{"id":"https://openalex.org/W4308439401","doi":"https://doi.org/10.3389/fonc.2022.923679","title":"Therapeutic efficacy of 166Holmium siloxane in microbrachytherapy of induced glioblastoma in minipig tumor model","display_name":"Therapeutic efficacy of 166Holmium siloxane in microbrachytherapy of induced glioblastoma in minipig tumor model","publication_year":2022,"publication_date":"2022-11-07","ids":{"openalex":"https://openalex.org/W4308439401","doi":"https://doi.org/10.3389/fonc.2022.923679","pmid":"https://pubmed.ncbi.nlm.nih.gov/36419904","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9677531"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2022.923679","doi":"https://doi.org/10.3389/fonc.2022.923679","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.923679","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.923679/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.923679/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030404604","display_name":"Mehrdad Khoshnevis","orcid":"https://orcid.org/0000-0003-0609-0898","observed_orcids":["https://orcid.org/0000-0003-0609-0898"]},"institutions":[{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210104684","display_name":"VetAgro Sup","ror":"https://ror.org/01c7wz417","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210104684"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Mehrdad Khoshnevis","raw_affiliation_strings":["Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037420313","display_name":"Richard Brown","orcid":"https://orcid.org/0000-0001-6989-9200","observed_orcids":["https://orcid.org/0000-0001-6989-9200"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Richard Brown","raw_affiliation_strings":["Inserm, UMR1037 CRCT, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, UMR1037 CRCT, Toulouse, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210087620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033276164","display_name":"Sara Belluco","orcid":"https://orcid.org/0000-0002-7209-6879","observed_orcids":["https://orcid.org/0000-0002-7209-6879"]},"institutions":[{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210104684","display_name":"VetAgro Sup","ror":"https://ror.org/01c7wz417","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210104684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sara Belluco","raw_affiliation_strings":["Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039535181","display_name":"Ilyes Zahi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092929","display_name":"Novartis (France)","ror":"https://ror.org/00geypp27","country_code":"FR","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210092929"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ilyes Zahi","raw_affiliation_strings":["Advanced Accelerator Applications, a Novartis Company, Saint-Genis-Pouilly, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Accelerator Applications, a Novartis Company, Saint-Genis-Pouilly, France","institution_ids":["https://openalex.org/I4210092929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026271746","display_name":"Luca Maciocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092929","display_name":"Novartis (France)","ror":"https://ror.org/00geypp27","country_code":"FR","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210092929"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Luca Maciocco","raw_affiliation_strings":["Advanced Accelerator Applications, a Novartis Company, Saint-Genis-Pouilly, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Accelerator Applications, a Novartis Company, Saint-Genis-Pouilly, France","institution_ids":["https://openalex.org/I4210092929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060681461","display_name":"C. Bonnefont","orcid":"https://orcid.org/0000-0002-4059-4961","observed_orcids":["https://orcid.org/0000-0002-4059-4961"]},"institutions":[{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210104684","display_name":"VetAgro Sup","ror":"https://ror.org/01c7wz417","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210104684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Bonnefont-Rebeix","raw_affiliation_strings":["Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006065073","display_name":"Elodie Pillet","orcid":"https://orcid.org/0000-0002-2314-8548","observed_orcids":["https://orcid.org/0000-0002-2314-8548"]},"institutions":[{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210104684","display_name":"VetAgro Sup","ror":"https://ror.org/01c7wz417","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210104684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elodie Pillet-Michelland","raw_affiliation_strings":["Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046793028","display_name":"Jonathan Tranel","orcid":"https://orcid.org/0000-0003-0509-9823","observed_orcids":["https://orcid.org/0000-0003-0509-9823"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jonathan Tranel","raw_affiliation_strings":["Inserm, UMR1037 CRCT, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, UMR1037 CRCT, Toulouse, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210087620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006975425","display_name":"Thierry Roger","orcid":"https://orcid.org/0000-0001-5684-8770","observed_orcids":["https://orcid.org/0000-0001-5684-8770"]},"institutions":[{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210104684","display_name":"VetAgro Sup","ror":"https://ror.org/01c7wz417","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210104684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Roger","raw_affiliation_strings":["Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030700243","display_name":"Christophe Nennig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christophe Nennig","raw_affiliation_strings":["EVEON, 305 rue Aristide Berges, Montbonnot Saint Martin, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EVEON, 305 rue Aristide Berges, Montbonnot Saint Martin, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072519536","display_name":"Patrick Oudoire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Oudoire","raw_affiliation_strings":["EVEON, 305 rue Aristide Berges, Montbonnot Saint Martin, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EVEON, 305 rue Aristide Berges, Montbonnot Saint Martin, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012567188","display_name":"Lionel Marcon","orcid":"https://orcid.org/0000-0002-3190-3224","observed_orcids":["https://orcid.org/0000-0002-3190-3224"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133140","display_name":"Institut Lumi\u00e8re Mati\u00e8re","ror":"https://ror.org/0323bey33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210098836","https://openalex.org/I4210133140","https://openalex.org/I4405259976","https://openalex.org/I4405263940","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lionel Marcon","raw_affiliation_strings":["Institut Lumi\u00e8re Mati\u00e8re, UMR CNRS 5306, UCBL, Campus LyonTech - La Doua, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Lumi\u00e8re Mati\u00e8re, UMR CNRS 5306, UCBL, Campus LyonTech - La Doua, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210133140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105990096","display_name":"Olivier Tillement","orcid":"https://orcid.org/0000-0001-7166-6537","observed_orcids":["https://orcid.org/0000-0001-7166-6537"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133140","display_name":"Institut Lumi\u00e8re Mati\u00e8re","ror":"https://ror.org/0323bey33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210098836","https://openalex.org/I4210133140","https://openalex.org/I4405259976","https://openalex.org/I4405263940","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Tillement","raw_affiliation_strings":["Institut Lumi\u00e8re Mati\u00e8re, UMR CNRS 5306, UCBL, Campus LyonTech - La Doua, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Lumi\u00e8re Mati\u00e8re, UMR CNRS 5306, UCBL, Campus LyonTech - La Doua, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210133140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007058533","display_name":"C\u00e9dric Louis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9dric Louis","raw_affiliation_strings":["Nano-H SAS, 305 rue des Fours, Fontaines Saint Martin, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nano-H SAS, 305 rue des Fours, Fontaines Saint Martin, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037233208","display_name":"H\u00e9l\u00e8ne Gehan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Gehan","raw_affiliation_strings":["Nano-H SAS, 305 rue des Fours, Fontaines Saint Martin, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nano-H SAS, 305 rue des Fours, Fontaines Saint Martin, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068280775","display_name":"Manuel Bardi\u00e8s","orcid":"https://orcid.org/0000-0002-1766-727X","observed_orcids":["https://orcid.org/0000-0002-1766-727X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Manuel Bardi\u00e8s","raw_affiliation_strings":["Inserm, UMR1037 CRCT, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, UMR1037 CRCT, Toulouse, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210087620"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maurizio Mariani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maurizio Mariani","raw_affiliation_strings":["Advanced Accelerator Applications, a Novartis Company, Colleretto Giacosa, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Accelerator Applications, a Novartis Company, Colleretto Giacosa, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091906073","display_name":"Valeria Muzio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valeria Muzio","raw_affiliation_strings":["Advanced Accelerator Applications, a Novartis Company, Colleretto Giacosa, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Accelerator Applications, a Novartis Company, Colleretto Giacosa, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072643028","display_name":"Jean-Philippe Meunier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092929","display_name":"Novartis (France)","ror":"https://ror.org/00geypp27","country_code":"FR","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210092929"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Meunier","raw_affiliation_strings":["Advanced Accelerator Applications, a Novartis Company, Saint-Genis-Pouilly, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Accelerator Applications, a Novartis Company, Saint-Genis-Pouilly, France","institution_ids":["https://openalex.org/I4210092929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056814396","display_name":"Charlotte Duchemin","orcid":"https://orcid.org/0000-0002-3661-7833","observed_orcids":["https://orcid.org/0000-0002-3661-7833"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210127572","display_name":"IMT Atlantique","ror":"https://ror.org/030hj3061","country_code":"FR","type":"education","lineage":["https://openalex.org/I205703379","https://openalex.org/I4210127572"]},{"id":"https://openalex.org/I4210133362","display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules","ror":"https://ror.org/03fd77x13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210133362"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charlotte Duchemin","raw_affiliation_strings":["Subatech, CNRS/IN2P3, IMT Atlantique, Universit\u00e9 de Nantes, Nantes Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Subatech, CNRS/IN2P3, IMT Atlantique, Universit\u00e9 de Nantes, Nantes Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210127572","https://openalex.org/I4210133362","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053414721","display_name":"Nathalie Michel","orcid":"https://orcid.org/0000-0002-5939-6703","observed_orcids":["https://orcid.org/0000-0002-5939-6703"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210127572","display_name":"IMT Atlantique","ror":"https://ror.org/030hj3061","country_code":"FR","type":"education","lineage":["https://openalex.org/I205703379","https://openalex.org/I4210127572"]},{"id":"https://openalex.org/I4210133362","display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules","ror":"https://ror.org/03fd77x13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210133362"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405266032","display_name":"GIP Arronax","ror":"https://ror.org/050nt2059","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4405266032"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Michel","raw_affiliation_strings":["IP Arronax, Saint Herblain, France","Subatech, CNRS/IN2P3, IMT Atlantique, Universit\u00e9 de Nantes, Nantes Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IP Arronax, Saint Herblain, France","institution_ids":["https://openalex.org/I4405266032"]},{"raw_affiliation_string":"Subatech, CNRS/IN2P3, IMT Atlantique, Universit\u00e9 de Nantes, Nantes Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210127572","https://openalex.org/I4210133362","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004758726","display_name":"Estelle N\u2019tsiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210127572","display_name":"IMT Atlantique","ror":"https://ror.org/030hj3061","country_code":"FR","type":"education","lineage":["https://openalex.org/I205703379","https://openalex.org/I4210127572"]},{"id":"https://openalex.org/I4210133362","display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules","ror":"https://ror.org/03fd77x13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210133362"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405266032","display_name":"GIP Arronax","ror":"https://ror.org/050nt2059","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4405266032"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Estelle N\u2019Tsiba","raw_affiliation_strings":["IP Arronax, Saint Herblain, France","Subatech, CNRS/IN2P3, IMT Atlantique, Universit\u00e9 de Nantes, Nantes Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IP Arronax, Saint Herblain, France","institution_ids":["https://openalex.org/I4405266032"]},{"raw_affiliation_string":"Subatech, CNRS/IN2P3, IMT Atlantique, Universit\u00e9 de Nantes, Nantes Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210127572","https://openalex.org/I4210133362","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084897891","display_name":"F\u00e9rid Haddad","orcid":"https://orcid.org/0000-0001-6971-5969","observed_orcids":["https://orcid.org/0000-0001-6971-5969"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210127572","display_name":"IMT Atlantique","ror":"https://ror.org/030hj3061","country_code":"FR","type":"education","lineage":["https://openalex.org/I205703379","https://openalex.org/I4210127572"]},{"id":"https://openalex.org/I4210133362","display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules","ror":"https://ror.org/03fd77x13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210133362"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405266032","display_name":"GIP Arronax","ror":"https://ror.org/050nt2059","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4405266032"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ferid Haddad","raw_affiliation_strings":["IP Arronax, Saint Herblain, France","Subatech, CNRS/IN2P3, IMT Atlantique, Universit\u00e9 de Nantes, Nantes Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IP Arronax, Saint Herblain, France","institution_ids":["https://openalex.org/I4405266032"]},{"raw_affiliation_string":"Subatech, CNRS/IN2P3, IMT Atlantique, Universit\u00e9 de Nantes, Nantes Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210127572","https://openalex.org/I4210133362","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014474356","display_name":"Thierry Buronfosse","orcid":"https://orcid.org/0000-0001-6020-6703","observed_orcids":["https://orcid.org/0000-0001-6020-6703"]},"institutions":[{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210104684","display_name":"VetAgro Sup","ror":"https://ror.org/01c7wz417","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210104684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Buronfosse","raw_affiliation_strings":["Universit\u00e9 de Lyon, VetAgro Sup, Laboratoire de Biologie M\u00e9dicale, Marcy L'Etoile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lyon, VetAgro Sup, Laboratoire de Biologie M\u00e9dicale, Marcy L'Etoile, France","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064791594","display_name":"Claude Carozzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210104684","display_name":"VetAgro Sup","ror":"https://ror.org/01c7wz417","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210104684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Carozzo","raw_affiliation_strings":["Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064450704","display_name":"Fr\u00e9d\u00e9rique Ponce","orcid":"https://orcid.org/0000-0003-0741-0654","observed_orcids":["https://orcid.org/0000-0003-0741-0654"]},"institutions":[{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210104684","display_name":"VetAgro Sup","ror":"https://ror.org/01c7wz417","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210104684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9rique Ponce","raw_affiliation_strings":["Universit\u00e9 de Lyon, VetAgro Sup, Service de Canc\u00e9rologie, Marcy L'Etoile, France","Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lyon, VetAgro Sup, Service de Canc\u00e9rologie, Marcy L'Etoile, France","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, VetAgro Sup, UR ICE, Marcy L'Etoile, France","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5030404604"],"corresponding_institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.1248,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.38798033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"12","issue":null,"first_page":"923679","last_page":"923679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.38769999146461487,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9200000166893005},{"id":"https://openalex.org/keywords/holmium-166","display_name":"holmium-166","score":0.9549999833106995},{"id":"https://openalex.org/keywords/holmium-165","display_name":"holmium-165","score":0.8899999856948853},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.4129999876022339},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7958770990371704},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6699727773666382},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.5488930940628052},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.45599856972694397},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.44596540927886963},{"id":"https://openalex.org/C2777521759","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microparticle","level":2,"score":0.4252828359603882},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41383498907089233},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3520270586013794},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35085198283195496},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34956613183021545},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3201838731765747},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16831037402153015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06325805187225342},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fonc.2022.923679","doi":"https://doi.org/10.3389/fonc.2022.923679","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.923679","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.923679/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9677531","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9677531","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:36419904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36419904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03843369v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-03843369","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, 2022, 12, pp.923679. &#x27E8;10.3389/fonc.2022.923679&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8aada16306dc42f0904f1ec20a17adaf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8aada16306dc42f0904f1ec20a17adaf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2022.923679","doi":"https://doi.org/10.3389/fonc.2022.923679","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.923679","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.923679/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316512","display_name":"Bpifrance","ror":"https://ror.org/008zkt807"},{"id":"https://openalex.org/F4320318385","display_name":"Advanced Accelerator Applications","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308439401.pdf","grobid_xml":"https://content.openalex.org/works/W4308439401.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1560814177","https://openalex.org/W1893588436","https://openalex.org/W1978834636","https://openalex.org/W1996162972","https://openalex.org/W1998941426","https://openalex.org/W2028035236","https://openalex.org/W2029445057","https://openalex.org/W2040283668","https://openalex.org/W2058648826","https://openalex.org/W2061436674","https://openalex.org/W2068634088","https://openalex.org/W2080083059","https://openalex.org/W2091334103","https://openalex.org/W2096287682","https://openalex.org/W2108151310","https://openalex.org/W2128158076","https://openalex.org/W2136733671","https://openalex.org/W2138884296","https://openalex.org/W2139112748","https://openalex.org/W2140991124","https://openalex.org/W2141630574","https://openalex.org/W2143432704","https://openalex.org/W2148311954","https://openalex.org/W2208036228","https://openalex.org/W2333729741","https://openalex.org/W2346084667","https://openalex.org/W2460527749","https://openalex.org/W2503365563","https://openalex.org/W2531634073","https://openalex.org/W2555071250","https://openalex.org/W2590936958","https://openalex.org/W2594000433","https://openalex.org/W2609512644","https://openalex.org/W2725037490","https://openalex.org/W2758395134","https://openalex.org/W2763833914","https://openalex.org/W2795406273","https://openalex.org/W2801206601","https://openalex.org/W2960078024","https://openalex.org/W3006438030","https://openalex.org/W3036238706","https://openalex.org/W3037603513","https://openalex.org/W6739536462"],"related_works":["https://openalex.org/W3036238706","https://openalex.org/W4394799959","https://openalex.org/W16430871","https://openalex.org/W2758395134","https://openalex.org/W2107469984","https://openalex.org/W4410559414","https://openalex.org/W2091334103","https://openalex.org/W2016863832","https://openalex.org/W4392870509","https://openalex.org/W2901788439"],"abstract_inverted_index":{"Glioblastoma":[0],"is":[1,26],"considered":[2],"the":[3,16,22,40,44,82,154,164,186,190,207,224,227,231,238,241,244],"most":[4],"common":[5],"malignant":[6],"primary":[7],"tumor":[8,139,198],"of":[9,15,24,43,59,87,124,126,157,189,226,235,243],"central":[10],"nervous":[11],"system.":[12],"In":[13,47],"spite":[14],"current":[17],"standard":[18],"and":[19,102,144,150,171,180,202],"multimodal":[20],"treatment,":[21],"prognosis":[23],"glioblastoma":[25,45,69],"poor.":[27],"For":[28],"this":[29,48],"reason,":[30],"new":[31],"therapeutic":[32,57,187],"approaches":[33],"need":[34],"to":[35,38,55,115,138,211,223],"be":[36],"developed":[37],"improve":[39],"survival":[41,111,134],"time":[42,112,135],"patient.":[46],"study,":[49],"we":[50],"performed":[51],"a":[52,67,121,212],"preclinical":[53],"experiment":[54],"evaluate":[56],"efficacy":[58,196,208],"166Ho":[60,89,191,214],"microparticle":[61,85,192],"suspension":[62],"administered":[63],"by":[64],"microbrachytherapy":[65],"on":[66,185],"minipig":[68],"model.":[70],"Twelve":[71],"minipigs":[72,128],"were":[73,142],"divided":[74],"in":[75,129,147,197],"3":[76],"groups.":[77],"Minipigs":[78],"had":[79],"injections":[80,239],"into":[81],"tumor,":[83],"containing":[84],"suspensions":[86],"either":[88],"(group":[90,97,105],"1;":[91],"n":[92,99,107],"=":[93,100,108],"6)":[94],"or":[95],"165Ho":[96],"2;":[98],"3)":[101],"control":[103,181],"group":[104,130,158,178],"3;":[106],"3).":[109],"The":[110,132,200,233],"from":[113,136,163],"treatment":[114,137],"euthanasia":[116],"was":[117,160,175,209],"66":[118],"days":[119,146],"with":[120,218],"good":[122],"state":[123],"health":[125],"all":[127],"1.":[131],"median":[133],"related":[140,210],"death":[141],"8.6":[143],"7.3":[145],"groups":[148,167],"2":[149,179],"control,":[151],"respectively.":[152],"Statistically,":[153],"prolonged":[155],"life":[156],"1":[159],"significantly":[161],"different":[162],"two":[165],"other":[166],"(p":[168],"<":[169],"0.01),":[170],"no":[172],"significant":[173],"difference":[174],"observed":[176],"between":[177],"(p=0.09).":[182],"Our":[183],"trial":[184],"effect":[188],"demonstrated":[193],"an":[194,219],"excellent":[195],"control.":[199],"histological":[201],"immunohistochemical":[203],"analysis":[204],"showed":[205],"that":[206],"severe":[213],"induced":[215],"necrosis":[216],"combined":[217],"immune":[220],"response":[221],"due":[222],"presence":[225],"radioactive":[228],"microparticles":[229],"inside":[230],"tumors.":[232],"absence":[234],"reflux":[236],"following":[237],"confirms":[240],"safety":[242],"injection":[245],"device.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-11-11T00:00:00"}
