{"id":"https://openalex.org/W4308399178","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.1011","title":"1011 Antibody targeting NKG2D ligands MICA/B to unleash anti-tumor immunity of NK and ILC1 cells","display_name":"1011 Antibody targeting NKG2D ligands MICA/B to unleash anti-tumor immunity of NK and ILC1 cells","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308399178","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.1011"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2022-sitc2022.1011","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.1011","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-sitc2022.1011","pdf_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A1054.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A1054.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101666021","display_name":"Sizhe Liu","orcid":"https://orcid.org/0000-0003-1877-5448","observed_orcids":["https://orcid.org/0000-0003-1877-5448"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sizhe Liu","raw_affiliation_strings":["Northwestern University, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tyler Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Smith","raw_affiliation_strings":["Northwestern University, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100944134","display_name":"Lisha Zhu","orcid":"https://orcid.org/0000-0002-0278-2611","observed_orcids":["https://orcid.org/0000-0002-0278-2611","https://orcid.org/0009-0006-5880-1734"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisha Zhu","raw_affiliation_strings":["Univeristy of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univeristy of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022422325","display_name":"Payal Dhar","orcid":"https://orcid.org/0000-0001-5379-8675","observed_orcids":["https://orcid.org/0000-0001-5379-8675"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Payal Dhar","raw_affiliation_strings":["Northwestern University (*currently affiliated with BMS), Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University (*currently affiliated with BMS), Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101919644","display_name":"Jennifer D. Wu","orcid":"https://orcid.org/0000-0002-8925-268X","observed_orcids":["https://orcid.org/0000-0002-8925-268X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Wu","raw_affiliation_strings":["Northwestern University, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A1054","last_page":"A1054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nkg2d-ligands","display_name":"NKG2D ligands","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mica-b","display_name":"MICA/B","score":0.9399999976158142},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8119999766349792},{"id":"https://openalex.org/keywords/nk-cell-heterogeneity","display_name":"NK cell heterogeneity","score":0.703000009059906},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.828000009059906},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.8240000009536743},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6430000066757202},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.5720000267028809},{"id":"https://openalex.org/keywords/adoptive-nk-cell-therapy","display_name":"adoptive NK cell therapy","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2778867473","wikidata":"https://www.wikidata.org/wiki/Q17544382","display_name":"NKG2D","level":4,"score":0.7957226037979126},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6792212724685669},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6073955297470093},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5420937538146973},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5361672639846802},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5219059586524963},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.5164482593536377},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5007257461547852},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4803370535373688},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43862152099609375},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12498804926872253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2022-sitc2022.1011","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.1011","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-sitc2022.1011","pdf_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A1054.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2022-sitc2022.1011","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.1011","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-sitc2022.1011","pdf_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A1054.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308399178.pdf","grobid_xml":"https://content.openalex.org/works/W4308399178.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W2111728443","https://openalex.org/W2155481271","https://openalex.org/W2172283401","https://openalex.org/W2562858382","https://openalex.org/W2615520798","https://openalex.org/W4239692088","https://openalex.org/W4240688876","https://openalex.org/W6685039603"],"related_works":["https://openalex.org/W2795256310","https://openalex.org/W2567253817","https://openalex.org/W2978216064","https://openalex.org/W2887658661","https://openalex.org/W2964441241","https://openalex.org/W2524421518","https://openalex.org/W4308384987","https://openalex.org/W2593010745","https://openalex.org/W4308407083","https://openalex.org/W4393086613"],"abstract_inverted_index":{"Background":[0],"Natural":[1],"Killer":[2],"(NK)":[3],"cells,":[4,32],"the":[5,33,74,147,290,330],"founding":[6],"member":[7],"of":[8,22,30,35,59,110,133,149,161,168,176,184,191,219,251,304,316,333,362,431,461,472,494,521],"innate":[9,365,402],"lymphoid":[10,366,403],"cells":[11,115,164,198,280,323,367,530],"(ILCs),":[12],"contribute":[13,372],"to":[14,90,106,144,267,298,373],"tumor":[15,152,322,339,427],"control":[16],"via":[17,94,275],"direct":[18],"cytolysis":[19],"and":[20,25,80,112,138,189,204,212,243,259,272,301,412,531],"secretion":[21],"immune-modulatory":[23],"cytokines":[24],"chemokines.":[26],"Despite":[27],"well-characterized":[28],"roles":[29],"NK":[31,79,111,203,242,279,299,462],"involvement":[34],"other":[36],"ILC":[37,55],"family":[38],"members":[39],"in":[40,116,228,269,324,337,341,368,410,426,435],"cancer":[41,120],"is":[42,65],"less":[43],"understood.":[44],"Recent":[45],"reports":[46],"indicate":[47],"that":[48,311,354],"solid":[49],"tumors":[50,167,175,183,190,236],"are":[51,88],"populated":[52],"by":[53,239,545],"heterogenous":[54,241],"subsets.1":[56],"The":[57,171,246,470],"implication":[58],"such":[60],"heterogeneity":[61,303,332,361,409],"for":[62,73],"anti-tumor":[63,108,376],"immunity":[64,109],"not":[66,347],"entirely":[67],"clear.":[68],"MICA/B":[69,87],"serve":[70],"as":[71],"ligands":[72,425],"activating":[75],"receptor":[76],"NKG2D":[77,424],"on":[78,151,209,527],"CD8+":[81,113],"T":[82,114],"cells.":[83],"Yet":[84],"tumor-shed":[85],"soluble":[86,495],"shown":[89,105],"mediate":[91],"immune":[92,153,163,273],"suppression":[93],"multiple":[95],"mechanisms.2":[96],"We":[97,156,215],"designed":[98],"a":[99,117,342,432,522],"MIC-targeting":[100],"antibody":[101],"B10G5":[102,150,295,358],"which":[103,345,370],"was":[104,543],"enhance":[107],"murine":[118,343],"prostate":[119,338,467],"model":[121],"recapitulating":[122],"MIC":[123,356,496],"shedding":[124],"(TRAMP/MICB).3,4":[125],"In":[126],"this":[127],"study":[128],"we":[129,309,352],"performed":[130,157],"single-cell":[131,158],"characterization":[132],"intra-tumoral":[134],"ILCs":[135,336],"from":[136,165,221,318],"untreated":[137,177,185],"B10G5-treated":[139,192],"TRAMP/MICB":[140,169,235],"mice":[141,178,186,193],"(figure":[142],"1)":[143],"better":[145,374],"understand":[146],"effects":[148],"contexture.":[154],"Methods":[155],"RNA":[159],"sequencing":[160],"CD45+":[162],"pooled":[166],"mice.":[170],"samples":[172],"represent":[173],"well-differentiated":[174],"(n":[179],"=":[180],"7),":[181],"poorly-differentiated":[182],"(n=":[187,194],"4),":[188],"3)":[195],"respectively.":[196],"CD3-NK1.1+":[197],"were":[199,237],"further":[200],"sub-clustered":[201],"into":[202],"ILC1":[205,244],"subsets,":[206],"denoted":[207],"based":[208,408],"their":[210,265],"phenotypical":[211],"functional":[213,331],"profiles.":[214],"also":[216],"measured":[217],"cytotoxicity":[218,255,271,315,518],"PBMCs":[220,317],"healthy":[222,319],"donors":[223,320],"stimulated":[224],"with":[225,254,357],"MIC/B10G5":[226],"complexes":[227,313],"vitro":[229],"using":[230],"calcein":[231],"release":[232],"assay.5":[233],"Results":[234],"infiltrated":[238],"functionally":[240],"subsets.":[245],"subsets":[247,405],"exhibited":[248],"distinct":[249],"expression":[250],"genes":[252],"related":[253],"(GZMB,":[256],"PFR1,":[257],"TNFSF10)":[258],"immunomodulation":[260],"(IFNg,":[261],"XCL1,":[262],"CCL5),":[263],"suggesting":[264],"capacity":[266],"engage":[268],"both":[270],"modulation":[274],"diverse":[276],"pathways.":[277],"Notably,":[278],"had":[281],"higher":[282],"perforin":[283],"(PFR1)":[284],"expression,":[285],"whilst":[286],"ILC1s":[287],"exclusively":[288],"expressed":[289],"death":[291],"ligand":[292],"TRAIL":[293],"(TNSF10).":[294],"treatment":[296],"led":[297],"enrichment":[300],"increased":[302],"type":[305,334,363],"I":[306,335,364],"ILCs.":[307],"Lastly,":[308],"showed":[310,353],"sMIC/B10G5":[312],"enhanced":[314],"against":[321],"vitro.":[325],"Conclusions":[326],"Our":[327],"data":[328],"elucidated":[329],"microenvironment":[340],"model,":[344],"has":[346],"been":[348],"previously":[349],"characterized.":[350],"Moreover,":[351],"targeting":[355],"could":[359],"increase":[360],"vivo,":[369],"potentially":[371],"overall":[375],"responses.":[377],"References":[378],"Simoni":[379],"Y,":[380],"Fehlings":[381],"M,":[382],"Kl\u00f8verpris":[383],"HN,":[384],"McGovern":[385],"N,":[386],"Koo":[387],"SL,":[388],"Loh":[389],"CY,":[390],"Lim":[391],"S,":[392,443,455,508],"Kurioka":[393],"A,":[394,512],"Fergusson":[395],"JR,":[396],"Tang":[397],"CL,":[398],"Kam":[399],"MH.":[400],"Human":[401],"cell":[404,463],"possess":[406],"tissue-type":[407],"phenotype":[411],"frequency.":[413],"Immunity":[414],"2017":[415,504],"Jan":[416],"17;46(1):148\u201361.":[417],"Zhang":[418,478],"J,":[419,479],"Basher":[420],"F,":[421],"Wu":[422,458,490],"JD.":[423,459,491],"immunity:":[428],"two":[429],"sides":[430],"coin.":[433],"Frontiers":[434],"Immunology":[436],"2015":[437],"Mar":[438],"4;6:97.":[439],"Liu":[440,480],"G,":[441,483],"Lu":[442],"Wang":[444],"X,":[445],"Page":[446],"ST,":[447],"Higano":[448],"CS,":[449],"Plymate":[450],"SR,":[451],"Greenberg":[452],"NM,":[453],"Sun":[454],"Li":[456,482,488],"Z,":[457,489],"Perturbation":[460],"peripheral":[464],"homeostasis":[465],"accelerates":[466],"carcinoma":[468],"metastasis.":[469],"Journal":[471],"Clinical":[473,533],"Investigation":[474],"2013":[475],"Oct":[476],"1;123(10):4410\u201322.":[477],"D,":[481],"Staveley-O9Carroll":[484],"KF,":[485],"Graff":[486],"JN,":[487],"Antibody-mediated":[492],"neutralization":[493],"significantly":[497],"enhances":[498],"CTLA4":[499],"blockade":[500],"therapy.":[501],"Science":[502],"Advances":[503],"May":[505],"17;3(5):e1602133.":[506],"Neri":[507],"Mariani":[509],"E,":[510],"Meneghetti":[511],"Cattini":[513],"L,":[514],"Facchini":[515],"A.":[516],"Calcein-acetyoxymethyl":[517],"assay:":[519],"standardization":[520],"method":[523],"allowing":[524],"additional":[525],"analyses":[526],"recovered":[528],"effector":[529],"supernatants.":[532],"Diagnostic":[534],"Laboratory":[535],"Immunology.":[536],"2001":[537],"Nov":[538],"1;8(6):1131\u20135":[539],"Ethics":[540,548],"Approval":[541],"STU0020734":[542],"approved":[544],"Northwestern":[546],"University9s":[547],"Board.":[549],"Healthy":[550],"volunteers":[551],"have":[552],"given":[553],"informed":[554],"consent":[555],"before":[556],"taking":[557],"part.":[558]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-11-11T00:00:00"}
