{"id":"https://openalex.org/W4308549040","doi":"https://doi.org/10.7554/elife.80395","title":"An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria","display_name":"An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria","publication_year":2022,"publication_date":"2022-11-08","ids":{"openalex":"https://openalex.org/W4308549040","doi":"https://doi.org/10.7554/elife.80395","pmid":"https://pubmed.ncbi.nlm.nih.gov/36346214","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9678360"},"language":"en","primary_location":{"id":"doi:10.7554/elife.80395","doi":"https://doi.org/10.7554/elife.80395","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.80395","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.80395","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000516840","display_name":"Kuldeepkumar Ramnaresh Gupta","orcid":"https://orcid.org/0000-0001-7625-4224","observed_orcids":["https://orcid.org/0000-0001-7625-4224"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuldeepkumar R Gupta","raw_affiliation_strings":["Department of Microbial Pathogenesis, Yale University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-7625-4224","affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022178956","display_name":"Celena M. Gwin","orcid":"https://orcid.org/0000-0002-8928-7970","observed_orcids":["https://orcid.org/0000-0002-8928-7970"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celena M Gwin","raw_affiliation_strings":["Department of Microbial Pathogenesis, Yale University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-8928-7970","affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049769284","display_name":"Kathryn C. Rahlwes","orcid":"https://orcid.org/0000-0002-8101-5604","observed_orcids":["https://orcid.org/0000-0002-8101-5604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn C Rahlwes","raw_affiliation_strings":["Department of Microbiology, University of Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071273878","display_name":"Kyle J. Biegas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1629065","display_name":"Central Michigan University","ror":"https://ror.org/02xawj266","country_code":"US","type":"education","lineage":["https://openalex.org/I1629065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle J Biegas","raw_affiliation_strings":["Biochemistry, Cell, and Molecular Biology Program, Central Michigan University","Department of Chemistry and Biochemistry, Central Michigan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, Cell, and Molecular Biology Program, Central Michigan University","institution_ids":["https://openalex.org/I1629065"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Central Michigan University","institution_ids":["https://openalex.org/I1629065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101949047","display_name":"Chunyan Wang","orcid":"https://orcid.org/0000-0002-4254-4570","observed_orcids":["https://orcid.org/0000-0002-4254-4570"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunyan Wang","raw_affiliation_strings":["Department of Microbial Pathogenesis, Yale University School of Medicine","Microbial Sciences Institute, Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Microbial Sciences Institute, Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385855","display_name":"Jinho Park","orcid":"https://orcid.org/0000-0002-7623-2196","observed_orcids":["https://orcid.org/0000-0002-7623-2196"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Ho Park","raw_affiliation_strings":["Department of Microbial Pathogenesis, Yale University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362078","display_name":"Jun Liu","orcid":"https://orcid.org/0000-0003-3108-6735","observed_orcids":["https://orcid.org/0000-0003-3108-6735"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Liu","raw_affiliation_strings":["Department of Microbial Pathogenesis, Yale University School of Medicine","Microbial Sciences Institute, Yale University"],"raw_orcid":"https://orcid.org/0000-0003-3108-6735","affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Microbial Sciences Institute, Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085088306","display_name":"Benjamin M. Swarts","orcid":"https://orcid.org/0000-0001-8402-359X","observed_orcids":["https://orcid.org/0000-0001-8402-359X"]},"institutions":[{"id":"https://openalex.org/I1629065","display_name":"Central Michigan University","ror":"https://ror.org/02xawj266","country_code":"US","type":"education","lineage":["https://openalex.org/I1629065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin M Swarts","raw_affiliation_strings":["Biochemistry, Cell, and Molecular Biology Program, Central Michigan University","Department of Chemistry and Biochemistry, Central Michigan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, Cell, and Molecular Biology Program, Central Michigan University","institution_ids":["https://openalex.org/I1629065"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Central Michigan University","institution_ids":["https://openalex.org/I1629065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037971310","display_name":"Yasu S. Morita","orcid":"https://orcid.org/0000-0002-4514-9242","observed_orcids":["https://orcid.org/0000-0002-4514-9242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasu S Morita","raw_affiliation_strings":["Department of Microbiology, University of Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Massachusetts","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085923008","display_name":"E. Hesper Rego","orcid":"https://orcid.org/0000-0002-2973-8354","observed_orcids":["https://orcid.org/0000-0002-2973-8354"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E Hesper Rego","raw_affiliation_strings":["Department of Microbial Pathogenesis, Yale University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-2973-8354","affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085923008"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":2.3231,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90337019,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0617000013589859,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/polar-growth","display_name":"polar growth","score":0.6320000290870667},{"id":"https://openalex.org/keywords/asymmetric-cell-division","display_name":"asymmetric cell division","score":0.7699999809265137},{"id":"https://openalex.org/keywords/lamas","display_name":"lamas","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mmpl3","display_name":"MmpL3","score":0.9419999718666077},{"id":"https://openalex.org/keywords/trehalose-monomycolate","display_name":"trehalose monomycolate","score":0.925000011920929},{"id":"https://openalex.org/keywords/periplasmic-proteins","display_name":"periplasmic proteins","score":0.7910000085830688},{"id":"https://openalex.org/keywords/lipid-trafficking","display_name":"lipid trafficking","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cell-wall-synthesis","display_name":"cell wall biosynthesis","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.9406387805938721},{"id":"https://openalex.org/C29705727","wikidata":"https://www.wikidata.org/wiki/Q294562","display_name":"Polar","level":2,"score":0.5792558193206787},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5411943197250366},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.42319005727767944},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41639310121536255},{"id":"https://openalex.org/C40069579","wikidata":"https://www.wikidata.org/wiki/Q62494","display_name":"Polar coordinate system","level":2,"score":0.4145451486110687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4120393395423889},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34770017862319946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3143919110298157},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18218809366226196},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1213536262512207},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07311969995498657},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009171","descriptor_name":"Mycolic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019897","descriptor_name":"Periplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033903","descriptor_name":"Periplasmic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.7554/elife.80395","doi":"https://doi.org/10.7554/elife.80395","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.80395","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9678360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9678360","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:36346214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36346214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d2ce6e407dec4b2a9f3a6d527a6e74ef","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d2ce6e407dec4b2a9f3a6d527a6e74ef","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 11 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.80395","doi":"https://doi.org/10.7554/elife.80395","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.80395","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3768210757","display_name":"CAREER: Chemical Tools for Understanding the Mycomembrane of the Corynebacterineae","funder_award_id":"1654408","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5840893283","display_name":"Structural basis of phage infection and DNA ejection","funder_award_id":"R01GM110243","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6069094712","display_name":"\"The molecular mechanisms of asymmetric cell division in mycobacteria.\"","funder_award_id":"R01AI148255","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000865350","display_name":"Structure-Function Relationships in the Spirochetal Flagellar Motor","funder_award_id":"R01AI087946","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306148","display_name":"Pew Charitable Trusts","ror":"https://ror.org/02xhk2825"},{"id":"https://openalex.org/F4320314849","display_name":"Searle Scholars Program","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1981058570","https://openalex.org/W1986130458","https://openalex.org/W1987273310","https://openalex.org/W2005036750","https://openalex.org/W2005548636","https://openalex.org/W2012506575","https://openalex.org/W2034365378","https://openalex.org/W2057497603","https://openalex.org/W2068597581","https://openalex.org/W2095480650","https://openalex.org/W2110760619","https://openalex.org/W2119738836","https://openalex.org/W2122385388","https://openalex.org/W2125301421","https://openalex.org/W2132506910","https://openalex.org/W2133262376","https://openalex.org/W2134621852","https://openalex.org/W2135265913","https://openalex.org/W2142161929","https://openalex.org/W2152257820","https://openalex.org/W2155375392","https://openalex.org/W2165653600","https://openalex.org/W2574984917","https://openalex.org/W2586511962","https://openalex.org/W2586637020","https://openalex.org/W2593511418","https://openalex.org/W2593911600","https://openalex.org/W2617852583","https://openalex.org/W2761029119","https://openalex.org/W2781578389","https://openalex.org/W2789805902","https://openalex.org/W2807016569","https://openalex.org/W2889898520","https://openalex.org/W2913841228","https://openalex.org/W2921540359","https://openalex.org/W2922948832","https://openalex.org/W2941971473","https://openalex.org/W2946530668","https://openalex.org/W2953309325","https://openalex.org/W2954810968","https://openalex.org/W2962771066","https://openalex.org/W2965016808","https://openalex.org/W3015726667","https://openalex.org/W3178720296","https://openalex.org/W3183729560","https://openalex.org/W3184815001","https://openalex.org/W3189251816","https://openalex.org/W4206382093","https://openalex.org/W4220842272","https://openalex.org/W4283585861"],"related_works":["https://openalex.org/W7168283838","https://openalex.org/W1985728186","https://openalex.org/W2617852583","https://openalex.org/W4406686042","https://openalex.org/W2911464480","https://openalex.org/W4392662466","https://openalex.org/W2343291346","https://openalex.org/W4402846361","https://openalex.org/W4367367657","https://openalex.org/W4315754531"],"abstract_inverted_index":{"Mycobacteria,":[0],"including":[1],"the":[2,110,113,148,155,190,213,242,252,259],"human":[3],"pathogen":[4],"Mycobacterium":[5],"tuberculosis":[6],",":[7],"grow":[8],"by":[9,70],"inserting":[10],"new":[11],"cell":[12,103,111,235,253],"wall":[13,104],"material":[14],"at":[15,212],"their":[16],"poles.":[17],"This":[18],"process":[19],"and":[20,59,91,195,234,240],"that":[21,33,65,96,130,136,143,225,241],"of":[22,31,48,63,85,109,117,125,150,192,205,231,245,251,261],"division":[23],"are":[24,196],"asymmetric,":[25],"producing":[26],"a":[27,49,61,83,133,161,165,176,228,255],"phenotypically":[28],"heterogeneous":[29],"population":[30,62],"cells":[32,64,182,217],"respond":[34],"non-uniformly":[35],"to":[36,56,60,106,175,248],"stress":[37],"(Aldridge":[38],"et":[39,43,73],"al.,":[40,44,74],"2012;":[41],"Rego":[42],"2017).":[45,75],"Surprisingly,":[46],"deletion":[47],"single":[50],"gene":[51],"\u2013":[52,54,112],"lamA":[53,219],"leads":[55],"more":[57,67],"symmetry,":[58],"is":[66,132,227,254],"uniformly":[68],"killed":[69],"antibiotics":[71],"(Rego":[72],"How":[76],"does":[77],"LamA":[78,97],"create":[79],"asymmetry?":[80],"Here,":[81],"using":[82],"combination":[84],"quantitative":[86],"time-lapse":[87],"imaging,":[88],"bacterial":[89],"genetics,":[90],"lipid":[92],"profiling,":[93],"we":[94],"find":[95],"recruits":[98],"essential":[99,141],"proteins":[100],"involved":[101],"in":[102,147,168,189,216,238,258],"synthesis":[105],"one":[107,249],"side":[108,250],"old":[114,214],"pole.":[115],"One":[116],"these":[118],"proteins,":[119],"MSMEG_0317,":[120],"here":[121],"renamed":[122],"PgfA,":[123,206],"was":[124],"unknown":[126],"function.":[127],"We":[128],"show":[129],"PgfA":[131,158,185,226],"periplasmic":[134],"protein":[135,247],"interacts":[137,159],"with":[138,160,183],"MmpL3,":[139,209],"an":[140],"transporter":[142],"flips":[144],"mycolic":[145],"acids":[146],"form":[149],"trehalose":[151],"monomycolate":[152],"(TMM),":[153],"across":[154],"plasma":[156],"membrane.":[157],"TMM":[162,169],"analog":[163],"suggesting":[164],"direct":[166],"role":[167],"transport.":[170],"Yet":[171],"our":[172,222],"data":[173],"point":[174],"broader":[177],"function":[178],"as":[179,181],"well,":[180],"altered":[184],"levels":[186],"have":[187],"differences":[188],"abundance":[191],"other":[193],"lipids":[194,201],"differentially":[197],"reliant":[198],"on":[199],"those":[200],"for":[202],"survival.":[203],"Overexpression":[204],"but":[207],"not":[208],"restores":[210],"growth":[211,233],"poles":[215],"missing":[218],".":[220],"Together,":[221],"results":[223],"suggest":[224],"key":[229],"determinant":[230],"polar":[232],"envelope":[236],"composition":[237],"mycobacteria,":[239],"LamA-mediated":[243],"recruitment":[244],"this":[246],"required":[256],"step":[257],"establishment":[260],"cellular":[262],"asymmetry.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-11-12T00:00:00"}