{"id":"https://openalex.org/W4309167176","doi":"https://doi.org/10.1089/omi.2022.0138","title":"Drug Repositioning Identifies Six Drug Candidates for Systemic Autoimmune Diseases by Integrative Analyses of Transcriptomes from Scleroderma, Systemic Lupus Erythematosus, and Sjogren's Syndrome","display_name":"Drug Repositioning Identifies Six Drug Candidates for Systemic Autoimmune Diseases by Integrative Analyses of Transcriptomes from Scleroderma, Systemic Lupus Erythematosus, and Sjogren's Syndrome","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4309167176","doi":"https://doi.org/10.1089/omi.2022.0138","pmid":"https://pubmed.ncbi.nlm.nih.gov/36378860"},"language":"en","primary_location":{"id":"doi:10.1089/omi.2022.0138","doi":"https://doi.org/10.1089/omi.2022.0138","is_oa":false,"landing_page_url":"https://doi.org/10.1089/omi.2022.0138","pdf_url":null,"source":{"id":"https://openalex.org/S116972989","display_name":"OMICS A Journal of Integrative Biology","issn_l":"1536-2310","issn":["1536-2310","1557-8100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS: A Journal of Integrative Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028749898","display_name":"Elif Kubat \u00d6ktem","orcid":"https://orcid.org/0000-0003-0913-8527","observed_orcids":["https://orcid.org/0000-0003-0913-8527"]},"institutions":[{"id":"https://openalex.org/I57913696","display_name":"Istanbul Medeniyet University","ror":"https://ror.org/05j1qpr59","country_code":"TR","type":"education","lineage":["https://openalex.org/I57913696"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Elif Kubat Oktem","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-0913-8527","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, Istanbul, Turkey","institution_ids":["https://openalex.org/I57913696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067049269","display_name":"Metin Yazar","orcid":"https://orcid.org/0000-0002-2657-3072","observed_orcids":["https://orcid.org/0000-0002-2657-3072"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]},{"id":"https://openalex.org/I96268669","display_name":"Okan University","ror":"https://ror.org/054d5vq03","country_code":"TR","type":"education","lineage":["https://openalex.org/I96268669"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Metin Yazar","raw_affiliation_strings":["Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey","Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, Istanbul Okan University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]},{"raw_affiliation_string":"Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, Istanbul Okan University, Istanbul, Turkey","institution_ids":["https://openalex.org/I96268669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028749898"],"corresponding_institution_ids":["https://openalex.org/I57913696"],"apc_list":null,"apc_paid":null,"fwci":0.6754,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.6801051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"26","issue":"12","first_page":"683","last_page":"693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9879999756813049},{"id":"https://openalex.org/keywords/systemic-autoimmune-diseases","display_name":"systemic autoimmune diseases","score":0.9950000047683716},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/sjogren-s-syndrome","display_name":"Sj\u00f6gren's syndrome","score":0.9769999980926514},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.7620000243186951},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6069999933242798},{"id":"https://openalex.org/keywords/small-molecule-drug-candidates","display_name":"small molecule drug candidates","score":0.8899999856948853},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6230000257492065},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.890999972820282},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.8292620182037354},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7588179111480713},{"id":"https://openalex.org/C2779967694","wikidata":"https://www.wikidata.org/wiki/Q1383511","display_name":"Scleroderma (fungus)","level":3,"score":0.6704420447349548},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5934380888938904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5655089616775513},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.513041615486145},{"id":"https://openalex.org/C2779625490","wikidata":"https://www.wikidata.org/wiki/Q5340515","display_name":"Systemic scleroderma","level":3,"score":0.4196709394454956},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.41951557993888855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4170535206794739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30845993757247925},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3059151768684387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.302858829498291},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24288281798362732},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22401532530784607},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19259288907051086},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.13054358959197998},{"id":"https://openalex.org/C2778751314","wikidata":"https://www.wikidata.org/wiki/Q681160","display_name":"Dermatomyositis","level":2,"score":0.07404860854148865},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/omi.2022.0138","doi":"https://doi.org/10.1089/omi.2022.0138","is_oa":false,"landing_page_url":"https://doi.org/10.1089/omi.2022.0138","pdf_url":null,"source":{"id":"https://openalex.org/S116972989","display_name":"OMICS A Journal of Integrative Biology","issn_l":"1536-2310","issn":["1536-2310","1557-8100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS: A Journal of Integrative Biology","raw_type":"journal-article"},{"id":"pmid:36378860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36378860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Omics : a journal of integrative biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W911382732","https://openalex.org/W1972346280","https://openalex.org/W1979717925","https://openalex.org/W1979822055","https://openalex.org/W1987432765","https://openalex.org/W1989277387","https://openalex.org/W2016431114","https://openalex.org/W2016447788","https://openalex.org/W2024590500","https://openalex.org/W2038819442","https://openalex.org/W2058490319","https://openalex.org/W2067786443","https://openalex.org/W2074441508","https://openalex.org/W2079763590","https://openalex.org/W2094539776","https://openalex.org/W2094817491","https://openalex.org/W2103912979","https://openalex.org/W2104590104","https://openalex.org/W2105668062","https://openalex.org/W2111841685","https://openalex.org/W2116634113","https://openalex.org/W2119037907","https://openalex.org/W2120865735","https://openalex.org/W2123060905","https://openalex.org/W2124593509","https://openalex.org/W2129172946","https://openalex.org/W2130479394","https://openalex.org/W2130900979","https://openalex.org/W2136850043","https://openalex.org/W2143393758","https://openalex.org/W2151052146","https://openalex.org/W2154196978","https://openalex.org/W2156195480","https://openalex.org/W2156343903","https://openalex.org/W2156584537","https://openalex.org/W2159082915","https://openalex.org/W2159675211","https://openalex.org/W2162675359","https://openalex.org/W2166089777","https://openalex.org/W2167980479","https://openalex.org/W2190581194","https://openalex.org/W2202022139","https://openalex.org/W2294516783","https://openalex.org/W2489003193","https://openalex.org/W2491155763","https://openalex.org/W2547741362","https://openalex.org/W2559848531","https://openalex.org/W2603147066","https://openalex.org/W2607370927","https://openalex.org/W2616391641","https://openalex.org/W2746966848","https://openalex.org/W2791545164","https://openalex.org/W2899070097","https://openalex.org/W2899300345","https://openalex.org/W2923278922","https://openalex.org/W2928665623","https://openalex.org/W2939797295","https://openalex.org/W2940621923","https://openalex.org/W2944423813","https://openalex.org/W2950595506","https://openalex.org/W2958031011","https://openalex.org/W2969272216","https://openalex.org/W2969561067","https://openalex.org/W3021951900","https://openalex.org/W3041073688","https://openalex.org/W3044980221","https://openalex.org/W3102147110","https://openalex.org/W3112600195","https://openalex.org/W3128839088","https://openalex.org/W3151615034","https://openalex.org/W3168436232","https://openalex.org/W3182984054","https://openalex.org/W3209421368","https://openalex.org/W4200361762","https://openalex.org/W4221048803","https://openalex.org/W4233437719","https://openalex.org/W4281556061","https://openalex.org/W4298086773"],"related_works":["https://openalex.org/W4323050635","https://openalex.org/W4300510395","https://openalex.org/W2734718909","https://openalex.org/W4393072972","https://openalex.org/W7125138617","https://openalex.org/W4211262855","https://openalex.org/W7139981550","https://openalex.org/W4205102906","https://openalex.org/W2910863770","https://openalex.org/W2535496682"],"abstract_inverted_index":{"The":[0,109,127],"mechanisms":[1],"of":[2,15,43,123,133,143,174,195],"systemic":[3,16,47,107,196],"autoimmune":[4],"diseases":[5],"(ADs)":[6],"are":[7],"still":[8],"not":[9],"clearly":[10],"understood.":[11],"Understanding":[12],"the":[13,38,64,119,124,131,138,144,153,158,162,169],"etiology":[14],"ADs":[17,197],"and":[18,33,50,74,95,166,185,193],"identifying":[19],"new":[20,183,188],"therapeutic":[21],"targets":[22],"require":[23],"a":[24],"systems":[25],"science":[26],"approach.":[27],"Using":[28],"publicly":[29],"available":[30],"transcriptome":[31],"data":[32],"bioinformatic":[34],"analysis,":[35],"we":[36],"investigated":[37],"differential":[39],"gene":[40,58],"expression":[41],"profiles":[42],"patients":[44],"with":[45,137],"scleroderma,":[46],"lupus":[48],"erythematosus,":[49],"Sjogren's":[51],"syndrome.":[52],"Of":[53],"these":[54],"common":[55,134],"differentially":[56],"expressed":[57],"signatures,":[59],"208":[60],"were":[61,98],"regulated":[62],"in":[63,71],"same":[65],"direction":[66],"(either":[67],"upregulated":[68],"or":[69],"downregulated":[70],"all":[72],"datasets)":[73],"used":[75,116],"for":[76,106,112],"drug":[77,82,101,164,199],"repositioning.":[78,200],"Six":[79],"small":[80,147],"molecule":[81],"candidates":[83,165],"(KU-0063794,":[84],"YM-155":[85],"[sepantronium":[86],"bromide],":[87],"MST-312":[88],"[telomerase":[89],"inhibitor":[90],"IX],":[91],"PLX-4720,":[92],"ZM":[93],"336372,":[94],"528116.cdx":[96],"[PIK-75])":[97],"discovered":[99],"by":[100],"repositioning":[102],"as":[103],"potential":[104],"therapeutics":[105],"ADs.":[108],"Search":[110],"Tool":[111],"Chemical":[113],"Interactions":[114],"was":[115],"to":[117],"find":[118],"anticipated":[120,140,175],"target":[121,141,176],"genes":[122,142,167],"repositioned":[125,146,163],"molecules.":[126,148],"PI3K/AKT":[128],"pathway":[129],"topped":[130],"list":[132],"enriched":[135],"pathways":[136],"most":[139],"six":[145],"We":[149],"also":[150],"report":[151],"here":[152],"molecular":[154],"docking":[155],"findings":[156],"on":[157,190],"binding":[159],"affinity":[160],"between":[161],"from":[168],"protein-protein":[170],"interaction":[171],"network":[172],"modules":[173],"genes.":[177],"Taken":[178],"together,":[179],"this":[180],"study":[181],"provides":[182],"insights":[184],"opens":[186],"up":[187],"possibilities":[189],"both":[191],"pathogenesis":[192],"treatment":[194],"through":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-24T00:00:00"}
