{"id":"https://openalex.org/W4308976899","doi":"https://doi.org/10.1093/neuonc/noac209.1043","title":"TMET-38. LOSS OF FUNCTION OF CDK7 IS SYNTHETICALLY LETHAL WITH FATTY ACID OXIDATION INHIBITION IN GLIOBLASTOMA","display_name":"TMET-38. LOSS OF FUNCTION OF CDK7 IS SYNTHETICALLY LETHAL WITH FATTY ACID OXIDATION INHIBITION IN GLIOBLASTOMA","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308976899","doi":"https://doi.org/10.1093/neuonc/noac209.1043"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noac209.1043","doi":"https://doi.org/10.1093/neuonc/noac209.1043","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.1043","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii270/47021803/noac209.1043.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii270/47021803/noac209.1043.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081819949","display_name":"Trang Thi Thu Nguyen","orcid":"https://orcid.org/0000-0001-8747-9082","observed_orcids":["https://orcid.org/0000-0001-8747-9082"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trang Nguyen","raw_affiliation_strings":["Columbia University , New York, NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University , New York, NY , USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016632371","display_name":"Enyuan Shang","orcid":"https://orcid.org/0000-0001-5299-2636","observed_orcids":["https://orcid.org/0000-0001-5299-2636"]},"institutions":[{"id":"https://openalex.org/I54648344","display_name":"Bronx Community College","ror":"https://ror.org/04w6mxh75","country_code":"US","type":"education","lineage":["https://openalex.org/I54648344"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enyuan Shang","raw_affiliation_strings":["Bronx Community College , New York, NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bronx Community College , New York, NY , USA","institution_ids":["https://openalex.org/I54648344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100723539","display_name":"Chang Shu","orcid":"https://orcid.org/0000-0001-5619-0294","observed_orcids":["https://orcid.org/0000-0001-5619-0294"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang Shu","raw_affiliation_strings":["Columbia University , New York, NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University , New York, NY , USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035021544","display_name":"Hasan Orhan Akman","orcid":"https://orcid.org/0000-0003-4493-721X","observed_orcids":["https://orcid.org/0000-0003-4493-721X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hasan Akman","raw_affiliation_strings":["Columbia University , New York, NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University , New York, NY , USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052100404","display_name":"Benjamin Izar","orcid":"https://orcid.org/0000-0003-2379-6702","observed_orcids":["https://orcid.org/0000-0003-2379-6702"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Izar","raw_affiliation_strings":["Columbia University , New York, NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University , New York, NY , USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080479067","display_name":"Mike\u2010Andrew Westhoff","orcid":"https://orcid.org/0000-0003-3256-7100","observed_orcids":["https://orcid.org/0000-0003-3256-7100"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mike-Andrew Westhoff","raw_affiliation_strings":["Ulm University Medical Center , Ulm , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ulm University Medical Center , Ulm , Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087856756","display_name":"Georg Karpel\u2010Massler","orcid":"https://orcid.org/0000-0001-8236-5369","observed_orcids":["https://orcid.org/0000-0001-8236-5369"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georg Karpel-Massler","raw_affiliation_strings":["Ulm University Medical Center , Ulm , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ulm University Medical Center , Ulm , Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055848888","display_name":"Jeffrey N. Bruce","orcid":"https://orcid.org/0000-0002-6844-0286","observed_orcids":["https://orcid.org/0000-0002-6844-0286"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Bruce","raw_affiliation_strings":["Columbia University , New York , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University , New York , USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046673359","display_name":"Peter Canoll","orcid":"https://orcid.org/0000-0002-7001-0226","observed_orcids":["https://orcid.org/0000-0002-7001-0226"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Canoll","raw_affiliation_strings":["Columbia University , New York, NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University , New York, NY , USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019896041","display_name":"Markus David Siegelin","orcid":"https://orcid.org/0000-0001-7113-3634","observed_orcids":["https://orcid.org/0000-0001-7113-3634"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Siegelin","raw_affiliation_strings":["Columbia University , New York, NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University , New York, NY , USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"Supplement_7","first_page":"vii270","last_page":"vii270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.24220000207424164,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.18209999799728394,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk7-inhibition","display_name":"CDK7 inhibition","score":0.9079999923706055},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9430000185966492},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.847000002861023},{"id":"https://openalex.org/keywords/thz1","display_name":"THZ1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/etomoxir","display_name":"etomoxir","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9990000128746033},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7379999756813049},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6110000014305115},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.375}],"concepts":[{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.6149020195007324},{"id":"https://openalex.org/C2776441662","wikidata":"https://www.wikidata.org/wiki/Q2823314","display_name":"Tricarboxylic acid","level":4,"score":0.5125415325164795},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4937814176082611},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4742485582828522},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.47359994053840637},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.46570923924446106},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.45612916350364685},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44946956634521484},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4377228021621704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38486361503601074},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.37610918283462524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.337907075881958},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.30510783195495605},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noac209.1043","doi":"https://doi.org/10.1093/neuonc/noac209.1043","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.1043","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii270/47021803/noac209.1043.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9661204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9661204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noac209.1043","doi":"https://doi.org/10.1093/neuonc/noac209.1043","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.1043","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii270/47021803/noac209.1043.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308976899.pdf","grobid_xml":"https://content.openalex.org/works/W4308976899.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220872116","https://openalex.org/W2987517464","https://openalex.org/W934377285","https://openalex.org/W7202180337","https://openalex.org/W4413368332","https://openalex.org/W3140901034","https://openalex.org/W2986871395","https://openalex.org/W3112341618","https://openalex.org/W3141285961","https://openalex.org/W2948109903"],"abstract_inverted_index":{"Abstract":[0],"CDK7":[1,66,207],"has":[2],"been":[3],"identified":[4],"as":[5,125,127,175],"a":[6,13,37,136,168,212],"potential":[7,213],"drug":[8],"target":[9],"for":[10],"glioblastoma":[11],"(GBM),":[12],"highly":[14],"lethal":[15],"primary":[16],"brain":[17],"tumor.":[18],"However,":[19],"resistance":[20],"to":[21],"therapy":[22,215],"develops":[23],"quickly,":[24],"which":[25,131],"may":[26],"be":[27,211],"facilitated":[28],"by":[29,44,82,89,135,156,177],"drug-induced":[30],"reprogramming":[31],"of":[32,36,77,92,104,109,138,146,170,184,196,206],"metabolism.":[33,141],"By":[34],"combination":[35,102,158,162],"transcriptome":[38],"and":[39,49,52,61,64,173,186,208],"metabolite":[40],"screening":[41],"analyses":[42],"followed":[43],"carbon":[45],"tracing":[46],"(U-13C-Glucose,":[47],"U-13C-Glutamine":[48],"U-13C-Palmitic":[50],"acid)":[51],"extracellular":[53],"flux":[54],"analysis":[55],"we":[56],"demonstrated":[57,176],"that":[58,203],"both":[59,171],"genetic":[60],"pharmacological":[62],"(YKL-5-124":[63],"THZ1)":[65],"inhibition":[67,120],"elicited":[68,74],"substantial":[69,117],"metabolic":[70],"reprogramming.":[71],"Specifically,":[72],"CDK7i":[73,105],"an":[75,191],"increase":[76],"oxygen":[78],"consumption":[79],"rate":[80],"fueled":[81],"enhanced":[83,90],"fatty":[84],"acid":[85,94],"oxidation":[86],"(FAO)":[87],"manifested":[88],"labeling":[91],"citric":[93],"cycle":[95],"intermediates":[96],"from":[97,151],"palmitic":[98],"acid.":[99],"Consistently,":[100],"the":[101,152,157,161,181],"treatment":[103,163],"inhibitors":[106],"with":[107],"blockers":[108],"FAO":[110,209],"(etomoxir)":[111],"or":[112],"cellular":[113],"respiration":[114],"(gamitrinib)":[115],"exerted":[116],"synergistic":[118],"growth":[119],"in":[121,190],"patient":[122],"derived":[123],"xenograft":[124,194],"well":[126],"neurosphere":[128],"GBM":[129],"cultures,":[130],"was":[132],"mainly":[133],"driven":[134],"collapse":[137],"oxidative":[139],"energy":[140],"In":[142,198],"turn,":[143],"exogenous":[144],"administration":[145,183],"adenosine":[147],"triphosphate":[148],"partially":[149],"rescued":[150],"cell":[153],"death":[154],"induced":[155],"treatment.":[159],"Moreover,":[160],"activated":[164],"intrinsic":[165],"apoptosis":[166],"through":[167],"reduction":[169],"Mcl-1":[172],"Bcl-xL":[174],"rescue":[178],"experiments.":[179],"Finally,":[180],"combined":[182],"YKL-5-124":[185],"etomoxir":[187],"extended":[188],"overall":[189],"orthotopic":[192],"patient-derived":[193],"model":[195],"GBM.":[197,217],"summary,":[199],"these":[200],"data":[201],"support":[202],"simultaneous":[204],"targeting":[205],"might":[210],"novel":[214],"against":[216]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-20T00:00:00"}