{"id":"https://openalex.org/W4308896069","doi":"https://doi.org/10.1101/2022.11.10.515907","title":"Decoding murine cytomegalovirus","display_name":"Decoding murine cytomegalovirus","publication_year":2022,"publication_date":"2022-11-12","ids":{"openalex":"https://openalex.org/W4308896069","doi":"https://doi.org/10.1101/2022.11.10.515907"},"language":"en","primary_location":{"id":"doi:10.1101/2022.11.10.515907","doi":"https://doi.org/10.1101/2022.11.10.515907","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.11.10.515907","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/11/12/2022.11.10.515907.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/11/12/2022.11.10.515907.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012324889","display_name":"Manivel Lodha","orcid":"https://orcid.org/0000-0002-0258-1895","observed_orcids":["https://orcid.org/0000-0002-0258-1895"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manivel Lodha","raw_affiliation_strings":["Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068672473","display_name":"Ihsan Muchsin","orcid":"https://orcid.org/0000-0002-0447-7864","observed_orcids":["https://orcid.org/0000-0002-0447-7864"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ihsan Muchsin","raw_affiliation_strings":["Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110946007","display_name":"Christopher J\u00fcrges","orcid":"https://orcid.org/0000-0001-5617-6601","observed_orcids":["https://orcid.org/0000-0001-5617-6601"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christopher J\u00fcrges","raw_affiliation_strings":["Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025090132","display_name":"Vanda Jurani\u0107 Lisni\u0107","orcid":"https://orcid.org/0000-0002-7182-8927","observed_orcids":["https://orcid.org/0000-0002-7182-8927"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Vanda Juranic Lisnic","raw_affiliation_strings":["Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia","Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]},{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065045790","display_name":"Anne L\u2019Hernault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anne L\u2019hernault","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Box 157, Addenbrookes Hospital, Hills Road, CB2 0QQ, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Box 157, Addenbrookes Hospital, Hills Road, CB2 0QQ, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrzej J. Rutkowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrzej J. Rutkowski","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Box 157, Addenbrookes Hospital, Hills Road, CB2 0QQ, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Box 157, Addenbrookes Hospital, Hills Road, CB2 0QQ, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055288729","display_name":"Bhupesh Kumar Prusty","orcid":"https://orcid.org/0000-0001-7051-4670","observed_orcids":["https://orcid.org/0000-0001-7051-4670"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bhupesh Prusty","raw_affiliation_strings":["Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047566383","display_name":"Arnhild Grothey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arnhild Grothey","raw_affiliation_strings":["Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080146082","display_name":"Andrea Mili\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea Milic","raw_affiliation_strings":["Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040288107","display_name":"Thomas Hennig","orcid":"https://orcid.org/0000-0002-7788-1681","observed_orcids":["https://orcid.org/0000-0002-7788-1681"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Hennig","raw_affiliation_strings":["Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038051461","display_name":"Stipan Jonji\u0107","orcid":"https://orcid.org/0000-0001-5003-3108","observed_orcids":["https://orcid.org/0000-0001-5003-3108"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Stipan Jonjic","raw_affiliation_strings":["Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia","Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]},{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010083961","display_name":"Caroline C. Friedel","orcid":"https://orcid.org/0000-0003-3569-4877","observed_orcids":["https://orcid.org/0000-0003-3569-4877"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Caroline C. Friedel","raw_affiliation_strings":["Institute for Informatics, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Amalien Str. 17, 80333, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3569-4877","affiliations":[{"raw_affiliation_string":"Institute for Informatics, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Amalien Str. 17, 80333, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005259316","display_name":"Florian Erhard","orcid":"https://orcid.org/0000-0002-3574-6983","observed_orcids":["https://orcid.org/0000-0002-3574-6983"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Florian Erhard","raw_affiliation_strings":["Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3574-6983","affiliations":[{"raw_affiliation_string":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069299747","display_name":"Lars D\u00f6lken","orcid":"https://orcid.org/0000-0002-4651-3544","observed_orcids":["https://orcid.org/0000-0002-4651-3544"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210125858","display_name":"Helmholtz Institute for RNA-based Infection Research","ror":"https://ror.org/02a98s891","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210125858"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Lars D\u00f6lken","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Box 157, Addenbrookes Hospital, Hills Road, CB2 0QQ, Cambridge, UK","Helmholtz Institute for RNA-based Infection Research (HIRI), W\u00fcrzburg, Germany","Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4651-3544","affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Box 157, Addenbrookes Hospital, Hills Road, CB2 0QQ, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]},{"raw_affiliation_string":"Helmholtz Institute for RNA-based Infection Research (HIRI), W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210125858"]},{"raw_affiliation_string":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t-W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5005259316","https://openalex.org/A5069299747"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I25974101","https://openalex.org/I4210125858","https://openalex.org/I4210156194"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/murine-cytomegalovirus","display_name":"murine cytomegalovirus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/small-open-reading-frames","display_name":"small open reading frames","score":0.7329999804496765},{"id":"https://openalex.org/keywords/viral-transcripts","display_name":"viral RNA transcripts","score":0.5490000247955322},{"id":"https://openalex.org/keywords/immediate-early-genes","display_name":"immediate early genes","score":0.5170000195503235},{"id":"https://openalex.org/keywords/lytic-infection","display_name":"lytic infection","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2780530800","wikidata":"https://www.wikidata.org/wiki/Q7072921","display_name":"ORFS","level":5,"score":0.9795315861701965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7674218416213989},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.6549293994903564},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.6404808163642883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6267156004905701},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.56548011302948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5512437224388123},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5361765623092651},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.5011773109436035},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4287112355232239},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.357089638710022},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2471831738948822},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.11290854215621948},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.11.10.515907","doi":"https://doi.org/10.1101/2022.11.10.515907","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.11.10.515907","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/11/12/2022.11.10.515907.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.11.10.515907","doi":"https://doi.org/10.1101/2022.11.10.515907","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.11.10.515907","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/11/12/2022.11.10.515907.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1293573242","display_name":null,"funder_award_id":"FR2938/9-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3818521042","display_name":null,"funder_award_id":"FOR 2830","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5584713113","display_name":null,"funder_award_id":"DO1275/7-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6240108253","display_name":null,"funder_award_id":"ER927/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308896069.pdf","grobid_xml":"https://content.openalex.org/works/W4308896069.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1519422934","https://openalex.org/W1709815505","https://openalex.org/W1711939065","https://openalex.org/W1851333263","https://openalex.org/W1925735392","https://openalex.org/W1947600782","https://openalex.org/W1968426398","https://openalex.org/W1973091058","https://openalex.org/W1980438612","https://openalex.org/W1981509058","https://openalex.org/W1983148576","https://openalex.org/W1984554809","https://openalex.org/W1985596920","https://openalex.org/W1992308820","https://openalex.org/W2009478166","https://openalex.org/W2010005720","https://openalex.org/W2056028897","https://openalex.org/W2057563271","https://openalex.org/W2057652523","https://openalex.org/W2057692691","https://openalex.org/W2068242488","https://openalex.org/W2086157203","https://openalex.org/W2095778156","https://openalex.org/W2097691794","https://openalex.org/W2098407042","https://openalex.org/W2103441770","https://openalex.org/W2108367007","https://openalex.org/W2111968412","https://openalex.org/W2118590008","https://openalex.org/W2124805455","https://openalex.org/W2128902404","https://openalex.org/W2131777296","https://openalex.org/W2140807899","https://openalex.org/W2147611204","https://openalex.org/W2157303629","https://openalex.org/W2158266834","https://openalex.org/W2160321820","https://openalex.org/W2170698318","https://openalex.org/W2463069668","https://openalex.org/W2470361298","https://openalex.org/W2759506905","https://openalex.org/W2768048874","https://openalex.org/W2790274448","https://openalex.org/W2794350773","https://openalex.org/W2799445495","https://openalex.org/W2807753402","https://openalex.org/W2879734158","https://openalex.org/W2913823278","https://openalex.org/W2946985211","https://openalex.org/W2998217526","https://openalex.org/W3013566126","https://openalex.org/W3018762673","https://openalex.org/W3137046450","https://openalex.org/W3174633785","https://openalex.org/W3189169606","https://openalex.org/W3209569655","https://openalex.org/W4210468411","https://openalex.org/W4211228358"],"related_works":["https://openalex.org/W6945473279","https://openalex.org/W3103348119","https://openalex.org/W2111968412","https://openalex.org/W4210468411","https://openalex.org/W1606620911","https://openalex.org/W2010005720","https://openalex.org/W1994730816","https://openalex.org/W2087865269","https://openalex.org/W2340184405","https://openalex.org/W2160321820"],"abstract_inverted_index":{"Abstract":[0],"The":[1,99],"genomes":[2],"of":[3,52,62,71,75,106,135,139,149,170,206,222,235,295,315,322,356,367,373,380,399,430,474],"both":[4],"human":[5],"cytomegalovirus":[6,10,277,297],"(HCMV)":[7],"and":[8,92,96,124,183,293,348,443,490],"murine":[9,296,305],"(MCMV)":[11,298],"were":[12,339],"first":[13],"sequenced":[14],"over":[15],"20":[16],"years":[17],"ago.":[18],"Similar":[19],"to":[20,29,44,90,324,461],"HCMV,":[21],"the":[22,109,136,147,157,223,236,247,257,268,320,341,371,374,378,451],"MCMV":[23,64,152],"genome":[24],"had":[25],"initially":[26],"been":[27],"proposed":[28],"harbor":[30],"\u2248170":[31],"open":[32,330],"reading":[33,331],"frames":[34,332],"(ORFs).":[35,333],"More":[36],"recently,":[37],"omics":[38,76],"approaches":[39],"revealed":[40,167,426],"HCMV":[41],"gene":[42,65,114,204,278,299,346],"expression":[43,66,137,205,300,321,372,392],"be":[45,481],"substantially":[46],"more":[47,243],"complex":[48],"comprising":[49],"several":[50],"hundreds":[51,314],"translated":[53],"ORFs.":[54],"Here,":[55],"we":[56,130,161,217,360,469],"provide":[57,131,470],"a":[58,72,132,150,168,219,231,290,396,412,427,471],"state-of-the":[59],"art":[60],"reannotation":[61,294],"lytic":[63,302],"based":[67,389],"on":[68,274,390,486],"integrative":[69,309],"analysis":[70],"large":[73],"set":[74],"data.":[77],"Our":[78],"data":[79],"reveal":[80],"363":[81],"viral":[82,94,113,140,172,201,208,224,232,329,336,345,354,384,416,431,465],"transcription":[83,385,404],"start":[84,386,405],"sites":[85,387,406],"(TiSS)":[86,388],"that":[87,174,200,318,363,434],"give":[88,459],"rise":[89,460],"380":[91],"454":[93],"transcripts":[95,173,317,433],"ORFs,":[97,104],"respectively.":[98],"latter":[100],"include":[101],">200":[102],"small":[103,335],"some":[105],"which":[107,160,479],"represented":[108],"most":[110,342],"highly":[111,343],"expressed":[112,210,245,344,436,463],"products.":[115],"By":[116],"combining":[117],"TiSS":[118,233,458],"profiling":[119],"with":[120,403],"metabolic":[121,400],"RNA":[122,401],"labelling":[123,402],"chemical":[125],"nucleotide":[126],"conversion":[127],"sequencing":[128],"(dSLAM-seq),":[129],"detailed":[133],"picture":[134],"kinetics":[138,393],"transcription.":[141],"This":[142,312,408],"not":[143,253,409],"only":[144,410],"resulted":[145],"in":[146,194,211,280,304],"identification":[148],"novel":[151,316,428],"immediate":[153],"early":[154],"transcript":[155,418],"encoding":[156],"m166.5":[158,422],"ORF,":[159],"termed":[162],"ie4":[163,420],",":[164,421],"but":[165,189,424],"also":[166,361,425],"group":[169],"well-expressed":[171],"are":[175,435],"induced":[176],"later":[177,437],"than":[178,246,438],"canonical":[179,237,248,439],"true":[180,440],"late":[181,432,441],"genes":[182,442],"contain":[184],"an":[185,281,308,475],"initiator":[186],"element":[187],"(Inr)":[188],"no":[190],"TATA-":[191],"or":[192],"TATT-box":[193],"their":[195,391],"core":[196],"promoters.":[197],"We":[198,288,382,448],"show":[199,362],"uORFs":[202],"tune":[203,370],"longer":[207],"ORFs":[209,337,369,376],"cis":[212],"at":[213,377],"translational":[214],"level.":[215],"Finally,":[216],"identify":[218],"truncated":[220,464],"isoform":[221],"NK-cell":[225],"immune":[226],"evasin":[227],"m145":[228,238,249,452],"arising":[229],"from":[230],"downstream":[234,375],"mRNA.":[239],"Despite":[240],"being":[241],"\u22485-fold":[242],"abundantly":[244,462],"protein":[250],"it":[251],"was":[252],"required":[254],"for":[255,270,352,450,483],"downregulating":[256],"NK":[258],"cell":[259],"ligand,":[260],"MULT-I.":[261],"In":[262,467],"summary,":[263,468],"our":[264],"work":[265],"will":[266,480],"pave":[267],"way":[269],"future":[271,484],"mechanistic":[272],"studies":[273,485],"previously":[275],"unknown":[276,328,357,415,457],"products":[279,347],"important":[282,353,476],"virus":[283],"animal":[284],"model.":[285],"Author":[286],"summary":[287],"conducted":[289],"comprehensive":[291],"characterization":[292],"during":[301],"infection":[303],"fibroblasts":[306],"using":[307],"multi-omics":[310],"approach.":[311],"unveiled":[313],"explained":[319],"close":[323],"300":[325],"so":[326,413,455],"far":[327,414,456],"Interestingly,":[334],"(sORFs)":[338],"amongst":[340],"thus":[349],"presumably":[350],"encode":[351],"microproteins":[355],"function.":[358],"However,":[359],"sORFs":[364],"located":[365],"upstream":[366],"larger":[368],"level":[379],"translation.":[381],"classified":[383],"obtained":[394],"by":[395],"new":[397],"combination":[398],"profiling.":[407],"identified":[411],"immediate-early":[417],"(":[419],"RNA)":[423],"class":[429],"lack":[444],"TATA":[445],"box-like":[446],"motifs.":[447],"exemplify":[449],"locus":[453],"how":[454],"proteins.":[466],"state-of-the-art":[472],"annotation":[473],"model":[477],"virus,":[478],"instrumental":[482],"CMV":[487],"biology,":[488],"immunology":[489],"pathogenesis.":[491]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-11-19T00:00:00"}
