0001-6403-016X","observed_orcids":["https://orcid.org/0000-0001-6403-016X"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":true,"raw_author_name":"Abbas Dehghan","raw_affiliation_strings":["From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for"],"raw_orcid":"https://orcid.org/0000-0001-6403-016X","affiliations":[{"raw_affiliation_string":"From the Department of Epidemiology and Biostatistics (J.H., B.S., V.K., D.G., V.Z., S.P., P.E., K.K.T., M.-r.J., A.D.), School of Public Health, Imperial College London, United Kingdom; Singapore Institute for Clinical Sciences (SICS) (J.H.), Agency for Science, Technology and Research (A*STAR); Center for Life Course Health Research (V.K., S.P., J.A., S.K.-K., M.-r.J.), Faculty of Medicine, Research Unit of Mathematical Sciences (V.K.), University of Oulu, Finland; The Stanley Center for","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5081896930"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200","https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":7.4855,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.98565552,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"100","issue":"6","first_page":"e568","last_page":"e581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.10599999874830246,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.09380000084638596,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.9539999961853027},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.890999972820282},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.875},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/connective-tissue-diseases","display_name":"connective tissue diseases","score":0.8289999961853027},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.6660000085830688},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.675000011920929},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.6779999732971191},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.5580000281333923},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.49000000953674316},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.6359999775886536},{"id":"https://openalex.org/keywords/alzheimer-s-disease-risk","display_name":"Alzheimer's disease risk","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5892711877822876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5790817737579346},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.551811933517456},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4624592959880829},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34199315309524536},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23112934827804565}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1212/wnl.0000000000201489","doi":"https://doi.org/10.1212/wnl.0000000000201489","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000201489","pdf_url":"https://n.neurology.org/content/neurology/early/2022/11/16/WNL.0000000000201489.full.pdf","source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9946179","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9946179","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9946179/pdf/WNL-2022-201351.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Text"},{"id":"pmid:36384659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36384659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Observational Study"},{"id":"pmh:oai:utupub.fi:11111/49633","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/49633","pdf_url":"https://www.utupub.fi/bitstreams/92e479a7-48e7-487c-a6fa-6230cc960457/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/192850","raw_type":null},{"id":"pmh:oai:helda.helsinki.fi:10138/571364","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/571364","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/100578","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/100578","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"e581","raw_type":"Journal Article"},{"id":"pmh:oai:trepo.tuni.fi:10024/222371","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/222371","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"publishedVersion"},{"id":"pmh:oai:www.utupub.fi:10024/192850","doi":null,"is_oa":false,"landing_page_url":"https://www.utupub.fi/handle/10024/192850","pdf_url":null,"source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1212/wnl.0000000000201489","doi":"https://doi.org/10.1212/wnl.0000000000201489","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000201489","pdf_url":"https://n.neurology.org/content/neurology/early/2022/11/16/WNL.0000000000201489.full.pdf","source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1430203965","display_name":null,"funder_award_id":"MR/W029790/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320329730","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309246745.pdf","grobid_xml":"https://content.openalex.org/works/W4309246745.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W325383319","https://openalex.org/W1043653796","https://openalex.org/W1781481323","https://openalex.org/W1979895553","https://openalex.org/W1985453064","https://openalex.org/W2016499642","https://openalex.org/W2050180008","https://openalex.org/W2074229539","https://openalex.org/W2106379479","https://openalex.org/W2115411392","https://openalex.org/W2119852447","https://openalex.org/W2144168223","https://openalex.org/W2155533485","https://openalex.org/W2194307286","https://openalex.org/W2240089400","https://openalex.org/W2566908060","https://openalex.org/W2591074368","https://openalex.org/W2613124881","https://openalex.org/W2744015013","https://openalex.org/W2762103136","https://openalex.org/W2770598799","https://openalex.org/W2787437662","https://openalex.org/W2794968960","https://openalex.org/W2803072880","https://openalex.org/W2805712258","https://openalex.org/W2806080613","https://openalex.org/W2808883316","https://openalex.org/W2818417770","https://openalex.org/W2889787710","https://openalex.org/W2914311398","https://openalex.org/W2916749909","https://openalex.org/W2922233651","https://openalex.org/W2967683178","https://openalex.org/W2973981479","https://openalex.org/W2981759597","https://openalex.org/W3000167481","https://openalex.org/W3036226369","https://openalex.org/W3046177744","https://openalex.org/W3093279792","https://openalex.org/W3093451235","https://openalex.org/W3094128444","https://openalex.org/W3097582086","https://openalex.org/W3115500001","https://openalex.org/W3127967490","https://openalex.org/W3172294552","https://openalex.org/W3182356919","https://openalex.org/W3182997864","https://openalex.org/W4211103501","https://openalex.org/W4280535567"],"related_works":["https://openalex.org/W4407265112","https://openalex.org/W7155897032","https://openalex.org/W3163739806","https://openalex.org/W4411449093","https://openalex.org/W2559526259","https://openalex.org/W3115500001","https://openalex.org/W7126250645","https://openalex.org/W7138445003","https://openalex.org/W7160943585","https://openalex.org/W4413756367"],"abstract_inverted_index":{"Objectives:":[0],"Whether":[1],"chronic":[2,48,100,207],"autoimmune":[3,49,101,208],"inflammatory":[4,19,32,38,50,102,105,130,143,197,209,213,283,300,321,329,338],"diseases":[5,20,39,51,198,210,284,301],"causally":[6],"affect":[7],"the":[8,16,22,28,35,63,97,185,297],"risk":[9,23,53,109,230,247,303],"of":[10,24,30,54,72,75,110,123,231,248,282,304,316],"AD":[11,25,55,124,232,271,290,305],"is":[12,306],"controversial.":[13],"We":[14,43],"characterised":[15],"relationship":[17],"between":[18,37,99,206,299],"and":[21,26,40,52,108,173,190,211,245,264,302,311,340],"explore":[27],"role":[29],"circulating":[31,104,212,216],"biomarkers":[33,322],"in":[34,62],"relationships":[36,98,205],"AD.":[41,111,341],"Methods:":[42],"performed":[44,90],"observational":[45],"analyses":[46],"for":[47,262,325],"using":[56,116],"data":[57,71,118,294],"from":[58,80,195,235],"2,047,513":[59],"participants":[60],"identified":[61,204],"UK":[64],"Clinical":[65],"Practice":[66],"Research":[67],"Datalink":[68],"(CPRD).":[69],"Using":[70,274],"a":[73,228,258,275,314],"total":[74],"more":[76],"than":[77],"1,100,000":[78],"individuals":[79],"15":[81],"large":[82],"scale":[83],"genome-wide":[84],"association":[85,298],"study":[86],"(GWAS)":[87],"datasets,":[88],"we":[89],"two-sample":[91,276],"Mendelian":[92],"randomisation":[93],"(MR)":[94],"to":[95,139,154,161,170,180,184,242,308],"investigate":[96],"diseases,":[103,330],"biomarker":[106],"levels,":[107],"Results:":[112],"Cox":[113],"regression":[114],"models":[115],"CPRD":[117],"showed":[119,323],"that":[120,296,334],"overall":[121],"incidence":[122],"was":[125,224,332],"higher":[126,229,289],"among":[127],"patients":[128],"with":[129,227,288,328],"bowel":[131],"disease":[132,250,266,339],"(IBD)":[133],"(hazard":[134],"ratio":[135,234],"(HR)=1.17;":[136],"95%CI":[137,152,159,168,178,240,252],"1.15":[138],"1.19;":[140],"P-value=2.1\u00d710-4),":[141],"other":[142],"polyarthropathies":[144],"&":[145],"systematic":[146],"connective":[147],"tissue":[148],"disorders":[149],"(OID)":[150],"(HR=1.13;":[151,158],"1.12":[153],"1.14;":[155],"P-value=8.6\u00d710-5),":[156],"psoriasis":[157],"1.10":[160],"1.16;":[162],"P-value=2.6\u00d710-4),":[163],"rheumatoid":[164],"arthritis":[165],"(RA)":[166],"(HR=1.08;":[167],"1.06":[169,241],"1.11;":[171],"P-value=4.0\u00d710-4),":[172],"multiple":[174],"sclerosis":[175],"(MS)":[176],"(HR=1.06;":[177],"1.04":[179],"1.07;":[181],"P-value=2.8\u00d710-4)":[182],"compared":[183],"age":[186],"(\u00b1":[187],"5":[188],"years)":[189],"sex-matched":[191],"comparison":[192],"groups":[193],"free":[194],"all":[196],"under":[199],"investigation.":[200],"Bidirectional":[201],"MR":[202,277],"analysis":[203],"biomarkers.":[214],"Particularly,":[215],"monokine":[217],"induced":[218],"by":[219],"gamma":[220],"interferon":[221],"(MIG)":[222],"level":[223],"suggestively":[225],"associated":[226,287],"(odds":[233],"inverse":[236],"variance":[237],"weighted":[238],"(ORIVW)=1.23;":[239],"1.42;":[243],"PIVW=0.007),":[244],"lower":[246],"Crohn\u2019s":[249,265],"(ORIVW=0.73;":[251],"-0.62,":[253],"0.86;":[254],"PIVW=1.3\u00d710-4).":[255],"Colocalisation":[256],"supported":[257],"common":[259],"causal":[260,310,326],"SNP":[261],"MIG":[263],"(posterior":[267,272],"probability=0.74)":[268],"but":[269],"not":[270,286],"probability=0.03).":[273],"approach,":[278],"genetically":[279],"predicted":[280],"risks":[281],"were":[285],"risk.":[291],"Conclusion:":[292],"Our":[293],"suggest":[295],"unlikely":[307],"be":[309,313],"may":[312],"result":[315],"confounding.":[317],"In":[318],"support,":[319],"while":[320],"evidence":[324,331],"associations":[327],"weak":[333],"they":[335],"affected":[336],"both":[337]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":10}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2022-11-25T00:00:00"}
