{"id":"https://openalex.org/W4308632672","doi":"https://doi.org/10.1146/annurev-pathol-042320-112212","title":"Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage","display_name":"Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage","publication_year":2022,"publication_date":"2022-11-09","ids":{"openalex":"https://openalex.org/W4308632672","doi":"https://doi.org/10.1146/annurev-pathol-042320-112212","pmid":"https://pubmed.ncbi.nlm.nih.gov/36351364","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10443898"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-pathol-042320-112212","doi":"https://doi.org/10.1146/annurev-pathol-042320-112212","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-pathol-042320-112212","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-pathol-042320-112212","source":{"id":"https://openalex.org/S188288600","display_name":"Annual Review of Pathology Mechanisms of Disease","issn_l":"1553-4006","issn":["1553-4006","1553-4014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pathology: Mechanisms of Disease","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-pathol-042320-112212","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077722450","display_name":"Maya E. Kotas","orcid":"https://orcid.org/0000-0002-8102-6346","observed_orcids":["https://orcid.org/0000-0002-8102-6346"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maya E. Kotas","raw_affiliation_strings":["Department of Medicine, University of California, San Francisco, California, USA","Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088871275","display_name":"Claire E. O\u2019Leary","orcid":"https://orcid.org/0000-0001-9052-4593","observed_orcids":["https://orcid.org/0000-0001-9052-4593"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire E. O'Leary","raw_affiliation_strings":["Current affiliation: Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison, Wisconsin, USA","Department of Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current affiliation: Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066993086","display_name":"Richard M. Locksley","orcid":"https://orcid.org/0000-0002-5468-6867","observed_orcids":["https://orcid.org/0000-0002-5468-6867"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard M. Locksley","raw_affiliation_strings":["Department of Medicine, University of California, San Francisco, California, USA","Department of Microbiology and Immunology, University of California, San Francisco, California, USA;","Howard Hughes Medical Institute, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of California, San Francisco, California, USA;","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066993086"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":0.8403,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.68395462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"18","issue":"1","first_page":"311","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuft-cells","display_name":"tuft cells","score":1.0},{"id":"https://openalex.org/keywords/cell-lineage","display_name":"cell lineage","score":0.5550000071525574},{"id":"https://openalex.org/keywords/antimicrobial-response","display_name":"antimicrobial response","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.9679999947547913},{"id":"https://openalex.org/keywords/epithelial-progenitors","display_name":"epithelial progenitors","score":0.8989999890327454},{"id":"https://openalex.org/keywords/transcriptional-programs","display_name":"transcriptional programs","score":0.6039999723434448},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7491967082023621},{"id":"https://openalex.org/C2777128398","wikidata":"https://www.wikidata.org/wiki/Q7851514","display_name":"Tuft","level":2,"score":0.6220784783363342},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.598476767539978},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5307267904281616},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4861183166503906},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.47342970967292786},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.47273293137550354},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4676363468170166},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43468040227890015},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.40541404485702515},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3827870190143585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23038294911384583},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09328505396842957},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1146/annurev-pathol-042320-112212","doi":"https://doi.org/10.1146/annurev-pathol-042320-112212","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-pathol-042320-112212","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-pathol-042320-112212","source":{"id":"https://openalex.org/S188288600","display_name":"Annual Review of Pathology Mechanisms of Disease","issn_l":"1553-4006","issn":["1553-4006","1553-4014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pathology: Mechanisms of Disease","raw_type":"journal-article"},{"id":"pmid:36351364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36351364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10443898","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10443898","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10443898/pdf/nihms-1923264.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Pathol","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2n65h3x2","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2n65h3x2","pdf_url":"https://escholarship.org/content/qt2n65h3x2/qt2n65h3x2.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annual Review of Pathology Mechanisms of Disease, vol 18, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1146/annurev-pathol-042320-112212","doi":"https://doi.org/10.1146/annurev-pathol-042320-112212","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-pathol-042320-112212","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-pathol-042320-112212","source":{"id":"https://openalex.org/S188288600","display_name":"Annual Review of Pathology Mechanisms of Disease","issn_l":"1553-4006","issn":["1553-4006","1553-4014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pathology: Mechanisms of Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4771216566","display_name":"Development and Function of Biliary Tuft Cells","funder_award_id":"F32DK121476","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5518156640","display_name":"Exploring the biology of persistent type 2 airway niches in asthma","funder_award_id":"P01HL107202","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6067177262","display_name":"Parasite immunity orchestrated by type 2 immune cells","funder_award_id":"R01AI026918","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7164229690","display_name":"Role of ILC2s in lung maintenance and repair","funder_award_id":"F32HL140868","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000913216","display_name":"Defining the role of tuft cells in allergic airway disease","funder_award_id":"K08HL155490","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306960","display_name":"A.P. Giannini Foundation","ror":"https://ror.org/01e3cnp62"},{"id":"https://openalex.org/F4320311186","display_name":"Giannini Foundation of Agricultural Economics","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308632672.pdf","grobid_xml":"https://content.openalex.org/works/W4308632672.grobid-xml"},"referenced_works_count":156,"referenced_works":["https://openalex.org/W1604616389","https://openalex.org/W1928972520","https://openalex.org/W1965859904","https://openalex.org/W1969482535","https://openalex.org/W1972871598","https://openalex.org/W1976133370","https://openalex.org/W1993508399","https://openalex.org/W1996543394","https://openalex.org/W2011789333","https://openalex.org/W2014911043","https://openalex.org/W2024121049","https://openalex.org/W2024748688","https://openalex.org/W2030398384","https://openalex.org/W2031062487","https://openalex.org/W2034697578","https://openalex.org/W2036927671","https://openalex.org/W2045281071","https://openalex.org/W2049038291","https://openalex.org/W2049300468","https://openalex.org/W2051244361","https://openalex.org/W2058189469","https://openalex.org/W2090279335","https://openalex.org/W2098090155","https://openalex.org/W2099051314","https://openalex.org/W2102032782","https://openalex.org/W2102882793","https://openalex.org/W2121171425","https://openalex.org/W2148132881","https://openalex.org/W2159291539","https://openalex.org/W2168671905","https://openalex.org/W2170342544","https://openalex.org/W2172061376","https://openalex.org/W2191813810","https://openalex.org/W2233158352","https://openalex.org/W2257201151","https://openalex.org/W2278768857","https://openalex.org/W2392895344","https://openalex.org/W2441337908","https://openalex.org/W2483248188","https://openalex.org/W2511665693","https://openalex.org/W2526568965","https://openalex.org/W2562236228","https://openalex.org/W2606735514","https://openalex.org/W2613078538","https://openalex.org/W2622254410","https://openalex.org/W2729843964","https://openalex.org/W2731177171","https://openalex.org/W2742044309","https://openalex.org/W2747595071","https://openalex.org/W2752506026","https://openalex.org/W2767423581","https://openalex.org/W2768413599","https://openalex.org/W2769220533","https://openalex.org/W2770880161","https://openalex.org/W2795229823","https://openalex.org/W2796954509","https://openalex.org/W2799094919","https://openalex.org/W2799871094","https://openalex.org/W2800773914","https://openalex.org/W2802153632","https://openalex.org/W2804651205","https://openalex.org/W2807333794","https://openalex.org/W2810630532","https://openalex.org/W2884303970","https://openalex.org/W2884680369","https://openalex.org/W2884767481","https://openalex.org/W2887886950","https://openalex.org/W2890689561","https://openalex.org/W2890828844","https://openalex.org/W2895548037","https://openalex.org/W2898786204","https://openalex.org/W2912913685","https://openalex.org/W2917132599","https://openalex.org/W2923551021","https://openalex.org/W2946627380","https://openalex.org/W2946718631","https://openalex.org/W2949711298","https://openalex.org/W2949885749","https://openalex.org/W2950891712","https://openalex.org/W2950975031","https://openalex.org/W2975559569","https://openalex.org/W2978071231","https://openalex.org/W2989690151","https://openalex.org/W2991005529","https://openalex.org/W2996279389","https://openalex.org/W2999110625","https://openalex.org/W2999168977","https://openalex.org/W2999722641","https://openalex.org/W3000625295","https://openalex.org/W3002202609","https://openalex.org/W3004163308","https://openalex.org/W3005514031","https://openalex.org/W3005551106","https://openalex.org/W3011692913","https://openalex.org/W3014740024","https://openalex.org/W3015908474","https://openalex.org/W3019097584","https://openalex.org/W3022532838","https://openalex.org/W3025913138","https://openalex.org/W3026537720","https://openalex.org/W3043034559","https://openalex.org/W3045098572","https://openalex.org/W3045953207","https://openalex.org/W3067105683","https://openalex.org/W3082278286","https://openalex.org/W3082964856","https://openalex.org/W3092907419","https://openalex.org/W3097328475","https://openalex.org/W3105022111","https://openalex.org/W3106000943","https://openalex.org/W3114988636","https://openalex.org/W3115769387","https://openalex.org/W3122187093","https://openalex.org/W3130542942","https://openalex.org/W3131547751","https://openalex.org/W3132168345","https://openalex.org/W3132844032","https://openalex.org/W3133141459","https://openalex.org/W3136594074","https://openalex.org/W3141787002","https://openalex.org/W3152512829","https://openalex.org/W3159762970","https://openalex.org/W3164574885","https://openalex.org/W3165378303","https://openalex.org/W3167178977","https://openalex.org/W3183467323","https://openalex.org/W3184145854","https://openalex.org/W3185540294","https://openalex.org/W3186681892","https://openalex.org/W3208526442","https://openalex.org/W3208737039","https://openalex.org/W3208838878","https://openalex.org/W3209475442","https://openalex.org/W3210924496","https://openalex.org/W3210937792","https://openalex.org/W3211767641","https://openalex.org/W3215965634","https://openalex.org/W4205163701","https://openalex.org/W4205281453","https://openalex.org/W4207045354","https://openalex.org/W4213096223","https://openalex.org/W4220669973","https://openalex.org/W4220734210","https://openalex.org/W4221000305","https://openalex.org/W4221070479","https://openalex.org/W4221108618","https://openalex.org/W4224221954","https://openalex.org/W4225165950","https://openalex.org/W4225398111","https://openalex.org/W4225884586","https://openalex.org/W4280571090","https://openalex.org/W4281382047","https://openalex.org/W4294991033","https://openalex.org/W4296325306","https://openalex.org/W4296583677","https://openalex.org/W4388002248"],"related_works":["https://openalex.org/W4416666904","https://openalex.org/W4224289044","https://openalex.org/W4404839831","https://openalex.org/W2924053568","https://openalex.org/W3097328475","https://openalex.org/W4402863781","https://openalex.org/W2917159052","https://openalex.org/W2799871094","https://openalex.org/W7162082935","https://openalex.org/W2946627380"],"abstract_inverted_index":{"Tuft":[0],"cells":[1,81,100],"are":[2,106],"found":[3],"in":[4,58,121],"tissues":[5],"with":[6,101],"distinct":[7],"stem":[8],"cell":[9,125],"compartments,":[10],"tissue":[11,59],"architecture,":[12],"and":[13,34,55,88,129],"luminal":[14],"exposures":[15],"but":[16],"converge":[17],"on":[18,37,41],"a":[19],"shared":[20],"transcriptional":[21],"program,":[22],"including":[23],"expression":[24],"of":[25,44,46,52,79],"taste":[26],"transduction":[27],"signaling":[28],"pathways.":[29],"Here,":[30],"we":[31,92],"summarize":[32],"seminal":[33],"recent":[35],"findings":[36],"tuft":[38,62,80,99,124],"cells,":[39],"focusing":[40],"major":[42],"categories":[43],"function-instigation":[45],"type":[47],"2":[48],"cytokine":[49],"responses,":[50,54],"orchestration":[51],"antimicrobial":[53],"emerging":[56],"roles":[57],"repair-and":[60],"describe":[61],"cell-derived":[63],"molecules":[64],"used":[65],"to":[66],"affect":[67],"these":[68],"functional":[69],"programs.":[70],"We":[71],"review":[72],"what":[73],"is":[74],"known":[75],"about":[76],"the":[77],"development":[78],"from":[82],"epithelial":[83],"progenitors":[84],"under":[85],"homeostatic":[86],"conditions":[87],"during":[89],"disease.":[90],"Finally,":[91],"discuss":[93],"evidence":[94],"that":[95],"immature,":[96],"or":[97,114],"nascent,":[98],"potential":[102],"for":[103],"diverse":[104],"functions":[105],"driven":[107],"toward":[108],"dominant":[109],"effector":[110],"programs":[111],"by":[112],"tissue-":[113],"perturbation-specific":[115],"contextual":[116],"cues,":[117],"which":[118],"may":[119],"result":[120],"heterogeneous":[122],"mature":[123],"phenotypes":[126],"both":[127],"within":[128],"between":[130],"tissues.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-11-13T00:00:00"}