{"id":"https://openalex.org/W4308564833","doi":"https://doi.org/10.1155/2022/2104880","title":"Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event-Related Potential","display_name":"Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event-Related Potential","publication_year":2022,"publication_date":"2022-11-08","ids":{"openalex":"https://openalex.org/W4308564833","doi":"https://doi.org/10.1155/2022/2104880","pmid":"https://pubmed.ncbi.nlm.nih.gov/36398135","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9666049"},"language":"en","primary_location":{"id":"doi:10.1155/2022/2104880","doi":"https://doi.org/10.1155/2022/2104880","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/2104880","pdf_url":"https://downloads.hindawi.com/journals/np/2022/2104880.pdf","source":{"id":"https://openalex.org/S185020647","display_name":"Neural Plasticity","issn_l":"1687-5443","issn":["1687-5443","2090-5904"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Plasticity","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/np/2022/2104880.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007748241","display_name":"John Olichney","orcid":"https://orcid.org/0009-0008-6640-7563","observed_orcids":["https://orcid.org/0009-0008-6640-7563"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Olichney","raw_affiliation_strings":["Center for Mind and Brain, University of California, Davis, Davis, CA, USA","Department of Neurology, University of California, Davis, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mind and Brain, University of California, Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Neurology, University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078786415","display_name":"Jiangyi Xia","orcid":"https://orcid.org/0000-0002-2246-2631","observed_orcids":["https://orcid.org/0000-0002-2246-2631"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiangyi Xia","raw_affiliation_strings":["Center for Mind and Brain, University of California, Davis, Davis, CA, USA","Department of Neurology, University of California, Davis, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mind and Brain, University of California, Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Neurology, University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001229778","display_name":"Kevin J. Church","orcid":"https://orcid.org/0000-0003-1261-7035","observed_orcids":["https://orcid.org/0000-0003-1261-7035"]},"institutions":[{"id":"https://openalex.org/I4210102871","display_name":"Athira Pharma (United States)","ror":"https://ror.org/01e1qb944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102871"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Church","raw_affiliation_strings":["Athira Pharma, Inc., Bothell, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Athira Pharma, Inc., Bothell, WA, USA","institution_ids":["https://openalex.org/I4210102871"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002356360","display_name":"Hans J. Moebius","orcid":"https://orcid.org/0000-0002-6311-0157","observed_orcids":["https://orcid.org/0000-0002-6311-0157"]},"institutions":[{"id":"https://openalex.org/I4210102871","display_name":"Athira Pharma (United States)","ror":"https://ror.org/01e1qb944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102871"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hans J. Moebius","raw_affiliation_strings":["Athira Pharma, Inc., Bothell, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6311-0157","affiliations":[{"raw_affiliation_string":"Athira Pharma, Inc., Bothell, WA, USA","institution_ids":["https://openalex.org/I4210102871"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002356360"],"corresponding_institution_ids":["https://openalex.org/I4210102871"],"apc_list":{"value":2830,"currency":"USD","value_usd":2830},"apc_paid":{"value":2830,"currency":"USD","value_usd":2830},"fwci":1.3584,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.80898438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"2022","issue":null,"first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p300-event-related-potential","display_name":"P300 event-related potential","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cognitive-biomarkers","display_name":"cognitive biomarkers","score":0.9049999713897705},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8999999761581421},{"id":"https://openalex.org/keywords/surrogate-markers","display_name":"surrogate markers","score":0.8149999976158142},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.6050000190734863},{"id":"https://openalex.org/keywords/p300-latency","display_name":"P300 latency","score":0.8220000267028809},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.7749999761581421},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"EEG","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cognitive-impairment-progression","display_name":"cognitive impairment progression","score":0.7450000047683716},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.770879864692688},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6386451125144958},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6223362684249878},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.5530366897583008},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5429747700691223},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5277367830276489},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4810924232006073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4749210774898529},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4385646879673004},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.41779080033302307},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41469722986221313},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40561726689338684},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2596338391304016},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.25344377756118774},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17201054096221924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018913","descriptor_name":"Event-Related Potentials, P300","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1155/2022/2104880","doi":"https://doi.org/10.1155/2022/2104880","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/2104880","pdf_url":"https://downloads.hindawi.com/journals/np/2022/2104880.pdf","source":{"id":"https://openalex.org/S185020647","display_name":"Neural Plasticity","issn_l":"1687-5443","issn":["1687-5443","2090-5904"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Plasticity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9666049","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9666049","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Plast","raw_type":"Text"},{"id":"pmid:36398135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36398135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural plasticity","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d447a06ff1024a6b9279d91802588e75","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d447a06ff1024a6b9279d91802588e75","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neural Plasticity, Vol 2022 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2022/2104880","doi":"https://doi.org/10.1155/2022/2104880","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/2104880","pdf_url":"https://downloads.hindawi.com/journals/np/2022/2104880.pdf","source":{"id":"https://openalex.org/S185020647","display_name":"Neural Plasticity","issn_l":"1687-5443","issn":["1687-5443","2090-5904"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Plasticity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G560953562","display_name":"Longitudinal Cognitive ERP studies: Advancement for AD Clinical Trials","funder_award_id":"R01AG048252","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308564833.pdf","grobid_xml":"https://content.openalex.org/works/W4308564833.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W336763887","https://openalex.org/W1499839459","https://openalex.org/W1905761500","https://openalex.org/W1908689422","https://openalex.org/W1965975645","https://openalex.org/W1974294921","https://openalex.org/W1974472707","https://openalex.org/W1976102438","https://openalex.org/W1980593516","https://openalex.org/W1981851389","https://openalex.org/W1983258883","https://openalex.org/W1986610543","https://openalex.org/W1987061142","https://openalex.org/W1987068036","https://openalex.org/W1988303256","https://openalex.org/W1988416430","https://openalex.org/W1997146742","https://openalex.org/W2001215523","https://openalex.org/W2002313059","https://openalex.org/W2002766546","https://openalex.org/W2004125846","https://openalex.org/W2004431052","https://openalex.org/W2005933475","https://openalex.org/W2006074147","https://openalex.org/W2007726724","https://openalex.org/W2008116354","https://openalex.org/W2008626135","https://openalex.org/W2011443351","https://openalex.org/W2017785191","https://openalex.org/W2022167326","https://openalex.org/W2023435925","https://openalex.org/W2026298079","https://openalex.org/W2029028291","https://openalex.org/W2046241542","https://openalex.org/W2046936062","https://openalex.org/W2049278187","https://openalex.org/W2049320707","https://openalex.org/W2049445666","https://openalex.org/W2049584306","https://openalex.org/W2051187326","https://openalex.org/W2057427474","https://openalex.org/W2059274090","https://openalex.org/W2063414869","https://openalex.org/W2064059030","https://openalex.org/W2064828227","https://openalex.org/W2069252545","https://openalex.org/W2077545887","https://openalex.org/W2080417590","https://openalex.org/W2082429191","https://openalex.org/W2089488143","https://openalex.org/W2091176863","https://openalex.org/W2092188436","https://openalex.org/W2094168665","https://openalex.org/W2095200583","https://openalex.org/W2095817882","https://openalex.org/W2097238420","https://openalex.org/W2102919438","https://openalex.org/W2102989840","https://openalex.org/W2105531001","https://openalex.org/W2105850078","https://openalex.org/W2107025363","https://openalex.org/W2114759739","https://openalex.org/W2116658855","https://openalex.org/W2117320030","https://openalex.org/W2120613434","https://openalex.org/W2121255954","https://openalex.org/W2129020745","https://openalex.org/W2137535664","https://openalex.org/W2141353749","https://openalex.org/W2145349005","https://openalex.org/W2155101755","https://openalex.org/W2159019462","https://openalex.org/W2160107924","https://openalex.org/W2167840686","https://openalex.org/W2168334242","https://openalex.org/W2186118805","https://openalex.org/W2339593431","https://openalex.org/W2346816744","https://openalex.org/W2395269282","https://openalex.org/W2403623328","https://openalex.org/W2496393055","https://openalex.org/W2518788015","https://openalex.org/W2563148843","https://openalex.org/W2603268278","https://openalex.org/W2610795807","https://openalex.org/W2612594570","https://openalex.org/W2735311168","https://openalex.org/W2740614417","https://openalex.org/W2745570192","https://openalex.org/W2755571042","https://openalex.org/W2760109299","https://openalex.org/W2767711842","https://openalex.org/W2791470905","https://openalex.org/W2798059479","https://openalex.org/W2903280503","https://openalex.org/W2906105053","https://openalex.org/W2914144149","https://openalex.org/W2942812535","https://openalex.org/W2963100704","https://openalex.org/W2969011625","https://openalex.org/W2974165126","https://openalex.org/W2997245841","https://openalex.org/W3022798786","https://openalex.org/W3040892386","https://openalex.org/W3085465572","https://openalex.org/W3092454327","https://openalex.org/W3112551195","https://openalex.org/W3113027022","https://openalex.org/W3119530595","https://openalex.org/W3122326283","https://openalex.org/W3136985640","https://openalex.org/W3152590429","https://openalex.org/W3159973816","https://openalex.org/W3173562357","https://openalex.org/W3175181240","https://openalex.org/W3176123863","https://openalex.org/W3195042026","https://openalex.org/W3197098889","https://openalex.org/W3200521760","https://openalex.org/W3200856680","https://openalex.org/W3205596058","https://openalex.org/W4200435398","https://openalex.org/W4213146203","https://openalex.org/W4250910084","https://openalex.org/W6740773356"],"related_works":["https://openalex.org/W2304724352","https://openalex.org/W7162876816","https://openalex.org/W2059274090","https://openalex.org/W2126592553","https://openalex.org/W3209366877","https://openalex.org/W2906105053","https://openalex.org/W2485205424","https://openalex.org/W7051980008","https://openalex.org/W1978336504","https://openalex.org/W2137615441"],"abstract_inverted_index":{"Neurodegenerative":[0],"diseases,":[1],"such":[2,96],"as":[3,60,62,97,132,198,217],"Alzheimer's":[4],"disease":[5],"(AD),":[6],"and":[7,29,107,112,114,173,204,241],"their":[8],"associated":[9],"deterioration":[10],"of":[11,17,23,34,42,57,82,105,125,141,152,189,195],"cognitive":[12,239],"function":[13],"are":[14,73,110],"common":[15],"causes":[16],"disability.":[18],"The":[19,164],"slowly":[20],"developing":[21],"pathology":[22],"neurodegenerative":[24],"diseases":[25],"necessitates":[26],"early":[27,43],"diagnosis":[28,44],"monitored":[30],"long-term":[31],"treatment.":[32,244],"Lack":[33],"effective":[35],"therapies":[36],"coupled":[37],"with":[38,229],"an":[39,51],"improved":[40],"rate":[41,81],"in":[45,78,143,187,201,225,227],"our":[46],"aging":[47],"population":[48],"have":[49],"created":[50],"urgent":[52],"need":[53,64],"for":[54,65,68,76,136,146,222],"the":[55,63,80,123,126,138,150,185,192,233],"development":[56,145],"novel":[58],"drugs,":[59],"well":[61],"reliable":[66],"biomarkers":[67],"treatment":[69],"response.":[70],"These":[71],"issues":[72],"especially":[74],"relevant":[75],"AD,":[77],"which":[79],"clinical":[83,144],"trial":[84],"drug":[85,243],"failures":[86],"has":[87,181],"been":[88,182],"very":[89],"high.":[90],"Frequently":[91],"used":[92],"biomarker":[93,135,200],"evaluation":[94],"procedures,":[95],"positron":[98],"emission":[99],"tomography":[100],"or":[101,118],"cerebrospinal":[102],"fluid":[103],"measurements":[104],"phospho-tau":[106],"amyloid":[108],"beta,":[109],"invasive":[111],"costly,":[113],"not":[115],"universally":[116],"available":[117],"accessible.":[119],"This":[120],"review":[121],"considers":[122],"functionality":[124],"event-related":[127],"potential":[128,140,193],"(ERP)":[129],"P300":[130,159,165,179,197,215],"methodology":[131],"a":[133,199,218],"surrogate":[134],"predicting":[137],"procognitive":[139],"drugs":[142],"neurocognitive":[147],"disorders.":[148],"Through":[149],"application":[151],"standardized":[153],"electroencephalography":[154],"(EEG)":[155],"described":[156],"here,":[157],"ERP":[158,178,196,214],"can":[160],"be":[161],"reliably":[162],"measured.":[163],"waveform":[166],"objectively":[167],"measures":[168],"large-scale":[169],"neuronal":[170],"network":[171],"functioning":[172],"working":[174],"memory":[175],"processes.":[176],"Increased":[177],"latency":[180,216],"reported":[183],"throughout":[184],"literature":[186],"disorders":[188],"cognition,":[190],"supporting":[191],"utility":[194],"many":[202],"neurological":[203],"neuropsychiatric":[205],"disorders,":[206],"including":[207],"AD.":[208],"Specifically,":[209],"evidence":[210],"presented":[211],"here":[212],"supports":[213],"quantitative,":[219],"unbiased":[220],"measure":[221],"detecting":[223],"changes":[224],"cognition":[226],"patients":[228],"AD":[230],"dementia":[231],"through":[232],"progression":[234],"from":[235],"mild":[236],"to":[237],"moderate":[238],"impairment":[240],"after":[242]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-12T00:00:00"}