{"id":"https://openalex.org/W4308334532","doi":"https://doi.org/10.3389/fphar.2022.989169","title":"Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts","display_name":"Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts","publication_year":2022,"publication_date":"2022-11-03","ids":{"openalex":"https://openalex.org/W4308334532","doi":"https://doi.org/10.3389/fphar.2022.989169","pmid":"https://pubmed.ncbi.nlm.nih.gov/36408252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9673045"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2022.989169","doi":"https://doi.org/10.3389/fphar.2022.989169","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.989169","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4308334532"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2022.989169","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042109589","display_name":"Kaj E. C. Blokland","orcid":"https://orcid.org/0000-0002-1807-6359","observed_orcids":["https://orcid.org/0000-0002-1807-6359"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU","NL"],"is_corresponding":false,"raw_author_name":"Kaj E.C. Blokland","raw_affiliation_strings":["National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis, Sydney, NSW, Australia","University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, NSW, Australia","University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I42131985"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, NSW, Australia","institution_ids":["https://openalex.org/I78757542"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026691687","display_name":"Mehmet Nizamoglu","orcid":"https://orcid.org/0000-0002-3663-4107","observed_orcids":["https://orcid.org/0000-0002-3663-4107"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mehmet Nizamoglu","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103012905","display_name":"Habibie Habibie","orcid":"https://orcid.org/0000-0001-8547-5571","observed_orcids":["https://orcid.org/0000-0001-8547-5571"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I98301867","display_name":"Hasanuddin University","ror":"https://ror.org/00da1gf19","country_code":"ID","type":"education","lineage":["https://openalex.org/I98301867"]}],"countries":["ID","NL"],"is_corresponding":false,"raw_author_name":"Habibie Habibie","raw_affiliation_strings":["Hasanuddin University, Faculty of Pharmacy, Makassar, Indonesia","University of Groningen, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hasanuddin University, Faculty of Pharmacy, Makassar, Indonesia","institution_ids":["https://openalex.org/I98301867"]},{"raw_affiliation_string":"University of Groningen, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Groningen, the Netherlands","institution_ids":["https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063717190","display_name":"Theo Borghuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Theo Borghuis","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014959455","display_name":"Michael J. Schuliga","orcid":"https://orcid.org/0000-0001-6742-5028","observed_orcids":["https://orcid.org/0000-0001-6742-5028"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Schuliga","raw_affiliation_strings":["University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, NSW, Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090741922","display_name":"Barbro N. Melgert","orcid":"https://orcid.org/0000-0001-7091-907X","observed_orcids":["https://orcid.org/0000-0001-7091-907X"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Barbro N. Melgert","raw_affiliation_strings":["University of Groningen, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","University of Groningen, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Groningen, Netherlands","University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Groningen, the Netherlands","institution_ids":["https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Groningen, Netherlands","institution_ids":["https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030526109","display_name":"Darryl A. Knight","orcid":"https://orcid.org/0000-0002-4064-6127","observed_orcids":["https://orcid.org/0000-0002-4064-6127"]},"institutions":[{"id":"https://openalex.org/I4210133496","display_name":"Providence Health Care Research Institute","ror":"https://ror.org/04b2d5d26","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210133496"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU","CA"],"is_corresponding":false,"raw_author_name":"Darryl A. Knight","raw_affiliation_strings":["National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis, Sydney, NSW, Australia","Providence Health Care Research Institute, Vancouver, BC, Canada","University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I42131985"]},{"raw_affiliation_string":"Providence Health Care Research Institute, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I4210133496"]},{"raw_affiliation_string":"University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, NSW, Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084790572","display_name":"Corry\u2010Anke Brandsma","orcid":"https://orcid.org/0000-0001-8911-3658","observed_orcids":["https://orcid.org/0000-0001-8911-3658"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Corry-Anke Brandsma","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017204183","display_name":"Simon D. Pouwels","orcid":"https://orcid.org/0000-0001-7345-8061","observed_orcids":["https://orcid.org/0000-0001-7345-8061"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Simon D. Pouwels","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072324055","display_name":"Janette Kay Burgess","orcid":"https://orcid.org/0000-0001-9868-9966","observed_orcids":["https://orcid.org/0000-0001-9868-9966"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Janette K. Burgess","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072324055"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":3.1745,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.93418454,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"13","issue":null,"first_page":"989169","last_page":"989169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.18960000574588776,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substrate-stiffness","display_name":"substrate stiffness","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.781000018119812},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9330000281333923},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.8880000114440918},{"id":"https://openalex.org/keywords/extracellular-matrix-stiffness","display_name":"extracellular matrix stiffness","score":0.6710000038146973},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.7409999966621399},{"id":"https://openalex.org/keywords/yap-nuclear-translocation","display_name":"YAP nuclear translocation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9139999747276306},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.9240000247955322},{"id":"https://openalex.org/keywords/decorin","display_name":"decorin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/fibulin-1","display_name":"fibulin-1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.7402563095092773},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7320850491523743},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.651397705078125},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.6373440623283386},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5529862642288208},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5265707969665527},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5170150995254517},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.512287974357605},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.4783896207809448},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.47237685322761536},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.448022723197937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43165791034698486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3666417896747589},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3603687882423401},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3491663932800293},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30655115842819214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22330015897750854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12448927760124207},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10875454545021057},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.09560856223106384}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.3389/fphar.2022.989169","doi":"https://doi.org/10.3389/fphar.2022.989169","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.989169","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"doi:10.1101/2022.09.27.509806","doi":"https://doi.org/10.1101/2022.09.27.509806","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.09.27.509806","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/09/28/2022.09.27.509806.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:36408252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36408252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9673045","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9673045/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:db3ba90f7fe2417081a0e39944672a7b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/db3ba90f7fe2417081a0e39944672a7b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 13 (2022)","raw_type":"article"},{"id":"pmh:oai:pure.rug.nl:openaire/8243e68e-b933-4f9f-865c-9aadc06e853a","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/8243e68e-b933-4f9f-865c-9aadc06e853a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blokland, K E C, Nizamoglu, M, Habibie, H, Borghuis, T, Schuliga, M, Melgert, B N, Knight, D A, Brandsma, C-A, Pouwels, S D & Burgess, J K 2022, 'Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts', Frontiers in Pharmacology, vol. 13, 989169. https://doi.org/10.3389/fphar.2022.989169","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/659651ba-935d-491f-b324-659e19b3a8ec","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/659651ba-935d-491f-b324-659e19b3a8ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, 13:989169. Frontiers Media SA","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/8243e68e-b933-4f9f-865c-9aadc06e853a","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/8243e68e-b933-4f9f-865c-9aadc06e853a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, 13:989169. Frontiers Media SA","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uon:54219","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.13/1496712","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2022.989169","doi":"https://doi.org/10.3389/fphar.2022.989169","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.989169","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G979479477","display_name":null,"funder_award_id":"015.013.010.","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320316301","display_name":"Stichting De Cock-Hadders","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320933","display_name":"Rijksuniversiteit Groningen","ror":"https://ror.org/012p63287"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320323105","display_name":"Universitair Medisch Centrum Groningen","ror":"https://ror.org/03cv38k47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308334532.pdf","grobid_xml":"https://content.openalex.org/works/W4308334532.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W201653061","https://openalex.org/W1914659192","https://openalex.org/W1965498876","https://openalex.org/W1966553422","https://openalex.org/W1968922109","https://openalex.org/W1969049128","https://openalex.org/W1971010914","https://openalex.org/W2008132884","https://openalex.org/W2022215414","https://openalex.org/W2023463621","https://openalex.org/W2028169108","https://openalex.org/W2029378715","https://openalex.org/W2034568094","https://openalex.org/W2049133415","https://openalex.org/W2049528194","https://openalex.org/W2058738554","https://openalex.org/W2060299760","https://openalex.org/W2062461864","https://openalex.org/W2063140011","https://openalex.org/W2069790486","https://openalex.org/W2090285054","https://openalex.org/W2099540110","https://openalex.org/W2099709490","https://openalex.org/W2109995938","https://openalex.org/W2115852450","https://openalex.org/W2116043657","https://openalex.org/W2119419588","https://openalex.org/W2136581706","https://openalex.org/W2142162781","https://openalex.org/W2146337514","https://openalex.org/W2159731793","https://openalex.org/W2168072233","https://openalex.org/W2172237567","https://openalex.org/W2174788854","https://openalex.org/W2174936856","https://openalex.org/W2194995105","https://openalex.org/W2215128587","https://openalex.org/W2232971833","https://openalex.org/W2270498673","https://openalex.org/W2325590978","https://openalex.org/W2418260809","https://openalex.org/W2476542314","https://openalex.org/W2521465081","https://openalex.org/W2532869369","https://openalex.org/W2570320388","https://openalex.org/W2591114726","https://openalex.org/W2604477713","https://openalex.org/W2616087011","https://openalex.org/W2616658238","https://openalex.org/W2626192157","https://openalex.org/W2774226220","https://openalex.org/W2780599674","https://openalex.org/W2781527068","https://openalex.org/W2781657596","https://openalex.org/W2789483929","https://openalex.org/W2790455901","https://openalex.org/W2796781649","https://openalex.org/W2797060729","https://openalex.org/W2803205456","https://openalex.org/W2807045479","https://openalex.org/W2893710395","https://openalex.org/W2903757646","https://openalex.org/W2905016282","https://openalex.org/W2907894059","https://openalex.org/W2943185211","https://openalex.org/W2945041648","https://openalex.org/W2954445592","https://openalex.org/W2963945351","https://openalex.org/W2973157401","https://openalex.org/W2999282204","https://openalex.org/W3005652542","https://openalex.org/W3005768133","https://openalex.org/W3007491771","https://openalex.org/W3007823736","https://openalex.org/W3016279539","https://openalex.org/W3018118152","https://openalex.org/W3031389212","https://openalex.org/W3038398201","https://openalex.org/W3080362910","https://openalex.org/W3081182549","https://openalex.org/W3091982350","https://openalex.org/W3093182793","https://openalex.org/W3093594666","https://openalex.org/W3109155975","https://openalex.org/W3124524401","https://openalex.org/W3128846620","https://openalex.org/W3196897371","https://openalex.org/W3210407595","https://openalex.org/W4413138615"],"related_works":["https://openalex.org/W3175681161","https://openalex.org/W7161566759","https://openalex.org/W4406549188","https://openalex.org/W6925191249","https://openalex.org/W4409285669","https://openalex.org/W4225329996","https://openalex.org/W3192758820","https://openalex.org/W4387965170","https://openalex.org/W2794340792","https://openalex.org/W7066061457"],"abstract_inverted_index":{"In":[0],"fibrosis":[1,33,72,111],"remodelling":[2],"of":[3,69,99,141,144,190,218,232,237,250,262],"ECM":[4,47],"leads":[5],"to":[6,45,56,104,128,175,185,221,247],"changes":[7,13,44],"in":[8,73,153],"composition":[9,50],"and":[10,26,39,51,86,110,165,202,205,226,235],"stiffness.":[11],"Such":[12],"can":[14],"have":[15,30],"a":[16,251,257,263],"major":[17],"impact":[18],"on":[19,97,115,170,181],"cell":[20],"functions":[21],"including":[22,48],"proliferation,":[23],"secretory":[24,240],"profile":[25],"differentiation.":[27],"Several":[28],"studies":[29],"reported":[31],"that":[32,43,82,216,229],"is":[34],"characterised":[35],"by":[36],"increased":[37,52,64],"senescence":[38,70,109],"accumulating":[40],"evidence":[41],"suggests":[42],"the":[46,238,248],"altered":[49],"stiffness":[53,65,223],"may":[54,245],"contribute":[55,246],"premature":[57],"cellular":[58],"senescence.":[59],"This":[60,243],"study":[61],"investigated":[62],"if":[63],"could":[66],"modulate":[67],"markers":[68],"and/or":[71],"primary":[74,91],"human":[75],"lung":[76,95,219],"fibroblasts.":[77],"Using":[78],"hydrogels":[79,101,119,183],"representing":[80],"stiffnesses":[81],"fall":[83],"within":[84],"healthy":[85],"fibrotic":[87,222,233,264],"ranges,":[88],"we":[89,136],"cultured":[90,114],"fibroblasts":[92,180,220,255],"from":[93],"non-diseased":[94],"tissue":[96,160],"top":[98],"these":[100],"for":[102],"up":[103],"7":[105,211],"days":[106],"before":[107],"assessing":[108],"markers.":[112],"Fibroblasts":[113],"stiffer":[116,171,182],"(\u00b115":[117],"kPa)":[118],"showed":[120],"higher":[121,139,166,188,206],"Yes-associated":[122],"protein-1":[123],"(YAP)":[124],"nuclear":[125,145],"translocation":[126],"compared":[127,184],"soft":[129,186],"hydrogels.":[130],"When":[131],"looking":[132],"at":[133],"senescence-associated":[134],"proteins":[135],"also":[137],"found":[138],"secretion":[140],"receptor":[142],"activator":[143],"factor":[146,162],"kappa-B":[147],"ligand":[148],"(RANKL)":[149],"but":[150],"no":[151],"change":[152],"transforming":[154],"growth":[155,161],"factor-\u03b21":[156],"(TGF-\u03b21)":[157],"or":[158],"connective":[159],"(CTGF)":[163],"expression":[164,189],"decorin":[167],"protein":[168,208],"deposition":[169,209],"matrices.":[172],"With":[173],"respect":[174],"genes":[176,225],"associated":[177],"with":[178],"fibrosis,":[179],"had":[187],"smooth":[191],"muscle":[192],"alpha":[193],"(\u03b1)-2":[194],"actin":[195],"(":[196],"ACTA2)":[197],",":[198],"collagen":[199],"(COL)":[200],"1A1":[201],"fibulin-1":[203],"(Fbln1)":[204],"Fbln1":[207],"after":[210],"days.":[212],"Our":[213],"results":[214],"show":[215],"exposure":[217],"activates":[224],"secreted":[227],"factors":[228],"are":[230],"part":[231,236],"responses":[234],"Senescence-associated":[239],"phenotype":[241],"(SASP).":[242],"overlap":[244],"creation":[249],"feedback":[252],"loop":[253],"whereby":[254],"create":[256],"perpetuating":[258],"cycle":[259],"reinforcing":[260],"progression":[261],"response.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2022-11-11T00:00:00"}