{"id":"https://openalex.org/W4308720174","doi":"https://doi.org/10.3390/pharmaceutics14112417","title":"Anabolic Peptide-Enriched Stealth Nanoliposomes for Effective Anti-Osteoporotic Therapy","display_name":"Anabolic Peptide-Enriched Stealth Nanoliposomes for Effective Anti-Osteoporotic Therapy","publication_year":2022,"publication_date":"2022-11-09","ids":{"openalex":"https://openalex.org/W4308720174","doi":"https://doi.org/10.3390/pharmaceutics14112417","pmid":"https://pubmed.ncbi.nlm.nih.gov/36365235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9697760"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics14112417","doi":"https://doi.org/10.3390/pharmaceutics14112417","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14112417","pdf_url":"https://www.mdpi.com/1999-4923/14/11/2417/pdf?version=1667979217","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/14/11/2417/pdf?version=1667979217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086789236","display_name":"Sagar Salave","orcid":"https://orcid.org/0000-0003-3000-1998","observed_orcids":["https://orcid.org/0000-0003-3000-1998"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sagar Salave","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India"],"raw_orcid":"https://orcid.org/0000-0003-3000-1998","affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006125872","display_name":"Dhwani Rana","orcid":"https://orcid.org/0000-0002-1591-9226","observed_orcids":["https://orcid.org/0000-0002-1591-9226"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dhwani Rana","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India"],"raw_orcid":"https://orcid.org/0000-0002-1591-9226","affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037192790","display_name":"Hemant Kumar","orcid":"https://orcid.org/0000-0002-6434-0245","observed_orcids":["https://orcid.org/0000-0002-6434-0245"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hemant Kumar","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India"],"raw_orcid":"https://orcid.org/0000-0002-6434-0245","affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044395046","display_name":"Nagavendra Kommineni","orcid":"https://orcid.org/0000-0003-4771-7925","observed_orcids":["https://orcid.org/0000-0003-4771-7925"]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nagavendra Kommineni","raw_affiliation_strings":["Center for Biomedical Research, Population Council, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-4771-7925","affiliations":[{"raw_affiliation_string":"Center for Biomedical Research, Population Council, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070755475","display_name":"Derajram M. Benival","orcid":"https://orcid.org/0000-0002-3527-9158","observed_orcids":["https://orcid.org/0000-0002-3527-9158"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Derajram Benival","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India","institution_ids":["https://openalex.org/I4210102411"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044395046","https://openalex.org/A5070755475"],"corresponding_institution_ids":["https://openalex.org/I4210102411","https://openalex.org/I4210132262"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":1.2087,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.73055107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"11","first_page":"2417","last_page":"2417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.08799999952316284,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/teriparatide","display_name":"teriparatide","score":0.8349999785423279},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/anabolic-therapy","display_name":"anabolic therapy","score":0.8429999947547913},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.8360000252723694},{"id":"https://openalex.org/keywords/box-behnken-design","display_name":"Box-Behnken design","score":0.8529999852180481},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7689999938011169},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.6959999799728394},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9279999732971191},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mineralized-nodule-formation","display_name":"mineralized nodule formation","score":0.859000027179718},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.8199999928474426},{"id":"https://openalex.org/keywords/peptide-delivery","display_name":"peptide delivery","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.6361939907073975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6361716985702515},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5815351605415344},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.5730926394462585},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5424509644508362},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.46888136863708496},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4487246870994568},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.42663347721099854},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4258272051811218},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4219841957092285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38484418392181396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3376578688621521},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25445324182510376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23806893825531006},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.23003193736076355},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics14112417","doi":"https://doi.org/10.3390/pharmaceutics14112417","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14112417","pdf_url":"https://www.mdpi.com/1999-4923/14/11/2417/pdf?version=1667979217","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:36365235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36365235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9697760","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9697760/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1ee19487788740459fc0e6d31d39fad6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1ee19487788740459fc0e6d31d39fad6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 14, Iss 11, p 2417 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics14112417","doi":"https://doi.org/10.3390/pharmaceutics14112417","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14112417","pdf_url":"https://www.mdpi.com/1999-4923/14/11/2417/pdf?version=1667979217","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308720174.pdf","grobid_xml":"https://content.openalex.org/works/W4308720174.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1996153457","https://openalex.org/W1997772128","https://openalex.org/W1999481657","https://openalex.org/W2010506651","https://openalex.org/W2013298590","https://openalex.org/W2052681016","https://openalex.org/W2070941740","https://openalex.org/W2097603366","https://openalex.org/W2148340482","https://openalex.org/W2285090680","https://openalex.org/W2412853498","https://openalex.org/W2555570490","https://openalex.org/W2576154328","https://openalex.org/W2599276599","https://openalex.org/W2741771838","https://openalex.org/W2768043256","https://openalex.org/W2773120698","https://openalex.org/W2804846127","https://openalex.org/W2893291240","https://openalex.org/W2896289132","https://openalex.org/W2899194680","https://openalex.org/W3014598717","https://openalex.org/W3027962816","https://openalex.org/W3093750928","https://openalex.org/W3094237392","https://openalex.org/W3142966725","https://openalex.org/W3177780934","https://openalex.org/W3190348790","https://openalex.org/W4200113450","https://openalex.org/W4211221406","https://openalex.org/W4292176890","https://openalex.org/W4293108820","https://openalex.org/W4293252932","https://openalex.org/W4294408506"],"related_works":["https://openalex.org/W4293252932","https://openalex.org/W4283391415","https://openalex.org/W4320492400","https://openalex.org/W2013298590","https://openalex.org/W2944157558","https://openalex.org/W1996153457","https://openalex.org/W2070941740","https://openalex.org/W4200113450","https://openalex.org/W4406268718","https://openalex.org/W7215977131"],"abstract_inverted_index":{"The":[0,106,134,178,198],"objective":[1],"of":[2,18,44,52,139,162,192,200,208],"the":[3,16,19,31,50,78,158,163,190,201,206,209],"present":[4,202],"work":[5],"was":[6,27,69],"to":[7,48,73,144,212],"develop":[8],"PTH":[9],"(1-34)-loaded":[10],"stealth":[11],"nanoliposomes":[12],"(PTH-LPs)":[13],"by":[14,21],"employing":[15],"use":[17],"Quality":[20],"Design":[22,67],"(QbD)":[23],"approach.":[24],"Risk":[25],"identification":[26],"carried":[28,100],"out":[29,101],"using":[30,38],"Ishikawa":[32],"fishbone":[33],"diagram.":[34],"PTH-LPs":[35,72,156,171,184,216],"were":[36,99,142],"optimized":[37,140],"Box":[39],"Behnken":[40],"Design,":[41],"a":[42,83,117,130],"type":[43],"response":[45],"surface":[46],"methodology":[47],"examine":[49],"effect":[51],"independent":[53],"variables":[54,57],"on":[55,102,121],"dependent":[56],"such":[58],"as":[59],"particle":[60,122,135],"size":[61,123,136],"and":[62,95,124,137,150],"percentage":[63],"entrapment":[64],"efficiency":[65],"(%EE).":[66],"space":[68],"generated":[70],"for":[71],"reduce":[74],"interbatch":[75],"variability":[76],"during":[77],"formulation":[79,141],"development":[80],"process.":[81],"Furthermore,":[82],"cytotoxicity":[84],"assay,":[85,88,91],"cell":[86,167,179],"proliferation":[87,180],"calcium":[89],"calorimetric":[90],"mineralized":[92,193],"nodule":[93],"formation,":[94],"cellular":[96],"uptake":[97],"assay":[98],"MG-63":[103,176,196],"osteoblast-like":[104],"cells.":[105,177,197],"results":[107],"obtained":[108],"from":[109],"these":[110],"procedures":[111],"demonstrated":[112,205],"that":[113,183],"lipid":[114],"concentration":[115,128],"had":[116],"significant":[118],"positive":[119],"impact":[120],"%EE,":[125],"whereas":[126],"cholesterol":[127],"showed":[129,157,170],"reduction":[131],"in":[132,195,215,221],"%EE.":[133],"%EE":[138],"found":[143],"be":[145],"147.76":[146],"\u00b1":[147,152],"2.14":[148],"nm":[149],"69.18":[151],"3.62%,":[153],"respectively.":[154],"Optimized":[155],"sustained":[159],"release":[160],"profile":[161],"drug.":[164],"In":[165],"vitro":[166],"evaluation":[168],"studies":[169],"have":[172],"good":[173],"biocompatibility":[174],"with":[175,217],"study":[181,203],"revealed":[182],"induced":[185],"osteoblast":[186],"differentiation":[187],"which":[188],"improved":[189,218],"formation":[191],"nodules":[194],"outcome":[199],"conclusively":[204],"potential":[207],"QbD":[210],"concept":[211],"build":[213],"quality":[214],"osteoanabolic":[219],"therapy":[220],"osteoporosis.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-11-15T00:00:00"}