{"id":"https://openalex.org/W4308928855","doi":"https://doi.org/10.1016/j.freeradbiomed.2022.10.233","title":"Targeting Hemoproteins with Carbon Monoxide Prevents Hyperoxia-induced Cartilage Injury","display_name":"Targeting Hemoproteins with Carbon Monoxide Prevents Hyperoxia-induced Cartilage Injury","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308928855","doi":"https://doi.org/10.1016/j.freeradbiomed.2022.10.233"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2022.10.233","doi":"https://doi.org/10.1016/j.freeradbiomed.2022.10.233","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2022.10.233","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020707778","display_name":"Suryamin Liman","orcid":"https://orcid.org/0000-0001-7066-9429","observed_orcids":["https://orcid.org/0000-0001-7066-9429"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suryamin Liman","raw_affiliation_strings":["The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034539865","display_name":"Paige Kluz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige Kluz","raw_affiliation_strings":["The University of Wisconsin, Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Wisconsin, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024019014","display_name":"Piedad C. G\u00f3mez-Contreras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piedad C. Gomez-Contreras","raw_affiliation_strings":["The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110946040","display_name":"Madeline R. Hines","orcid":"https://orcid.org/0000-0002-3857-4101","observed_orcids":["https://orcid.org/0000-0002-3857-4101"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeline Hines","raw_affiliation_strings":["The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076490442","display_name":"Elise L. Femino","orcid":"https://orcid.org/0000-0001-9490-1093","observed_orcids":["https://orcid.org/0000-0001-9490-1093"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise Femino","raw_affiliation_strings":["The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062864407","display_name":"Maxwell Y. Sakyi","orcid":"https://orcid.org/0000-0002-8873-4484","observed_orcids":["https://orcid.org/0000-0002-8873-4484"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxwell Sakyi","raw_affiliation_strings":["Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emily Witt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Witt","raw_affiliation_strings":["The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088498661","display_name":"James D. Byrne","orcid":"https://orcid.org/0000-0002-6436-2866","observed_orcids":["https://orcid.org/0000-0002-6436-2866"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Byrne","raw_affiliation_strings":["The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090026354","display_name":"Jessica E. Goetz","orcid":"https://orcid.org/0000-0002-7197-5978","observed_orcids":["https://orcid.org/0000-0002-7197-5978"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Goetz","raw_affiliation_strings":["The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005845679","display_name":"Mitchell C. Coleman","orcid":"https://orcid.org/0000-0002-5116-801X","observed_orcids":["https://orcid.org/0000-0002-5116-801X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell Coleman","raw_affiliation_strings":["The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10388529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"192","issue":null,"first_page":"126","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/heme-proteins","display_name":"heme proteins","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cartilage-damage","display_name":"cartilage damage","score":0.9490000009536743},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8360000252723694},{"id":"https://openalex.org/keywords/chondroprotection","display_name":"chondroprotection","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.7432796955108643},{"id":"https://openalex.org/C512735826","wikidata":"https://www.wikidata.org/wiki/Q2025","display_name":"Carbon monoxide","level":3,"score":0.710537850856781},{"id":"https://openalex.org/C20705724","wikidata":"https://www.wikidata.org/wiki/Q902628","display_name":"Hemeprotein","level":4,"score":0.6328508853912354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5538029670715332},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.26432254910469055},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.22457602620124817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2084900438785553},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0976380705833435},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2022.10.233","doi":"https://doi.org/10.1016/j.freeradbiomed.2022.10.233","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2022.10.233","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070145711","https://openalex.org/W2132658958","https://openalex.org/W4391939298","https://openalex.org/W2992345005","https://openalex.org/W4409146147","https://openalex.org/W1989720925","https://openalex.org/W2257040242","https://openalex.org/W4234394659","https://openalex.org/W7137638339","https://openalex.org/W4378217111"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-11-19T00:00:00"}
