{"id":"https://openalex.org/W4308377273","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0058","title":"58 Examining elevated TMB and clinical benefit of 1L immune checkpoint inhibitor in advanced NSCLC","display_name":"58 Examining elevated TMB and clinical benefit of 1L immune checkpoint inhibitor in advanced NSCLC","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308377273","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0058"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2022-sitc2022.0058","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0058","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-sitc2022.0058","pdf_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A64.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A64.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059652753","display_name":"David Paul Carbone","orcid":"https://orcid.org/0000-0003-3002-1921","observed_orcids":["https://orcid.org/0000-0003-3002-1921"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Carbone","raw_affiliation_strings":["The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054580205","display_name":"Jacob M. Sands","orcid":"https://orcid.org/0000-0003-4663-7464","observed_orcids":["https://orcid.org/0000-0003-4663-7464"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Sands","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044148216","display_name":"Gerald Li","orcid":"https://orcid.org/0000-0002-5617-6262","observed_orcids":["https://orcid.org/0000-0002-5617-6262"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald Li","raw_affiliation_strings":["Foundation Medicine, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062019987","display_name":"Alexa Betzig Schrock","orcid":"https://orcid.org/0000-0003-0106-9096","observed_orcids":["https://orcid.org/0000-0003-0106-9096"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa Schrock","raw_affiliation_strings":["Foundation Medicine, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025819053","display_name":"Ryon P. Graf","orcid":"https://orcid.org/0000-0002-8065-4148","observed_orcids":["https://orcid.org/0000-0002-8065-4148"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryon Graf","raw_affiliation_strings":["Foundation Medicine, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379649","display_name":"Liangliang Zhang","orcid":"https://orcid.org/0000-0002-2501-8819","observed_orcids":["https://orcid.org/0000-0002-2501-8819"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liangliang Zhang","raw_affiliation_strings":["Foundation Medicine, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032382717","display_name":"Karthikeyan Murugesan","orcid":"https://orcid.org/0000-0002-2275-1126","observed_orcids":["https://orcid.org/0000-0002-2275-1126"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karthikeyan Murugesan","raw_affiliation_strings":["Foundation Medicine, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088559019","display_name":"Jeffrey S. Ross","orcid":"https://orcid.org/0000-0001-8494-2596","observed_orcids":["https://orcid.org/0000-0001-8494-2596"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Ross","raw_affiliation_strings":["Foundation Medicine, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066813002","display_name":"Khaled A. Tolba","orcid":"https://orcid.org/0000-0001-5493-1474","observed_orcids":["https://orcid.org/0000-0001-5493-1474"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khaled Tolba","raw_affiliation_strings":["Foundation Medicine, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045665778","display_name":"Geoffrey R. Oxnard","orcid":"https://orcid.org/0000-0003-1054-8240","observed_orcids":["https://orcid.org/0000-0003-1054-8240"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Oxnard","raw_affiliation_strings":["Foundation Medicine, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034444686","display_name":"Richard S.P. Huang","orcid":"https://orcid.org/0000-0001-8395-5168","observed_orcids":["https://orcid.org/0000-0001-8395-5168"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Huang","raw_affiliation_strings":["Foundation Medicine, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018054038","display_name":"David Robert Spigel","orcid":"https://orcid.org/0000-0003-3215-9465","observed_orcids":["https://orcid.org/0000-0003-3215-9465"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Spigel","raw_affiliation_strings":["Sarah Cannon Research Institute, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute, Nashville, TN, USA","institution_ids":["https://openalex.org/I4210100810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A64","last_page":"A64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8539999723434448},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.765999972820282},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8809999823570251},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7229999899864197},{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.6380000114440918},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6809999942779541},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9829999804496765},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5709999799728394},{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.781000018119812},{"id":"https://openalex.org/keywords/comprehensive-genomic-profiling","display_name":"comprehensive genomic profiling","score":0.765999972820282},{"id":"https://openalex.org/keywords/non-squamous-histology","display_name":"non-squamous histology","score":0.8130000233650208},{"id":"https://openalex.org/keywords/treatment-selection","display_name":"treatment selection","score":0.3790000081062317},{"id":"https://openalex.org/keywords/flatiron-health","display_name":"Flatiron Health","score":0.5040000081062317},{"id":"https://openalex.org/keywords/foundation-medicine","display_name":"Foundation Medicine","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6173939108848572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5315259099006653},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5265648365020752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4808105230331421},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.43844446539878845},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4325450658798218},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4096345007419586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19929853081703186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09549328684806824},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.07864800095558167},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2022-sitc2022.0058","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0058","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-sitc2022.0058","pdf_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A64.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2022-sitc2022.0058","doi":"https://doi.org/10.1136/jitc-2022-sitc2022.0058","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-sitc2022.0058","pdf_url":"https://jitc.bmj.com/content/jitc/10/Suppl_2/A64.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308377273.pdf","grobid_xml":"https://content.openalex.org/works/W4308377273.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4317207526","https://openalex.org/W3182921423","https://openalex.org/W3216645156","https://openalex.org/W2970981278","https://openalex.org/W3118366712","https://openalex.org/W4388077092","https://openalex.org/W2889694972","https://openalex.org/W3157770914","https://openalex.org/W3101922870","https://openalex.org/W3137960754"],"abstract_inverted_index":{"Background":[0],"For":[1],"patients":[2,67,82,107,122,248,257],"with":[3,68,249],"advanced":[4,291],"non-small":[5],"cell":[6,101],"lung":[7],"carcinoma":[8],"(NSCLC),":[9],"immune":[10],"check":[11],"point":[12],"inhibitor":[13],"(ICPI)":[14],"and":[15,26,48,94,131,145,170,194,309],"chemotherapy":[16],"(chemo)-ICPI":[17],"represent":[18],"2":[19],"distinct":[20],"first-line":[21,54,288],"standard-of-care":[22],"regimens":[23,120,285],"without":[24,262],"clear":[25],"established":[27],"biomarkers":[28],"to":[29,52,208,283,306],"inform":[30,53],"the":[31,40,71,110,183,226,269,287,300],"optimal":[32],"choice":[33],"for":[34,99,125,286],"individual":[35],"patients.":[36],"Here,":[37],"we":[38,154],"examined":[39],"complementary":[41],"roles":[42],"of":[43,271,277,290,299,313],"tumor":[44,100],"mutational":[45],"burden":[46],"(TMB)":[47],"PD-L1":[49,95,126,185,273],"immunohistochemistry":[50],"(IHC)":[51],"therapy":[55],"using":[56,86],"a":[57,156,200,311],"large":[58],"real-world":[59],"(rw)":[60],"data":[61],"set.":[62],"Methods":[63],"The":[64],"study":[65,235,301,307],"included":[66,108,310],"NSCLC":[69],"from":[70,116],"Flatiron":[72],"Health":[73],"(FH)-Foundation":[74],"Medicine":[75],"(FMI)":[76],"de-identified":[77],"clinico-genomic":[78],"database":[79],"(CGDB).":[80],"All":[81],"underwent":[83],"genomic":[84,90],"testing":[85],"FMI\u2019s":[87],"tissue":[88],"comprehensive":[89],"profiling":[91],"(CGP)":[92],"assay":[93,97],"IHC":[96],"scored":[98],"staining":[102],"(TS).":[103],"Results":[104],"Of":[105],"2,165":[106],"in":[109,159,216,225,258,268],"analysis,":[111],"150":[112],"exhibited":[113],"durable":[114],"benefit":[115],"first":[117],"line":[118],"ICPI":[119,152,209,224,261],"(these":[121],"were":[123],"enriched":[124],"TS":[127],"\u226550,":[128],"non-squamous":[129],"histology,":[130],"TMB":[132,138,142,148,180,189,227,240,252],"\u226520":[133,228,253],"mutations/Megabase":[134],"[muts/Mb]).":[135],"Comparing":[136],"low":[137,184],"(<10":[139],"muts/Mb),":[140,144],"high":[141,147],"(10\u201319":[143],"very":[146],"(\u226520":[149],"muts/Mb)":[150],"receiving":[151],"alone,":[153],"observed":[155,219],"stepwise":[157],"increase":[158,281],"median":[160],"rwPFS":[161,203,217],"(real":[162,172],"world-progression":[163],"free":[164],"survival)":[165,174],"(6.5,":[166],"7.5,":[167],"17.2":[168],"months)":[169,178],"rwOS":[171],"world-overall":[173],"(10.1,":[175],"11.8,":[176],"26.9":[177],"as":[179,243],"increased.":[181],"In":[182],"(TS":[186],"<50%)":[187],"cohort,":[188],"<10":[190],"muts/Mb":[191,196,229,254],"(HR:0.70":[192],"[0.54\u20130.92])":[193],"10\u201319":[195],"(HR:0.48":[197],"[0.32\u20130.72])":[198],"showed":[199],"more":[201],"favorable":[202],"on":[204],"chemoICPI":[205],"when":[206,220],"compared":[207],"alone":[210],"while":[211],"no":[212],"significant":[213],"additional":[214],"increases":[215],"is":[218],"adding":[221],"chemo":[222,263],"onto":[223],"(HR:1.18":[230],"[0.56\u20132.48])":[231],"cohort.":[232],"Conclusions":[233],"This":[234],"provides":[236],"evidence":[237],"that":[238],"higher":[239],"cut-offs,":[241],"such":[242],"20":[244],"muts/Mb,":[245],"can":[246],"identify":[247,256],"prolonged":[250],"benefit.":[251],"may":[255],"whom":[259],"an":[260],"could":[264,280],"be":[265],"considered,":[266],"even":[267],"setting":[270],"lower":[272],"levels.":[274],"Prospective":[275],"validation":[276],"these":[278],"findings":[279],"access":[282],"chemo-sparing":[284],"treatment":[289],"NSCLC.":[292],"Ethics":[293],"Approval":[294],"Institutional":[295],"Review":[296],"Board":[297],"approval":[298],"protocol":[302],"was":[303],"obtained":[304],"prior":[305],"conduct":[308],"waiver":[312],"informed":[314],"consent.":[315]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-11-11T00:00:00"}