{"id":"https://openalex.org/W4309017271","doi":"https://doi.org/10.1093/neuonc/noac209.704","title":"NIMG-86. REVEALING THE BIOLOGY BEHIND MRI SIGNATURES IN GLIOBLASTOMA","display_name":"NIMG-86. REVEALING THE BIOLOGY BEHIND MRI SIGNATURES IN GLIOBLASTOMA","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4309017271","doi":"https://doi.org/10.1093/neuonc/noac209.704"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noac209.704","doi":"https://doi.org/10.1093/neuonc/noac209.704","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.704","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii185/47020463/noac209.704.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii185/47020463/noac209.704.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089332804","display_name":"Erika M. Lewis","orcid":"https://orcid.org/0000-0001-6156-0990","observed_orcids":["https://orcid.org/0000-0001-6156-0990"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika Lewis","raw_affiliation_strings":["Arizona State University , Tempe, AZ , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University , Tempe, AZ , USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016790638","display_name":"Nhan L. Tran","orcid":"https://orcid.org/0000-0003-0908-9964","observed_orcids":["https://orcid.org/0000-0003-0908-9964"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nhan Tran","raw_affiliation_strings":["Mayo Clinic , Phoenix, AZ , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic , Phoenix, AZ , USA","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014011778","display_name":"Kristin R. Swanson","orcid":"https://orcid.org/0000-0002-2464-6119","observed_orcids":["https://orcid.org/0000-0002-2464-6119"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Swanson","raw_affiliation_strings":["Mayo Clinic , Phoenix, AZ , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic , Phoenix, AZ , USA","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058133357","display_name":"Leland Hu","orcid":"https://orcid.org/0000-0001-9282-7619","observed_orcids":["https://orcid.org/0000-0001-9282-7619"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leland Hu","raw_affiliation_strings":["Mayo Clinic , Phoenix, AZ , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic , Phoenix, AZ , USA","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074006758","display_name":"Christopher L. Plaisier","orcid":"https://orcid.org/0000-0003-3273-5717","observed_orcids":["https://orcid.org/0000-0003-3273-5717"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Plaisier","raw_affiliation_strings":["Arizona State University , Tempe, AZ , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University , Tempe, AZ , USA","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"Supplement_7","first_page":"vii185","last_page":"vii185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/multiparametric-mri","display_name":"multiparametric MRI","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.6589999794960022},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6650000214576721},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/t2-signal","display_name":"T2 signal","score":0.7850000262260437},{"id":"https://openalex.org/keywords/flt-1","display_name":"Flt-1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/kdr","display_name":"KDR","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.44600000977516174},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C78221974","wikidata":"https://www.wikidata.org/wiki/Q18030425","display_name":"PDGFRB","level":3,"score":0.6691589951515198},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5930903553962708},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5286450982093811},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4710657000541687},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43786340951919556},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43259236216545105},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4295562505722046},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4281577467918396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36288344860076904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36249303817749023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3605666756629944},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.17394566535949707},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11373522877693176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10645410418510437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noac209.704","doi":"https://doi.org/10.1093/neuonc/noac209.704","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.704","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii185/47020463/noac209.704.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9660729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9660729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noac209.704","doi":"https://doi.org/10.1093/neuonc/noac209.704","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.704","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii185/47020463/noac209.704.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309017271.pdf","grobid_xml":"https://content.openalex.org/works/W4309017271.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389795741","https://openalex.org/W7151850369","https://openalex.org/W4220950070","https://openalex.org/W2031740204","https://openalex.org/W1929984647","https://openalex.org/W242046620","https://openalex.org/W2042524329","https://openalex.org/W2519238003","https://openalex.org/W44288063","https://openalex.org/W4414799539"],"abstract_inverted_index":{"Abstract":[0],"The":[1,96,106,138],"brain":[2,47,153],"is":[3],"notoriously":[4],"difficult":[5],"to":[6,31,213,257],"access":[7],"because":[8],"of":[9,41,136,166,182,237,242],"its":[10],"location":[11],"and":[12,17,116,132,179,186,230,232,261],"protective":[13],"mechanisms,":[14],"both":[15,183],"internal":[16],"external.":[18],"Imaging-based":[19],"approaches,":[20],"such":[21,226],"as":[22,227],"multiparametric":[23],"magnetic":[24],"resonance":[25],"imaging":[26,51,60],"(mpMRI),":[27],"provide":[28],"a":[29,38,119,146,173,254],"method":[30,140],"bypass":[32],"these":[33,200,243],"obstacles.":[34],"mpMRI":[35,247],"can":[36],"capture":[37],"wide":[39],"range":[40],"data":[42,94],"from":[43,95,163],"tumors":[44],"embedded":[45],"in":[46],"tissue":[48],"through":[49,156],"various":[50],"features.":[52],"However,":[53],"the":[54,67,91,112,123,133,151,164,167,180,197,204,214,235],"biological":[55],"function":[56],"captured":[57],"by":[58,144],"each":[59],"feature":[61,131],"remains":[62],"largely":[63],"unknown,":[64],"particularly":[65],"within":[66,111],"aggressive":[68],"disease":[69],"glioblastoma":[70],"multiforme":[71],"(GBM).":[72],"We":[73],"integrated":[74],"our":[75],"GBM":[76,170,258],"SYstems":[77],"Genetics":[78],"Network":[79],"AnaLysis":[80],"(gbmSYGNAL)":[81],"gene":[82],"regulatory":[83],"network":[84,108],"(Plaisier,":[85],"et":[86],"al.":[87],"2016),":[88],"based":[89],"on":[90],"multi-omic":[92],"patient":[93,103],"Cancer":[97],"Genome":[98],"Atlas":[99],"(TCGA),":[100],"with":[101,223,234],"mpMRI-localized":[102],"tumor":[104],"biopsies.":[105],"gbmSYGNAL":[107],"was":[109],"reconstructed":[110],"new":[113],"image-localized":[114],"biopsies,":[115],"associations":[117],"revealed":[118],"strong":[120],"connection":[121],"between":[122,176],"spoiled":[124],"gradient":[125],"recalled":[126],"echo":[127],"+":[128],"contrast":[129,147],"(SPGR+C)":[130],"immune":[134,192],"hallmarks":[135],"cancer.":[137],"SPGR+C":[139,177],"generates":[141],"an":[142],"image":[143],"employing":[145],"agent":[148],"that":[149,160,190],"bypasses":[150],"blood":[152,158],"barrier":[154],"(BBB)":[155],"leaky":[157,201],"vessels":[159],"have":[161],"weakened":[162],"force":[165],"rapidly":[168],"growing":[169],"tumor.":[171],"Furthermore,":[172],"significant":[174],"association":[175,222],"signal":[178],"presence":[181,236],"infiltrating":[184],"macrophages":[185],"T":[187],"cells":[188,193],"indicated":[189],"peripheral":[191],"may":[194],"also":[195],"cross":[196],"BBB":[198],"at":[199],"sites.":[202],"Separately,":[203],"mean":[205],"diffusivity":[206],"(MD)":[207],"&":[208],"T2":[209],"features":[210,219,248],"were":[211],"linked":[212],"sustained":[215],"angiogenesis":[216],"hallmark.":[217],"These":[218],"displayed":[220],"high":[221],"angiogenic":[224],"genes,":[225],"FLT1,":[228],"KDR,":[229],"PDGFRB,":[231],"correlated":[233],"histologically":[238],"identified":[239],"vessels.":[240],"Detection":[241],"disease-relevant":[244],"functions":[245],"via":[246],"has":[249],"powerful":[250],"clinical":[251],"applications,":[252],"providing":[253],"non-invasive":[255],"approach":[256],"diagnosis,":[259],"prognosis,":[260],"treatment":[262],"direction.":[263]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-20T00:00:00"}
