{"id":"https://openalex.org/W4308399424","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0544","title":"544 Companion diagnostic assays for pembrolizumab in patients with MSI-H/dMMR tumors","display_name":"544 Companion diagnostic assays for pembrolizumab in patients with MSI-H/dMMR tumors","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308399424","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0544"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2022-sitc2022.0544","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0544","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-sitc2022.0544","pdf_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A569.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A569.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065206480","display_name":"Aur\u00e9lien Marabelle","orcid":"https://orcid.org/0000-0002-5816-3019","observed_orcids":["https://orcid.org/0000-0002-5816-3019"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aurelien Marabelle","raw_affiliation_strings":["Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081856892","display_name":"Jeff Cesario","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Cesario","raw_affiliation_strings":["Merck & Co., Inc., Rahway, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, NJ, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lixin Lang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lixin Lang","raw_affiliation_strings":["Merck & Co., Inc., Rahway, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, NJ, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077921482","display_name":"Deepti Aurora-Garg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepti Aurora-Garg","raw_affiliation_strings":["Merck & Co., Inc., Rahway, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, NJ, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021662658","display_name":"Siddhartha Krishan Mathur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddhartha Krishan Mathur","raw_affiliation_strings":["Merck & Co., Inc., Rahway, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, NJ, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072171783","display_name":"Diane J. Levitan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Levitan","raw_affiliation_strings":["Merck & Co., Inc., Rahway, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, NJ, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015848881","display_name":"Deborah Card","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deb Card","raw_affiliation_strings":["Merck & Co., Inc., Rahway, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, NJ, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100538150","display_name":"Fan Jin","orcid":"https://orcid.org/0000-0001-8521-2843","observed_orcids":["https://orcid.org/0000-0001-8521-2843"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Jin","raw_affiliation_strings":["Merck & Co., Inc., Rahway, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, NJ, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080190853","display_name":"David Eli Adelberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Adelberg","raw_affiliation_strings":["Merck & Co., Inc., Rahway, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, NJ, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079480540","display_name":"Thierry Andr\u00e9","orcid":"https://orcid.org/0000-0002-5103-7095","observed_orcids":["https://orcid.org/0000-0002-5103-7095"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Andr\u00e9","raw_affiliation_strings":["Sorbonne University and Saint Antoine Ho, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorbonne University and Saint Antoine Ho, Paris, France","institution_ids":["https://openalex.org/I39804081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087674709","display_name":"Amy K. Wehn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Wehn","raw_affiliation_strings":["Merck & Co., Inc., Rahway, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, NJ, United States","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A569","last_page":"A569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.14839999377727509,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9950000047683716},{"id":"https://openalex.org/keywords/microsatellite-instability-high","display_name":"microsatellite instability-high","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.9290000200271606},{"id":"https://openalex.org/keywords/foundationone-cdx","display_name":"FoundationOne CDx","score":0.9950000047683716},{"id":"https://openalex.org/keywords/assay-concordance","display_name":"assay concordance","score":0.8759999871253967},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.5130000114440918},{"id":"https://openalex.org/keywords/advanced-colorectal-cancer","display_name":"advanced colorectal cancer","score":0.6800000071525574},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.7950000166893005},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.8631462454795837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8170098066329956},{"id":"https://openalex.org/C2780416959","wikidata":"https://www.wikidata.org/wiki/Q22907415","display_name":"Companion diagnostic","level":3,"score":0.7129071950912476},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.6916732788085938},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6783791780471802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6741054058074951},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.5809521079063416},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5587874054908752},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5202823281288147},{"id":"https://openalex.org/C2779115348","wikidata":"https://www.wikidata.org/wiki/Q14911688","display_name":"MSH2","level":5,"score":0.4637582302093506},{"id":"https://openalex.org/C111425858","wikidata":"https://www.wikidata.org/wiki/Q14911708","display_name":"MLH1","level":5,"score":0.43450769782066345},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3372253179550171},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.18842706084251404},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.08010512590408325},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2022-sitc2022.0544","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0544","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-sitc2022.0544","pdf_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A569.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2022-sitc2022.0544","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0544","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-sitc2022.0544","pdf_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A569.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308399424.pdf","grobid_xml":"https://content.openalex.org/works/W4308399424.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7214069847","https://openalex.org/W4402534264","https://openalex.org/W3170450105","https://openalex.org/W2763176328","https://openalex.org/W2900485986","https://openalex.org/W3172525861","https://openalex.org/W2737084095","https://openalex.org/W4296020023","https://openalex.org/W4407789762","https://openalex.org/W2984359187"],"abstract_inverted_index":{"Background":[0],"Pembrolizumab":[1],"is":[2,222],"approved":[3,423],"in":[4,93,224,230,446],"the":[5,40,68,94,104,149,174,203,246,269,293,316,329,350,371,425,447],"United":[6],"States":[7],"for":[8,39,112,209,328],"unresectable":[9],"or":[10,89,100,430],"metastatic":[11],"microsatellite":[12],"instability-high":[13],"(MSI-H)/mismatch":[14],"repair\u2013deficient":[15],"(dMMR)":[16],"solid":[17],"tumors":[18,201,234,335],"that":[19],"progress":[20],"after":[21],"treatment.":[22],"As":[23],"part":[24],"of":[25,42,103,331,389,406],"a":[26,31,177,404],"post-marketing":[27],"commitment,":[28],"we":[29],"conducted":[30],"pan-tumor":[32],"bridging":[33,49],"study":[34,50,96,106,417,435],"to":[35,53,123,193,337,339,349,364,368,444],"determine":[36],"MSI/MMR":[37,124],"status":[38,125],"purpose":[41],"developing":[43],"2":[44,69],"companion":[45,70,128,154,343],"diagnostic":[46,71,129,155,344],"assays.":[47,65],"This":[48,394],"was":[51,73,157,190,259,262,266,283,286,290,305,308,312,381,396],"designed":[52],"evaluate":[54],"clinical":[55,84,150,204,241,247,270,351,372,448],"outcomes":[56],"with":[57,62,78,199,232,333,358],"second-line":[58],"pembrolizumab":[59,113,369],"and":[60,144,153,168,185,250,264,273,288,295,310,318,361,419],"concordance":[61,348,357],"local":[63,83],"enrollment":[64],"Concordance":[66],"between":[67,148],"assays":[72,130,156,298,321,345],"also":[74,191],"assessed.":[75],"Methods":[76],"Patients":[77],"MSI-H/dMMR":[79,200,233,334],"tumors,":[80],"determined":[81,126],"per":[82,119,202],"trial":[85,151,205,242,248,271,352,373],"assay":[86,152,206,249,252,272,276],"(IHC,":[87],"PCR,":[88],"NGS),":[90],"who":[91],"enrolled":[92],"KEYNOTE-164":[95],"(advanced":[97,107],"colorectal":[98],"cancer)":[99,109],"cohort":[101,219],"K":[102],"KEYNOTE-158":[105,218],"non-colorectal":[108],"were":[110,207,228,256,280,302,362,422],"reevaluated":[111],"efficacy":[114,175,210],"(objective":[115],"response":[116],"rate":[117],"[ORR]":[118],"RECIST":[120],"v1.1)":[121],"according":[122],"by":[127,159,383,398,424],"(Roche":[131],"Tissue":[132],"Diagnostics":[133],"MMR":[134],"RxDx":[135],"Panel":[136],"[RTD;":[137],"IHC":[138],"using":[139,173],"MLH1,":[140],"MSH2,":[141],"MSH6,":[142],"PMS2]":[143],"FoundationOne\u00aeCDx":[145],"[NGS]).":[146],"Agreement":[147],"evaluated":[158],"overall":[160],"percent":[161,165,170],"agreement":[162,166,171],"(OPA),":[163],"positive":[164],"(PPA),":[167],"negative":[169],"(NPA)":[172],"population;":[176],"supplemental":[178],"population":[179],"(KEYNOTE":[180],"158":[181],"cohorts":[182],"A-J,":[183],"KEYNOTE-177,":[184],"commercially":[186],"procured":[187],"tumor":[188],"bank)":[189],"used":[192],"assess":[194],"NPA.":[195],"Results":[196],"444":[197],"patients":[198,231,332,439],"analyzed":[208],"(n":[211,253,277,299],"=":[212,216,254,278,300],"123,":[213],"KEYNOTE-164;":[214],"n":[215],"321,":[217],"K).":[220],"ORR":[221],"reported":[223],"table":[225],"1;":[226],"responses":[227],"enriched":[229],"(RTD":[235],"assay:":[236,243],"34.7%;":[237],"FoundationOne":[238,274,296,319],"CDx:":[239],"43.0%;":[240],"31.8%).":[244],"When":[245,268,292],"RTD":[251,294,317],"934)":[255],"compared,":[257,281,303],"OPA":[258,282,304],"90.9%,":[260],"PPA":[261,285,307],"72.0%,":[263],"NPA":[265,289,311],"98.5%.":[267],"CDx":[275,297,320],"1174)":[279],"94.5%,":[284],"69.8%,":[287],"99.3%.":[291],"662)":[301],"95.9%,":[306],"87.0%,":[309],"97.1%.":[313],"Conclusions":[314],"Although":[315],"measure":[322],"different":[323],"analytes,":[324],"they":[325,354],"are":[326],"comparable":[327],"selection":[330],"likely":[336],"respond":[338],"pembrolizumab.":[340],"Despite":[341],"both":[342],"having":[346],"lower":[347],"assay,":[353],"demonstrated":[355],"high":[356],"each":[359,434],"other":[360],"able":[363],"better":[365],"identify":[366],"responders":[367],"than":[370],"assay.":[374],"Acknowledgements":[375],"Medical":[376],"writing":[377],"and/or":[378],"editorial":[379],"assistance":[380,395],"provided":[382,440],"Holly":[384],"C.":[385],"Cappelli,":[386],"PhD,":[387],"CMPP,":[388],"ApotheCom":[390],"(Yardley,":[391],"PA,":[392],"USA).":[393],"funded":[397],"Merck":[399,407],"Sharp":[400],"&":[401,408],"Dohme":[402],"LLC,":[403],"subsidiary":[405],"Co.,":[409],"Inc.,":[410],"Rahway,":[411],"NJ,":[412],"USA.":[413],"Ethics":[414],"Approval":[415],"The":[416],"protocol":[418],"all":[420],"amendments":[421],"relevant":[426],"institutional":[427],"review":[428],"board":[429],"ethics":[431],"committee":[432],"at":[433],"site.":[436],"Consent":[437],"All":[438],"written":[441],"informed":[442],"consent":[443],"participate":[445],"trial.":[449]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-11-11T00:00:00"}