{"id":"https://openalex.org/W4308554161","doi":"https://doi.org/10.1158/2643-3230.bcd-22-0007","title":"Distinct Genetically Determined Origins of Myd88 / BCL2 -Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies","display_name":"Distinct Genetically Determined Origins of Myd88 / BCL2 -Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies","publication_year":2022,"publication_date":"2022-11-07","ids":{"openalex":"https://openalex.org/W4308554161","doi":"https://doi.org/10.1158/2643-3230.bcd-22-0007","pmid":"https://pubmed.ncbi.nlm.nih.gov/36346827","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9816818"},"language":"en","primary_location":{"id":"doi:10.1158/2643-3230.bcd-22-0007","doi":"https://doi.org/10.1158/2643-3230.bcd-22-0007","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.bcd-22-0007","pdf_url":null,"source":{"id":"https://openalex.org/S4210239195","display_name":"Blood Cancer Discovery","issn_l":"2643-3230","issn":["2643-3230","2643-3249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1158/2643-3230.bcd-22-0007","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012506836","display_name":"Ruth Fl\u00fcmann","orcid":"https://orcid.org/0000-0002-7147-7557","observed_orcids":["https://orcid.org/0000-0002-7147-7557"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ruth Fl\u00fcmann","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","5Max Planck Institute for Biology of Ageing, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7147-7557","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"5Max Planck Institute for Biology of Ageing, Cologne, Germany","institution_ids":["https://openalex.org/I4210153965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039171181","display_name":"Julia Hansen","orcid":"https://orcid.org/0000-0001-7828-1269","observed_orcids":["https://orcid.org/0000-0001-7828-1269"]},"institutions":[{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Hansen","raw_affiliation_strings":["5Max Planck Institute for Biology of Ageing, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7828-1269","affiliations":[{"raw_affiliation_string":"5Max Planck Institute for Biology of Ageing, Cologne, Germany","institution_ids":["https://openalex.org/I4210153965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016367718","display_name":"Benedikt W. Pelzer","orcid":"https://orcid.org/0000-0002-1892-3650","observed_orcids":["https://orcid.org/0000-0002-1892-3650"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Benedikt W. Pelzer","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","6Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-1892-3650","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"6Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048948327","display_name":"Pascal Nieper","orcid":"https://orcid.org/0000-0003-0607-3561","observed_orcids":["https://orcid.org/0000-0003-0607-3561"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pascal Nieper","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0607-3561","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049889438","display_name":"Tim Lohmann","orcid":"https://orcid.org/0000-0002-3216-0784","observed_orcids":["https://orcid.org/0000-0002-3216-0784"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Lohmann","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3216-0784","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026425216","display_name":"Ilmars Kisis","orcid":"https://orcid.org/0000-0001-6207-3991","observed_orcids":["https://orcid.org/0000-0001-6207-3991"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ilmars Kisis","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6207-3991","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033924154","display_name":"Tobias Ri\u00ebt","orcid":"https://orcid.org/0000-0002-8211-7071","observed_orcids":["https://orcid.org/0000-0002-8211-7071"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Riet","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8211-7071","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061725234","display_name":"Viktoria Kohlhas","orcid":"https://orcid.org/0000-0001-8133-1001","observed_orcids":["https://orcid.org/0000-0001-8133-1001"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Viktoria Kohlhas","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8133-1001","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080354347","display_name":"Phuong\u2010Hien Nguyen","orcid":"https://orcid.org/0000-0002-3249-7264","observed_orcids":["https://orcid.org/0000-0002-3249-7264"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Phuong-Hien Nguyen","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3249-7264","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068488866","display_name":"Martin Peifer","orcid":"https://orcid.org/0000-0002-5243-5503","observed_orcids":["https://orcid.org/0000-0002-5243-5503"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Peifer","raw_affiliation_strings":["2Center for Molecular Medicine, University of Cologne, Cologne, Germany","7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5243-5503","affiliations":[{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036973535","display_name":"Nima Abedpour","orcid":"https://orcid.org/0000-0002-2933-8035","observed_orcids":["https://orcid.org/0000-0002-2933-8035"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nima Abedpour","raw_affiliation_strings":["2Center for Molecular Medicine, University of Cologne, Cologne, Germany","7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2933-8035","affiliations":[{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082867904","display_name":"Graziella Bosco","orcid":"https://orcid.org/0000-0001-6601-4518","observed_orcids":["https://orcid.org/0000-0001-6601-4518"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Graziella Bosco","raw_affiliation_strings":["7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6601-4518","affiliations":[{"raw_affiliation_string":"7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058511375","display_name":"Roman Kurt Thomas","orcid":"https://orcid.org/0000-0001-9132-4876","observed_orcids":["https://orcid.org/0000-0001-9132-4876"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roman K. Thomas","raw_affiliation_strings":["7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9132-4876","affiliations":[{"raw_affiliation_string":"7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026085333","display_name":"Moritz Kochanek","orcid":"https://orcid.org/0000-0001-6879-9996","observed_orcids":["https://orcid.org/0000-0001-6879-9996"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Moritz Kochanek","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6879-9996","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027437406","display_name":"Jacqueline Kn\u00fcfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jacqueline Kn\u00fcfer","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089411144","display_name":"Lorenz Jonigkeit","orcid":"https://orcid.org/0000-0003-1059-8977","observed_orcids":["https://orcid.org/0000-0003-1059-8977"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lorenz Jonigkeit","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1059-8977","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036966030","display_name":"Filippo Beleggia","orcid":"https://orcid.org/0000-0003-0234-7094","observed_orcids":["https://orcid.org/0000-0003-0234-7094"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Filippo Beleggia","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0234-7094","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"7Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002388229","display_name":"Alessandra M. E. Holzem","orcid":"https://orcid.org/0000-0002-3241-3446","observed_orcids":["https://orcid.org/0000-0002-3241-3446"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alessandra Holzem","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3241-3446","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006712577","display_name":"Reinhard B\u00fcttner","orcid":"https://orcid.org/0000-0001-8806-4786","observed_orcids":["https://orcid.org/0000-0001-8806-4786"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhard B\u00fcttner","raw_affiliation_strings":["8Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8806-4786","affiliations":[{"raw_affiliation_string":"8Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003729966","display_name":"Philipp Lohneis","orcid":"https://orcid.org/0000-0002-4797-0018","observed_orcids":["https://orcid.org/0000-0002-4797-0018"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Lohneis","raw_affiliation_strings":["8Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4797-0018","affiliations":[{"raw_affiliation_string":"8Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003738338","display_name":"J\u00f6rn Meinel","orcid":"https://orcid.org/0000-0003-2224-2580","observed_orcids":["https://orcid.org/0000-0003-2224-2580"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rn Meinel","raw_affiliation_strings":["8Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2224-2580","affiliations":[{"raw_affiliation_string":"8Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016691886","display_name":"Monika Ortmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Monika Ortmann","raw_affiliation_strings":["8Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014839908","display_name":"Thors\ufefften Persigehl","orcid":"https://orcid.org/0000-0001-5928-4405","observed_orcids":["https://orcid.org/0000-0001-5928-4405"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thorsten Persigehl","raw_affiliation_strings":["9Department of Radiology and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5928-4405","affiliations":[{"raw_affiliation_string":"9Department of Radiology and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077834","display_name":"Michael J. Hallek","orcid":"https://orcid.org/0000-0002-7425-4455","observed_orcids":["https://orcid.org/0000-0002-7425-4455"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Hallek","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7425-4455","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039656907","display_name":"Dinis Pedro Calado","orcid":"https://orcid.org/0000-0001-8239-7184","observed_orcids":["https://orcid.org/0000-0001-8239-7184"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dinis Pedro Calado","raw_affiliation_strings":["10The Francis Crick Institute, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-8239-7184","affiliations":[{"raw_affiliation_string":"10The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039167759","display_name":"Markus Martin Chmielewski","orcid":"https://orcid.org/0000-0001-9348-5219","observed_orcids":["https://orcid.org/0000-0001-9348-5219"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Chmielewski","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9348-5219","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067129030","display_name":"Sebastian Klein","orcid":"https://orcid.org/0000-0002-2188-9377","observed_orcids":["https://orcid.org/0000-0002-2188-9377"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Klein","raw_affiliation_strings":["11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2188-9377","affiliations":[{"raw_affiliation_string":"11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4391767962","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083112108","display_name":"Joachim Rudolf G\u00f6thert","orcid":"https://orcid.org/0000-0001-8957-6732","observed_orcids":["https://orcid.org/0000-0001-8957-6732"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim R. G\u00f6thert","raw_affiliation_strings":["11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8957-6732","affiliations":[{"raw_affiliation_string":"11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4391767962","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074215180","display_name":"Bjoern Chapuy","orcid":"https://orcid.org/0000-0002-6485-8773","observed_orcids":["https://orcid.org/0000-0002-6485-8773","https://orcid.org/0000-0002-0886-9769"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bjoern Chapuy","raw_affiliation_strings":["12Department of Hematology, Oncology and Tumorimmunology, Charit\u00e9, University Medical Center Berlin, Campus Benjamin Franklin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6485-8773","affiliations":[{"raw_affiliation_string":"12Department of Hematology, Oncology and Tumorimmunology, Charit\u00e9, University Medical Center Berlin, Campus Benjamin Franklin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050253682","display_name":"Branko Zevnik","orcid":"https://orcid.org/0000-0001-7845-9522","observed_orcids":["https://orcid.org/0000-0001-7845-9522"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Branko Zevnik","raw_affiliation_strings":["2Center for Molecular Medicine, University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7845-9522","affiliations":[{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072937215","display_name":"Frank Thomas Wunderlich","orcid":"https://orcid.org/0000-0002-9209-3501","observed_orcids":["https://orcid.org/0000-0002-9209-3501"]},"institutions":[{"id":"https://openalex.org/I4210110850","display_name":"Max Planck Institute for Metabolism Research","ror":"https://ror.org/0199g0r92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210110850"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Thomas Wunderlich","raw_affiliation_strings":["13Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9209-3501","affiliations":[{"raw_affiliation_string":"13Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany","institution_ids":["https://openalex.org/I4210110850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040054777","display_name":"Bastian von Tresckow","orcid":"https://orcid.org/0000-0003-1410-4487","observed_orcids":["https://orcid.org/0000-0003-1410-4487"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bastian von Tresckow","raw_affiliation_strings":["11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1410-4487","affiliations":[{"raw_affiliation_string":"11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4391767962","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028710105","display_name":"Ron Daniel Jachimowicz","orcid":"https://orcid.org/0000-0001-9522-7061","observed_orcids":["https://orcid.org/0000-0001-9522-7061"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ron D. Jachimowicz","raw_affiliation_strings":["1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","2Center for Molecular Medicine, University of Cologne, Cologne, Germany","3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","5Max Planck Institute for Biology of Ageing, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9522-7061","affiliations":[{"raw_affiliation_string":"1Department I of Internal Medicine, Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"2Center for Molecular Medicine, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"4Mildred Scheel School of Oncology, Aachen Bonn Cologne D\u00fcsseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"5Max Planck Institute for Biology of Ageing, Cologne, Germany","institution_ids":["https://openalex.org/I4210153965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019770989","display_name":"Ari M. Melnick","orcid":"https://orcid.org/0000-0002-8074-2287","observed_orcids":["https://orcid.org/0000-0002-8074-2287"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ari M. Melnick","raw_affiliation_strings":["6Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-8074-2287","affiliations":[{"raw_affiliation_string":"6Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030035319","display_name":"Hans Christian Reinhardt","orcid":"https://orcid.org/0000-0001-5706-9349","observed_orcids":["https://orcid.org/0000-0001-5706-9349"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hans Christian Reinhardt","raw_affiliation_strings":["11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5706-9349","affiliations":[{"raw_affiliation_string":"11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4391767962","https://openalex.org/I62318514"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046660376","display_name":"Gero Knittel","orcid":"https://orcid.org/0000-0001-8395-3701","observed_orcids":["https://orcid.org/0000-0001-8395-3701"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gero Knittel","raw_affiliation_strings":["11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8395-3701","affiliations":[{"raw_affiliation_string":"11Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, West German Cancer Center, German Cancer Consortium (DKTK partner site Essen), Center for Molecular Biotechnology, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4391767962","https://openalex.org/I62318514"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5030035319"],"corresponding_institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4391767962","https://openalex.org/I62318514"],"apc_list":null,"apc_paid":null,"fwci":2.1641,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.88047181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"78","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/myd88-mutation","display_name":"MYD88 mutation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9330000281333923},{"id":"https://openalex.org/keywords/blimp-1","display_name":"Blimp-1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/spib","display_name":"Spi-B","score":0.9800000190734863},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cd19-car-t-cell-therapy","display_name":"CD19 CAR T-cell therapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mouse-lymphoma-model","display_name":"mouse lymphoma model","score":0.703000009059906},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.720266580581665},{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.7094079256057739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.617636501789093},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.5919146537780762},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5702441930770874},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.47662460803985596},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.44987714290618896},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.43301212787628174},{"id":"https://openalex.org/C2781214270","wikidata":"https://www.wikidata.org/wiki/Q4692282","display_name":"Aggressive lymphoma","level":4,"score":0.43247953057289124},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.4177413582801819},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.414247989654541},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3337131142616272},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.28045257925987244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26413604617118835},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2556079626083374},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.21214386820793152},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1949160099029541},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1856609582901001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18406552076339722},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.14613234996795654},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14438313245773315}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010950","descriptor_name":"Plasma Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010950","descriptor_name":"Plasma Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1158/2643-3230.bcd-22-0007","doi":"https://doi.org/10.1158/2643-3230.bcd-22-0007","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.bcd-22-0007","pdf_url":null,"source":{"id":"https://openalex.org/S4210239195","display_name":"Blood Cancer Discovery","issn_l":"2643-3230","issn":["2643-3230","2643-3249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Discovery","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9816818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9816818","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Discov","raw_type":"Text"},{"id":"pmid:36346827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36346827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood cancer discovery","raw_type":"Editorial"},{"id":"pmh:oai:figshare.com:article/21879165","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Distinct_genetically_determined_origins_of_Myd88_Bcl2-driven_aggressive_lymphoma_rationalize_targeted_therapeutic_intervention_strategies_/21879165","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.25418/crick.21879165","doi":"https://doi.org/10.25418/crick.21879165","is_oa":true,"landing_page_url":"https://doi.org/10.25418/crick.21879165","pdf_url":null,"source":{"id":"https://openalex.org/S7407051354","display_name":"The Francis Crick Institute","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801081054","host_organization_name":"The Francis Crick Institute","host_organization_lineage":["https://openalex.org/I2801081054"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25418/crick.21879165.v1","doi":"https://doi.org/10.25418/crick.21879165.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25418/crick.21879165.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407051354","display_name":"The Francis Crick Institute","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801081054","host_organization_name":"The Francis Crick Institute","host_organization_lineage":["https://openalex.org/I2801081054"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1158/2643-3230.bcd-22-0007","doi":"https://doi.org/10.1158/2643-3230.bcd-22-0007","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.bcd-22-0007","pdf_url":null,"source":{"id":"https://openalex.org/S4210239195","display_name":"Blood Cancer Discovery","issn_l":"2643-3230","issn":["2643-3230","2643-3249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1172517160","display_name":null,"funder_award_id":"EKFS-2014-A06","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G155567881","display_name":null,"funder_award_id":"e:Med 01ZX1303A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2341771234","display_name":null,"funder_award_id":"SFB1430-A09","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2919460492","display_name":null,"funder_award_id":"CC2078","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G379299795","display_name":null,"funder_award_id":"RE2246/13-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4198881371","display_name":"Mechanisms of mature B-cell tumour pathogenesis and of the interplay between host-immunity and these tumours.","funder_award_id":"MR/J008060/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4898304","display_name":null,"funder_award_id":"SFB1399\u2010A01","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5078730493","display_name":null,"funder_award_id":"16857","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6859473992","display_name":"SFB 1530: Aufkl\u00e4rung und Targeting pathogener Mechanismen bei BZellNeoplasien","funder_award_id":"455784452","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6888785958","display_name":null,"funder_award_id":"10057","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G7740455030","display_name":null,"funder_award_id":"1117240 and 70113041","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"},{"id":"https://openalex.org/G774629903","display_name":null,"funder_award_id":"2016\u2010Kolleg\u201019","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G7758852082","display_name":null,"funder_award_id":"I-65-412.20-2016","funder_id":"https://openalex.org/F4320320947","funder_display_name":"German-Israeli Foundation for Scientific Research and Development"},{"id":"https://openalex.org/G8701471633","display_name":null,"funder_award_id":"70113307","funder_id":"https://openalex.org/F4320323557","funder_display_name":"Dr. Mildred Scheel Stiftung f\u00fcr Krebsforschung"}],"funders":[{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320947","display_name":"German-Israeli Foundation for Scientific Research and Development","ror":"https://ror.org/00tntzp09"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320323557","display_name":"Dr. Mildred Scheel Stiftung f\u00fcr Krebsforschung","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1020989877","https://openalex.org/W1566926046","https://openalex.org/W1970854602","https://openalex.org/W1975593726","https://openalex.org/W1976564639","https://openalex.org/W1980268334","https://openalex.org/W1994470704","https://openalex.org/W2005735929","https://openalex.org/W2018466312","https://openalex.org/W2029525307","https://openalex.org/W2037796411","https://openalex.org/W2043799126","https://openalex.org/W2049790267","https://openalex.org/W2051241958","https://openalex.org/W2082538818","https://openalex.org/W2103563361","https://openalex.org/W2105409819","https://openalex.org/W2108927999","https://openalex.org/W2116031853","https://openalex.org/W2119147717","https://openalex.org/W2122599803","https://openalex.org/W2130997237","https://openalex.org/W2136060045","https://openalex.org/W2144451670","https://openalex.org/W2147246240","https://openalex.org/W2148654292","https://openalex.org/W2150587745","https://openalex.org/W2151558930","https://openalex.org/W2216217499","https://openalex.org/W2310716991","https://openalex.org/W2326263722","https://openalex.org/W2507682680","https://openalex.org/W2518361335","https://openalex.org/W2582696216","https://openalex.org/W2598700764","https://openalex.org/W2735792449","https://openalex.org/W2737103301","https://openalex.org/W2744261860","https://openalex.org/W2762450632","https://openalex.org/W2794376169","https://openalex.org/W2797584152","https://openalex.org/W2800170673","https://openalex.org/W2801763724","https://openalex.org/W2805012568","https://openalex.org/W2809013389","https://openalex.org/W2894667044","https://openalex.org/W2897425209","https://openalex.org/W2948517706","https://openalex.org/W3016044607","https://openalex.org/W3039382149","https://openalex.org/W3040048187","https://openalex.org/W3046812880","https://openalex.org/W3092023747","https://openalex.org/W3097430589","https://openalex.org/W3105850195","https://openalex.org/W3119778789","https://openalex.org/W3158954628","https://openalex.org/W4200201081","https://openalex.org/W4283023614","https://openalex.org/W4283585825"],"related_works":["https://openalex.org/W7045593866","https://openalex.org/W7010997053","https://openalex.org/W3217656995","https://openalex.org/W4310125562","https://openalex.org/W4389736542","https://openalex.org/W4389429900","https://openalex.org/W2326263722","https://openalex.org/W4294771467","https://openalex.org/W2549159623","https://openalex.org/W2944726942"],"abstract_inverted_index":{"Genomic":[0],"profiling":[1],"revealed":[2,183],"the":[3,17,41,94,175,215],"identity":[4],"of":[5,10,43,121,161,177,187,194],"at":[6],"least":[7],"5":[8],"subtypes":[9],"diffuse":[11],"large":[12],"B-cell":[13],"lymphoma":[14],"(DLBCL),":[15],"including":[16],"MCD/C5":[18],"cluster":[19],"characterized":[20],"by":[21,204],"aberrations":[22,39],"in":[23,104,116,119,149,197,214],"MYD88,":[24],"BCL2,":[25],"PRDM1,":[26],"and/or":[27],"SPIB.":[28],"We":[29,49,191],"generated":[30,170],"mouse":[31,171],"models":[32,182],"harboring":[33],"B":[34,72,76,99],"cell-specific":[35],"Prdm1":[36],"or":[37,63],"Spib":[38],"on":[40],"background":[42],"oncogenic":[44],"Myd88":[45],"and":[46,55,74,88,118,142,159],"Bcl2":[47],"lesions.":[48],"deployed":[50],"whole-exome":[51],"sequencing,":[52],"transcriptome,":[53],"flow-cytometry,":[54],"mass":[56],"cytometry":[57],"analyses":[58],"to":[59,145,165],"demonstrate":[60,108],"that":[61,109],"Prdm1-":[62],"Spib-altered":[64],"lymphomas":[65,79,128],"display":[66],"molecular":[67],"features":[68],"consistent":[69],"with":[70,93],"prememory":[71],"cells":[73],"light-zone":[75,87],"cells,":[77],"whereas":[78],"lacking":[80],"these":[81,162],"alterations":[82],"were":[83,129,143],"enriched":[84],"for":[85,97],"late":[86],"plasmablast-associated":[89],"gene":[90],"sets.":[91],"Consistent":[92],"phenotypic":[95],"evidence":[96],"increased":[98],"cell":[100,147],"receptor":[101],"signaling":[102],"activity":[103,115,186,193],"Prdm1-altered":[105,127],"lymphomas,":[106],"we":[107,169],"combined":[110,188],"BTK/BCL2":[111,189],"inhibition":[112],"displays":[113],"therapeutic":[114],"mice":[117],"five":[120],"six":[122],"relapsed/refractory":[123],"DLBCL":[124,153],"patients.":[125,200],"Moreover,":[126],"immunogenic":[130],"upon":[131],"transplantation":[132],"into":[133],"immuno-competent":[134],"hosts,":[135],"displayed":[136],"an":[137],"actionable":[138],"PD-L1":[139],"surface":[140],"expression,":[141],"sensitive":[144],"antimurine-CD19-CAR-T":[146],"therapy,":[148],"vivo.":[150],"SIGNIFICANCE:":[151],"Relapsed/refractory":[152],"remains":[154],"a":[155],"major":[156],"medical":[157],"challenge,":[158],"most":[160],"patients":[163],"succumb":[164],"their":[166],"disease.":[167],"Here,":[168],"models,":[172],"faithfully":[173],"recapitulating":[174],"biology":[176],"MYD88-driven":[178],"human":[179],"DLBCL.":[180],"These":[181],"robust":[184],"preclinical":[185],"inhibition.":[190],"confirmed":[192],"this":[195],"regimen":[196],"pretreated":[198],"non-GCB-DLBCL":[199],"See":[201],"related":[202],"commentary":[203],"Leveille":[205],"et":[206],"al.,":[207],"p.":[208,220],"8.":[209],"This":[210,217],"article":[211],"is":[212],"highlighted":[213],"In":[216],"Issue":[218],"feature,":[219],"1.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-11-12T00:00:00"}
