{"id":"https://openalex.org/W4308548733","doi":"https://doi.org/10.1080/17435390.2022.2142169","title":"Nickel nanoparticles induce epithelial-mesenchymal transition in human bronchial epithelial cells via the HIF-1\u03b1/HDAC3 pathway","display_name":"Nickel nanoparticles induce epithelial-mesenchymal transition in human bronchial epithelial cells via the HIF-1\u03b1/HDAC3 pathway","publication_year":2022,"publication_date":"2022-09-14","ids":{"openalex":"https://openalex.org/W4308548733","doi":"https://doi.org/10.1080/17435390.2022.2142169","pmid":"https://pubmed.ncbi.nlm.nih.gov/36345150","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9892310"},"language":"en","primary_location":{"id":"doi:10.1080/17435390.2022.2142169","doi":"https://doi.org/10.1080/17435390.2022.2142169","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17435390.2022.2142169","pdf_url":null,"source":{"id":"https://openalex.org/S193535841","display_name":"Nanotoxicology","issn_l":"1743-5390","issn":["1743-5390","1743-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotoxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9892310","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003794405","display_name":"Jiali Yuan","orcid":"https://orcid.org/0000-0003-2236-0827","observed_orcids":["https://orcid.org/0000-0003-2236-0827"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiali Yuan","raw_affiliation_strings":["Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022706237","display_name":"Yiqun Mo","orcid":"https://orcid.org/0000-0003-2598-9268","observed_orcids":["https://orcid.org/0000-0003-2598-9268"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiqun Mo","raw_affiliation_strings":["Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017244097","display_name":"Yuanbao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanbao Zhang","raw_affiliation_strings":["Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333788","display_name":"Yue Zhang","orcid":"https://orcid.org/0000-0002-3148-8833","observed_orcids":["https://orcid.org/0000-0002-3148-8833"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Zhang","raw_affiliation_strings":["Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003371947","display_name":"Qunwei Zhang","orcid":"https://orcid.org/0000-0001-8609-9192","observed_orcids":["https://orcid.org/0000-0001-8609-9192"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qunwei Zhang","raw_affiliation_strings":["Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003371947"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":0.9128,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.68823766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"16","issue":"6-8","first_page":"695","last_page":"712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.4169999957084656,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.4169999957084656,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.14059999585151672,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.11460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nickel-nanoparticles","display_name":"nickel nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hdac3","display_name":"HDAC3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":1.0},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/beas-2b","display_name":"BEAS-2B","score":0.8669999837875366},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/lung-carcinogenesis","display_name":"lung carcinogenesis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/titanium-dioxide-nanoparticles","display_name":"titanium dioxide nanoparticles","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7775055170059204},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.7598658204078674},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7582879662513733},{"id":"https://openalex.org/C13721689","wikidata":"https://www.wikidata.org/wiki/Q18033475","display_name":"HDAC3","level":5,"score":0.6647273302078247},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.6073020696640015},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.40551772713661194},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3935641646385193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38859403133392334},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3752078115940094},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36202484369277954},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19430330395698547},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.16634634137153625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13281327486038208},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/17435390.2022.2142169","doi":"https://doi.org/10.1080/17435390.2022.2142169","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17435390.2022.2142169","pdf_url":null,"source":{"id":"https://openalex.org/S193535841","display_name":"Nanotoxicology","issn_l":"1743-5390","issn":["1743-5390","1743-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotoxicology","raw_type":"journal-article"},{"id":"pmid:36345150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36345150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotoxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9892310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9892310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanotoxicology","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9892310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9892310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanotoxicology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1427689408","display_name":"Mechanisms underlying metal nanoparticle-induced lung injury and fibrosis","funder_award_id":"R01HL147856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5557517102","display_name":"Mechanisms of carcinogenic effects of nickel nanoparticles","funder_award_id":"R21ES028911","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7566664120","display_name":"The role of microRNA miR-21 in nickel nanoparticles-induced MMPs production","funder_award_id":"R15ES023693","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8204022981","display_name":"University of Louisville Center for Integrative Environmental Health Sciences","funder_award_id":"P30ES030283","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1185736310","https://openalex.org/W1711743004","https://openalex.org/W1965220319","https://openalex.org/W1967850671","https://openalex.org/W1980538516","https://openalex.org/W1993334467","https://openalex.org/W2005088466","https://openalex.org/W2007138098","https://openalex.org/W2009592923","https://openalex.org/W2015545918","https://openalex.org/W2020104547","https://openalex.org/W2022598284","https://openalex.org/W2024486369","https://openalex.org/W2047178549","https://openalex.org/W2051152566","https://openalex.org/W2055660557","https://openalex.org/W2058582218","https://openalex.org/W2072535567","https://openalex.org/W2076511723","https://openalex.org/W2089714089","https://openalex.org/W2103665811","https://openalex.org/W2122368908","https://openalex.org/W2123639306","https://openalex.org/W2129927282","https://openalex.org/W2135935424","https://openalex.org/W2144288460","https://openalex.org/W2147718842","https://openalex.org/W2154589460","https://openalex.org/W2165667685","https://openalex.org/W2167154455","https://openalex.org/W2167611872","https://openalex.org/W2172266351","https://openalex.org/W2286612125","https://openalex.org/W2411683606","https://openalex.org/W2423435882","https://openalex.org/W2471786891","https://openalex.org/W2580243775","https://openalex.org/W2618947559","https://openalex.org/W2671981991","https://openalex.org/W2756480356","https://openalex.org/W2760038547","https://openalex.org/W2792925875","https://openalex.org/W2795208162","https://openalex.org/W2807640716","https://openalex.org/W2883140744","https://openalex.org/W2888790527","https://openalex.org/W2892759967","https://openalex.org/W2912769469","https://openalex.org/W2913481174","https://openalex.org/W2950416140","https://openalex.org/W2967133612","https://openalex.org/W2970795148","https://openalex.org/W3012240350","https://openalex.org/W3014118812","https://openalex.org/W3016840787","https://openalex.org/W3035838036","https://openalex.org/W3043008626","https://openalex.org/W3048942453","https://openalex.org/W3083478401","https://openalex.org/W3084685188","https://openalex.org/W3092039012","https://openalex.org/W3105169752","https://openalex.org/W3113129509","https://openalex.org/W3127399859","https://openalex.org/W3136688855","https://openalex.org/W3155424102","https://openalex.org/W3165288008","https://openalex.org/W3196799895","https://openalex.org/W3201530105","https://openalex.org/W3213214654","https://openalex.org/W4210601794","https://openalex.org/W4220755566","https://openalex.org/W4226365996","https://openalex.org/W4301268755"],"related_works":["https://openalex.org/W2022598284","https://openalex.org/W7165148389","https://openalex.org/W4366262821","https://openalex.org/W2792925875","https://openalex.org/W4390901936","https://openalex.org/W3213214654","https://openalex.org/W3043008626","https://openalex.org/W7117657110","https://openalex.org/W3209384228","https://openalex.org/W3165288008"],"abstract_inverted_index":{"We":[0],"and":[1,14,45,57,81,89,110,154,160,179,196,247],"others":[2],"have":[3],"previously":[4],"demonstrated":[5],"that":[6,63,210],"exposure":[7,64,147,211],"to":[8,29,65,68,121,128,145,201,212],"nickel":[9],"nanoparticles":[10],"(Nano-Ni)":[11],"caused":[12,72],"fibrogenic":[13],"carcinogenic":[15],"effects;":[16],"however,":[17],"the":[18,31,69,77,85,118,132,150,176,215,241],"underlying":[19,47],"mechanisms":[20,48,243],"are":[21],"still":[22],"not":[23,124],"fully":[24],"understood.":[25],"This":[26],"study":[27],"aimed":[28],"investigate":[30],"effects":[32],"of":[33,79,87,95,131,152,158,166,184,217,240,244],"Nano-Ni":[34,96,146,213],"on":[35],"epithelial-mesenchymal":[36],"transition":[37],"(EMT)":[38],"in":[39,53,76,84,97,100,117,125,149,168,193,219],"human":[40,101,220],"bronchial":[41,102,221],"epithelial":[42,103,222],"cells":[43,119,133,223],"(BEAS-2B)":[44],"its":[46],"since":[49],"EMT":[50,98,170,218],"is":[51],"involved":[52],"both":[54],"cancer":[55],"pathogenesis":[56],"tissue":[58],"fibrosis.":[59],"Our":[60,232],"results":[61],"showed":[62],"Nano-Ni,":[66,122],"compared":[67],"control":[70,203],"Nano-TiO2,":[71],"a":[73,135,163],"remarkable":[74],"decrease":[75],"expression":[78,86,200],"E-cadherin":[80,153],"an":[82,92],"increase":[83],"vimentin":[88,159],"\u03b1-SMA,":[90,161],"indicating":[91],"inducible":[93],"role":[94,165],"development":[99,216],"cells.":[104],"HIF-1\u03b1":[105,137,167],"nuclear":[106],"accumulation,":[107],"HDAC3":[108,177,185,230],"upregulation,":[109],"decreased":[111],"histone":[112,181,194,226],"acetylation":[113,195,227],"were":[114],"also":[115,174],"observed":[116],"exposed":[120,127],"but":[123],"those":[126],"Nano-TiO2.":[129],"Pretreatment":[130],"with":[134,186],"specific":[136,187],"inhibitor,":[138],"CAY10585,":[139],"or":[140],"HIF-1\u03b1-specific":[141],"siRNA":[142,188],"transfection":[143],"prior":[144],"resulted":[148],"restoration":[151],"abolished":[155],"Nano-Ni-induced":[156,169,191,245],"upregulation":[157,178],"suggesting":[162],"crucial":[164],"development.":[171],"CAY10585":[172],"pretreatment":[173],"attenuated":[175],"increased":[180],"acetylation.":[182],"Inhibition":[183],"significantly":[189],"restrained":[190],"reduction":[192],"restored":[197],"EMT-related":[198],"protein":[199],"near":[202],"levels.":[204],"In":[205],"summary,":[206],"our":[207],"findings":[208,233],"suggest":[209],"promotes":[214],"by":[224],"decreasing":[225],"through":[228],"HIF-1\u03b1-mediated":[229],"upregulation.":[231],"may":[234],"provide":[235],"information":[236],"for":[237],"further":[238],"understanding":[239],"molecular":[242],"fibrosis":[246],"carcinogenesis.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-12T00:00:00"}
