{"id":"https://openalex.org/W4308678751","doi":"https://doi.org/10.1080/14656566.2022.2141569","title":"Efficacy and safety of Tregopil, a novel, ultra-rapid acting oral prandial insulin analog, as part of a basal-bolus regimen in type 2 diabetes: a randomized, active-controlled phase 2/3 study","display_name":"Efficacy and safety of Tregopil, a novel, ultra-rapid acting oral prandial insulin analog, as part of a basal-bolus regimen in type 2 diabetes: a randomized, active-controlled phase 2/3 study","publication_year":2022,"publication_date":"2022-11-02","ids":{"openalex":"https://openalex.org/W4308678751","doi":"https://doi.org/10.1080/14656566.2022.2141569","pmid":"https://pubmed.ncbi.nlm.nih.gov/36352762"},"language":"en","primary_location":{"id":"doi:10.1080/14656566.2022.2141569","doi":"https://doi.org/10.1080/14656566.2022.2141569","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14656566.2022.2141569","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2022/02/15/2022.02.15.22270708.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112247910","display_name":"Harold E. Lebovitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold E Lebovitz","raw_affiliation_strings":["Department of Medicine, State University of New York Health Science Center at Brooklyn, Brooklyn, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, State University of New York Health Science Center at Brooklyn, Brooklyn, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108481774","display_name":"Alexander Fleming","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Fleming","raw_affiliation_strings":["Kinexum Services LLC, Harpers Ferry, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kinexum Services LLC, Harpers Ferry, WV, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048059210","display_name":"Alan D. Cherrington","orcid":"https://orcid.org/0000-0001-8927-2560","observed_orcids":["https://orcid.org/0000-0001-8927-2560"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan D Cherrington","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine-Basic Sciences, Nashville, TENN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine-Basic Sciences, Nashville, TENN, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033769407","display_name":"Shashank Joshi","orcid":"https://orcid.org/0000-0002-0990-5821","observed_orcids":["https://orcid.org/0000-0002-0990-5821","https://orcid.org/0000-0003-2741-5022"]},"institutions":[{"id":"https://openalex.org/I2800084889","display_name":"Lilavati Hospital & Research Centre","ror":"https://ror.org/00rm3wf49","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800084889"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shashank Joshi","raw_affiliation_strings":["Consultant Endocrinologist, Joshi Clinic and Lilavati Hospital, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Endocrinologist, Joshi Clinic and Lilavati Hospital, Mumbai, India","institution_ids":["https://openalex.org/I2800084889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071740303","display_name":"Sandeep N. Athalye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143327","display_name":"Biocon (India)","ror":"https://ror.org/047kynf18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210143327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandeep N Athalye","raw_affiliation_strings":["Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210143327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041082309","display_name":"Subramanian Loganathan","orcid":"https://orcid.org/0000-0001-7186-0049","observed_orcids":["https://orcid.org/0000-0001-7186-0049"]},"institutions":[{"id":"https://openalex.org/I4210143327","display_name":"Biocon (India)","ror":"https://ror.org/047kynf18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210143327"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Subramanian Loganathan","raw_affiliation_strings":["Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0001-7186-0049","affiliations":[{"raw_affiliation_string":"Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210143327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048525102","display_name":"Ashwini Vishweswaramurthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143327","display_name":"Biocon (India)","ror":"https://ror.org/047kynf18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210143327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashwini Vishweswaramurthy","raw_affiliation_strings":["Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210143327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104909617","display_name":"Jayanti Panda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143327","display_name":"Biocon (India)","ror":"https://ror.org/047kynf18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210143327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jayanti Panda","raw_affiliation_strings":["Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210143327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075141813","display_name":"Ashwani Marwah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143327","display_name":"Biocon (India)","ror":"https://ror.org/047kynf18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210143327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashwani Marwah","raw_affiliation_strings":["Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development and Medical Affairs, Biocon Biologics Limited, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210143327"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5041082309"],"corresponding_institution_ids":["https://openalex.org/I4210143327"],"apc_list":null,"apc_paid":null,"fwci":2.969,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.91651941,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"16","first_page":"1855","last_page":"1863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-aspart","display_name":"insulin aspart","score":0.890999972820282},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.972000002861023},{"id":"https://openalex.org/keywords/multiple-daily-injections","display_name":"multiple daily insulin injections","score":0.9279999732971191},{"id":"https://openalex.org/keywords/postprandial-glycemic-control","display_name":"postprandial glucose control","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/insulin-glargine","display_name":"insulin glargine","score":0.7870000004768372},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8468302488327026},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.8413048386573792},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6702687740325928},{"id":"https://openalex.org/C2779908123","wikidata":"https://www.wikidata.org/wiki/Q2754775","display_name":"Insulin aspart","level":4,"score":0.6439850330352783},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5866835713386536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.580893337726593},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47632962465286255},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.45020121335983276},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.44295886158943176},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.37161707878112793},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34314459562301636}],"mesh":[{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D061267","descriptor_name":"Insulin Aspart","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/14656566.2022.2141569","doi":"https://doi.org/10.1080/14656566.2022.2141569","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14656566.2022.2141569","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"doi:10.1101/2022.02.15.22270708","doi":"https://doi.org/10.1101/2022.02.15.22270708","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.02.15.22270708","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/02/15/2022.02.15.22270708.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:36352762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36352762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on pharmacotherapy","raw_type":"Randomized Controlled Trial"}],"best_oa_location":{"id":"doi:10.1101/2022.02.15.22270708","doi":"https://doi.org/10.1101/2022.02.15.22270708","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.02.15.22270708","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/02/15/2022.02.15.22270708.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310069","display_name":"Biocon","ror":"https://ror.org/047kynf18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308678751.pdf","grobid_xml":"https://content.openalex.org/works/W4308678751.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1820763965","https://openalex.org/W2009042585","https://openalex.org/W2014856755","https://openalex.org/W2073977794","https://openalex.org/W2076693232","https://openalex.org/W2079118015","https://openalex.org/W2082504721","https://openalex.org/W2093145852","https://openalex.org/W2112851047","https://openalex.org/W2117343153","https://openalex.org/W2127854940","https://openalex.org/W2139306665","https://openalex.org/W2139993114","https://openalex.org/W2145428270","https://openalex.org/W2170700107","https://openalex.org/W2170897377","https://openalex.org/W2281837728","https://openalex.org/W2292946576","https://openalex.org/W2335829884","https://openalex.org/W2585623369","https://openalex.org/W2765125109","https://openalex.org/W2786036177","https://openalex.org/W3185968027","https://openalex.org/W4212929213","https://openalex.org/W4213149640","https://openalex.org/W4213210402","https://openalex.org/W4237478041"],"related_works":["https://openalex.org/W4409377206","https://openalex.org/W2809524082","https://openalex.org/W2809057090","https://openalex.org/W2612230287","https://openalex.org/W2968262147","https://openalex.org/W3014035905","https://openalex.org/W3039681635","https://openalex.org/W4289778809","https://openalex.org/W2132308332","https://openalex.org/W2029761237"],"abstract_inverted_index":{"Background":[0],"Efficacy":[1],"and":[2,27,30,42,64,87,95,151],"safety":[3],"of":[4],"ultra-rapid":[5],"acting":[6],"oral":[7],"prandial":[8,184],"insulin":[9,14,25],"Tregopil":[10,53,111,127,158,173,179],"was":[11,71,170],"compared":[12],"with":[13,19,38,172,186],"aspart":[15],"(IAsp)":[16],"in":[17,76,110,122],"patients":[18,37],"type":[20],"2":[21],"diabetes":[22],"(T2D)":[23],"on":[24],"glargine":[26],"metformin.Research":[28],"design":[29],"methods":[31],"In":[32],"this":[33],"open-label,":[34],"active-controlled":[35],"trial,":[36],"T2D,":[39],"HbA1c":[40,77,103],"\u22657%\u2013\u22649%":[41],"2-h":[43],"postprandial":[44,192,200],"glucose":[45],"(PPG)":[46],"\u2265180":[47],"mg/dL":[48,145],"were":[49,194,202],"randomized":[50],"1:1:1":[51],"to":[52,196],"(30":[54,113],"mg,":[55,60],"n":[56,61,66],"=":[57,62,67,149],"30;":[58],"45":[59,116],"31)":[63],"IAsp,":[65,197],"30.":[68],"Primary":[69],"outcome":[70],"change":[72],"from":[73,90],"baseline":[74],"(CFB)":[75],"at":[78,107,162,209],"week":[79,108],"24.":[80],"Secondary":[81],"outcomes":[82],"included":[83],"PPG":[84,88,153],"excursion":[85],"(PPGE)":[86],"assessed":[89],"standardized":[91],"test":[92],"meal":[93],"(STM)":[94],"9-point":[96],"self-monitored":[97],"blood":[98],"glucose.Results":[99],"The":[100,205],"observed":[101],"mean":[102],"did":[104],"not":[105],"improve":[106],"24":[109],"groups":[112],"mg":[114,117],"[0.15%],":[115],"[0.22%]":[118],"vs.":[119],"a":[120],"reduction":[121],"IAsp":[123,135,175],"group":[124,128],"[\u22120.77%]).":[125],"Combined":[126],"showed":[129,159],"better":[130,156],"1-h":[131,152],"PPGE":[132,161],"control":[133],"versus":[134,165],"following":[136],"STM":[137],"(CFB,":[138],"estimated":[139],"treatment":[140],"difference,":[141],"95%":[142],"CI,":[143],"\u221245.33":[144],"[\u221271.91,":[146],"\u221218.75],":[147],"p":[148],"0.001)":[150],"trended":[154],"toward":[155],"control.":[157],"lower":[160,171],"15":[163],"min":[164],"IAsp.":[166],"Clinically":[167],"significant":[168],"hypoglycemia":[169],"versus.":[174],"(rate":[176],"ratio:":[177],"0.69).Conclusions":[178],"demonstrated":[180],"an":[181],"ultrafast,":[182],"short-duration":[183],"profile":[185],"good":[187],"safety.":[188],"While":[189],"Tregopil\u2019s":[190],"early":[191],"effects":[193,201],"comparable":[195],"its":[198],"late":[199],"inferior.Trial":[203],"registration":[204],"trial":[206],"is":[207],"registered":[208],"ClinicalTrials.gov":[210],"(CT.gov":[211],"identifier:":[212],"NCT03430856).":[213]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-11-14T00:00:00"}
