{"id":"https://openalex.org/W4309167170","doi":"https://doi.org/10.1007/s00405-022-07729-5","title":"Pepsin enhances glycolysis to promote malignant transformation of vocal fold leukoplakia epithelial cells with dysplasia","display_name":"Pepsin enhances glycolysis to promote malignant transformation of vocal fold leukoplakia epithelial cells with dysplasia","publication_year":2022,"publication_date":"2022-11-16","ids":{"openalex":"https://openalex.org/W4309167170","doi":"https://doi.org/10.1007/s00405-022-07729-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/36380093","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9988773"},"language":"en","primary_location":{"id":"doi:10.1007/s00405-022-07729-5","doi":"https://doi.org/10.1007/s00405-022-07729-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00405-022-07729-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00405-022-07729-5.pdf","source":{"id":"https://openalex.org/S163740676","display_name":"European Archives of Oto-Rhino-Laryngology","issn_l":"0937-4477","issn":["0937-4477","1434-4726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Archives of Oto-Rhino-Laryngology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00405-022-07729-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102217639","display_name":"Haitong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haitong Li","raw_affiliation_strings":["Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100679882","display_name":"Shasha Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shasha Zhang","raw_affiliation_strings":["Department of Otolaryngology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006364436","display_name":"Shui\u2010Hong Zhou","orcid":"https://orcid.org/0000-0002-7163-2289","observed_orcids":["https://orcid.org/0000-0002-7163-2289","https://orcid.org/0000-0002-9545-0068"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuihong Zhou","raw_affiliation_strings":["Department of Otolaryngology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032959437","display_name":"Yang\u2010Yang Bao","orcid":"https://orcid.org/0000-0001-7857-9954","observed_orcids":["https://orcid.org/0000-0001-7857-9954"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangyang Bao","raw_affiliation_strings":["Department of Otolaryngology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037761067","display_name":"Xiaojuan Cao","orcid":"https://orcid.org/0000-0002-9676-5838","observed_orcids":["https://orcid.org/0000-0002-9676-5838"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojuan Cao","raw_affiliation_strings":["Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004201927","display_name":"Lifang Shen","orcid":"https://orcid.org/0000-0001-5884-1345","observed_orcids":["https://orcid.org/0000-0001-5884-1345"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifang Shen","raw_affiliation_strings":["Department of Otolaryngology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115883473","display_name":"Bin Xu","orcid":"https://orcid.org/0000-0002-0318-1287","observed_orcids":["https://orcid.org/0000-0002-0318-1287","https://orcid.org/0009-0006-0576-2399"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Xu","raw_affiliation_strings":["Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073408436","display_name":"Weimin Gao","orcid":"https://orcid.org/0000-0001-6407-3258","observed_orcids":["https://orcid.org/0000-0001-6407-3258"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weimin Gao","raw_affiliation_strings":["Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053686418","display_name":"Yunzhen Luo","orcid":"https://orcid.org/0000-0001-6143-2315","observed_orcids":["https://orcid.org/0000-0001-6143-2315","https://orcid.org/0009-0005-5104-9503","https://orcid.org/0000-0002-9359-3401"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunzhen Luo","raw_affiliation_strings":["Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China. luoyunzhen@sohu.com","Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-9359-3401","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China. luoyunzhen@sohu.com","institution_ids":["https://openalex.org/I4210092870"]},{"raw_affiliation_string":"Department of Otolaryngology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053686418"],"corresponding_institution_ids":["https://openalex.org/I4210092870"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.9474,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.69440905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"280","issue":"4","first_page":"1841","last_page":"1854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.2971000075340271,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pepsin","display_name":"pepsin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vocal-fold-leukoplakia","display_name":"vocal fold leukoplakia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dysplasia","display_name":"dysplasia","score":0.8579999804496765},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.878000020980835},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.902999997138977},{"id":"https://openalex.org/keywords/hexokinase-2","display_name":"hexokinase 2","score":0.7459999918937683},{"id":"https://openalex.org/keywords/respiratory-chain-complex-i","display_name":"respiratory chain complex I","score":0.7289999723434448},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/fdg-uptake","display_name":"FDG uptake","score":0.8379999995231628},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.6643002033233643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5515614748001099},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5495641231536865},{"id":"https://openalex.org/C2777952866","wikidata":"https://www.wikidata.org/wiki/Q24722601","display_name":"GLUT1","level":4,"score":0.528287947177887},{"id":"https://openalex.org/C2779826832","wikidata":"https://www.wikidata.org/wiki/Q982914","display_name":"Hexokinase","level":4,"score":0.5166807174682617},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.48379963636398315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41580596566200256},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3965676426887512},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39092129468917847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35419416427612305},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.3092268109321594},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1593431830406189},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11434236168861389},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007971","descriptor_name":"Leukoplakia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00405-022-07729-5","doi":"https://doi.org/10.1007/s00405-022-07729-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00405-022-07729-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00405-022-07729-5.pdf","source":{"id":"https://openalex.org/S163740676","display_name":"European Archives of Oto-Rhino-Laryngology","issn_l":"0937-4477","issn":["0937-4477","1434-4726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Archives of Oto-Rhino-Laryngology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9988773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9988773","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Arch Otorhinolaryngol","raw_type":"Text"},{"id":"pmid:36380093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36380093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00405-022-07729-5","doi":"https://doi.org/10.1007/s00405-022-07729-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00405-022-07729-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00405-022-07729-5.pdf","source":{"id":"https://openalex.org/S163740676","display_name":"European Archives of Oto-Rhino-Laryngology","issn_l":"0937-4477","issn":["0937-4477","1434-4726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Archives of Oto-Rhino-Laryngology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309167170.pdf","grobid_xml":"https://content.openalex.org/works/W4309167170.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1529313052","https://openalex.org/W1559558197","https://openalex.org/W1856704067","https://openalex.org/W1999163659","https://openalex.org/W2012135330","https://openalex.org/W2014058353","https://openalex.org/W2019843278","https://openalex.org/W2020076608","https://openalex.org/W2030714977","https://openalex.org/W2031424123","https://openalex.org/W2043364216","https://openalex.org/W2061198554","https://openalex.org/W2072902622","https://openalex.org/W2094781230","https://openalex.org/W2100262552","https://openalex.org/W2101631890","https://openalex.org/W2102888413","https://openalex.org/W2150419930","https://openalex.org/W2155984813","https://openalex.org/W2292401026","https://openalex.org/W2400133354","https://openalex.org/W2547142542","https://openalex.org/W2605375039","https://openalex.org/W2740055629","https://openalex.org/W2751075481","https://openalex.org/W2767871109","https://openalex.org/W2793405385","https://openalex.org/W2796797624","https://openalex.org/W2802345478","https://openalex.org/W2827119614","https://openalex.org/W2889273501","https://openalex.org/W2897541663","https://openalex.org/W2905085764","https://openalex.org/W2907122372","https://openalex.org/W2911701377","https://openalex.org/W2918012079","https://openalex.org/W2944667882","https://openalex.org/W2946608565","https://openalex.org/W2954486714","https://openalex.org/W2963760980","https://openalex.org/W2981601064","https://openalex.org/W2983231685","https://openalex.org/W3000613737","https://openalex.org/W3010886264","https://openalex.org/W3016425065","https://openalex.org/W3024763931","https://openalex.org/W3039811471","https://openalex.org/W3044092193","https://openalex.org/W3047326261","https://openalex.org/W3084150740","https://openalex.org/W3093907389","https://openalex.org/W3094203332","https://openalex.org/W3117379398","https://openalex.org/W3208338749","https://openalex.org/W3213324066","https://openalex.org/W3214290624","https://openalex.org/W4210539397","https://openalex.org/W4223564164","https://openalex.org/W4225263834","https://openalex.org/W4281621325"],"related_works":["https://openalex.org/W4401200805","https://openalex.org/W4210539397","https://openalex.org/W3044092193","https://openalex.org/W2101631890","https://openalex.org/W2915293327","https://openalex.org/W2090947706","https://openalex.org/W4404436551","https://openalex.org/W1571298115","https://openalex.org/W2566232500","https://openalex.org/W2953547667"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1],"mechanism":[2],"underlying":[3],"malignant":[4],"transformation":[5],"of":[6,15,18,31,113,117,136,165,178,199,207],"vocal":[7],"fold":[8],"leukoplakia":[9],"(VFL)":[10],"and":[11,39,41,49,65,74,83,115,133,147,150,154,173,175,201,223,233],"the":[12,16,29,93,111,124,163,190,197],"precise":[13],"role":[14],"expression":[17,112,156,198],"pepsin":[19,33,114,129,195,217],"in":[20,120,157,205],"VFL":[21,35,121,137,158,179,208,219],"remain":[22],"unclear.":[23],"This":[24],"study":[25],"aimed":[26],"to":[27,54,240],"investigate":[28],"effects":[30],"acidified":[32,128,194,216],"on":[34],"epithelial":[36,138,159,180,209,220],"cell":[37,71,131,181,221],"growth":[38,132,174,222],"migration,":[40],"also":[42],"identify":[43],"pertinent":[44],"molecular":[45],"mechanisms.":[46],"METHODS:":[47],"Immunochemistry":[48],"Western":[50],"blotting":[51],"were":[52,76,90,182],"performed":[53],"measure":[55],"glucose":[56],"transporter":[57],"type":[58],"1":[59],"(GLUT1),":[60],"monocarboxylate":[61],"transporters":[62],"4":[63],"(MCT4),":[64],"Hexokinase-II":[66],"(HK-II)":[67],"expressions.":[68],"Cell":[69],"viability,":[70],"cycle,":[72],"apoptosis,":[73],"migration":[75,134,176,224],"investigated":[77],"by":[78,189,226],"CCK-8":[79],"assay,":[80,86],"flow":[81],"cytometry":[82],"Transwell":[84],"chamber":[85],"respectively.":[87],"Glycolysis-related":[88],"contents":[89],"determined":[91],"using":[92,104],"corresponding":[94],"kits.":[95],"Mitochondrial":[96],"HK-II":[97,200],"was":[98,109,186,213],"photographed":[99],"under":[100],"a":[101],"confocal":[102],"microscope":[103],"Mito-Tracker":[105],"Red.":[106],"RESULTS:":[107],"It":[108,212],"found:":[110],"proportion":[116],"pepsin+":[118],"cells":[119],"increased":[122,125,196],"with":[123,162],"dysplasia":[126],"grade;":[127],"enhanced":[130,151,202],"capabilities":[135,177],"cells,":[139],"reduced":[140],"mitochondrial":[141,228],"respiratory":[142,229],"chain":[143],"complex":[144,230],"I":[145,231],"activity":[146,232],"oxidative":[148,238],"phosphorylation,":[149],"aerobic":[152,241],"glycolysis":[153,191],"GLUT1":[155,166],"cells;":[160],"along":[161],"transfection":[164],"overexpression":[167],"plasmid,":[168],"18FFDG":[169],"uptake,":[170],"lactate":[171],"secretion":[172],"increased;":[183],"this":[184],"effect":[185],"partially":[187],"blocked":[188],"inhibitor":[192],"2-deoxy-glucose;":[193],"its":[203],"distribution":[204],"mitochondria":[206],"cells.":[210],"CONCLUSION:":[211],"concluded":[214],"that":[215],"enhances":[218],"abilities":[225],"reducing":[227],"promoting":[234],"metabolic":[235],"reprogramming":[236],"from":[237],"phosphorylation":[239],"glycolysis.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-24T00:00:00"}