{"id":"https://openalex.org/W4309008570","doi":"https://doi.org/10.3390/pharmaceutics14112441","title":"Pharmacogenetic Study of the Impact of ABCB1 Single Nucleotide Polymorphisms on the Response to Cyclosporine in Psoriasis Patients","display_name":"Pharmacogenetic Study of the Impact of ABCB1 Single Nucleotide Polymorphisms on the Response to Cyclosporine in Psoriasis Patients","publication_year":2022,"publication_date":"2022-11-11","ids":{"openalex":"https://openalex.org/W4309008570","doi":"https://doi.org/10.3390/pharmaceutics14112441","pmid":"https://pubmed.ncbi.nlm.nih.gov/36432633","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9693450"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics14112441","doi":"https://doi.org/10.3390/pharmaceutics14112441","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14112441","pdf_url":"https://www.mdpi.com/1999-4923/14/11/2441/pdf?version=1668596034","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/14/11/2441/pdf?version=1668596034","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044692108","display_name":"Alexander N. Chernov","orcid":"https://orcid.org/0000-0003-2464-7370","observed_orcids":["https://orcid.org/0000-0003-2464-7370"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]},{"id":"https://openalex.org/I4210126033","display_name":"Institute of Experimental Medicine","ror":"https://ror.org/0344x6030","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126033"]}],"countries":["IL","RU"],"is_corresponding":false,"raw_author_name":"Alexandr Chernov","raw_affiliation_strings":["Department of General Pathology and Pathological Physiology, Institute of Experimental Medicine, St. Petersburg 197376, Russia","Department of Life Sciences, Ben-Gurion University, Beer Sheva 84105, Israel"],"raw_orcid":"https://orcid.org/0000-0003-2464-7370","affiliations":[{"raw_affiliation_string":"Department of General Pathology and Pathological Physiology, Institute of Experimental Medicine, St. Petersburg 197376, Russia","institution_ids":["https://openalex.org/I4210126033"]},{"raw_affiliation_string":"Department of Life Sciences, Ben-Gurion University, Beer Sheva 84105, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002428948","display_name":"Daria Kilina","orcid":"https://orcid.org/0000-0002-3919-5867","observed_orcids":["https://orcid.org/0000-0002-3919-5867"]},"institutions":[{"id":"https://openalex.org/I3018698992","display_name":"Federal Almazov North-West Medical Research Centre","ror":"https://ror.org/03qepc107","country_code":"RU","type":"facility","lineage":["https://openalex.org/I3018698992"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Daria Kilina","raw_affiliation_strings":["HLA Laboratory, V.A. Almazov National Medical Research Center of the Ministry of Health of Russia, St. Petersburg 197341, Russia"],"raw_orcid":"https://orcid.org/0000-0002-3919-5867","affiliations":[{"raw_affiliation_string":"HLA Laboratory, V.A. Almazov National Medical Research Center of the Ministry of Health of Russia, St. Petersburg 197341, Russia","institution_ids":["https://openalex.org/I3018698992","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tatiana Smirnova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatiana Smirnova","raw_affiliation_strings":["City Dispensary of Dermatology and Venereology, St. Petersburg 192102, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City Dispensary of Dermatology and Venereology, St. Petersburg 192102, Russia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042984006","display_name":"Elvira S. Galimova","orcid":"https://orcid.org/0000-0002-8773-0932","observed_orcids":["https://orcid.org/0000-0002-8773-0932"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Elvira Galimova","raw_affiliation_strings":["Interdisciplinary Laboratory for Neurobiology, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Laboratory for Neurobiology, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I163234304"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5042984006"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I163234304"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":1.8817,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.83186531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"11","first_page":"2441","last_page":"2441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9660000205039978},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.9559999704360962},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.8539999723434448},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.640999972820282},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.7229999899864197},{"id":"https://openalex.org/keywords/russian-population","display_name":"Russian population","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.850065290927887},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.701724648475647},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.6636691093444824},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5612279772758484},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.55623859167099},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5537442564964294},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49928927421569824},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4419180750846863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42101195454597473},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37279659509658813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36887913942337036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3542347550392151},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15821930766105652},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics14112441","doi":"https://doi.org/10.3390/pharmaceutics14112441","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14112441","pdf_url":"https://www.mdpi.com/1999-4923/14/11/2441/pdf?version=1668596034","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:36432633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36432633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9693450","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9693450/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c5d1bf042f74485c966fa8969662452e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c5d1bf042f74485c966fa8969662452e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 14, Iss 11, p 2441 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics14112441","doi":"https://doi.org/10.3390/pharmaceutics14112441","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14112441","pdf_url":"https://www.mdpi.com/1999-4923/14/11/2441/pdf?version=1668596034","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2941981607","display_name":null,"funder_award_id":"075-15-2022-302","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"}],"funders":[{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4309008570.pdf","grobid_xml":"https://content.openalex.org/works/W4309008570.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1806066555","https://openalex.org/W1975261946","https://openalex.org/W1975445668","https://openalex.org/W1975902763","https://openalex.org/W1977235697","https://openalex.org/W1983888778","https://openalex.org/W1985531753","https://openalex.org/W1986239798","https://openalex.org/W1986346099","https://openalex.org/W1999393212","https://openalex.org/W2008230245","https://openalex.org/W2009966911","https://openalex.org/W2013047801","https://openalex.org/W2014966268","https://openalex.org/W2015500397","https://openalex.org/W2016318120","https://openalex.org/W2018353645","https://openalex.org/W2021447846","https://openalex.org/W2025292895","https://openalex.org/W2039667371","https://openalex.org/W2040077636","https://openalex.org/W2050497622","https://openalex.org/W2052405801","https://openalex.org/W2054458932","https://openalex.org/W2056941568","https://openalex.org/W2057721497","https://openalex.org/W2058830337","https://openalex.org/W2060504690","https://openalex.org/W2071899771","https://openalex.org/W2072352017","https://openalex.org/W2086478906","https://openalex.org/W2090910729","https://openalex.org/W2090971729","https://openalex.org/W2093105834","https://openalex.org/W2103666129","https://openalex.org/W2112001901","https://openalex.org/W2112886039","https://openalex.org/W2117944128","https://openalex.org/W2120003923","https://openalex.org/W2126753667","https://openalex.org/W2133175627","https://openalex.org/W2135934437","https://openalex.org/W2136564762","https://openalex.org/W2137478099","https://openalex.org/W2148010543","https://openalex.org/W2150957222","https://openalex.org/W2152664025","https://openalex.org/W2154415991","https://openalex.org/W2157619323","https://openalex.org/W2162184683","https://openalex.org/W2162530578","https://openalex.org/W2169804509","https://openalex.org/W2363352740","https://openalex.org/W2399510069","https://openalex.org/W2403839061","https://openalex.org/W2406300220","https://openalex.org/W2411996261","https://openalex.org/W2484686817","https://openalex.org/W2514770153","https://openalex.org/W2529786315","https://openalex.org/W2588110128","https://openalex.org/W2588710572","https://openalex.org/W2616136378","https://openalex.org/W2754632195","https://openalex.org/W2793840801","https://openalex.org/W2806850582","https://openalex.org/W2906718759","https://openalex.org/W2973199885","https://openalex.org/W2980941667","https://openalex.org/W3012780328","https://openalex.org/W3107856293","https://openalex.org/W3131992565","https://openalex.org/W3161448988","https://openalex.org/W3199376446","https://openalex.org/W6664871026","https://openalex.org/W6665031860","https://openalex.org/W6707556103","https://openalex.org/W6713322431"],"related_works":["https://openalex.org/W2057721497","https://openalex.org/W7160728351","https://openalex.org/W4305014090","https://openalex.org/W2077822931","https://openalex.org/W1964535567","https://openalex.org/W7010552530","https://openalex.org/W2387816453","https://openalex.org/W2020885803","https://openalex.org/W2046906822","https://openalex.org/W2049687579"],"abstract_inverted_index":{"Psoriasis":[0],"is":[1,16,190,215],"a":[2,17,65,118,164,194],"chronic,":[3],"T":[4,24],"cell-mediated":[5],"skin":[6],"disease":[7],"affecting":[8],"2\u20133%":[9],"of":[10,47,55,212,218],"the":[11,42,53,62,73,87,131,135,139,168,172,182,187,210,216,225,230,237,246,269],"Caucasian":[12],"population.":[13,227,248],"Cyclosporine":[14],"A":[15,28,124],"calcineurin":[18],"inhibitor":[19],"that":[20,59,186],"acts":[21],"selectively":[22],"on":[23],"cells.":[25],"The":[26,45,77,107,206],"cyclosporine":[27,66,122,169,198,244],"treatment":[29,67],"response":[30,63,120,166,196],"has":[31],"been":[32],"suggested":[33],"to":[34,51,64,121,167,197,209,221,243,254],"be":[35,222],"modulated":[36],"by":[37,94],"single-nucleotide":[38],"polymorphisms":[39,159],"(SNPs)":[40],"in":[41,68,86,134,138,171,200,224,245,261,268],"ABCB1":[43,56,74,78,108,136,155,238],"gene.":[44],"aim":[46],"this":[48],"research":[49],"was":[50,128],"evaluate":[52],"effect":[54],"genetic":[57,239],"variants":[58,240],"could":[60],"affect":[61],"Russian":[69,226,247],"psoriasis":[70,91,201],"patients":[71,89,202],"with":[72,90,117,163,193],"genotype":[75],"status.":[76],"T-129C,":[79],"G1199A,":[80],"C1236T,":[81,109],"G2677T/A":[82,110,158],"and":[83,102,111,142,157,175,241,258],"C3435T":[84,112,132],"SNPs":[85,113],"168":[88],"were":[92,114,160],"genotyped":[93],"PCR-RFLP":[95],"(polymerase":[96],"chain":[97],"reaction-restriction":[98],"fragment":[99],"length":[100],"polymorphism)":[101],"TaqMan":[103],"SNP":[104,133],"genotyping":[105],"assays.":[106],"significantly":[115,161,191],"associated":[116,162,192],"negative":[119,165,195],"therapy.":[123],"very":[125],"strong":[126],"association":[127,235],"evident":[129],"for":[130],"gene":[137],"allele,":[140],"dominant":[141,174],"recessive":[143,176],"models":[144,177],"(OR":[145],"=":[146,149,152],"2.58,":[147],"OR":[148,151],"4.01,":[150],"2.50,":[153],"respectively).":[154],"C1236T":[156],"therapy":[170,199],"codominant,":[173],"(p":[178,203],"\u02c2":[179,204],"0.05).":[180,205],"Additionally,":[181],"haplotype":[183,189],"analysis":[184],"identified":[185],"TGC":[188],"current":[207],"study":[208],"best":[211],"our":[213,256],"knowledge":[214],"first":[217],"its":[219,266],"kind":[220],"performed":[223],"In":[228],"conclusion,":[229],"present":[231],"results":[232],"suggest":[233],"an":[234],"between":[236],"unresponsiveness":[242],"Further,":[249],"larger":[250],"studies":[251],"are":[252],"necessary":[253],"confirm":[255],"findings":[257],"replicate":[259],"them":[260],"various":[262],"ethnic":[263],"populations":[264],"before":[265],"implementation":[267],"clinical":[270],"practice.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-11-20T00:00:00"}