{"id":"https://openalex.org/W43089621","doi":null,"title":"Regulation of arousal by adenosine A1 and A2A receptors in the prefrontal cortex of C57BL/6J mouse","display_name":"Regulation of arousal by adenosine A1 and A2A receptors in the prefrontal cortex of C57BL/6J mouse","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W43089621","mag":"43089621"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/61642","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/61642","pdf_url":"https://hdl.handle.net/2027.42/61642","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/61642","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055632233","display_name":"Van Dort","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Van Dort","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"J Christa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Christa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.9649999737739563},{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":1.0},{"id":"https://openalex.org/keywords/arousal","display_name":"arousal","score":0.6470000147819519},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9559999704360962},{"id":"https://openalex.org/keywords/adenosine-signaling","display_name":"adenosine signaling","score":0.7310000061988831},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.68365877866745},{"id":"https://openalex.org/C2778491162","wikidata":"https://www.wikidata.org/wiki/Q3063865","display_name":"Adenosine A2A receptor","level":5,"score":0.6559472680091858},{"id":"https://openalex.org/C36951298","wikidata":"https://www.wikidata.org/wiki/Q379784","display_name":"Arousal","level":2,"score":0.6084209084510803},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6019619703292847},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.573107123374939},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.48495936393737793},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3833869695663452},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.3585151433944702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2942633032798767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2829614281654358},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25336238741874695},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.252410888671875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24414509534835815},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.08566507697105408}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/61642","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/61642","pdf_url":"https://hdl.handle.net/2027.42/61642","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:43089621","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/61642","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/61642","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/61642","pdf_url":"https://hdl.handle.net/2027.42/61642","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W43089621.pdf","grobid_xml":"https://content.openalex.org/works/W43089621.grobid-xml"},"referenced_works_count":228,"referenced_works":["https://openalex.org/W15515072","https://openalex.org/W20521823","https://openalex.org/W60086252","https://openalex.org/W60844192","https://openalex.org/W81777342","https://openalex.org/W341127872","https://openalex.org/W1481865416","https://openalex.org/W1482008299","https://openalex.org/W1522048223","https://openalex.org/W1523255158","https://openalex.org/W1529387617","https://openalex.org/W1530697542","https://openalex.org/W1538619854","https://openalex.org/W1556074533","https://openalex.org/W1557481078","https://openalex.org/W1612453552","https://openalex.org/W1663417729","https://openalex.org/W1750985838","https://openalex.org/W1909205931","https://openalex.org/W1914381346","https://openalex.org/W1922174779","https://openalex.org/W1927415847","https://openalex.org/W1965193720","https://openalex.org/W1966814202","https://openalex.org/W1967856232","https://openalex.org/W1968442442","https://openalex.org/W1968599797","https://openalex.org/W1969146881","https://openalex.org/W1969502078","https://openalex.org/W1969924717","https://openalex.org/W1972505501","https://openalex.org/W1972709709","https://openalex.org/W1973515958","https://openalex.org/W1974357745","https://openalex.org/W1975749330","https://openalex.org/W1976626141","https://openalex.org/W1977452481","https://openalex.org/W1978348024","https://openalex.org/W1978476682","https://openalex.org/W1978979311","https://openalex.org/W1979514279","https://openalex.org/W1979921133","https://openalex.org/W1980118758","https://openalex.org/W1980611143","https://openalex.org/W1980755879","https://openalex.org/W1981070044","https://openalex.org/W1983837566","https://openalex.org/W1984758322","https://openalex.org/W1985093721","https://openalex.org/W1985525186","https://openalex.org/W1986105622","https://openalex.org/W1986359178","https://openalex.org/W1986373976","https://openalex.org/W1987438611","https://openalex.org/W1987447951","https://openalex.org/W1989451432","https://openalex.org/W1990015064","https://openalex.org/W1991411987","https://openalex.org/W1992126265","https://openalex.org/W1993661896","https://openalex.org/W1995025219","https://openalex.org/W1996094759","https://openalex.org/W1997201994","https://openalex.org/W1999567494","https://openalex.org/W2000422225","https://openalex.org/W2001508159","https://openalex.org/W2002996187","https://openalex.org/W2004683657","https://openalex.org/W2005234955","https://openalex.org/W2005984731","https://openalex.org/W2006975775","https://openalex.org/W2007735192","https://openalex.org/W2007845355","https://openalex.org/W2008698261","https://openalex.org/W2009833394","https://openalex.org/W2011694298","https://openalex.org/W2012565922","https://openalex.org/W2016047619","https://openalex.org/W2016432775","https://openalex.org/W2016463543","https://openalex.org/W2016609992","https://openalex.org/W2016863258","https://openalex.org/W2017237202","https://openalex.org/W2017249024","https://openalex.org/W2017573472","https://openalex.org/W2017803035","https://openalex.org/W2018160227","https://openalex.org/W2018582923","https://openalex.org/W2019191372","https://openalex.org/W2020690996","https://openalex.org/W2023491924","https://openalex.org/W2024591810","https://openalex.org/W2025035050","https://openalex.org/W2027059558","https://openalex.org/W2027122341","https://openalex.org/W2027444377","https://openalex.org/W2029215893","https://openalex.org/W2029782870","https://openalex.org/W2032183569","https://openalex.org/W2034059302","https://openalex.org/W2034450065","https://openalex.org/W2035474281","https://openalex.org/W2035828589","https://openalex.org/W2036798654","https://openalex.org/W2037471264","https://openalex.org/W2038963210","https://openalex.org/W2039620230","https://openalex.org/W2040473331","https://openalex.org/W2040527392","https://openalex.org/W2040895424","https://openalex.org/W2040936181","https://openalex.org/W2041008464","https://openalex.org/W2041960301","https://openalex.org/W2043153453","https://openalex.org/W2043533591","https://openalex.org/W2044721801","https://openalex.org/W2045706183","https://openalex.org/W2047132238","https://openalex.org/W2047164164","https://openalex.org/W2048224897","https://openalex.org/W2048475589","https://openalex.org/W2051368312","https://openalex.org/W2052003026","https://openalex.org/W2053659412","https://openalex.org/W2054222982","https://openalex.org/W2055656488","https://openalex.org/W2056038740","https://openalex.org/W2057623849","https://openalex.org/W2058185503","https://openalex.org/W2059805470","https://openalex.org/W2060865308","https://openalex.org/W2062230026","https://openalex.org/W2062636034","https://openalex.org/W2062883133","https://openalex.org/W2065626832","https://openalex.org/W2065702465","https://openalex.org/W2070268380","https://openalex.org/W2071509975","https://openalex.org/W2072070847","https://openalex.org/W2072606072","https://openalex.org/W2072796242","https://openalex.org/W2072954312","https://openalex.org/W2073509504","https://openalex.org/W2074150435","https://openalex.org/W2074671627","https://openalex.org/W2074698131","https://openalex.org/W2074729665","https://openalex.org/W2078642157","https://openalex.org/W2079274909","https://openalex.org/W2079706522","https://openalex.org/W2081945207","https://openalex.org/W2083143366","https://openalex.org/W2083731532","https://openalex.org/W2083947597","https://openalex.org/W2084742018","https://openalex.org/W2085211455","https://openalex.org/W2085741321","https://openalex.org/W2086246680","https://openalex.org/W2086372244","https://openalex.org/W2087740844","https://openalex.org/W2087986475","https://openalex.org/W2088291447","https://openalex.org/W2088462720","https://openalex.org/W2089012546","https://openalex.org/W2089225240","https://openalex.org/W2090320548","https://openalex.org/W2090965983","https://openalex.org/W2091321131","https://openalex.org/W2092411461","https://openalex.org/W2092830214","https://openalex.org/W2093036913","https://openalex.org/W2093072166","https://openalex.org/W2093266759","https://openalex.org/W2093583433","https://openalex.org/W2093671244","https://openalex.org/W2094804227","https://openalex.org/W2094958774","https://openalex.org/W2095061120","https://openalex.org/W2095191683","https://openalex.org/W2099078941","https://openalex.org/W2099779245","https://openalex.org/W2103903531","https://openalex.org/W2106688439","https://openalex.org/W2109166831","https://openalex.org/W2114469246","https://openalex.org/W2117704176","https://openalex.org/W2120228672","https://openalex.org/W2124209030","https://openalex.org/W2126233790","https://openalex.org/W2131332104","https://openalex.org/W2131336888","https://openalex.org/W2132768644","https://openalex.org/W2134563387","https://openalex.org/W2134766199","https://openalex.org/W2135826809","https://openalex.org/W2136717001","https://openalex.org/W2137198290","https://openalex.org/W2138127541","https://openalex.org/W2141304520","https://openalex.org/W2144196501","https://openalex.org/W2144928730","https://openalex.org/W2145758516","https://openalex.org/W2146981914","https://openalex.org/W2147473077","https://openalex.org/W2149179613","https://openalex.org/W2150265247","https://openalex.org/W2150665192","https://openalex.org/W2151219940","https://openalex.org/W2154242803","https://openalex.org/W2156798177","https://openalex.org/W2159335904","https://openalex.org/W2165594126","https://openalex.org/W2165898385","https://openalex.org/W2166892980","https://openalex.org/W2169610220","https://openalex.org/W2170160388","https://openalex.org/W2177094260","https://openalex.org/W2187094704","https://openalex.org/W2273601764","https://openalex.org/W2319881106","https://openalex.org/W2333286633","https://openalex.org/W2402754428","https://openalex.org/W2409111871","https://openalex.org/W2410329339","https://openalex.org/W2412297233","https://openalex.org/W2415190292","https://openalex.org/W2418349902","https://openalex.org/W2601080163"],"related_works":["https://openalex.org/W2088462720","https://openalex.org/W7063744913","https://openalex.org/W2514668791","https://openalex.org/W2158783892","https://openalex.org/W3100916756","https://openalex.org/W2419001253","https://openalex.org/W3137399549","https://openalex.org/W218622899","https://openalex.org/W7096147419","https://openalex.org/W7098107847"],"abstract_inverted_index":{"Adenosine":[0],"levels":[1],"in":[2,66,90,134,150,221,227,277,313,334],"the":[3,23,45,57,82,128,145,151,171,187,213,222,228,244,263,271,278,305,314,335],"basal":[4],"forebrain":[5],"and":[6,26,49,63,73,77,87,99,108,112,121,161,175,209,218,241,280,290,310,319,326,330],"cortex":[7,41],"increase":[8],"with":[9],"prolonged":[10],"wakefulness":[11,17,174,327],"to":[12,44,55,158,196,243,265],"promote":[13],"sleep.":[14,78,178],"Caffeine":[15],"increases":[16],"by":[18,59,136,185,285,297],"blocking":[19,137],"adenosine":[20,31,61,85,106,139,149,155,166,216,234,288,308],"receptors,":[21],"yet":[22],"neurotransmitter":[24,275],"systems":[25],"brain":[27],"regions":[28],"through":[29,154,193],"which":[30,60,186,286],"receptor":[32,110,168,236,239,254],"blockade":[33],"causes":[34],"arousal":[35,191,198,295,321],"are":[36,262],"incompletely":[37],"understood.":[38],"The":[39,125,201,302],"prefrontal":[40],"(PFC)":[42],"contributes":[43],"regulation":[46],"of":[47,105,164,232,270],"sleep":[48,160,325],"wakefulness.":[50,162],"This":[51],"thesis":[52],"research":[53],"sought":[54],"elucidate":[56],"mechanisms":[58],"A1":[62,86,107,140,156,167,217,238,253,289,309],"A2A":[64,88,109,219,235,291,311],"receptors":[65,89,157,220,292,312],"PFC":[67,92,94,138,152,172,188,223,245,272,287,315],"modulate":[68,93,159,224,293,316,324,331],"acetylcholine":[69],"(ACh)":[70],"release,":[71,96,117,249],"behavioral":[72,97,190,294,320],"electroencephalographic":[74],"(EEG)":[75],"arousal,":[76,98,133],"Aim":[79,142,210],"1":[80],"tested":[81,144,212],"hypothesis":[83,146,214],"that":[84,130,147,182,215,267,282,307],"mouse":[91],"ACh":[95,116,225,248,258,300,317,332],"EEG":[100,122],"delta":[101,123],"power.":[102,124],"Microdialysis":[103,230],"administration":[104],"agonists":[111],"antagonists":[113],"significantly":[114],"altered":[115],"anesthesia":[118],"recovery":[119],"time,":[120],"data":[126],"support":[127,304],"interpretation":[129,306],"caffeine":[131,242],"promotes":[132],"part,":[135],"receptors.":[141],"2":[143],"endogenous":[148],"acts":[153],"Microinjection":[163],"an":[165,233,252],"antagonist":[169],"into":[170],"increased":[173,246],"decreased":[176,256],"NREM":[177],"These":[179,260],"results":[180,303],"suggest":[181,281],"one":[183,283],"mechanism":[184,284],"modulates":[189],"is":[192,296],"descending":[194],"input":[195],"caudal":[197],"control":[199],"centers.":[200],"pontine":[202],"reticular":[203],"formation":[204],"(PRF)":[205],"regulates":[206],"sleep/wake":[207],"states":[208],"3":[211],"release":[226,276,318,333],"PRF.":[229],"delivery":[231],"agonist,":[237],"antagonist,":[240],"PRF":[247,257,299,336],"whereas":[250],"administering":[251],"agonist":[255],"release.":[259,301],"findings":[261],"first":[264],"demonstrate":[266],"pharmacological":[268],"manipulation":[269],"can":[273],"alter":[274],"PRF,":[279],"altering":[298],"(Aim":[322,328,337],"1);":[323],"2);":[329],"3).":[338]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}