{"id":"https://openalex.org/W4308977203","doi":"https://doi.org/10.1093/neuonc/noac209.1042","title":"TMET-37. SODIUM-DEPENDENT GLUCOSE TRANSPORTER 2 (SGLT2) IS OVEREXPRESSED IN THE MAJORITY OF ATRTS AND A SUBSET OF PEDIATRIC PATIENTS WITH HIGH-GRADE GLIOMA; A POTENTIAL IMAGING AND THERAPEUTIC TARGET","display_name":"TMET-37. SODIUM-DEPENDENT GLUCOSE TRANSPORTER 2 (SGLT2) IS OVEREXPRESSED IN THE MAJORITY OF ATRTS AND A SUBSET OF PEDIATRIC PATIENTS WITH HIGH-GRADE GLIOMA; A POTENTIAL IMAGING AND THERAPEUTIC TARGET","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308977203","doi":"https://doi.org/10.1093/neuonc/noac209.1042"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noac209.1042","doi":"https://doi.org/10.1093/neuonc/noac209.1042","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.1042","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii270/47021789/noac209.1042.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii270/47021789/noac209.1042.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079259769","display_name":"Ali Nabavizadeh","orcid":"https://orcid.org/0000-0002-0380-4552","observed_orcids":["https://orcid.org/0000-0002-0380-4552"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Nabavizadeh","raw_affiliation_strings":["Hospital of the University of Pennsylvania , Philadelphia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the University of Pennsylvania , Philadelphia , USA","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100661293","display_name":"Chao Zhao","orcid":"https://orcid.org/0000-0003-1739-1151","observed_orcids":["https://orcid.org/0000-0003-1739-1151"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao Zhao","raw_affiliation_strings":["Children's Hospital of Philadelphia , Philadelphia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia , Philadelphia , USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel Martinez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Martinez","raw_affiliation_strings":["CHOP , Philadelphia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHOP , Philadelphia , USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011780968","display_name":"Ariana Familiar","orcid":"https://orcid.org/0000-0002-9315-8653","observed_orcids":["https://orcid.org/0000-0002-9315-8653"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariana Familiar","raw_affiliation_strings":["Children's Hospital of Philadelphia , Philadelphia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia , Philadelphia , USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078178928","display_name":"Mateusz Koptyra","orcid":"https://orcid.org/0000-0002-3857-6633","observed_orcids":["https://orcid.org/0000-0002-3857-6633"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mateusz Koptyra","raw_affiliation_strings":["Children's Hospital of Philadelphia , Philadelphia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia , Philadelphia , USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010134057","display_name":"Joseph E. Ippolito","orcid":"https://orcid.org/0000-0003-1913-5573","observed_orcids":["https://orcid.org/0000-0003-1913-5573"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Ippolito","raw_affiliation_strings":["Washington University in St. Louis School of Medicine , Saint Louis, MO , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis School of Medicine , Saint Louis, MO , USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053768944","display_name":"Joshua B. Rubin","orcid":"https://orcid.org/0000-0002-7395-1937","observed_orcids":["https://orcid.org/0000-0002-7395-1937","https://orcid.org/0000-0002-8580-7801"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Rubin","raw_affiliation_strings":["Washington University in St. Louis School of Medicine , Saint Louis , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis School of Medicine , Saint Louis , USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109247507","display_name":"Philip B Storm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip B Storm","raw_affiliation_strings":["Children's Hospital of Philadelpia , Philadelphia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelpia , Philadelphia , USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086085263","display_name":"Adam Cain Resnick","orcid":"https://orcid.org/0000-0003-0436-4189","observed_orcids":["https://orcid.org/0000-0003-0436-4189"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam C Resnick","raw_affiliation_strings":["Children's Hospital of Philadelphia , Philadelphia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia , Philadelphia , USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056872026","display_name":"Mariarita Santi","orcid":"https://orcid.org/0000-0002-6728-3450","observed_orcids":["https://orcid.org/0000-0002-6728-3450"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariarita Santi","raw_affiliation_strings":["CHOP , Philadelphia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHOP , Philadelphia , USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"Supplement_7","first_page":"vii270","last_page":"vii270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sglt2","display_name":"SGLT2","score":0.8730000257492065},{"id":"https://openalex.org/keywords/atypical-teratoid-rhabdoid-tumor","display_name":"atypical teratoid/rhabdoid tumor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ependymoma","display_name":"ependymoma","score":1.0},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/tumor-imaging-biomarkers","display_name":"tumor imaging biomarkers","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.8199735879898071},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7253103256225586},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.680388331413269},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.6392074823379517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5473936796188354},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5310851335525513},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4749479591846466},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42360612750053406},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4176042973995209},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4119150638580322},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3747332692146301},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3482872247695923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2838682532310486},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0993611216545105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0886085033416748},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noac209.1042","doi":"https://doi.org/10.1093/neuonc/noac209.1042","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.1042","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii270/47021789/noac209.1042.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9661013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9661013","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noac209.1042","doi":"https://doi.org/10.1093/neuonc/noac209.1042","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.1042","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii270/47021789/noac209.1042.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308977203.pdf","grobid_xml":"https://content.openalex.org/works/W4308977203.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400885902","https://openalex.org/W2922801372","https://openalex.org/W3080019751","https://openalex.org/W2910943791","https://openalex.org/W1883655199","https://openalex.org/W4387160852","https://openalex.org/W4281647399","https://openalex.org/W1983298232","https://openalex.org/W7165727466","https://openalex.org/W7099042512"],"abstract_inverted_index":{"Abstract":[0],"Sodium":[1],"glucose":[2,9,15,27],"cotransporters":[3],"(SGLT)":[4],"are":[5,36],"a":[6,37,49,54,61,213,248,281,289],"class":[7,39],"of":[8,12,40,56,81,99,114,196,222,226,232,243,253,278,283,298],"transporters":[10,16],"independent":[11],"the":[13,19,97,119,135,220,240,244,276],"conventional":[14],"(GLUT).":[17],"Like":[18],"GLUT,":[20],"SGLT2":[21,34,100,137,192,206,264],"plays":[22],"an":[23,70],"important":[24],"role":[25],"in":[26,29,53,64,191,212,219,251,268,275],"uptake":[28,89],"many":[30],"solid":[31,57],"cancers.":[32,58],"Importantly,":[33],"inhibitors":[35],"new":[38],"anti-diabetic":[41],"drugs":[42],"and":[43,112,142,158,179,189,203,216,234,272,280,286,296],"have":[44,134],"recently":[45],"been":[46],"investigated":[47],"as":[48],"potential":[50],"anti-cancer":[51],"therapy":[52,297],"variety":[55],"In":[59,258],"fact,":[60],"recent":[62],"study":[63],"adult":[65],"high-grade":[66,82],"gliomas":[67,149],"showed":[68],"that":[69,132,239,263,292],"SGLT-specific":[71],"PET":[72],"imaging":[73,295],"probe":[74],"([18F]":[75],"Me-4FDG)":[76],"is":[77,273],"sensitive":[78],"for":[79],"visualization":[80],"glioma":[83],"(HGG)":[84],"with":[85,126,255],"superior":[86],"tumor-normal":[87],"brain":[88,103,128,270],"relative":[90],"to":[91,95,147,176],"18F-FDG-PET.":[92],"We":[93],"aimed":[94],"investigate":[96],"expression":[98,138,193,267],"within":[101],"pediatric":[102,127,269,284],"tumor":[104],"subtypes":[105],"using":[106],"RNA":[107,120],"sequencing":[108,121],"data":[109,122],"from":[110,123],"PedcBioPortal":[111],"immunohistochemistry":[113,207],"tissue":[115],"microarrays":[116],"(TMAs).":[117],"Using":[118],"603":[124],"patients":[125],"tumors,":[129],"we":[130],"found":[131],"HGGs":[133,188],"highest":[136],"(Z":[139,150,155,160],"score=0.13\u00b1":[140],"1.03)":[141],"were":[143,228,236],"significantly":[144,170],"higher":[145,171],"compared":[146,175],"low-grade":[148],"score=":[151],"-0.12,":[152],"p=0.049),":[153],"medulloblastomas":[154,177,233],"score=-0.28,":[156],"p=0.001),":[157],"ependymomas":[159,180,235],"score=-0.30,":[161],"p=0.002).":[162],"Atypical":[163],"teratoid":[164],"rhabdoid":[165],"tumors":[166,254,271],"(ATRT)":[167],"also":[168],"had":[169],"Z":[172],"score":[173],"(0.10\u00b10.67)":[174],"(p=0.038),":[178],"(p=0.049).":[181],"There":[182],"was":[183],"no":[184],"significant":[185],"difference":[186],"between":[187],"ATRTs":[190,204,227],"(p=0.899).":[194],"Analysis":[195],"4":[197],"TMAs":[198],"including":[199],"HGGs,":[200,285],"medulloblastomas,":[201],"ependymomas,":[202],"after":[205],"demonstrated":[208],"strong":[209],"membranous":[210,241],"staining":[211,218,245],"small":[214],"subset":[215,282],"moderate-weak":[217],"majority":[221,225,231,277],"HGGs.":[223],"The":[224,230],"positive.":[229],"negative,":[237],"noting":[238],"nature":[242],"may":[246,287],"be":[247],"limiting":[249],"factor":[250],"evaluation":[252],"less":[256],"cytoplasm.":[257],"conclusion,":[259],"our":[260],"work":[261],"demonstrates":[262],"has":[265],"heterogeneous":[266],"overexpressed":[274],"ATRTs,":[279],"represent":[288],"compelling":[290],"paradigm":[291],"integrates":[293],"metabolic":[294],"these":[299],"tumors.":[300]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-11-20T00:00:00"}
