{"id":"https://openalex.org/W4308976558","doi":"https://doi.org/10.1093/neuonc/noac209.956","title":"RBIO-04. STEREOTACTIC RADIOSURGERY REPROGRAMS MACROPHAGE, MICROGLIA, AND CD8+ T CELL POPULATIONS IN THE GLIOBLASTOMA IMMUNE MICROENVIRONMENT","display_name":"RBIO-04. STEREOTACTIC RADIOSURGERY REPROGRAMS MACROPHAGE, MICROGLIA, AND CD8+ T CELL POPULATIONS IN THE GLIOBLASTOMA IMMUNE MICROENVIRONMENT","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308976558","doi":"https://doi.org/10.1093/neuonc/noac209.956"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noac209.956","doi":"https://doi.org/10.1093/neuonc/noac209.956","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.956","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii247/47021148/noac209.956.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii247/47021148/noac209.956.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005749201","display_name":"Jacob S. Young","orcid":"https://orcid.org/0000-0002-5499-4325","observed_orcids":["https://orcid.org/0000-0002-5499-4325"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob S Young","raw_affiliation_strings":["University of California San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002702755","display_name":"Nam Woo Cho","orcid":"https://orcid.org/0000-0002-5785-9698","observed_orcids":["https://orcid.org/0000-0002-5785-9698"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nam Woo Cho","raw_affiliation_strings":["University of California, San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004797765","display_name":"Calixto\u2010Hope G. Lucas","orcid":"https://orcid.org/0000-0002-8347-9592","observed_orcids":["https://orcid.org/0000-0002-8347-9592"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calixto-Hope Lucas","raw_affiliation_strings":["University of California, San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045754","display_name":"Kyounghee Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyounghee Seo","raw_affiliation_strings":["University of California, San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072181454","display_name":"Raquel Alves dos Santos","orcid":"https://orcid.org/0000-0002-0075-2099","observed_orcids":["https://orcid.org/0000-0002-0075-2099"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raquel Santos","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019140507","display_name":"Joanna J. Phillips","orcid":"https://orcid.org/0000-0002-3789-8120","observed_orcids":["https://orcid.org/0000-0002-3789-8120"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna J Phillips","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047028132","display_name":"Tomoko Ozawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoko Ozawa","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006262715","display_name":"Mitchel Stuart Berger","orcid":"https://orcid.org/0000-0003-1983-4892","observed_orcids":["https://orcid.org/0000-0003-1983-4892"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchel S Berger","raw_affiliation_strings":["University of California, San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007540843","display_name":"David Ronan Raleigh","orcid":"https://orcid.org/0000-0001-9299-8864","observed_orcids":["https://orcid.org/0000-0001-9299-8864"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Raleigh","raw_affiliation_strings":["Department of Pathology, University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19797155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"Supplement_7","first_page":"vii247","last_page":"vii248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stereotactic-radiosurgery","display_name":"stereotactic radiosurgery","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.968999981880188},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.7409999966621399},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.5669999718666077},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.4779999852180481},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7070000171661377},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.4659999907016754},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.5},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.656000018119812},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.6330000162124634},{"id":"https://openalex.org/keywords/il-27","display_name":"IL-27","score":0.5460000038146973},{"id":"https://openalex.org/keywords/il-28","display_name":"IL-28","score":0.5440000295639038},{"id":"https://openalex.org/keywords/il-29","display_name":"IL-29","score":0.7170000076293945},{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.5590000152587891},{"id":"https://openalex.org/keywords/il-36","display_name":"IL-36","score":0.5709999799728394},{"id":"https://openalex.org/keywords/il-37","display_name":"IL-37","score":0.6129999756813049},{"id":"https://openalex.org/keywords/il-38","display_name":"IL-38","score":0.722000002861023},{"id":"https://openalex.org/keywords/il-40","display_name":"IL-40","score":0.7049999833106995},{"id":"https://openalex.org/keywords/il-41","display_name":"IL-41","score":0.8009999990463257},{"id":"https://openalex.org/keywords/il-42","display_name":"IL-42","score":0.746999979019165},{"id":"https://openalex.org/keywords/il-43","display_name":"IL-43","score":0.8330000042915344},{"id":"https://openalex.org/keywords/il-44","display_name":"IL-44","score":0.8230000138282776},{"id":"https://openalex.org/keywords/il-45","display_name":"IL-45","score":0.7900000214576721},{"id":"https://openalex.org/keywords/il-46","display_name":"IL-46","score":0.8029999732971191},{"id":"https://openalex.org/keywords/il-47","display_name":"IL-47","score":0.8619999885559082},{"id":"https://openalex.org/keywords/il-48","display_name":"IL-48","score":0.8640000224113464},{"id":"https://openalex.org/keywords/il-49","display_name":"IL-49","score":0.8460000157356262},{"id":"https://openalex.org/keywords/il-50","display_name":"IL-50","score":0.8379999995231628},{"id":"https://openalex.org/keywords/il-51","display_name":"IL-51","score":0.8240000009536743},{"id":"https://openalex.org/keywords/il-52","display_name":"IL-52","score":0.8799999952316284},{"id":"https://openalex.org/keywords/il-53","display_name":"IL-53","score":0.8709999918937683},{"id":"https://openalex.org/keywords/il-54","display_name":"IL-54","score":0.8859999775886536},{"id":"https://openalex.org/keywords/il-55","display_name":"IL-55","score":0.8859999775886536},{"id":"https://openalex.org/keywords/il-56","display_name":"IL-56","score":0.8830000162124634},{"id":"https://openalex.org/keywords/il","display_name":"IL","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7863935232162476},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.749282717704773},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6869614124298096},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6746938228607178},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5974627137184143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5058102607727051},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.47579798102378845},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.4540298283100128},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40274763107299805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35784798860549927},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.247422456741333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1898041069507599},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.164443701505661}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noac209.956","doi":"https://doi.org/10.1093/neuonc/noac209.956","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.956","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii247/47021148/noac209.956.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9661083","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9661083","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noac209.956","doi":"https://doi.org/10.1093/neuonc/noac209.956","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noac209.956","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii247/47021148/noac209.956.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308976558.pdf","grobid_xml":"https://content.openalex.org/works/W4308976558.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4327608421","https://openalex.org/W4408448414","https://openalex.org/W3169129117","https://openalex.org/W4416449579","https://openalex.org/W7171570951","https://openalex.org/W2508691589","https://openalex.org/W3126304647","https://openalex.org/W3013766663","https://openalex.org/W4388047739","https://openalex.org/W6940654504"],"abstract_inverted_index":{"Abstract":[0],"INTRODUCTION":[1],"Fractionated":[2],"radiotherapy":[3,23,36],"is":[4,24,42],"a":[5,295],"first-line":[6],"treatment":[7,60,128,197],"for":[8,119,139],"glioblastoma,":[9],"but":[10,31],"daily":[11],"ionizing":[12,62],"radiation":[13,63],"prevents":[14],"durable":[15],"immune":[16,40,48,144,164,180,237],"infiltration":[17,225,233,246],"of":[18,34,57,87,135,234,254,281],"the":[19,32,38,84,133,178,235,285],"tumor":[20,105],"microenvironment.":[21,238],"Hypofractionated":[22],"used":[25,99],"to":[26,100,160,173,184,195,297],"treat":[27],"glioblastomas":[28,107],"at":[29,132],"recurrence,":[30],"impact":[33],"hypofractionated":[35],"on":[37],"glioblastoma":[39,58,77,102,179,189,236,266,287],"microenvironment":[41,49,145,181,288],"incompletely":[43],"understood.":[44],"Here":[45],"we":[46],"define":[47,161],"changes":[50],"across":[51],"multiple":[52],"immunocompetent":[53,88,200],"intracranial":[54,201],"mouse":[55,202],"models":[56,203],"after":[59,127,137,247,259],"with":[61,110,299],"mimicking":[64],"stereotactic":[65],"radiosurgery":[66],"(SRS)":[67],"in":[68,182,198,274],"humans.":[69],"METHODS":[70],"Syngeneic":[71],"GL261":[72],"(3x105":[73],"cells/mouse)":[74,80],"or":[75,114,122,131,158,162,168,229,279],"SB28":[76],"cells":[78],"(3x104":[79],"were":[81,108,117,147],"implanted":[82],"into":[83],"frontal":[85],"lobe":[86],"C57BL/6J":[89],"mice":[90],"(18":[91],"mice/arm":[92],"x":[93],"4":[94],"arms).":[95],"Intracranial":[96],"bioluminescence":[97],"was":[98],"assess":[101],"growth.":[103],"After":[104],"engraftment,":[106],"treated":[109],"conformal":[111],"SRS":[112,187,221,263,278],"(18Gy/1Fx)":[113],"sham.":[115],"Glioblastomas":[116],"collected":[118],"histologic,":[120],"single-cell,":[121],"molecular":[123,175],"analyses":[124,240],"5":[125],"days":[126,206,214],"(6":[129],"mice/arm)":[130],"time":[134],"euthanasia":[136],"monitoring":[138],"survival":[140,193],"(12":[141],"mice/arm).":[142],"Glioblastoma":[143,249],"responses":[146],"assessed":[148],"using":[149],"(1)":[150],"H&E,":[151],"(2)":[152],"single":[153],"cell":[154,165,232,243,272],"mass":[155],"cytometry":[156],"(CyTOF)":[157],"IHC":[159],"validate":[163],"changes,":[166],"respectively,":[167],"(3)":[169],"multiplexed":[170],"cytokine":[171,250],"assays":[172],"elucidate":[174],"mechanisms":[176,283],"reprograming":[177],"response":[183],"SRS.":[185,248,260],"RESULTS":[186],"attenuated":[188],"growth":[190],"and":[191,226,244,269],"prolonged":[192],"compared":[194],"sham":[196],"both":[199],"(GL261:":[204],"14":[205],"versus":[207,215],"27":[208],"days,":[209,217],"p<":[210],"0.001,":[211],"SB28:":[212],"19":[213],"22":[216],"p=0.001).":[218],"CyTOF":[219],"showed":[220],"decreased":[222],"immunosuppressive":[223,286],"macrophage":[224],"increased":[227],"microglia":[228,245],"CD8+":[230,270],"T":[231,242,271],"Histologic":[239],"validated":[241],"analysis":[251],"revealed":[252],"inhibition":[253,280],"pro-tumor/anti-inflammatory":[255,282],"cytokines":[256],"(IL6,":[257],"LIF)":[258],"CONCLUSIONS":[261],"Single-fraction":[262],"durably":[264],"reprograms":[265],"macrophage,":[267],"microglia,":[268],"populations":[273],"preclinical":[275],"models,":[276],"suggesting":[277],"underlying":[284],"represent":[289],"immunogenic":[290],"therapies":[291],"that":[292],"may":[293],"offer":[294],"benefit":[296],"patients":[298],"glioblastoma.":[300]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-20T00:00:00"}