{"id":"https://openalex.org/W4308336523","doi":"https://doi.org/10.3389/fdata.2022.1016606","title":"WINNER: A network biology tool for biomolecular characterization and prioritization","display_name":"WINNER: A network biology tool for biomolecular characterization and prioritization","publication_year":2022,"publication_date":"2022-11-04","ids":{"openalex":"https://openalex.org/W4308336523","doi":"https://doi.org/10.3389/fdata.2022.1016606","pmid":"https://pubmed.ncbi.nlm.nih.gov/36407327"},"language":"en","primary_location":{"id":"doi:10.3389/fdata.2022.1016606","doi":"https://doi.org/10.3389/fdata.2022.1016606","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdata.2022.1016606","pdf_url":null,"source":{"id":"https://openalex.org/S4210201220","display_name":"Frontiers in Big Data","issn_l":"2624-909X","issn":["2624-909X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Big Data","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fdata.2022.1016606","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086559814","display_name":"Thanh Minh Nguyen","orcid":"https://orcid.org/0000-0002-8440-1594","observed_orcids":["https://orcid.org/0000-0002-8440-1594"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thanh Nguyen","raw_affiliation_strings":["Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States","Informatics Institute in School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Informatics Institute in School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041167576","display_name":"Zongliang Yue","orcid":"https://orcid.org/0000-0001-8290-123X","observed_orcids":["https://orcid.org/0000-0001-8290-123X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zongliang Yue","raw_affiliation_strings":["Informatics Institute in School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Informatics Institute in School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075464588","display_name":"Radomir M. Slominski","orcid":"https://orcid.org/0000-0002-2929-1118","observed_orcids":["https://orcid.org/0000-0002-2929-1118"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Radomir Slominski","raw_affiliation_strings":["Informatics Institute in School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Informatics Institute in School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024947185","display_name":"Robert S. Welner","orcid":"https://orcid.org/0000-0003-2498-9469","observed_orcids":["https://orcid.org/0000-0003-2498-9469"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Welner","raw_affiliation_strings":["Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC), School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC), School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030985040","display_name":"Jianyi Jay Zhang","orcid":"https://orcid.org/0000-0002-3955-6554","observed_orcids":["https://orcid.org/0000-0002-3955-6554"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianyi Zhang","raw_affiliation_strings":["Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058469124","display_name":"Jake Y. Chen","orcid":"https://orcid.org/0000-0001-8829-7504","observed_orcids":["https://orcid.org/0000-0001-8829-7504","https://orcid.org/0009-0002-2151-9381","https://orcid.org/0000-0002-6112-415X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jake Y. Chen","raw_affiliation_strings":["Informatics Institute in School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Informatics Institute in School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058469124"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":1150,"currency":"USD","value_usd":1150},"apc_paid":{"value":1150,"currency":"USD","value_usd":1150},"fwci":0.4141,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.5116244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"5","issue":null,"first_page":"1016606","last_page":"1016606"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/network-biology","display_name":"network biology","score":0.7429999709129333},{"id":"https://openalex.org/keywords/gene-prioritization","display_name":"gene prioritization","score":0.8759999871253967},{"id":"https://openalex.org/keywords/network-based-inference","display_name":"network-based inference","score":0.5690000057220459},{"id":"https://openalex.org/keywords/guilt-by-association","display_name":"guilt by association","score":0.8460000157356262},{"id":"https://openalex.org/keywords/node-ranking","display_name":"node ranking","score":0.7369999885559082},{"id":"https://openalex.org/keywords/network-growth","display_name":"network expansion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/network-randomization","display_name":"network randomization","score":0.8709999918937683},{"id":"https://openalex.org/keywords/gene-networks","display_name":"gene networks","score":0.36500000953674316},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8389999866485596},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9639999866485596},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.7525185346603394},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5341595411300659},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.531938374042511},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4669089913368225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45891958475112915},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.40553587675094604},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2995164096355438},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.22224336862564087},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.1452886462211609},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.09098580479621887}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fdata.2022.1016606","doi":"https://doi.org/10.3389/fdata.2022.1016606","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdata.2022.1016606","pdf_url":null,"source":{"id":"https://openalex.org/S4210201220","display_name":"Frontiers in Big Data","issn_l":"2624-909X","issn":["2624-909X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Big Data","raw_type":"journal-article"},{"id":"pmid:36407327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36407327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in big data","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9672476","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9672476","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Big Data","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:afe593dc8c904998b61703c6ba34812d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/afe593dc8c904998b61703c6ba34812d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Big Data, Vol 5 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fdata.2022.1016606","doi":"https://doi.org/10.3389/fdata.2022.1016606","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdata.2022.1016606","pdf_url":null,"source":{"id":"https://openalex.org/S4210201220","display_name":"Frontiers in Big Data","issn_l":"2624-909X","issn":["2624-909X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Big Data","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.44999998807907104,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G300335665","display_name":null,"funder_award_id":"U54TR001005","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G491799376","display_name":null,"funder_award_id":"P01 HL160476)","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5340532724","display_name":null,"funder_award_id":"R01HL150078","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G9000347814","display_name":null,"funder_award_id":"U54TR001005","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000859519","display_name":"Mechanisms that Govern Cardiomyocyte Proliferation and Remuscularization following Ventricular Injury","funder_award_id":"5p01hl160476-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G913627488","display_name":"Role of bone marrow Tregs in maintaining stromal cell function","funder_award_id":"R01HL150078","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":151,"referenced_works":["https://openalex.org/W156645367","https://openalex.org/W1503899947","https://openalex.org/W1565180787","https://openalex.org/W1566952502","https://openalex.org/W1592868488","https://openalex.org/W1647856483","https://openalex.org/W1854214752","https://openalex.org/W1923336327","https://openalex.org/W1964698839","https://openalex.org/W1965302838","https://openalex.org/W1966519033","https://openalex.org/W1969038150","https://openalex.org/W1972233468","https://openalex.org/W1973144539","https://openalex.org/W1975685675","https://openalex.org/W1976569548","https://openalex.org/W1979958627","https://openalex.org/W1983007670","https://openalex.org/W1984581368","https://openalex.org/W1984828417","https://openalex.org/W1985531339","https://openalex.org/W1986657538","https://openalex.org/W1989172386","https://openalex.org/W2003516452","https://openalex.org/W2005431883","https://openalex.org/W2007339547","https://openalex.org/W2011041903","https://openalex.org/W2011849452","https://openalex.org/W2017274683","https://openalex.org/W2018276789","https://openalex.org/W2020755434","https://openalex.org/W2032143276","https://openalex.org/W2034368202","https://openalex.org/W2035005072","https://openalex.org/W2035847235","https://openalex.org/W2036565476","https://openalex.org/W2037250671","https://openalex.org/W2039402692","https://openalex.org/W2051616601","https://openalex.org/W2064492246","https://openalex.org/W2064790088","https://openalex.org/W2066325577","https://openalex.org/W2068537457","https://openalex.org/W2070448217","https://openalex.org/W2070734183","https://openalex.org/W2073654379","https://openalex.org/W2073944569","https://openalex.org/W2075897300","https://openalex.org/W2080240378","https://openalex.org/W2081375228","https://openalex.org/W2085934079","https://openalex.org/W2090247362","https://openalex.org/W2092247630","https://openalex.org/W2094155177","https://openalex.org/W2096173332","https://openalex.org/W2097789418","https://openalex.org/W2098898117","https://openalex.org/W2102992354","https://openalex.org/W2103478816","https://openalex.org/W2104406447","https://openalex.org/W2104622981","https://openalex.org/W2105984192","https://openalex.org/W2107427447","https://openalex.org/W2109506073","https://openalex.org/W2109555487","https://openalex.org/W2110553827","https://openalex.org/W2111030344","https://openalex.org/W2112099582","https://openalex.org/W2117179247","https://openalex.org/W2118607021","https://openalex.org/W2124649657","https://openalex.org/W2126282366","https://openalex.org/W2126536892","https://openalex.org/W2127603354","https://openalex.org/W2130410032","https://openalex.org/W2130473558","https://openalex.org/W2133465414","https://openalex.org/W2134526812","https://openalex.org/W2138906045","https://openalex.org/W2146925231","https://openalex.org/W2149492645","https://openalex.org/W2150729174","https://openalex.org/W2151936673","https://openalex.org/W2152602212","https://openalex.org/W2154755614","https://openalex.org/W2154897810","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2160198684","https://openalex.org/W2162067157","https://openalex.org/W2162143298","https://openalex.org/W2166267715","https://openalex.org/W2169456326","https://openalex.org/W2171437346","https://openalex.org/W2176829802","https://openalex.org/W2179438025","https://openalex.org/W2182678905","https://openalex.org/W2214074259","https://openalex.org/W2394951375","https://openalex.org/W2503772393","https://openalex.org/W2521110250","https://openalex.org/W2531294657","https://openalex.org/W2537623931","https://openalex.org/W2558411436","https://openalex.org/W2559588208","https://openalex.org/W2580398445","https://openalex.org/W2581573542","https://openalex.org/W2588469192","https://openalex.org/W2592729027","https://openalex.org/W2607153830","https://openalex.org/W2610537770","https://openalex.org/W2624021832","https://openalex.org/W2726239078","https://openalex.org/W2752299790","https://openalex.org/W2767701190","https://openalex.org/W2768074158","https://openalex.org/W2777149863","https://openalex.org/W2789374663","https://openalex.org/W2883350147","https://openalex.org/W2884217607","https://openalex.org/W2889924971","https://openalex.org/W2898788303","https://openalex.org/W2899478022","https://openalex.org/W2901212686","https://openalex.org/W2930902918","https://openalex.org/W2933399873","https://openalex.org/W2939514640","https://openalex.org/W2952128040","https://openalex.org/W2952700880","https://openalex.org/W2962756421","https://openalex.org/W2969263349","https://openalex.org/W2996448448","https://openalex.org/W3002587352","https://openalex.org/W3019964615","https://openalex.org/W3044467369","https://openalex.org/W3046889901","https://openalex.org/W3082522803","https://openalex.org/W3116876779","https://openalex.org/W3118594101","https://openalex.org/W3168198375","https://openalex.org/W3169730782","https://openalex.org/W4206965224","https://openalex.org/W4221031812","https://openalex.org/W4233120011","https://openalex.org/W4254466172","https://openalex.org/W4255324924","https://openalex.org/W4281642555","https://openalex.org/W4283796144","https://openalex.org/W4289253660","https://openalex.org/W4388290870","https://openalex.org/W6796005052"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Background":[0],"and":[1,68,89,105,167,279,292,317,334],"contribution":[2,185],"In":[3,285],"network":[4,103,110,162,192,209,222,235,330,340,372],"biology,":[5],"molecular":[6,70,101,168],"functions":[7],"can":[8,344],"be":[9],"characterized":[10],"by":[11,204,296,306],"network-based":[12],"inference,":[13],"or":[14,57,358],"\u201cguilt-by-associations.\u201d":[15],"PageRank-like":[16],"tools":[17],"have":[18,213],"been":[19],"applied":[20],"in":[21,37,49,72,123,200,207],"the":[22,31,38,97,113,124,130,150,158,179,184,190,196,220,247,263,290,329],"study":[23],"of":[24,34,46,99,132,139,153,164,183,186,198,219,246,265,354],"biomolecular":[25,87,160],"interaction":[26,102,161],"networks":[27,74],"to":[28,61,65,117,120,157,189,324,349],"obtain":[29],"further":[30],"relative":[32,180],"significance":[33,152,182],"all":[35,112,286],"molecules":[36,156,166,203],"network.":[39,125],"However,":[40],"there":[41,368],"is":[42,144,173,369],"a":[43,85,145,174,242,268,338,352],"great":[44],"deal":[45],"inherent":[47],"noise":[48],"widely":[50],"accessible":[51],"data":[52,79,104],"sets":[53],"for":[54],"gene-to-gene":[55],"associations":[56],"protein-protein":[58],"interactions.":[59,169],"How":[60],"develop":[62],"robust":[63],"tests":[64],"expand,":[66],"filter,":[67],"rank":[69],"entities":[71],"disease-specific":[73],"remains":[75],"an":[76,107],"ad":[77],"hoc":[78],"analysis":[80],"process.":[81],"Results":[82],"We":[83,194,212,261],"describe":[84],"new":[86,347],"characterization":[88],"prioritization":[90],"tool":[91,348],"calledWeightedIn-NetworkNodeExpansion":[92],"andRanking":[93],"(WINNER).":[94],"It":[95],"takes":[96],"input":[98],"any":[100],"generates":[106],"optionally":[108],"expanded":[109,291],"with":[111,232,252,267],"nodes":[114],"ranked":[115],"according":[116],"their":[118],"relevance":[119],"one":[121],"another":[122],"To":[126],"help":[127],"users":[128,343],"assess":[129],"robustness":[131,197],"results,":[133],"WINNER":[134,199,266,297,320,342],"provides":[135],"two":[136],"different":[137],"types":[138],"statistics.":[140],"The":[141,170],"first":[142],"type":[143,172],"node-expansionp-value,":[146],"which":[147,176,228],"helps":[148,177],"evaluate":[149,178,351],"statistical":[151,181],"adding":[154],"\u201cnon-seed\u201d":[155],"original":[159],"consisting":[163],"\u201cseed\u201d":[165],"second":[171],"node-rankingp-value,":[175],"each":[187],"node":[188,216,333],"overall":[191],"architecture.":[193],"validated":[195,240],"ranking":[201,226,321,326],"top":[202],"spiking":[205],"noises":[206],"several":[208],"permutation":[210],"experiments.":[211],"found":[214],"that":[215,241],"degree\u2013preservation":[217],"randomization":[218,236],"gene":[221,234,308],"produced":[223,360],"normally":[224],"distributed":[225],"scores,":[227],"outperform":[229],"those":[230,304],"made":[231],"other":[233,307,325],"techniques.":[237],"Furthermore,":[238],"we":[239],"more":[243,301],"significant":[244],"proportion":[245],"WINNER-ranked":[248],"genes":[249,294],"was":[250],"associated":[251],"disease":[253,299],"biology":[254,300,363],"than":[255,303],"existing":[256],"methods":[257,327],"such":[258],"as":[259,365,367],"PageRank.":[260],"demonstrated":[262],"performance":[264],"few":[269],"case":[270,288],"studies,":[271,289],"including":[272,312],"Alzheimer's":[273],"disease,":[274],"breast":[275,282],"cancer,":[276],"myocardial":[277],"infarctions,":[278],"Triple":[280],"negative":[281],"cancer":[283],"(TNBC).":[284],"these":[287],"top-ranked":[293],"identified":[295,305],"reveal":[298],"significantly":[302],"prioritizing":[309],"software":[310],"tools,":[311],"Ingenuity":[313],"Pathway":[314],"Analysis":[315],"(IPA)":[316],"DiAMOND.":[318],"Conclusion":[319],"strongly":[322],"correlates":[323],"when":[328],"covers":[331],"sufficient":[332],"edge":[335],"information,":[336],"indicating":[337],"high":[339],"quality.":[341],"use":[345],"this":[346],"robustly":[350],"list":[353],"candidate":[355],"genes,":[356],"proteins,":[357],"metabolites":[359],"from":[361],"high-throughput":[362],"experiments,":[364],"long":[366],"available":[370],"gene/protein/metabolic":[371],"information.":[373]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
