{"id":"https://openalex.org/W4309108402","doi":"https://doi.org/10.1158/1538-7445.panca22-c006","title":"Abstract C006: Loss of the MGAT5 glycosyltransferase sensitizes pancreatic tumor cells to immune clearance","display_name":"Abstract C006: Loss of the MGAT5 glycosyltransferase sensitizes pancreatic tumor cells to immune clearance","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4309108402","doi":"https://doi.org/10.1158/1538-7445.panca22-c006"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca22-c006","doi":"https://doi.org/10.1158/1538-7445.panca22-c006","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca22-c006","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052814766","display_name":"Erin E. Hollander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Hollander","raw_affiliation_strings":["1University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057187872","display_name":"Ben Z. Stanger","orcid":"https://orcid.org/0000-0003-0410-4037","observed_orcids":["https://orcid.org/0000-0003-0410-4037"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Stanger","raw_affiliation_strings":["1University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"22_Supplement","first_page":"C006","last_page":"C006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mgat5","display_name":"MGAT5","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glycosyltransferases","display_name":"glycosyltransferases","score":0.8569999933242798},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.7720000147819519},{"id":"https://openalex.org/keywords/tumor-associated-glycans","display_name":"tumor-associated glycans","score":0.8370000123977661},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.7799999713897705},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/cd4-cd8-t-cells","display_name":"CD4+CD8+ T cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/immunological-memory","display_name":"immunological memory","score":0.824999988079071},{"id":"https://openalex.org/keywords/therapeutic-vaccination","display_name":"therapeutic vaccination","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6857603788375854},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6842994689941406},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5961583256721497},{"id":"https://openalex.org/C2777996000","wikidata":"https://www.wikidata.org/wiki/Q7130412","display_name":"Pancreatic tumor","level":4,"score":0.5799866318702698},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.564413845539093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5442100763320923},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5081222057342529},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4708912968635559},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.44747161865234375},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41645243763923645},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3301452696323395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca22-c006","doi":"https://doi.org/10.1158/1538-7445.panca22-c006","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca22-c006","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7135323088","https://openalex.org/W4399928906","https://openalex.org/W358841342","https://openalex.org/W2126195886","https://openalex.org/W4401232125","https://openalex.org/W4412883056","https://openalex.org/W1531421007","https://openalex.org/W6907863923","https://openalex.org/W4410039387","https://openalex.org/W3180690010"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1,348],"ductal":[2],"adenocarcinoma":[3],"(PDAC)":[4],"is":[5,27,55],"currently":[6],"the":[7,15,78,106,185,199,215,259,286,294,304,307,313,329,343],"third":[8],"leading":[9],"cause":[10],"of":[11,22,39,80,100,109,115,127,182,198,217,288,296,306,328,342],"cancer-related":[12],"death":[13],"in":[14,33,61,89,94,117,130,142,149,171,178,195,206,227,280,285],"United":[16],"States.":[17],"The":[18,74],"five-year":[19],"survival":[20],"rate":[21],"less":[23],"than":[24],"nine":[25],"percent":[26],"attributed":[28],"mainly":[29],"to":[30,57,138,210,269,302,336],"a":[31,37,45,59,98,139,251,278],"difficulty":[32],"early":[34],"detection":[35],"and":[36,64,84,92,221,236,310,318],"lack":[38],"effective":[40],"treatments.":[41],"Tumor-associated":[42],"glycans":[43],"represent":[44],"potential":[46],"anti-tumor":[47,319],"target":[48],"for":[49,124],"two":[50],"reasons:":[51],"(i)":[52],"protein":[53],"glycosylation":[54,317],"known":[56],"play":[58],"role":[60],"tumor":[62,72,90,143,168,183,246,265,271,290,334],"progression,":[63],"(ii)":[65],"alternatively":[66],"glycosylated":[67],"proteins":[68],"may":[69],"function":[70],"as":[71,152,154],"neoantigens.":[73],"glycosyltransferase":[75,331],"MGAT5":[76,116,135,162,186,233,282,330],"catalyzes":[77],"formation":[79,287],"beta-1,6-N-acetylglucosamine":[81],"branched":[82],"glycans,":[83],"overexpression":[85],"has":[86],"been":[87],"implicated":[88],"growth":[91,170,204],"metastasis":[93],"multiple":[95],"cancers.":[96],"Using":[97],"panel":[99],"clonal":[101],"cell":[102,169,266],"lines":[103],"that":[104,113,245],"recapitulate":[105],"immune":[107,175,337],"heterogeneity":[108],"PDAC,":[110],"we":[111],"found":[112,209],"knockout":[114,260],"some":[118],"clones":[119,132],"(\u201cT":[120],"cell-inflamed\"":[121],"tumors)":[122],"allows":[123],"complete":[125],"clearance":[126,338],"tumors":[128,240],"while":[129],"other":[131],"(\u201cnon-T":[133],"cell-inflamed\u201d)":[134],"deficiency":[136],"led":[137,268],"marked":[140],"decrease":[141],"growth.":[144,272],"This":[145],"phenotype":[146],"was":[147,208,248],"confirmed":[148],"orthotopic":[150],"injection":[151,156,267],"well":[153],"subcutaneous":[155],"into":[157,191],"syngeneic":[158],"mice.":[159],"By":[160],"contrast,":[161],"loss":[163,283],"had":[164],"no":[165],"impact":[166],"on":[167,214,347],"vitro.":[172],"To":[173],"probe":[174],"system":[176],"involvement":[177],"this":[179],"robust":[180],"rejection":[181,247],"growth,":[184],"KO":[187,234],"cells":[188,220,235,335],"were":[189,230],"injected":[190],"Nod/Scid":[192],"mice,":[193],"resulting":[194],"full":[196],"rescue":[197],"phenotype.":[200],"Tumor":[201,224],"eradication":[202],"or":[203],"inhibition":[205],"vivo":[207],"be":[211],"dependent":[212],"specifically":[213],"presence":[216],"CD4/CD8":[218],"T":[219],"dendritic":[222],"cells.":[223],"challenge":[225],"experiments,":[226],"which":[228,281],"mice":[229],"immunized":[231],"with":[232,238,250,258,263,277],"challenged":[237],"wild-type":[239,264],"four":[241],"weeks":[242],"later,":[243],"revealed":[244],"associated":[249],"durable":[252],"immunologic":[253],"memory.":[254],"Finally,":[255],"therapeutic":[256],"vaccination":[257],"line":[261],"concomitantly":[262],"decreased":[270],"These":[273],"results":[274,284],"are":[275],"consistent":[276],"model":[279],"new":[289],"antigens":[291,309],"and/or":[292],"enhances":[293],"immunogenicity":[295],"pre-existing":[297],"antigens.":[298],"Ongoing":[299],"work":[300],"seeks":[301],"determine":[303],"identity":[305],"responsible":[308],"further":[311],"investigate":[312],"relationship":[314],"between":[315],"altered":[316],"immunity.":[320],"Citation":[321],"Format:":[322],"Erin":[323],"Hollander,":[324],"Ben":[325],"Stanger.":[326],"Loss":[327],"sensitizes":[332],"pancreatic":[333],"[abstract].":[339],"In:":[340],"Proceedings":[341],"AACR":[344],"Special":[345],"Conference":[346],"Cancer;":[349],"2022":[350],"Sep":[351],"13-16;":[352],"Boston,":[353],"MA.":[354],"Philadelphia":[355],"(PA):":[356],"AACR;":[357],"Cancer":[358],"Res":[359],"2022;82(22":[360],"Suppl):Abstract":[361],"nr":[362],"C006.":[363]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2022-11-22T00:00:00"}
