{"id":"https://openalex.org/W4308335701","doi":"https://doi.org/10.31083/j.fbl2711301","title":"Antibody-Drug Conjugates Targeting Tumor-Specific Mucin Glycoepitopes","display_name":"Antibody-Drug Conjugates Targeting Tumor-Specific Mucin Glycoepitopes","publication_year":2022,"publication_date":"2022-11-04","ids":{"openalex":"https://openalex.org/W4308335701","doi":"https://doi.org/10.31083/j.fbl2711301","pmid":"https://pubmed.ncbi.nlm.nih.gov/36472102"},"language":"en","primary_location":{"id":"doi:10.31083/j.fbl2711301","doi":"https://doi.org/10.31083/j.fbl2711301","is_oa":true,"landing_page_url":"https://doi.org/10.31083/j.fbl2711301","pdf_url":"https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711301/pdf","source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711301/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022059549","display_name":"Julyanne Brassard","orcid":"https://orcid.org/0000-0001-9093-674X","observed_orcids":["https://orcid.org/0000-0001-9093-674X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julyanne Brassard","raw_affiliation_strings":["School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106479385","display_name":"Michael R. Hughes","orcid":"https://orcid.org/0000-0002-7925-6070","observed_orcids":["https://orcid.org/0000-0002-7925-6070"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael R. Hughes","raw_affiliation_strings":["School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106175032","display_name":"Calvin D. Roskelley","orcid":"https://orcid.org/0000-0003-0939-8900","observed_orcids":["https://orcid.org/0000-0003-0939-8900"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Calvin D. Roskelley","raw_affiliation_strings":["Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041571580","display_name":"Kelly Marshall McNagny","orcid":"https://orcid.org/0000-0003-4737-3499","observed_orcids":["https://orcid.org/0000-0003-4737-3499"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Kelly M. McNagny","raw_affiliation_strings":["School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041571580"],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.6905,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.63705108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"11","first_page":"301","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":1.0},{"id":"https://openalex.org/keywords/mucin","display_name":"mucin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/podocalyxin","display_name":"podocalyxin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.996999979019165},{"id":"https://openalex.org/keywords/muc5ac","display_name":"MUC5AC","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7310793399810791},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.728854238986969},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.6331185698509216},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.5368561744689941},{"id":"https://openalex.org/C2777421810","wikidata":"https://www.wikidata.org/wiki/Q21145188","display_name":"MUC1","level":3,"score":0.5266836881637573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5171846151351929},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5052943825721741},{"id":"https://openalex.org/C106686826","wikidata":"https://www.wikidata.org/wiki/Q741206","display_name":"Glycomics","level":4,"score":0.4813552498817444},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4164649546146393},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.4096033573150635},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.38171663880348206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38025474548339844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3571433126926422},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24011868238449097},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.22493809461593628},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21217894554138184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15446066856384277}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.31083/j.fbl2711301","doi":"https://doi.org/10.31083/j.fbl2711301","is_oa":true,"landing_page_url":"https://doi.org/10.31083/j.fbl2711301","pdf_url":"https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711301/pdf","source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},{"id":"pmid:36472102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36472102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioscience (Landmark edition)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:71d9ca3fa2974276880422fd0d88c864","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/71d9ca3fa2974276880422fd0d88c864","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioscience-Landmark, Vol 27, Iss 11, p 301 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.31083/j.fbl2711301","doi":"https://doi.org/10.31083/j.fbl2711301","is_oa":true,"landing_page_url":"https://doi.org/10.31083/j.fbl2711301","pdf_url":"https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711301/pdf","source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4725276726","display_name":null,"funder_award_id":"PJT- 166180","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320319965","display_name":"Michael Smith Health Research BC","ror":"https://ror.org/020x39229"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308335701.pdf","grobid_xml":"https://content.openalex.org/works/W4308335701.grobid-xml"},"referenced_works_count":123,"referenced_works":["https://openalex.org/W28705092","https://openalex.org/W107353983","https://openalex.org/W197316820","https://openalex.org/W935079945","https://openalex.org/W1182461782","https://openalex.org/W1549382023","https://openalex.org/W1549835226","https://openalex.org/W1559594348","https://openalex.org/W1563109378","https://openalex.org/W1832002274","https://openalex.org/W1902656581","https://openalex.org/W1955152276","https://openalex.org/W1967796432","https://openalex.org/W1975303054","https://openalex.org/W1977301054","https://openalex.org/W1978739865","https://openalex.org/W1985355087","https://openalex.org/W1987220212","https://openalex.org/W1994218552","https://openalex.org/W1995611890","https://openalex.org/W1996344455","https://openalex.org/W1997526159","https://openalex.org/W1998022379","https://openalex.org/W2000228858","https://openalex.org/W2006604518","https://openalex.org/W2010427283","https://openalex.org/W2019338014","https://openalex.org/W2021953032","https://openalex.org/W2022215700","https://openalex.org/W2022216962","https://openalex.org/W2027461800","https://openalex.org/W2033958784","https://openalex.org/W2034609970","https://openalex.org/W2037412915","https://openalex.org/W2038722446","https://openalex.org/W2038933154","https://openalex.org/W2041417541","https://openalex.org/W2044434705","https://openalex.org/W2046737947","https://openalex.org/W2047317128","https://openalex.org/W2048448616","https://openalex.org/W2052278606","https://openalex.org/W2060356198","https://openalex.org/W2062777788","https://openalex.org/W2064497459","https://openalex.org/W2076190156","https://openalex.org/W2085212074","https://openalex.org/W2086139797","https://openalex.org/W2086160302","https://openalex.org/W2087392940","https://openalex.org/W2095643532","https://openalex.org/W2100925219","https://openalex.org/W2102719470","https://openalex.org/W2104722177","https://openalex.org/W2105978645","https://openalex.org/W2109120895","https://openalex.org/W2109937431","https://openalex.org/W2111178763","https://openalex.org/W2113624094","https://openalex.org/W2121080375","https://openalex.org/W2123823400","https://openalex.org/W2124476281","https://openalex.org/W2131885678","https://openalex.org/W2137548222","https://openalex.org/W2139761471","https://openalex.org/W2143338611","https://openalex.org/W2150173080","https://openalex.org/W2154305402","https://openalex.org/W2159098596","https://openalex.org/W2170257687","https://openalex.org/W2244035233","https://openalex.org/W2249448939","https://openalex.org/W2260740467","https://openalex.org/W2268378753","https://openalex.org/W2315322079","https://openalex.org/W2331319236","https://openalex.org/W2403210488","https://openalex.org/W2412744232","https://openalex.org/W2484253333","https://openalex.org/W2528617158","https://openalex.org/W2547539304","https://openalex.org/W2555191434","https://openalex.org/W2632900143","https://openalex.org/W2746254865","https://openalex.org/W2765851819","https://openalex.org/W2769426045","https://openalex.org/W2783146090","https://openalex.org/W2793280487","https://openalex.org/W2795265373","https://openalex.org/W2804732351","https://openalex.org/W2805306682","https://openalex.org/W2806672295","https://openalex.org/W2807830322","https://openalex.org/W2883329981","https://openalex.org/W2887786763","https://openalex.org/W2909520791","https://openalex.org/W2909703266","https://openalex.org/W2912891382","https://openalex.org/W2951071083","https://openalex.org/W2995730973","https://openalex.org/W3016513720","https://openalex.org/W3018468001","https://openalex.org/W3025417971","https://openalex.org/W3027143183","https://openalex.org/W3036675924","https://openalex.org/W3093537091","https://openalex.org/W3108323391","https://openalex.org/W3116046341","https://openalex.org/W3128485166","https://openalex.org/W3128646645","https://openalex.org/W3167038561","https://openalex.org/W3169689826","https://openalex.org/W3201634689","https://openalex.org/W3204317968","https://openalex.org/W4200277285","https://openalex.org/W4200296775","https://openalex.org/W4206719507","https://openalex.org/W4210399538","https://openalex.org/W4220847494","https://openalex.org/W4223962346","https://openalex.org/W4225415108","https://openalex.org/W4235277799","https://openalex.org/W4283313052"],"related_works":["https://openalex.org/W2593281753","https://openalex.org/W2344851944","https://openalex.org/W2060705043","https://openalex.org/W4307946532","https://openalex.org/W4386770953","https://openalex.org/W2088202934","https://openalex.org/W2094438822","https://openalex.org/W1984245894","https://openalex.org/W2046553400","https://openalex.org/W1987386449"],"abstract_inverted_index":{"Finding":[0],"the":[1,11,52],"ideal":[2,73,99],"epitope":[3,30],"to":[4,22,34,51,59,150,156],"target":[5],"is":[6],"a":[7],"key":[8],"element":[9],"for":[10,101,138],"development":[12],"of":[13,54,75,86],"an":[14],"antibody-drug":[15],"conjugate":[16],"(ADC).":[17],"To":[18],"maximize":[19],"drug":[20],"delivery":[21],"tumor":[23],"cells":[24,36],"and":[25,37,105,111,125,153,160],"reduce":[26],"side":[27],"effects,":[28],"this":[29,79],"should":[31],"be":[32],"specific":[33],"cancer":[35,43,60,152],"spare":[38],"all":[39],"normal":[40],"tissue.":[41],"During":[42],"progression,":[44],"glycosylation":[45,56],"pathways":[46],"are":[47,63,89],"frequently":[48,67],"altered":[49,76],"leading":[50],"generation":[53],"new":[55],"patterns":[57],"selective":[58],"cells.":[61],"Mucins":[62],"highly":[64],"glycosylated":[65],"proteins":[66],"expressed":[68,119,130],"on":[69,120,131],"tumors":[70],"and,":[71,95],"thus,":[72],"presenters":[74],"glycoepitopes.":[77,107],"In":[78],"review,":[80],"we":[81,142],"describe":[82],"three":[83],"different":[84],"types":[85],"glycoepitopes":[87,118,129],"that":[88],"recognized":[90],"by":[91],"monoclonal":[92],"antibodies":[93],"(mAb)":[94],"therefore,":[96],"serve":[97],"as":[98,135],"scaffolds":[100],"ADC;":[102],"glycan-only,":[103],"glycopeptide":[104],"shielded-peptide":[106],"We":[108],"review":[109],"pre-clinical":[110],"clinical":[112],"results":[113],"obtained":[114],"with":[115],"ADCs":[116,149],"targeting":[117,128],"MUC1":[121],"or":[122,133],"podocalyxin":[123],"(Podxl)":[124],"two":[126],"mAbs":[127],"MUC16":[132],"MUC5AC":[134],"potential":[136],"candidates":[137],"ADC":[139],"development.":[140],"Finally,":[141],"discuss":[143],"current":[144],"limits":[145],"in":[146],"using":[147],"glycoepitope-targeting":[148],"treat":[151],"propose":[154],"methods":[155],"improve":[157],"their":[158],"efficacy":[159],"specificity.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}