{"id":"https://openalex.org/W4308725906","doi":"https://doi.org/10.3389/fphar.2022.1008946","title":"Multicenter, randomized controlled trial of traditional Japanese medicine, kakkonto with shosaikotokakikyosekko, for mild and moderate coronavirus disease patients","display_name":"Multicenter, randomized controlled trial of traditional Japanese medicine, kakkonto with shosaikotokakikyosekko, for mild and moderate coronavirus disease patients","publication_year":2022,"publication_date":"2022-11-09","ids":{"openalex":"https://openalex.org/W4308725906","doi":"https://doi.org/10.3389/fphar.2022.1008946","pmid":"https://pubmed.ncbi.nlm.nih.gov/36438822","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9682103"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2022.1008946","doi":"https://doi.org/10.3389/fphar.2022.1008946","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.1008946","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2022.1008946","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047638458","display_name":"Shin Takayama","orcid":"https://orcid.org/0000-0002-6388-4566","observed_orcids":["https://orcid.org/0000-0002-6388-4566"]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shin Takayama","raw_affiliation_strings":["Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021087067","display_name":"Takao Namiki","orcid":"https://orcid.org/0000-0003-1047-7999","observed_orcids":["https://orcid.org/0000-0003-1047-7999"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Namiki","raw_affiliation_strings":["Department of Japanese-Oriental (Kampo) Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Japanese-Oriental (Kampo) Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005505151","display_name":"Ryutaro Arita","orcid":"https://orcid.org/0000-0003-4676-7242","observed_orcids":["https://orcid.org/0000-0003-4676-7242"]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryutaro Arita","raw_affiliation_strings":["Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060975539","display_name":"Rie Ono","orcid":"https://orcid.org/0000-0001-9237-4701","observed_orcids":["https://orcid.org/0000-0001-9237-4701"]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rie Ono","raw_affiliation_strings":["Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052091264","display_name":"Akiko Kikuchi","orcid":"https://orcid.org/0000-0001-8368-0651","observed_orcids":["https://orcid.org/0000-0001-8368-0651"]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Kikuchi","raw_affiliation_strings":["Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020384932","display_name":"Minoru Ohsawa","orcid":"https://orcid.org/0000-0002-5417-8248","observed_orcids":["https://orcid.org/0000-0002-5417-8248"]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Ohsawa","raw_affiliation_strings":["Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059886372","display_name":"Natsumi Saito","orcid":"https://orcid.org/0000-0002-3313-7316","observed_orcids":["https://orcid.org/0000-0002-3313-7316","https://orcid.org/0000-0001-5674-0508"]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsumi Saito","raw_affiliation_strings":["Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003560112","display_name":"Satoko Suzuki","orcid":"https://orcid.org/0000-0002-2491-2958","observed_orcids":["https://orcid.org/0000-0002-2491-2958","https://orcid.org/0009-0005-9874-4247"]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoko Suzuki","raw_affiliation_strings":["Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015216142","display_name":"Hajime Nakae","orcid":"https://orcid.org/0000-0003-3733-3530","observed_orcids":["https://orcid.org/0000-0003-3733-3530"]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Nakae","raw_affiliation_strings":["Department of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine, Akita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine, Akita, Japan","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068067571","display_name":"Seiichi Kobayashi","orcid":"https://orcid.org/0000-0003-1347-3395","observed_orcids":["https://orcid.org/0000-0003-1347-3395"]},"institutions":[{"id":"https://openalex.org/I4405284525","display_name":"Japanese Red Cross Ishinomaki Hospital","ror":"https://ror.org/03qbehn19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405284525"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiichi Kobayashi","raw_affiliation_strings":["Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan","institution_ids":["https://openalex.org/I4405284525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073616146","display_name":"Tetsuhiro Yoshino","orcid":"https://orcid.org/0000-0001-6172-1926","observed_orcids":["https://orcid.org/0000-0001-6172-1926"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuhiro Yoshino","raw_affiliation_strings":["Center for Kampo Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Kampo Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049659161","display_name":"Tomoaki Ishigami","orcid":"https://orcid.org/0000-0001-8488-9879","observed_orcids":["https://orcid.org/0000-0001-8488-9879"]},"institutions":[{"id":"https://openalex.org/I4210099218","display_name":"Yokohama City University Hospital","ror":"https://ror.org/010hfy465","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099218"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Ishigami","raw_affiliation_strings":["Department of Cardiology, Yokohama City University Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Yokohama City University Hospital, Yokohama, Japan","institution_ids":["https://openalex.org/I4210099218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081704034","display_name":"K\u014dichiro Tanaka","orcid":"https://orcid.org/0000-0002-2132-8318","observed_orcids":["https://orcid.org/0000-0002-2132-8318"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichiro Tanaka","raw_affiliation_strings":["Department of Traditional Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Medicine, Faculty of Medicine, Toho University, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046553307","display_name":"Kotaro Nochioka","orcid":"https://orcid.org/0000-0001-8297-8624","observed_orcids":["https://orcid.org/0000-0001-8297-8624"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Nochioka","raw_affiliation_strings":["Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Airi Takagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Airi Takagi","raw_affiliation_strings":["Clinical Research Data Center, Tohoku University Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Data Center, Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033519257","display_name":"Masaru Mimura","orcid":"https://orcid.org/0000-0002-3874-5273","observed_orcids":["https://orcid.org/0000-0002-3874-5273"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Mimura","raw_affiliation_strings":["Center for Kampo Medicine, Keio University School of Medicine, Tokyo, Japan","Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Kampo Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071947905","display_name":"Takuhiro Yamaguchi","orcid":"https://orcid.org/0000-0002-7961-9417","observed_orcids":["https://orcid.org/0000-0002-7961-9417"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuhiro Yamaguchi","raw_affiliation_strings":["Division of Biostatistics, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102733074","display_name":"Tadashi Ishii","orcid":"https://orcid.org/0000-0003-2961-2214","observed_orcids":["https://orcid.org/0000-0003-2961-2214"]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Ishii","raw_affiliation_strings":["Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Support for Regional Medicine (General and Kampo medicine), Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024154064","display_name":"Akito Hisanaga","orcid":"https://orcid.org/0009-0006-7616-728X","observed_orcids":["https://orcid.org/0009-0006-7616-728X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akito Hisanaga","raw_affiliation_strings":["Hospital Bando, Bando, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Bando, Bando, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111994880","display_name":"Kazuo Mitani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuo Mitani","raw_affiliation_strings":["Medical Corporation Mitani Family Clinic, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Corporation Mitani Family Clinic, Osaka, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070102703","display_name":"Takashi Ito","orcid":"https://orcid.org/0000-0002-2516-3362","observed_orcids":["https://orcid.org/0000-0002-2516-3362"]},"institutions":[{"id":"https://openalex.org/I4210161703","display_name":"Akashi Medical Center","ror":"https://ror.org/04j6ay666","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161703"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Ito","raw_affiliation_strings":["Akashi Clinic Kanda, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Akashi Clinic Kanda, Tokyo, Japan","institution_ids":["https://openalex.org/I4210161703"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5047638458"],"corresponding_institution_ids":["https://openalex.org/I4210093896"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.5394,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.9144422,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"1008946","last_page":"1008946"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.3634999990463257,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kampo-medicine","display_name":"Kampo medicine","score":0.8209999799728394},{"id":"https://openalex.org/keywords/kakkonto","display_name":"Kakkonto","score":0.9800000190734863},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mild-to-moderate-covid-19","display_name":"mild to moderate COVID-19","score":0.8809999823570251},{"id":"https://openalex.org/keywords/symptom-relief","display_name":"symptom relief","score":0.8069999814033508},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8510000109672546},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.847000002861023},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.690239429473877},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6902273893356323},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6789535880088806},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.635331392288208},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.5880140066146851},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5309160351753235},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5189840197563171},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5134192705154419},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.4737616181373596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45104312896728516},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.3519033193588257},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3471486270427704},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2929416596889496},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.2045697271823883},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18432959914207458},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.18380799889564514}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2022.1008946","doi":"https://doi.org/10.3389/fphar.2022.1008946","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.1008946","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9682103","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9682103","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:36438822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36438822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:479b8d441e994b259618aa6eed0d2948","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/479b8d441e994b259618aa6eed0d2948","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2022.1008946","doi":"https://doi.org/10.3389/fphar.2022.1008946","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.1008946","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G2925667759","display_name":"Development of an effective Kampo education program that integrates lectures and practical training, and verification of its educational effects","funder_award_id":"19K10503","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W2147478433","https://openalex.org/W2593007620","https://openalex.org/W2972813359","https://openalex.org/W3008028633","https://openalex.org/W3009912996","https://openalex.org/W3015608194","https://openalex.org/W3024536180","https://openalex.org/W3025744748","https://openalex.org/W3036865214","https://openalex.org/W3083605260","https://openalex.org/W3090457442","https://openalex.org/W3091349350","https://openalex.org/W3092719542","https://openalex.org/W3092864497","https://openalex.org/W3101672167","https://openalex.org/W3125201916","https://openalex.org/W3131306856","https://openalex.org/W3132920033","https://openalex.org/W3151114703","https://openalex.org/W3153676716","https://openalex.org/W3157695710","https://openalex.org/W3158276912","https://openalex.org/W3161563529","https://openalex.org/W3164160541","https://openalex.org/W3168573291","https://openalex.org/W3176605970","https://openalex.org/W3180564861","https://openalex.org/W3184891196","https://openalex.org/W3196565865","https://openalex.org/W3196942436","https://openalex.org/W3204153794","https://openalex.org/W3208080692","https://openalex.org/W3211185008","https://openalex.org/W3216029874","https://openalex.org/W4200051875","https://openalex.org/W4200206478","https://openalex.org/W4205241609","https://openalex.org/W4212904481","https://openalex.org/W4220686298","https://openalex.org/W4220699376","https://openalex.org/W4220814154","https://openalex.org/W4220848096","https://openalex.org/W4220849403","https://openalex.org/W4281382576","https://openalex.org/W4281700140","https://openalex.org/W4284691971","https://openalex.org/W4286009139","https://openalex.org/W4292148078","https://openalex.org/W4293280590","https://openalex.org/W4295420158","https://openalex.org/W4296163792","https://openalex.org/W4308012847","https://openalex.org/W6846531621"],"related_works":["https://openalex.org/W4385285438","https://openalex.org/W3090457442","https://openalex.org/W6939467298","https://openalex.org/W4308012847","https://openalex.org/W3184891196","https://openalex.org/W3114426105","https://openalex.org/W3092719542","https://openalex.org/W3176605970","https://openalex.org/W3092864497","https://openalex.org/W7139931384"],"abstract_inverted_index":{"The":[0,71,83,120],"traditional":[1],"Japanese":[2],"(Kampo)":[3],"medicine,":[4],"kakkonto":[5,52],"with":[6,18,206,213],"shosaikotokakikyosekko,":[7],"has":[8],"antiviral":[9],"and":[10,20,41,55,95],"anti-inflammatory":[11],"effects.":[12],"In":[13],"this":[14],"randomized":[15],"trial,":[16],"patients":[17,109],"mild":[19],"moderate":[21,176],"coronavirus":[22],"disease":[23,98,173,216],"(COVID-19)":[24],"were":[25,203],"randomly":[26],"allocated":[27],"to":[28,68,100,175],"the":[29,44,75,87,97,136,150,156,161,170,184,189],"control":[30,115,162,190],"group":[31,46,158,163,186,191],"receiving":[32,47],"conventional":[33,69],"treatment":[34],"for":[35,63,210],"symptom":[36,81,126],"relief":[37,94,127,144,212],"such":[38],"as":[39],"antipyretics":[40],"antitussives":[42],"or":[43],"Kampo":[45,157,185],"mixed":[48],"extract":[49],"granules":[50],"of":[51,77,89,107,125,142,172,215],"(2.5":[53,57],"g)":[54,58],"shosaikotokakikyosekko":[56,207],"three":[59],"times":[60],"a":[61,105],"day":[62],"14":[64],"days":[65,78,90],"in":[66,155,160,183,188,218],"addition":[67],"treatment.":[70],"main":[72],"outcome":[73,85],"was":[74,86,152,181],"number":[76,88],"until":[79,91],"total":[80,106],"relief.":[82],"secondary":[84],"each":[92],"symptom\u2019s":[93],"whether":[96],"progressed":[99],"respiratory":[101],"failure.":[102],"We":[103],"enrolled":[104],"161":[108],"(Kampo":[110],"group,":[111,116],"n":[112,117],"=":[113,118],"81;":[114],"80).":[119],"results":[121],"from":[122],"Kaplan\u2013Meier":[123],"estimates":[124],"showed":[128,148],"that":[129,149],"there":[130],"are":[131],"no":[132],"significant":[133,199],"differences":[134],"between":[135],"groups.":[137],"However,":[138],"covariate-adjusted":[139],"cumulative":[140],"incidence":[141],"fever":[143,211],"considering":[145],"competitive":[146],"risk":[147,171],"recovery":[151],"significantly":[153],"faster":[154],"than":[159,187],"(HR":[164],"1.76,":[165],"95%":[166,195],"CI":[167,196],"1.03\u20133.01).":[168],"Additionally,":[169],"progression":[174,217],"COVID-19":[177,219],"requiring":[178],"oxygen":[179],"inhalation":[180],"lower":[182],"(Risk":[192],"Difference":[193],"\u22120.13,":[194],"\u22120.27\u20130.01).":[197],"No":[198],"drug-related":[200],"side":[201],"effects":[202],"observed.":[204],"Kakkonto":[205],"is":[208],"effective":[209],"suppression":[214],"patients.":[220],"Clinical":[221],"Trial":[222],"Registration:":[223],"https://jrct.niph.go.jp/en-latest-detail/jRCTs021200020":[224],",":[225],"identifier":[226],"[jRCTs021200020]":[227]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-15T00:00:00"}
